Iodine induces apoptosis and inhibits cells from forming cancer, esophageal varicose Orthoiodosupplementation in a Primary Care PracticeJorge D. My medical practice is situated in the Appalachian Mountains close to Asheville, North Carolina.
One inch of ice in 3 days !!!It wasreal windy most of the day and I spent more time in the EskimoQuick Fish 3.The two holes in the shelter provided some steady action for perch and bluegills.
One of the major problems that we encounter in this location is a problem with hypothyroidism. The death lull kicked in around1230 and fishing picked back up again at 3pm.I landed the usual residents of the lake-- a few trout, afew nice crappies, perch and gills. Both of these studies were done at separate times by separate groups showing the exact number of 11.7%. This reinforces what we were taught, that iodine deficiency goes hand in hand with the manifestation of hypothyroidism.
I have on a weekly basis at least one phone call from a healthcare practitioner questioning whether the intake of iodine causes hypothyroidism and goiter. Plenty ofpanfish with a few perch hitting the 9-inch mark and a crappie thatwas almost 10 inches.I caught trout sporadically throughout the day, ending with 9. I often have to go back over the basics of thyroid physiology with these healthcare practitioners, and explain to them that iodine is essential for normal thyroid functions and that it is the manmade organic forms of iodine that are toxic (3). I have been using iodine supplementation in my practice over the last four years in amounts needed for whole body sufficiency (orthoiodosupplementation).
Orthoiodosupplementation is the daily amount of iodine required for whole body sufficiency (3-5). Prior to implementing orthoiodosupplementation, I perform a complete history and physical examination. If a mass is picked up on physical then another test that I order is an ultrasound of the thyroid. While undergoing ultrasound to evaluate the mass I will have my technician measure the thyroid volume.
Each lobe will have its length measured in centimeters, width measured in centimeters and height measured in centimeters. All three measurements are multiplied times each other and this gives the volume in cubic centimeters.
A volume size of 5 cc or less is suggestive of thyroid atrophy, another manifestation of iodine deficiency. Any solid mass that is picked up on ultrasound and shows itself to be greater in size than one centimeter by one centimeter will require a radioactive I-123 uptake and scan. This test should be done previous to starting any patient on iodine if a nodule is suspected. A nodule that does not pick up radioactive iodide is considered to be a cold nodule and would suggest the presence of thyroid cancer. Teddy told me the lake is completed covered and the ice might be about 1 inch orso.Teddy has patrolled and lived next toAntietam Lakealmostall his life and he knows the lake. Malignant tumors derived from the follicular epithelium are classified according to histological features.
The incidence of thyroid cancer is approximately nine per 100,000 in the population per year and this usually increases with age plateau after about age 50. Thyroid cancer at a young age (less than 20) or in older people (greater than 65) is usually associated with a worse prognosis. Additional important risk factors include a history of childhood head or neck irradiation, large nodule size greater than four centimeters, evidence for local tumor fixation or invasion into lymph nodes, and the presence of metastasis.
In my small practice of around 5,000 patients, I have found five thyroid cancers in one year. If multiple nodules of the thyroid gland are found at the time of ultrasound then the diagnosis of multinodular thyroid goiter is considered even if the gland is normal in size. I request serum T4 (the main hormone produced by the thyroid), free T3 (the biologically active thyroid hormone at the cellular level) and a thyroid stimulating hormone (TSH) level. Following orthoiodosupplementation, serum T4 and TSH levels usually go down and free T3 stays steady. I have seen TSH sometimes go up rather than down while T4 and free T3 did not change or may have gone up some. This does not mean that the patient was developing hypothyroidism but that the brain was stimulating the body to make more sodium iodide symporters (NIS). The NIS are channels in the cell membrane that transport atoms into a cell as compared to a calcium channel or a sodium channel or a chloride channel where the channel only admits one atom to go through. The NIS transports sodium iodide into cells and has been found in all cell lines tested so far. Thyroid stimulating hormone, prolactin and oxytocin have been found to stimulate the making of NIS. While taking iodide, one may see an elevated TSH but we have to recognize that this is not a bad thing. Often a check of the patient’s T4, free T3 and TSH shows the T4 to go down, free T3 going down and TSH going up.
The nutritional status of the patient will determine its response to orthoiodosupplementation (3). It is crucial that the thyroid gland has plenty of antioxidants in its cells and many other nutrients. We have found that giving a multivitamin for women with PMS (Optivitea ) improves the response to orthoiodosupplementation. There isplenty of rainfall predicted for that area.Most of the fish sitting in the estuary should be entering the river as I type this.
