This article takes a look at the top fat loss supplement ingredients, and shows you how to build your own fat burning stack or choose the best product for your needs. Before we delve into what supplements you should consider when building your own “fat-loss stack” it’s important to keep in mind that no amount of supplements will ever “do the work for you” or make up for poor dietary habits and lack of exercise. Therefore, the supplements analyzed herein should be used in conjunction with proper exercise and diet, not as a replacement for those lifestyle factors.
When to take— As a starting point (and to assess your tolerance), try taking caffeine on an empty stomach about an hour before training. How it works—Research seems to suggest that, when taken pre-exercise, yohimbine enhances lipolytic (fat releasing) activity via blockade of alpha-2 adrenergic receptors in adipocytes and stimulation of catecholamine release. How much to take—As with caffeine, yohimbine intake needs to be carefully monitored so as not to overdo things. When to take—It is preferable to take yohimbine about 20-30 minutes pre-exercise (especially cardiovascular activity) and on an empty stomach. Synephrine is another stimulant compound extracted primarily from Citrus aurantium tree leaves (and is also found in trace quantities in orange-derived food products). How it works—It appears that synephrine works primarily through stimulation of beta-adrenergic receptors, thereby increasing concentrations of catecholamines in the blood which in turn activate lipolysis in adipocytes. How much to take—Synephrine should be taken in quantities quite similar to that of yohimbine.
When to take—Since synephrine appears to enhance lipolysis primarily by agonism of beta-adrenergic receptors, this should preferably be taken prior to exercise (say 30-60 minutes preworkout). How it works—Research supports that the mechanism for increased metabolic expenditure after ingestion of capsaicin is based on beta-adrenergic stimulation.
When to take—It is generally preferred to take capsaicin with meals since it may cause gastric irritation on an empty stomach; if you can tolerate otherwise than feel free to dose it at other times.
Green tea extract has become a common ingredient in many fat-burning products mainly due to its ability to raise caloric expenditure (similar to that of capsaicin). How it works—Epigallocatechin gallate acts as an inhibitor of the enzyme catechol-O-methyl transferase, which serves to breakdown catecholamines. How much to take—This will depend on the concentration of EGCG provided by the green tea extract you use.
PQQ is a natural compound contained in quinoproteins (often found in bacteria), and is primarily retrieved from fermented soybeans. How it works—PQQ acts as a cellular messenger mimicking some of the most fundamental effects of exercise, ultimately increasing the body’s natural production of the hormone Irisin.
How much to take—Placebo-controlled safety studies in humans show the consumption of PQQ at 20mg and 60mg per day is effective and safe.


When to take—Timing of PQQ is not too important since its effects are somewhat latent and develop after continual use has been established. How it works—As with other catecholamine inducers, RK has been shown to significantly increase norepinephrine-induced lipolysis in white adipose tissue.
How much to take—Typical doses for RK range from 200-400mg per day (divided into at least two doses).
When to take— It is suggested to take raspberry ketone twice per day, with one of those servings preferably 30-60 minutes before working out. Now that we have covered some of the more potent fat-burning agents on the supplement market, we can now put the above information to good use and provide some sample supplement stacks to help you achieve the body you want. Bear in mind these are just templates, be creative and use the information in this guide to help you build your own personal fat-loss supplement stack!
Currently, some of these ingredients are not available “in bulk” or as standalones in the Muscle & Strength Supplement store.
Nutrex Lipo-6 Black – Contains caffeine, synephrine, yohimbine and a few other ingredients. MuscleTech HydroxyCut Hardcore Elite – Has caffeine, yohimbine and some other notable fat-burning ingredients that are not part of this guide. MusclePharm Shred Matrix – Contains caffeine, yohimbine, EGCG, capsaicin, and a few other compounds not discussed herein. VPX Meltdown – Similar in composition to Lipo-6 Black with the addition of a few other compounds.
Again, the options are really limitless, so use the info in this guide to find the fat-loss stack that suits you best!
2013 y?l?nda 87 kilo ile baslad?g? diyette bir y?lda 20 kilo vererek 67 kilo olmay? basard?.
This comes as no surprise given that most people starting an exercise routine are generally looking to lose body-fat and improve their body composition. For efficacy, it is recommended that you first and foremost get your nutrition and training regimen on track before spending money on fat-burning supplements. Since cAMP and cGMP are crucial messengers in cell signal transduction, the metabolic processes in the cell are sent into “overdrive” after the ingestion of PDE inhibitors. This elevation in calorie expenditure can further be bolstered by caffeine’s promotion of catecholamine activity. If you prefer to take caffeine with a meal, give yourself a bit more time before hitting the gym. It is an antagonist of alpha-2 adrenergic receptors and acts as a monoamine oxidase inhibitor (MAOI).


Literature has supported the finding that capsaicin acts to increase metabolic expenditure. The primary constituent in green tea leaves responsible for this metabolic effect is the antioxidant epigallocathechin gallate (EGCG). Therefore, ingestion of EGCG enhances the activity of neurotransmitters like dopamine and epinephrine, which positively effects fat burning.
The most intriguing finding behind PQQ thus far is that it acts to create new mitochondria in cells (a process referred to as mitochondrial biogenesis).
In humans, Irisin release can be considered one of the most important effects of physical activity, as circulating Irisin levels are negatively correlated with age, insulin, cholesterol, and adiponectin and positively correlated with fat free mass and ghrelin. However, Muscle & Strength carries a plethora of products that contain most of these ingredients. Also contains all the other ingredients in this guide besides yohimbine, synephrine, and raspberry ketone.
So for example, you could purchase Haleo OnPoint and then buy yohimbine, synephrine, and raspberry ketone separately. If you find your performance in the gym is indeed bolstered after caffeine ingestion, than there is little reason to alter your approach.
Dose response effects of a caffeine-containing energy drink on muscle performance: a repeated measures design. However, eating large amounts of hot peppers to reach nominal doses of capsacinoids is impractical due to gastric irritation and other digestive qualms. Effects of red-pepper diet on the energy metabolism in men.Journal of nutritional science and vitaminology, 41(6), 647. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta?analysis. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis.Medical hypotheses, 58(6), 491-495. Caffeine lowers perceptual response and increases power output during high-intensity cycling. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance. The major green tea polyphenol,(-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat–fed mice.



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