Figure 1: Obesity and cachexia and their association with markers of metabolic syndrome in RA. Pre-RA is associated with slight obesity, increased subcutaneous and visceral fat mass, as well as proatherogenic lipid and adipokine profiles.
Department of Angiology, Institute of Medicine, University of Debrecen Clinical Centre, Moricz Zs str, Debrecen 4032, Hungary. Departments of Internal Medicine and Rheumatology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands. Division of Metabolic Diseases, Institute of Medicine, University of Debrecen Medical and Health Sciences Centre, Nagyerdei str 98, Debrecen 4032, Hungary.
Department of Rheumatology, Szent Ferenc Hospital, Csabai kapu street 41, Miskolc 3529, Hungary. Department of Rheumatology, Institute of Medicine, University of Debrecen, Faculty of Medicine, Nagyerdei str.
Working like a support glove they offer help in opening jars, using knives, or turning doorknobs. Cooper Hands offer compression, but are made from a breathable fabric, that instead of reducing circulation actually aids it. These gloves are made of ultra light compression material that allows the skin to breath even as it supports and works to reduce the swelling, and tenderness associated with this type of condition. The gloves only extend passed the second knuckle of the fingers, and this allows the wearer to have sensitivity in the fingers. The result of this technology is the benefit of both copper and compression, while still being able to wear the gloves for long periods of time and even while sleeping to offset the problems of stiffness, pain, and swelling.
The benefits of both copper and compression are widely known by those who suffer from arthritic conditions. Using compression after injury or when there’s swelling works in the same way as elevating the swelling tissue. Copper has been an alternative medical aid for arthritis for thousands of years.  Even in Ancient Greece suffers of arthritis were prescribed copper jewelry because it was believed this metal actually absorbed the pain and swelling. Copper Hands used both compression and copper to offer the optimum support, comfort, and relief from the symptoms of arthritis. While other products on the market offer one of these benefits, Copper Hands gives the wearer the advantage of all three. These gloves are not available in stores, and can be ordered only through authorized sites and sources. Another reason to take care to order these gloves specifically is that not only are these unique in their benefits, there is also a money back guarantee. Only Copper Gloves are infused with copper in an ultra-light weight material that works to offer support to joints. With confidence that the wearer will be happy, the customer’s satisfaction is 100% guaranteed. The return should include information including the order number, the complete name, address, and billing phone number of the person who made the order along with an email address if possible.
Controlling weight is one important factor in preventing some forms of this condition since additional weight on the joint can cause damage.
Getting physical exams for a wellness check can also help in maintain the health of the joint. My Mom loves to garden, but she started having a problem with her fingers swelling up and painful she wasn’t able to do much. Unlike some compression gloves that are very restrictive, these gloves are offer both compression and flexibility.
People who have tried Copper Hands find these gloves help with many types of arthritis affecting the wrist, hand, and fingers including osteoarthritis. Copper Hands are machine washable, but it’s recommended to use a gentle soap and a lower cycle. Metabolic syndrome, a cluster of classical cardiovascular risk factors, including hypertension, obesity, glucose intolerance, and dyslipidemia is highly prevalent in patients with rheumatoid arthritis (RA). The study was conducted on 120 RA patients according to the 1987 revised American College of Rheumatology classification criteria, and 100 age and sex matched apparently healthy controls.
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased disability, morbidity and mortality [1, 2].
Statistical analysisStatistical analysis was performed with SPSS 13, 0 statistical software packages. ResultsDescription of the RA patientsA summary of the socio-demographic and clinical characteristics of the patients is presented in Table 2. Frequency of metabolic syndrome in the study population according to the definition used and comparison with healthy controlsThere was a great diversity in the reported prevalence rates according to the definition used (Table 3).
Associations of Metabolic syndrome in patients with RACharacteristics of patients with RA who had and who did not have Met S are presented in Table 4. DiscussionThis case-control study suggested that RA is associated with increased frequency of metabolic syndrome compared to control groups, but its frequency depends on the definition used. ConclusionIn summary, this study shows that rheum arthritis has been associated with increased prevalence of metabolic syndrome compared to control groups. Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular disease (CVD).
JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Since 2012, he has been the educational advisor of the Department of Angiology at the University of Debrecen Clinical Centre.
