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Iodine induces apoptosis and inhibits cells from forming cancer, esophageal varicose Orthoiodosupplementation in a Primary Care PracticeJorge D. When it comes to weight loss, whatever the motivation, whether it be a holiday, office party, New Year’s resolution etc. When aiming to lose 6 pounds in 3 weeks, it’s important to break this down and target 2 pounds per week.
The reasons behind this are simple – if the weight loss is greater than 2 pounds per week, you will be losing more muscle than fat. As I mentioned earlier, consuming less than you use is the key, to lose 2 pounds per week you will need to consume 1000 kcal less than you require every day! When looking at exercise it’s important to take on a programme which suits you, combining aerobic exercise and strength training will help increase calories used per day and also help tone your muscles. Try and get a quality portion of protein, such as grilled chicken or turkey which is low in fat. Snacks are a great way to keep those cravings at bay and to prevent you from getting over hungry and therefore stop over eating at meal times. The example diets below are broken down into Men and Women and in addition assume 500 kcal burned through exercise each day. All average calorie intakes are calculated using the ONS 2011 census data for average age and weight for men and women. Sport and exercise nutritionist Andrew Shepherd studied Sports and Exercise Science (BSc) and M.Dip Sport and Exercise Science specialising in Nutrition and Physiology at Sheffield Hallam University. After his retirement, he turned his passion to help athletes make the right choices so they can deliver their optimum performance and reach their goals. I would always recommend a slower weight loss per week than this, however, with for example athletes who need to make weight e.g.
Essentially the principle is to create a negative energy balance – use more than you consume. Based on your body weight with no exercise during the day you require approximately 2200 calories (this may vary slightly depending on multiple factors so if just a guide number).
The resistance training and creating tone is important, using your muscle will stimulate protein to repair their fibres, this will help reduce the amount of muscle lost during the weight lose period.
Alternatively go with a portion of fish like salmon or mackerel, offering quality protein along with those vital healthy fats and Omega’s. Try and go for homemade or “wholegrain, whole-wheat, or wholefoods” at this point to manage the calories.
Whilst studying, Andrew was a full time athlete training and competing with the City of Sheffield Swim Squad at a national and international level. Andy holds a BSc (Hons) in Sport and Exercise Science as well as a M.Dip in Sports and Exercise Science, Sports Nutrition and Physiology. To create a weight loss of 2 pounds per week I would recommend doing exercise to boost your energy expenditure and make it easier to create a negative energy balance.
This is a big challenge, and combining healthy eating and an increase in exercise will make this balance easier. In addition to these qualifications Andrew is also a High Performance Registrant with the SENr.
My medical practice is situated in the Appalachian Mountains close to Asheville, North Carolina. Make your salad colourful using various leaves, peppers, radish, and don’t be afraid to add a bit of raw vegetable like carrot or some fruit like some thin slices of orange. He works with a number of clubs and organisations across the country providing nutritional advice and support to Junior, World, Olympic, Paralympic and Commonwealth Games athletes. One of the major problems that we encounter in this location is a problem with hypothyroidism. Both of these studies were done at separate times by separate groups showing the exact number of 11.7%. This reinforces what we were taught, that iodine deficiency goes hand in hand with the manifestation of hypothyroidism. Nothing Comes Easy!!!!    2. I ate 4 small meals a day 4 hours a part from the food groups diagram at the top.
I have on a weekly basis at least one phone call from a healthcare practitioner questioning whether the intake of iodine causes hypothyroidism and goiter.
I often have to go back over the basics of thyroid physiology with these healthcare practitioners, and explain to them that iodine is essential for normal thyroid functions and that it is the manmade organic forms of iodine that are toxic (3).
One donut or a piece of cake will destroy all the work , effort and sacrifice that you have made during the day.
I have been using iodine supplementation in my practice over the last four years in amounts needed for whole body sufficiency (orthoiodosupplementation). Orthoiodosupplementation is the daily amount of iodine required for whole body sufficiency (3-5). Prior to implementing orthoiodosupplementation, I perform a complete history and physical examination. If a mass is picked up on physical then another test that I order is an ultrasound of the thyroid.
