Soy appear to have protective effects on metabolic and hormonal abnormalities of women with polycystic ovary syndrome (PCOS). More than 50 percent of women with PCOS will have diabetes or pre-diabetes (impaired glucose tolerance) before the age of 40.
The risk of heart attack is 4 to 7 times higher in women with PCOS than women of the same age without PCOS. Women with PCOS have high levels of LDL (bad) cholesterol and low levels of HDL (good) cholesterol.
MND: The soy phytoestrogen used in this study was Genistein, which is according to Wikipedia is an isoflavone.
OUR MISSIONHealth research is moving at such a fast pace that one needs an "ear to the ground" to follow and sift through the immense amount of data coming our way. Many patients mistakenly believe that constipation is a temporary and personal problem rather than a medical problem.
For those who do eventually seek medical care for this disorder, there are currently three treatment options: lifestyle and dietary changes, pharmacological treatments, and bio-feedback.
Lifestyle adjustments are typically suggested as a first line of treatment; these usually entail an increase in fluid intake, fiber consumption, and exercise.
Dietary fiber, believed to alleviate constipation by improving gastrointestinal transit and producing larger, softer stools, can be increased with the addition of high-fiber foods (such as vegetables and whole grains) to the diet or by taking commercially available supplements. Bulking agents are concentrated forms of fiber and are composed of naturally occurring psyllium or synthetic poly-saccharides or cellulose derivatives.
Other osmotic laxatives include lactulose, sugar alcohols (sorbitol or mannitol), and polyethylene glycol (PEG). Lactulose is a synthetic disaccharide that is broken down by bacteria in the colon to yield organic acids and carbon dioxide to lower the pH and soften the stool.
Sorbitol and mannitol, like lactulose, are poorly absorbed in the small intestine and produce abdominal distention and flatus. Polyethylene glycol is an inert polymer that is not absorbed by the gut; it is excreted unchanged in the feces.
Glycerine is an osmotic agent that is absorbed well in the small intestine and is therefore used as a suppository.


Stimulant laxatives not only stimulate intestinal motility but also affect mucosal transport. A randomized double-blind, placebo-controlled, crossover study in patients with chronic idiopathic constipation demonstrated that colchicine increased the number of bowel movements and accelerated colon transit time compared with placebo. Both physicians and patients are aware of the limitations of the current laxative treatment options for chronic constipation (Figure 3). Ideal treatments would address the lack of consistent efficacy and potential side effects associated with these agents, such as electrolyte imbalance.
Isoflavones are organic compounds which, in addition to antioxydant properties, influence sexual hormone metabolism.
The staff is not medically trained and posts are of a journalistic nature and not in lieu of medical advice. Only 26% of patients meeting the Rome II diagnostic criteria for this condition are thought to seek medical attention.
In addition, the social stigma and embarrassment surrounding discussions of bodily functions may deter some people from seeking medical help. There is a shortage of adequately controlled trials evaluating the efficacy of these lifestyle changes. Unfortunately, increasing fiber has a tendency to cause undesirable side effects, such as bloating and increased flatulence, that make long-term patient compliance less likely. They add water and additional solid material to stool, which may improve chronic constipation in a manner similar to that of fiber naturally contained in the diet. They include saline laxatives such as magnesium hydroxide (milk of magnesia) and sodium phosphate (phosphate soda).
The main disadvantages of lactulose are abdominal distention, flatulence, and its overly sweet taste. It is recommended that 250 ml of water ingested with 17 g of MiraLax, although it might be difficult for some patients to consume this much water. Examples include docusate sodium (Colace), diphenyl methanes (bisacodyl), anthraquinones (Cascara sagrada and senna), and castor oil. The laxative effect of the anthra-quinones is secondary to net water secretion and the stimulation of colon motility.


In a 2004 report, 91% of primary care physicians expressed a wish for better treatment options for constipation.
They would also be available to the large numbers of patients with chronic constipation, independent of age or sex. Attempts to self-treat with over-the-counter products resulted in slightly more than $700 million in sales of laxatives in 2004. Habit training to achieve a regular bowel movement schedule has been studied primarily in children. This osmotic laxative is indicated for short-term, intermittent use only (up to two weeks).
The side effects of stimulant laxatives include abdominal cramping and melanosis coli with anthraquinones. Similarly, misoprostol stimulates intestinal transit time and has been shown to be effective in the treatment of chronic constipation. Only 50% of patients being treated for chronic constipation were satisfied with their current laxative treatment. Increasing fluid intake does not appear to affect stool volume output, probably because most of the ingested water is absorbed in the small intestine before it can enter the colon. However, a small amount of magnesium and phosphate is actively absorbed in the small intestine, and hypermagnesemia and hyperphosphatemia can occur, especially in patients with renal failure.
However, side effects can be a limiting factor in the use of these agents for long-term therapy. Taken together, these statistics demonstrate the need for more satisfactory therapeutic options.
Similarly, regular exercise (as perceived by the average person) has no established link to constipation relief.
In a placebo-controlled study, docusate had no effect on stool weight, stool frequency, stool water, or mean transit time.



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