This condition makes household tasks difficult, and it can seriously diminish the enjoyment of hobbies, and past times. Copper Hands also aids with circulation and provides comfort even as they support the joints of the hands and fingers. The joints of the hand are supported giving the wearer a more confident grip when tackling daily tasks such opening a bottle, turning a doorknob, or using a pair of hedge clippers. Compress will improve the circulation, but wearing many such gloves too long is difficult as the material used is often heavy, and difficult to move through daily tasks while wearing. This makes it easier to perform tasks such as typing, holding paper objects, or picking up small items. Copper is infused in the gloves, but doesn’t weigh down the material or make the gloves feel too heavily. Copper Hands gloves offer the type of support the wearer will find supportive, but not constricting. This helps to keep the pressure of the blood from filling the affected area and reduces fluids draining into the joint. In fact, the modern research indicates that animals benefit from copper in that they see relief from tissue and joint damage. Products that are not Copper Hands and don’t carry the logo will not offer the same benefits. At times throughout the year the demand for Copper Hands is greater than at other times of the year, so while it might not take up to 6 weeks those ordering should understand that due to volume this wait is a possibility. Processing will usually take place within 24 hours, but shipping can take longer depending on order volume. Anyone who is dissatisfied with this product for any reason can simply return it within 30 days for a refund of the purchase price excluding the shipping and handling costs. Details regarding the reason for the return should be included, along with whether a full return or replacement is desired. It is best to ship these back using Ground method, which can be tracked through, UPS, FedEx or USPS Priority mail. While it is often associated with aging, there are a number of arthritic conditions that can cause these symptoms at any age. The swelling of the joint, and the lack of stability in the joint affect the muscles tendons, and even the skin around the affected joint.
This will make the joint unstable, and the lack of confidence the person feels in using the joint can lead to a lack of use, which can in turn speed its degeneration. For example being just ten pounds overweight will place a force equal to 30 pounds on the knee joint with every step. Taking care of the joints when working out, and using a seatbelt while driving in a car are both good ways of preventing this type of risk. It’s possible to wear these gloves while sleeping because they offer comfort even when at rest. I was thinking of quitting my job, and taking early retirement, but I just wasn’t ready to give it up yet. He’s tried several compression gloves, and keeps taking them off, because he says they actually make the pain worse. They have also relieved problems for those with repetitive injury, or those recovering from other types of hand injury that involve swelling and pain.


If there’s a stain on the gloves it’s best to add the cleaner to this part of the glove before placing it in washer.
The aim of the study was to assess the frequency of metabolic syndrome (MS) in RA patients, and to evaluate the relationships between metabolic syndrome and RA.
The frequency of metabolic syndrome was assessed using six Metabolic Syndrome definitions (Joint Consensus 2009, National Cholesterol Education Programme 2004 and 2001, International Diabetes Federation, World Health Organisation and European Group for Study of Insulin Resistance).
Higher systemic inflammatory marker, and glucocorticoids use were independent predictors associated with the presence of metabolic syndrome in patients with RA. The definition of metabolic syndrome focus on the presence of diabetes, glucose intolerance or insulin resistance together with the presence of at least two other components from a list of five components. The statistical analysis of patient questionnaire data involved computation of means, medians, standard deviations, ranges for quantitative variables; and numbers and percentages for qualitative variables. The Results presented were only for the NCEP 2004 criteria, but were very similar when we used other criteria, despite the difference in prevalence.
The factors included in the multivariate analysis were age, HAQ, glucorticoids use, and ESR.
Higher systemic inflammatory markers (ESR) and glucocorticoid use were independent predictors associated with the presence of metabolic syndrome in patients with RA.The metabolic syndrome describes a constellation of major risk factors for cardiovascular diseases (CVDs) such as atherogenic dyslipidemia, obesity, hypertension and diabetes. A higher systemic inflammatory marker and glucocorticoid use were independent predictors associated with the presence of metabolic syndrome in patients with RA. The prevalence of metabolic syndrome (MetS)—a major contributor to CVD—in RA seems to be increased, suggesting that systemic inflammation and antirheumatic therapy may contribute to its presence. In established RA, patients with highly active disease have body mass, lipid and adipokine profiles that contrast with those of patients with well-controlled RA.
Frequently those who experience the pain and stiffness of arthritis in their hands and fingers wish they had some way to strengthen their hands, which would also sooth the pain at the same time.
Compression gloves are known to help with support, but unlike others, these gloves are infused with cooper. Copper has been used for generations to help with the pain and swelling that plague those who suffer from joint pain, stiffness, and tenderness in the muscles that arthritis sufferers endure. This ultra-light material however is wearable even while sleeping, and doesn’t constrict movement.