While undergoing ultrasound to evaluate the mass I will have my technician measure the thyroid volume. I tried to eat only foods that were easily digested and that  moved through my digestive system rapidly, such as raw fruits , veggies, chicken , salmon and tuna . Each lobe will have its length measured in centimeters, width measured in centimeters and height measured in centimeters.
Following my plan,  you must count your calories and realize that the more calories you eat , the more exercise you must do to burn those calories. All three measurements are multiplied times each other and this gives the volume in cubic centimeters.
The Green Tea has sodium which will help prevent cramps that may occur because of  excessive perspiration during your workout.
A volume size of 5 cc or less is suggestive of thyroid atrophy, another manifestation of iodine deficiency. Any solid mass that is picked up on ultrasound and shows itself to be greater in size than one centimeter by one centimeter will require a radioactive I-123 uptake and scan. This test should be done previous to starting any patient on iodine if a nodule is suspected.


A nodule that does not pick up radioactive iodide is considered to be a cold nodule and would suggest the presence of thyroid cancer. With a treadmill , I can  walk or Jog  3-4 miles per day without worrying about the weather or other elements that  may present a problem . Inorder  not  to  over work your muscles by doing too much at one time , you can break-up your 3 miles in intervals , half in the mornings and half before bed time .
I exercised  15-20 minutes ,  using rope exercises for stretching  to stay toned. Also , I do 100 to  200  abdominal  crunches  to tighten the  stomach muscles.
Malignant tumors derived from the follicular epithelium are classified according to histological features. Being a retired Health and Physical Education Teacher for over 30 years , exercising and working out tends to come natural for me. The incidence of thyroid cancer is approximately nine per 100,000 in the population per year and this usually increases with age plateau after about age 50. Thyroid cancer at a young age (less than 20) or in older people (greater than 65) is usually associated with a worse prognosis. Additional important risk factors include a history of childhood head or neck irradiation, large nodule size greater than four centimeters, evidence for local tumor fixation or invasion into lymph nodes, and the presence of metastasis. In my small practice of around 5,000 patients, I have found five thyroid cancers in one year. If multiple nodules of the thyroid gland are found at the time of ultrasound then the diagnosis of multinodular thyroid goiter is considered even if the gland is normal in size.
I request serum T4 (the main hormone produced by the thyroid), free T3 (the biologically active thyroid hormone at the cellular level) and a thyroid stimulating hormone (TSH) level. Following orthoiodosupplementation, serum T4 and TSH levels usually go down and free T3 stays steady. I have seen TSH sometimes go up rather than down while T4 and free T3 did not change or may have gone up some.
This does not mean that the patient was developing hypothyroidism but that the brain was stimulating the body to make more sodium iodide symporters (NIS). The NIS are channels in the cell membrane that transport atoms into a cell as compared to a calcium channel or a sodium channel or a chloride channel where the channel only admits one atom to go through. The NIS transports sodium iodide into cells and has been found in all cell lines tested so far.
Thyroid stimulating hormone, prolactin and oxytocin have been found to stimulate the making of NIS.
While taking iodide, one may see an elevated TSH but we have to recognize that this is not a bad thing. Often a check of the patient’s T4, free T3 and TSH shows the T4 to go down, free T3 going down and TSH going up.
The nutritional status of the patient will determine its response to orthoiodosupplementation (3). It is crucial that the thyroid gland has plenty of antioxidants in its cells and many other nutrients. We have found that giving a multivitamin for women with PMS (Optivitea ) improves the response to orthoiodosupplementation. Iodine deficiency causes fibrocystic breast disease (FBD) with nodules, cyst enlargement, pain and scar tissue.
Initially, this syndrome occurs in the premenstrual phase of a cycle or involves the whole cycle. In 1928 an autopsy series reported a three percent incidence of FBD, whereas in 1973 an autopsy report quoted an 89% incidence.