Iodine deficiency causes fibrocystic breast disease (FBD) with nodules, cyst enlargement, pain and scar tissue. Initially, this syndrome occurs in the premenstrual phase of a cycle or involves the whole cycle. Anglers tend to give you space, the scenery is beautiful and the Osprey's always put on a show.
In 1928 an autopsy series reported a three percent incidence of FBD, whereas in 1973 an autopsy report quoted an 89% incidence. A review by the American Academy of Pathology gives a minimum incidence for FBD of 50% but suggests that 80% of North American women are afflicted with the syndrome during their reproductive lifetime. He was able to develop a protocol and a scoring system that helps doctors assess how severe a woman’s FBD is. I would recommend that this scoring system be utilized by physicians in their own medical practice.
A precise method of recording the patient’s data will help both physicians and patients see the improvement that occurs following orthoiodosupplementation.
The pathological changes that can occur in FBD are noted as micronodularity, tenderness, fibrous tissue plaques, macrocysts and turgidity. Wednesday was spent in the upper fly zone and wasslow in the morning but pretty consistent in the afternoon.
For example if the micro nodularity of macrocysts disease was present in the upper half of the breasts the numerical score would be one for micro nodularity and two for the two breast quadrants scoring a total of three. If all five changes occurred in all quadrants in one breast the score would be 4 (all four breast quadrants) x5 (all five changes) equals 20 and for both breasts would be 40.


Patients are also encouraged to evaluate their own symptomology as expressed by a number of zero equals symptoms worse, one equals symptoms unchanged, two equals less pain only premenstrual discomfort, three equals no pain unable to predict menstruation. Zero equals no palpable abnormalities normal, one equals is score of less than 7.2 and a score greater than 7 but less than the pretreatment score and three equals a score greater than the pretreatment score (See Table I). Ialso landed a smallmouth bass, a few small brown trout, afew small rainbows (steelhead smolts ?), a fallfishand a baby AtlanticSalmon. The Mohawk egg pattern accounted for many smaller fish and the salmon sized Light Spruce fly produced a few hookups.
Last years--One Day Trip-- hot fly,Olive bugger with White marabou tail and redcrystal flash also received plenty of attention and did account for 2 fish.
The guyI was fishing withused plenty of flies with smaller bucktail flies doing most of the damage. After a full year at 50 mg iodine per day (4 tablets of Iodorala ), the patients mean score dropped to 3.8. He didhook-up with a few fish while usingmy Death Stonefly, landing one nice Coho.I can tell you this---the next few weeks will provide some serious action. There are fish in the system at this moment and with the water release at 1800 CFS and the rain. The other findings of micronodularity, tenderness, fibrous tissue plaques, macrocysts and turgidity will take almost a full year to fully go away.
Optimum amount for most patients for FBD is 50 mg (4 tablets) per day continued indefinitely. It was while treating a large 320-pound woman with insulin dependent diabetes that we learned a valuable lesson regarding the role of iodine in hormone receptor function.
She was then started on insulin during her hospitalization and was instructed on the use of a home glucometer.
Two weeks later on her return office visit for a checkup of her insulin dependent diabetes she was informed that during her hospital physical examination she was noted to have FBD. One week later she called us requesting to lower the level of insulin due to having problems with hypoglycemia. She was told to continue to drop her insulin levels as long as she was experiencing hypoglycemia and to monitor her blood sugars carefully with her glucometer. Four weeks later during an office visit her glucometer was downloaded to my office computer, which showed her to have an average random blood sugar of 98. I praised the patient for her diligent efforts to control her diet and her good work at keeping her sugars under control with the insulin. She then informed me that she had come off her insulin three weeks earlier and had not been taking any medications to lower her blood sugar.
When asked what she felt the big change was, she felt that her diabetes was under better control due to the use of iodine.
Two years later and 70 pounds lighter this patient continues to have excellent glucose control on iodine 50 mg per day.
We since have done a study of twelve diabetics and in six cases we were able to wean all of these patients off of medications for their diabetes and were able to maintain a hemoglobin A1C of less than 5.8 with the average random blood sugar of less than 100. All diabetic patients were able to lower the total amount of medications necessary to control their diabetes. The one insulin dependent diabetic was able to reduce the intake of Lantus insulin from 98 units to 44 units per day within a period of a few weeks.
The pool we were fishing was loaded with suckers and chubs and I did see a few trout and a couple of nice sized smallmouth bass.