Many find relief from using gloves for swelling arthritic hands and fingers, and from using similar compression such as leggings for swelling in the knees or ankles. Rather than cutting off the flow of blood these gloves will help the circulation through even if fingers, thumb or wrist joints are swollen.
Those suffering from this condition can experience pain and limited function in any joint in the body. If an injury does occur it’s important to have it treated properly, and to take precaution as specified by a doctor to minimize the effect on the joint. Repetitive motions such as typing should be monitored to ensure that strain isn’t damaging the joint of the hands, fingers, and wrist. Since the 1970’s many people in American have worn copper bracelets in order to find relief from these issues. The doctor I was seeing suggested surgery, and while this helped I still had stiffness, and quite a bit of pain by lunchtime. They helped so much with waking up, that I started wearing them in the daytime when it starts to get bad and these are good for me making it through my day. Nothing I tried was help for my swollen up wrist, and the joints of my fingers were starting to hurt too. These findings suggest that physicians should screen for metabolic syndrome in patients with RA to control its components and therefore reduce the risk of cardiovascular disease in these patients. Therefore, the European League Against Rheumatism (EULAR) guidelines recommend that cardiovascular risk screening and management to be urgently done in patients with RA [4].Metabolic syndrome and Inflammation are intimately linked. Sample t test were used to compare quantitative data and the chi-square test for qualitative data. The most updated Joint Consensus 2009 criteria and most commonly used NCEP 2004 reporting a rate of 32.4%. These associated risk factors have been previously called syndrome X2 or the insulin resistance syndrome [29].The frequency of metabolic syndrome has varied markedly between different studies [30], most likely because of the lack of accepted criteria for the definition of metabolic syndrome.
We aimed to determine the prevalence of MetS in RA, to identify the potential factors associated with its presence, and to evaluate the influence of antirheumatic drugs on the occurrence of MetS in a cohort of Moroccan patients with RA. The open fingertip design and breathable fabric allows for sensitive tasks such as typing, using scissors, or playing video games. This type of firm support also gives the person wearing the gloves more confidence in gripping objects since the joints are better supported. It’s possible to download and print a sizing chart, and printed charts should be used rather than use the sizing charts while on a computer screen.
Men, women and children can be affected by arthritis, but the earlier someone receives a diagnosis and receives treatment the better the prognosis. Mobility is difficult not only because the joint degenerates, but because of the pain with movement. Osteoarthritis will typically affect the joints that have sustained injury or repeat damage in the past.
The fingerless design makes it easy to do close work such as sewing, while still having more support for the wrist and hands while doing heavier jobs. The gloves work on the same principle allowing the wearer to absorb small amounts of the copper through the skin.
The after surgery gloves they gave me worked for a while, but you can’t wear those forever. Place them on counter or safe place so they lay flat will help the gloves remain in good shape.
Multivariate logistic regression models were constructed and odds ratios (OR) and 95% confidence intervals (CI) were calculated to investigate the independence of the predictors of individual RA-related characteristics and Met S.
No significant differences were seen between the two groups according to disease activity and disease duration. Recently, Karvounaris et al found a frequency of metabolic syndrome (defined according to the NCEP ATP III criteria) in RA patients (40%), comparable with their control population [29]. The prevalence of MetS was assessed cross-sectionally in 179 patients with RA over a period of 17 months (July 2011–December 2012). Obesity in RA is characterized by increased visceral fat mass but normal subcutaneous fat mass.
Along with support the traction on the gloves allows for opening water bottles, jars, or similar tasks with fewer problems than standard gloves that often slip. She wasn’t too happy when she saw the gloves because she didn’t like the way they looked, but after trying them out she was delighted!
Most people have no problem with wearing the gloves for several hours at a time while doing most work, or when relaxing. Recently, other abnormalities such as prothrombotic states, non-alcoholic fatty liver disease and sleep apnea have been added to the entity of the syndrome, making its definition even more complex [6]. The patients also completed the validated Arabic translation of the Health Assessment Questionnaire (HAQ) [19], which served to evaluate functional disability; the HAQ score can range from 0 (no disability) to 3 (greatest possible disability). The majority of patients with RA were currently treated with disease-modifying anti-rheumatic drugs (DMARDs) (96%).
In South Asia, Dodani and al found that the frequency of metabolic syndrome was 13.3% and 40%, respectively, according to WHO and NCEP ATP III criteria [31].