A review by the American Academy of Pathology gives a minimum incidence for FBD of 50% but suggests that 80% of North American women are afflicted with the syndrome during their reproductive lifetime. He was able to develop a protocol and a scoring system that helps doctors assess how severe a woman’s FBD is. I would recommend that this scoring system be utilized by physicians in their own medical practice.
A precise method of recording the patient’s data will help both physicians and patients see the improvement that occurs following orthoiodosupplementation. The pathological changes that can occur in FBD are noted as micronodularity, tenderness, fibrous tissue plaques, macrocysts and turgidity. IF I CAN DO IT , SO CAN YOU.                                                                                    GOOD LUCK                         LOSE 6-8 POUNDS  With proper exercise the loss of 6- to 8 pounds can reduce your   chance of Diabetes risk by 30% or more. For example if the micro nodularity of macrocysts disease was present in the upper half of the breasts the numerical score would be one for micro nodularity and two for the two breast quadrants scoring a total of three. If all five changes occurred in all quadrants in one breast the score would be 4 (all four breast quadrants) x5 (all five changes) equals 20 and for both breasts would be 40. Also , the reduction of 10 to 12 pounds will reduce excessive back problems.                          LOSE 13-15 POUNDS  Will have a signicant affect on your blood pressure.
Patients are also encouraged to evaluate their own symptomology as expressed by a number of zero equals symptoms worse, one equals symptoms unchanged, two equals less pain only premenstrual discomfort, three equals no pain unable to predict menstruation.
Zero equals no palpable abnormalities normal, one equals is score of less than 7.2 and a score greater than 7 but less than the pretreatment score and three equals a score greater than the pretreatment score (See Table I). Your Corvette is a special purchase, and you want it to be a decision you can look back on with pride . Ultimately, you'll have to attend to practical matters but right now, just let your imagination run free. Get yourself a book about Corvettes or read the Corvette history pages here and around the Internet. After a full year at 50 mg iodine per day (4 tablets of Iodorala ), the patients mean score dropped to 3.8. Chances are good that you've already got a good idea of your dream Corvette, or you will find that one era of  Corvette speaks to you more than the others. The point of the exercise is to narrow down your search to a range of several year corvette and a  certain corvette body style - maybe with a list of desired features. Ask yourself if you really want an automatic or manual transmission corvette  , do you want a car to modify and race, or just a classic corvette cruiser? Perhaps most importantly, do you plan to do a lot of restoration work to make this Corvette truly your own creation, or do you want a turn-key corvette "new car" experience? The other findings of micronodularity, tenderness, fibrous tissue plaques, macrocysts and turgidity will take almost a full year to fully go away. Optimum amount for most patients for FBD is 50 mg (4 tablets) per day continued indefinitely.


It was while treating a large 320-pound woman with insulin dependent diabetes that we learned a valuable lesson regarding the role of iodine in hormone receptor function. She was then started on insulin during her hospitalization and was instructed on the use of a home glucometer.
Two weeks later on her return office visit for a checkup of her insulin dependent diabetes she was informed that during her hospital physical examination she was noted to have FBD. One week later she called us requesting to lower the level of insulin due to having problems with hypoglycemia. She was told to continue to drop her insulin levels as long as she was experiencing hypoglycemia and to monitor her blood sugars carefully with her glucometer.
Four weeks later during an office visit her glucometer was downloaded to my office computer, which showed her to have an average random blood sugar of 98. I praised the patient for her diligent efforts to control her diet and her good work at keeping her sugars under control with the insulin.
She then informed me that she had come off her insulin three weeks earlier and had not been taking any medications to lower her blood sugar. When asked what she felt the big change was, she felt that her diabetes was under better control due to the use of iodine. Two years later and 70 pounds lighter this patient continues to have excellent glucose control on iodine 50 mg per day.
We since have done a study of twelve diabetics and in six cases we were able to wean all of these patients off of medications for their diabetes and were able to maintain a hemoglobin A1C of less than 5.8 with the average random blood sugar of less than 100.