If C-peptide is absent then we feel there is no insulin being produced and we have not been able to help this particular group of patients to get off their insulin. We have been able to help these patients lower the total amount of insulin needed to control their glucose. When patients take between 12.5 to 50 mg of iodine per day, it seems that the body becomes increasingly more responsive to thyroid hormones (3-5). Clur (17) has postulated that iodization of tyrosine residues in the hydrophobic portion of these receptors normalize their response to the corresponding hormone. Optimal intake of iodine in amounts two orders of magnitude greater than iodine levels needed for goiter control may be required for iodization of these receptors (4). The insulin receptor tyrosine kinase plays a major role in signal transduction distal to the receptor as the primary event leads to subsequent phosphorylation of cytoplasmic proteins, called insulin receptors substrate proteins (IRS).
The IRS proteins are cytoplasmic proteins, with multiple tyrosine phosphorylation sites, and phosphorylation of IRS proteins has been implicated as the first post receptor step in insulin signal transmission.
Any questions as to what to tie, just shoot me an email or use the Contact 2Bonthewater page.
I have one patient with liver fatty infiltration who had varicosities of the esophagus with bleeding. Once she started on iodine for FDB we noticed that her GI bleeding stopped and the varicose veins of her stomach and esophagus disappeared. At its worse this ovarian pathology is very similar to that of polycystic ovarian syndrome (PCOS).
The patients have successfully been brought under control with the use of 50 mg of iodine per day. All that cold water coming from a quarry and the creek itself in that area is near lifeless.
Control with these patients meaning cysts are gone, periods every 28 days and type 2 diabetes mellitus under control. Ideally, all patients should have an iodine loading test prior to orthoiodosupplementation.
This test is one in which 50 mg of iodine is given after discard of the first morning void.
The bridge is now being painted a Hunter Green color.Most of the creeks in the OleyValley are really low. All urine is collected for the next 24 hours including the first morning urine void the next day.
Even with the rain, the creeks remain very low.A I have a trip scheduled to the Salmon River planned inlate September thanks to Jack. Without Jack's kindness and awesomeness, I would not be going salmon fishing.A I have startedtyingflies for the upcoming salmon trip. The lab is a CLIA approved high complexity testing laboratory in the state of North Carolina.
Zoe competed in a National Beauty pageant and won honorable mention in the beauty competition (FYI -- Zoe wears no make-up, fake hairor fake teethand she competes in the natural division--she is my little girl and I would never DRESS HER UP like all those crazy folks you see on TV). We dressed as fishermen, answered a question about each other and then Zoe did some fly casting on stage. The majority of the loading tests that are performed at FFP Lab are on women ages 31 – 70 years old.
Zoe was crowned Little Queen when she won the Pennsylvania state pageant back in 2006 while competing in a Sunburst pageant. In 667 patients analyzed, the mean level of excretion was about 18 mg for all age groups no patient achieved whole body sufficiency prior to orthoiodosupplementation.
This suggests that of a total 50 mg of iodine given, the patients on the average retained a mean of 32 mg into their body on the first go around. There are plenty of out of the way smaller streams that are teeming with Smallmouths, Carp and a variety of Panfish.


Following orthoiodosupplementation, patients have described vivid dreams, dissipated depression, no more cold extremities, more energy and less fatigue.
One patient after taking four pills of iodine lost eight pounds of fluid weight in 24 hours. Patients who have been constipated for over ten years have now noted daily bowel movements. Perkiomen Creek -- air temp 89 degrees, checked the temperature at two spots, temps were 70 and 69 degrees -- Taken between 415-425 pmA Manatawny Creek -- air temp was 88 degrees, checked the temperature at three spots, temps were 76 degrees at Red Covered Bridge, 74 degrees above TIKI bar and 76 degrees below the Rt. After treating over 1,000 patients with iodine, I have at no time seen the Wolff-Chaikoff Effect.
Goiter is associated with breast cancer, stomach cancer, esophageal cancer, ovarian cancer and endometrial cancer . This heatwave has made most ofthe local trout streams too warm to fishfor the catch and release angler. I feel that those patients with the lowest excretion rates and the highest absorption of iodine on the iodine loading test are the ones with the highest risk for development of cancer. From literally hundreds of phone interviews with patients over the last two years, the levels of iodine excretion that seem to raise the highest alarm are those in which the excretion is somewhere around 10 mg or less per 24 hours in patients age 35 and up.