These helpful, easy to wear gloves can be worn overnight to help increase circulation while sleeping so in the morning the wearer doesn’t wake to painful stiffness. They are so comfy I wear them driving in to work and I only take them off when I eat lunch. I love working on my boat, and I can use these gloves when I doing the heavy stuff, and with the no fingers on the gloves I don’t have to take them off to pick up stuff like nails or when working with lines.
Besides the many components and clinical implications of metabolic syndrome, there are still no clearly defined diagnostic criteria. Methotrexate, Sulphasalazine, hydroxychloroquine use was not significantly associated with the presence of the Met S.
Since 2000, he has worked as a rheumatologist and clinical research scientist at the Jan van Breemen Institute (JBI) and at the VU University Medical Centre, Amsterdam, Netherlands. The joint will become stiff, and many feel abnormal sensations in the area around the joint. She is now hinting for another pair, and I will get her another pair because it’s worth it to see he r getting out again. I’ve think it’s possible some of the swelling is down, and I don’t get stopped by so much with something hurting. Several studies have examined the prevalence of Met S in RA subjects and whether it is increased compared to subjects without RA, but the results have been inconsistent, maybe due to the differences in metabolic syndrome definitions and in study populations [7, 8].
HHN: have been involved in drafting the manuscript or revising it critically for important intellectual content and given final approval of the version to be published.


Multivariate logistic regression model was constructed to identify independent predictors of MetS in patients with RA. Rev Bras Reumatol 5:260–2687.Toms TE, Panoulas VF, John H, Douglas KM, Kitas GD (2009) Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect?
I’ve told my family how much they have helped me, and told my family members who have problems they should try these. The frequency of metabolic syndrome in RA patients is influenced not only by traditional factors such as race, age, and dietary habits, but also by disease-specific factors.Morocco is one of the countries of North Africa with unmet need of sustainable healthcare delivery systems.
Such diversity can be explained by differences in the baseline characteristics and disease characteristics [37].The factors found in this study to be associated independently with the metabolic syndrome in RA, irrespective of the definition used, included higher systemic inflammatory markers, and glucocorticoid usage. According to the International Diabetes Federation (IDF) a waist circumference value less than 80 cm indicate low risk of type 2 diabetes, coronary heart disease or hypertension [21]. In our study, we didna€™t find an association between older age and metabolic syndrome contrary to others studies [15, 16]. In a multivariate logistic regression model, the severity of RA and less methotrexate use were identified as significant independent predictors of the presence of MetS in RA patients. Data from small studies in the region showed that RA is frequently diagnosed late and many patients present with active disease and severe disability.
BP was measured by a mercury sphygmomanometer in the sitting position after five minutes of rest. The association with older age is not surprising, because in the general population, metabolic syndrome has been shown to affect primarily older subjects, as a consequence of age-related modification of some of its components [38]. Dr Nurmohamed is an investigator of large interventional cohort studies in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. Despite this, only a small proportion of patients receive DMARDs particularly biologic DMARDS, and the scarcity of medical and social resources is a barrier to appropriate treatment in many countries [9a€“14]. The association between higher ESR and the presence of metabolic syndrome in patients with RA in our study was also previously reported [38]. Methotrexate therapy was identified as an independent factor associated with a reduced risk of having MetS in these patients, suggesting a drug-specific mechanism and making methotrexate a first-line disease-modifying antirheumatic drug in RA patients who are at high risk of developing MetS. These findings further support the role of chronic inflammation in insulin resistance development [39, 40]. C-reactive protein (CRP), ESR, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were determined by standard laboratory methods. However, ESR can be affected by a number of comorbid conditions (renal disease) as well as age. González-Gay gained his medical degree in 1980 from University of Cantabria, Spain.
The second study is COMORA study: comorbidities in RA (data not yet published), these two studies suggest a high disease activity in our country (300 patients from 10 centers of the country), the use of high-dose of corticoids, and a more frequent association with hyeprtension pressure, dyslipidemia, overweight and less frequent exposure to tobacco and alcohol. Furthermore, metabolic syndrome is an inflammatory condition, and thus ESR may be elevated to some degree by the presence of metabolic syndrome. A renal function assessment was performed by estimation of glomerular filtration rate according to the Modification of Diet in Renal Disease (MDRD) equation.Metabolic syndromeMetabolic syndrome is a cluster of classical cardiovascular risk factors (obesity, glucose intolerance, dyslipidaemia, and hypertension). Moreover, the cross-sectional design of our study limit the ability to describe causal relationships to the associations detected.Another finding from this study was the association between glucocorticoids use and the presence of metabolic syndrome. He obtained a PhD based on studies performed at Mayo Clinic in Rochester, MN, USA on collagen-induced arthritis and rheumatoid arthritis.