All diabetic patients were able to lower the total amount of medications necessary to control their diabetes. The one insulin dependent diabetic was able to reduce the intake of Lantus insulin from 98 units to 44 units per day within a period of a few weeks.
If C-peptide is absent then we feel there is no insulin being produced and we have not been able to help this particular group of patients to get off their insulin.
We have been able to help these patients lower the total amount of insulin needed to control their glucose.
When patients take between 12.5 to 50 mg of iodine per day, it seems that the body becomes increasingly more responsive to thyroid hormones (3-5).
Clur (17) has postulated that iodization of tyrosine residues in the hydrophobic portion of these receptors normalize their response to the corresponding hormone.
Optimal intake of iodine in amounts two orders of magnitude greater than iodine levels needed for goiter control may be required for iodization of these receptors (4). The insulin receptor tyrosine kinase plays a major role in signal transduction distal to the receptor as the primary event leads to subsequent phosphorylation of cytoplasmic proteins, called insulin receptors substrate proteins (IRS). The IRS proteins are cytoplasmic proteins, with multiple tyrosine phosphorylation sites, and phosphorylation of IRS proteins has been implicated as the first post receptor step in insulin signal transmission.
I have one patient with liver fatty infiltration who had varicosities of the esophagus with bleeding. Once she started on iodine for FDB we noticed that her GI bleeding stopped and the varicose veins of her stomach and esophagus disappeared. At its worse this ovarian pathology is very similar to that of polycystic ovarian syndrome (PCOS). The patients have successfully been brought under control with the use of 50 mg of iodine per day. Control with these patients meaning cysts are gone, periods every 28 days and type 2 diabetes mellitus under control. Ideally, all patients should have an iodine loading test prior to orthoiodosupplementation. This test is one in which 50 mg of iodine is given after discard of the first morning void. All urine is collected for the next 24 hours including the first morning urine void the next day.
The lab is a CLIA approved high complexity testing laboratory in the state of North Carolina.
The majority of the loading tests that are performed at FFP Lab are on women ages 31 – 70 years old. In 667 patients analyzed, the mean level of excretion was about 18 mg for all age groups no patient achieved whole body sufficiency prior to orthoiodosupplementation.
This suggests that of a total 50 mg of iodine given, the patients on the average retained a mean of 32 mg into their body on the first go around.
Following orthoiodosupplementation, patients have described vivid dreams, dissipated depression, no more cold extremities, more energy and less fatigue.
One patient after taking four pills of iodine lost eight pounds of fluid weight in 24 hours. Patients who have been constipated for over ten years have now noted daily bowel movements. After treating over 1,000 patients with iodine, I have at no time seen the Wolff-Chaikoff Effect. Goiter is associated with breast cancer, stomach cancer, esophageal cancer, ovarian cancer and endometrial cancer .
I feel that those patients with the lowest excretion rates and the highest absorption of iodine on the iodine loading test are the ones with the highest risk for development of cancer. From literally hundreds of phone interviews with patients over the last two years, the levels of iodine excretion that seem to raise the highest alarm are those in which the excretion is somewhere around 10 mg or less per 24 hours in patients age 35 and up. My observations at this point show that there is a definite increase in the incidence of breast cancer, stomach cancer, ovarian cancer or thyroid cancer. If a patient has the iodine loading test and has an iodine excretion of 10 mg or less in a 24-hour period, I initiate a cancer workup.
In 1976, a JAMA article showed that 6% of the female population was at risk for breast cancer (25)). Trends and Public Health Implications: Iodine Excretion Data from National Health and Nutrition Examination Surverys I and III (1971-1974 and 1988-1994). Clur, A., DI-Iodothyronine as Part of the Oestradiol and Catechol Oestrogen Receptor – The Role of Iodine, Thyroid Hormones and Melatonin in the Aetiology of Breast Cancer. Measurement of urinary iodide levels by ion-selective electrode: Improved sensitivity and specificity by chromatography on anion-exchange resin.




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