Maiden Creek below Ontelaunee Lake should provide anglers with some fishthat are willing to bite. My observations at this point show that there is a definite increase in the incidence of breast cancer, stomach cancer, ovarian cancer or thyroid cancer. If a patient has the iodine loading test and has an iodine excretion of 10 mg or less in a 24-hour period, I initiate a cancer workup.
In 1976, a JAMA article showed that 6% of the female population was at risk for breast cancer (25)). You can find Carp, Smallmouth Bass, Largemouth Bassand a wide assortment of panfish to keep you busy. Take some cold water with you !!!Your best way to keep the water cool is to freeze a bottle or two of water the night before you head out. As the day heats up, the water bottles will slowly melt, leaving you with nice cold waterto drink throughout the day. Trends and Public Health Implications: Iodine Excretion Data from National Health and Nutrition Examination Surverys I and III (1971-1974 and 1988-1994).
I fished for 30-minutes on Manatawny and landed 2 wild browns on a tan caddis dry fly in the area where the water temp was 68 degrees.
Temperature wise, if it is 90 degrees outside, pretty sure most, if not all of the local trout waters will be at 70 degrees or higher. We don't wantto kill the trout.The trout that survive through the summer will offerus great fishing in the fall. I have not made a trip to the Schuylkill River as of yet, but I'd bet the house that the smallie action should be pretty darn good.
You can also takeyour watercraft outbefore Epler atCross Keys Road or at Muhlenburg Township park which is below the PFBC Epler Access. There is little room to fish, unless you don't mind walking the shoreline that is covered with all types of vegetation, including Poison Ivy.
Pleny of fish to be caught in this body of water, that is if you can get to them.A Manatawny Creek fished OK.
Clur, A., DI-Iodothyronine as Part of the Oestradiol and Catechol Oestrogen Receptor – The Role of Iodine, Thyroid Hormones and Melatonin in the Aetiology of Breast Cancer.
This stretch used to provide some very nice smallmouth action, but the last few trips here have been poor. Switched to a spent spinner pattern and hooked up twice--snapped one off and landed a nice stocker brown. The water is up from recent rains inthe valley, but the stream was clear and in perfect condition. The Schuylkill River and a few tribs shouldprovide any cat or carp angler with a few bites each nite. Measurement of urinary iodide levels by ion-selective electrode: Improved sensitivity and specificity by chromatography on anion-exchange resin.
Channel catfish prefer dead baits andsmaller live bait, while the Flatheads prefer larger live bait. Carp will eatsmaller live bait including minnows andcrayfish along with the standard fare of homemade MUSH bait or whole kernel corn.The bottom line is--It doesn't really matter what bait you areusing. But, by now it was pitch black and it was raining pretty good and thelightning made it look like the 4th of July came early.I managed to land 2 fish on my emerger pattern androll 2 other trout. Started out at the mouth of Sacony Creek but there was some serious bridge work going on, so I left after a few casts. Caught some nice bluegills, onebrown trout, pumpkinseeds, green sunfish, agolden shiner and I almost hooked into a very nice largemouth bass.
Kids and water mean plenty of noise,lots of splashing and lots offun.Normally, 750pm is about the timethe sulphurs start popping off.
I saw some Iso's and huge stoneflies coming off and flying around.I caught a trophy Bluegill, no kidding check out the picture, almost 9 inches.
I left my headlamp in the truck so I had to walkout before it got too dark and miss the potential spinner fall. I then drove to another stretch of the crick and hooked up a few times fishing a brown spent spinner. I lost them at the bank.A Fish the mornings with a brown or white spent spinner and you might get a few takes on the surface.
My favorite is a "John's Spring Creek Pupa" tied in size 18 and 20 (Trout Flies of The East--page 93). I caught two brookies on a CDC sulphur dry fly and the rest of the fish were caught with nymphs. What an amazing fish, especially on a 2 wt bamboo fly rod with a fly reel that is dated to the 1930's or 1940's. What a specimen.He looked like a submarine swimming in the water !!My first impression of the leviathan is that it was a wild fish.
Tonights fishing provided a mixed bag of fish, a few smallwild brown trout, along with a few stocker browns, stockerrainbows and the brook trout.
I topped it all off with a visit to Ted's house to show off the bamboo fly rod and talk shop. It was about 40 degrees and raining.I didroll a larger fish on a midge, but aside from that, it was a very slow night. Cast down and across and hop the flies upoff the bottom with quick upward lifts of the fly rod.The fish would really strike hard. I still have not figured out whyone day I will catch all browns, one day I will catch all rainbows and some days, you will catch a little of everything.




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