It is thought to be associated with cardiovascular risk beyond the sum of its individual components [23], although this has recently been questioned.Currently used criteria to define Met SDespite the great interest in this subject, no consensus has been reached yet regarding the definition of Met S. This relationship may be explained by the effects of glucocorticoids on different components of the lipid profile.
From these data from cross-sectional studies in Africa, we can assume that the activity profile and Severity of RA in Africa is quite different from Western countries. To the contrary, the study among Mediterranean RA patients found that metabolic syndrome in RA is independent of gender and body mass index (BMI) [29, 32]. They have attempted to incorporate all the different parameters used to define MetS (Table 1). Current corticosteroid use does not increase the risk of metabolic syndrome [35, 41] while it may even reduce its prevalence [36]. González-Gay has also studied atherosclerosis in rheumatic diseases, in particular rheumatoid arthritis.
Hence, we aimed to assess the frequency of metabolic syndrome and its components and evaluate the supposed association with disease activity and severity of RA. In this study, the prevalence of Met S was assessed according to all existing definitions (JC, NCEP 2004, NCEP 2001, WHO, IDF, EGIR (Table 1) in order to establish the range of discrepancy between them. On the other hand, the risk of having moderate to severe RA is higher in patients with metabolic syndrome than in those without the syndrome [29]. Furthermore, another study showed that the use of glucocorticoids is not associated with the presence of metabolic syndrome [41].
Her current research focuses on the role of oxidative stress in metabolic syndrome with a special emphasis on elucidating the relationships of adipokines in lipid metabolism (especially HDL, its antioxidant properties and its correlation with various adipokines).
Dessein and coworkers found that corticosteroid use was not associated with dyslipidemia in RA patients [42] but was associated with insulin resistance. She also conducts intensive research on adipokines in obesity and in systemic inflammatory disorders.
Therefore, the lipoprotein effects of glucocorticoids are unlikely to be the sole cause (if any) of the impact of these drugs on cardiovascular risk.
In the literature, Glucocorticoid use is associated with adverse lipid profiles in the general population, and its long-term use is a risk factor for CVD [43]. He previously served as Dean of the Medical Faculty and as President of the University of Debrecen Medical and Health Science Center. His research, which involves numerous international collaborations, focuses on dyslipidaemia and lipoprotein metabolism, as well as risk factors for atherosclerosis, oxidative stress, and adipokines.
The cross-sectional design and small size of our study limit the ability to describe causal relationships to the associations detected. Furthermore; the small sample size of this study, and recruitment from a single center, which is a tertiary care center with recruitment of the most active and severe disease expose to bias selection and the risk of surestmation of the real frequency of metabolic syndrome.
She specialized in rheumatology in 2010 and has worked in the Semmelweis Hospital in Miskolc, Hungary since 2009. The international COMORA study (comorbidities in RA); in which Morocco has participated with 300 patients across 10 centers in the country (private and public structures) will be interesting, it can given the frequency of metabolic syndrome and its components and compared these data through countries. Further prospective studies should prove valuable in determining these causal relationships.
She then specialized in rheumatology and now works as a rheumatologist at the Semmelweis Hospital in Miskolc, Hungary.
He specialized in internal medicine, rheumatology, clinical immunology, and rehabilitation.
He has been Head of the Departement of Rheumatology and Rehabilitation at the Semmelweis Teaching Hospital in Miskolc, Hungary since 1988.
Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis. Since 1992, he has led the intensive care and therapeutic plasmapheresis unit at the Department of Internal Medicine, University of Debrecen.
Antiphospholipid syndrome, underlying inflammation in atherosclerosis, endothelial dysfunction and microcirculatory disorders are the main fields of his research.
He has published more than 150 articles in international and Hungarian journals and authored nine book chapters. He has been the chairman of the Therapeutic Apheresis Committee and Academic Committee of Debrecen, Angiological Chapter. He has been Head of the Department of Rheumatology at the University of Debrecen since 2001. His major research interests are rheumatoid arthritis, vascular alterations in rheumatic diseases, pathogenesis of bone destruction, secondary cancer in rheumatic diseases, and molecular mechanisms of biological therapy.
He has published more than 170 papers in international journals, authored nine books and published 60 book chapters. He is a member of four international and 10 Hungarian societies, editor of Immunology Quarterly and acts as a reviewer for 20 journals.
Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis.



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