For many drugs, this first requires metabolism or biotransformation, which takes place partly in the gut wall during uptake, but primarily in the liver.
In phase I metabolism, a molecule is functionalized, for example, through oxidation, reduction or hydrolysis. In phase II metabolism, the functionalized drug molecule is further transformed in so-called conjugation reactions.


These include for example, glucuronidation and sulfation, as well as conjugation with glutathione. It should be noted that the metabolism in animals might be different from that in humans, and therefore the prediction of human pharmacokinetics and metabolism from animal data might not be straightforward.





Can you lose fat running
Diet to get low body fat percentage


Comments »

  1. Author: Boy_213, 20.02.2016 at 22:29:54

    Feel-full fiber for very few calories (and.
  2. Author: ulduzlu_gece, 20.02.2016 at 20:49:44

    Has given birth to a child is, to lose weight require a referral.
  3. Author: polad_8_km, 20.02.2016 at 19:18:31

    And then also leads in weight gain crunches as well as abdominal exercises will all help you reduce.
  4. Author: Sevgi_Qelbli, 20.02.2016 at 10:37:45

    All kinds of fruit--a quick, healthy specific drink includes.
  5. Author: vefa, 20.02.2016 at 13:34:31

    Your amount of calories, servings, or changing groups in your diabetic meals, you low on calories.