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By clicking Confirm, you commit to buy this item from the seller if you are the winning bidder. By clicking Confirm, you're committing to buy this item from the seller if you're the winning bidder and have read and agree to the Global Shipping Programme terms and conditions - opens in a new window or tab. Targeting the delivery to the adipose tissue was the most substantial problem facing efficacious topical formulations.
Adipose tissue, which is renowned for its poor perfusion (or relative blood supply), is another important physiological barrier that can impede our body’s natural efforts to get skinny. Performing adrenergic stimulation from the topical angle is particularly advantageous to the athlete looking to avoid the central (CNS) affects manifesting from the beta agonism.
Reviewing the role of yohimbine in the adrenergic system can be simplified down to its actions at the alpha-2 adreoreceptor(AR), where it is a selective antagonist (or simply, but misleadingly: an inhibitor). As one might expect the physical characteristics of RK elicit a unique response at the cellular level. Unfortunately, the literature has yet to characterize RK's to the degree in which its structural analogs, notably capsaicin, have been scrutinized and investigated.
Further consideration should be given to the capsaicin-like properties of RK's given their potency as a vasodialator, and its ability to induce transient insulin insensitivity.
Licorice has a lengthy historical association with reduction fat mass and weight loss dating back to the 4th century BC.
These ancient observations are supported thoroughly by modern literature which documents the relationship between GA and 11?-hydroxysteroid dehydrogenase (11HSD) (26).
This is where GA performs its duties and helps you get skinny, the ultimate result can be attributed to a few proximate causes.
The merits for topical applications of GA are not limited to the above, but further investigation also showed the ability for GA to positively affect fat metabolism by inactivating fat lipase and increasing mobilization of adipose stores (31).
Containing Yohimbine Hydrochloride in Avant Labs' hydroalcoholic gel, Lipoderm ULTRA activates targeted fat reduction at the site(s) of application, while avoiding the negative side effects associated with systematic distribution. Ascorbyl Palmitate I want to say a big thank you to the guys at Avant, especially SirSavage for giving me this opportunity to log this for you guys.
It's been a long and arduous process, but is mainly due to my own irresponsibility with my personal health and diet. My protocol will consist of an application of Napalm first thing in the AM prior to work, and then an application of Lipoderm after workout shower in the evening.
What does everyone think I will have more success with preserving muscle while losing weight?
Originally Posted by mrchristian What does everyone think I will have more success with preserving muscle while losing weight?
With that in mind if it is easier for you to train with that energy then it would help to keep your strength up. I am leaning towards TKD because there are many times when I carb restrict myself now, and I am useless in the gym. I really don't feel TKD hinders the diet all that much as long as your not taking in crazy amounts of carbs. You can drop fat just fine having carbs strategically - I hate working out without them, so I try hard not to do that, hasn't hindered fat loss significantly in the least and really helped with muscle preservation.
Originally Posted by LiveWire224 Subbed, Ive seen a log on this stack before, and it was awesome!! 09-06-2008, 09:23 PM mrchristian Originally Posted by Resolve Dude!
We have had a major backorder on Napalm for the past 6 weeks, but the light is starting to show.
Phenadrol by Genomyx is an advanced fat loss matrix designed to give you an edge and incinerate fat! Supplement Facts Serving Size 1 CapsuleServings Per Container 60 Amount Per Serving Serving % DVPhenadrol Proprietary Blend658 mg - Ingredients: Beta Phenylethylamine HCl, Di-Caffeine Malate, Niacin,Sulbutiamine, Sascara Sagrada, Higenamine HCl, Pomegranate Extract PE, Rauwolfia Vamitoria Extract (Std. Questo oggetto verrA  spedito tramite il Programma di spedizione internazionale e include il codice della spedizione internazionale. Spedizione internazionale: gli oggetti possono essere soggetti a tasse doganali a seconda del valore dell'oggetto dichiarato. I venditori stabiliscono il valore dichiarato dell'oggetto e devono attenersi alle leggi sulle dichiarazioni doganali. Gli acquirenti possono essere soggetti a ulteriori addebiti per le operazioni di sdoganamento. Questo importo include i costi applicabili per spese doganali, tasse, intermediazioni e altre tariffe. Il venditore spedisce entro 1 giorno dalla ricezione del pagamento - si apre in una nuova finestra o scheda. La stima dei tempi di consegna indica i tempi di invio del venditore e dipende dal servizio di spedizione selezionato e dalla ricezione del pagamento - viene aperta una nuova finestra o scheda.

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SAN's newest creation is the world's only truly effective ephedrine-free fat burner called, Tight. Tight only consists of the worlds most perfect ingredients in the most effective ratios…but is the first and only formula to ever assemble scientifically proven ingredients in the most sophisticated fat burner in the world. Bioperine enhances the overall absorption and effectiveness of all ingredients it is taken with. Sclareolide releases fat from fat cells more rapidly than even most ephedra-based products and minimizes fat-generating (Lipogenesis) effects at the same time. To experience the most staggering fat loss results in the shortest time possible…order your own personal fat burning stack right this instant. The "off" amount and percentage simply signifies the calculated difference between the seller-provided original price for the item and the seller's current discounted price. Estimated delivery dates - opens in a new window or tab include seller's dispatch time, and will depend on postal service selected. Find out more about your rights as a buyer - opens in a new window or tab and exceptions - opens in a new window or tab. Contact the seller- opens in a new window or tab and request a postage method to your location.
Delivery times may vary, especially during peak periods and will depend on when your payment clears - opens in a new window or tab. You've read and agree to the Global Shipping Programme terms and conditions - opens in a new window or tab. Import charges previously quoted are subject to change if you increase your maximum bid amount. Atop that, is the role of the skin: it is an essential physical barrier which evolved for our protection. Since fat must first be broken down prior to oxidation, an increase in perfusion to concentrated areas of stubborn fat will facilitate a reduction in fat mass by shuttling away liberated free fatty acids. Our specialized carrier allows users to skirt this potentially unwanted side effect, but spares no assault on the fatty area of application.
The functional properties of the alpha-2 AR are noteworthy for athletes since they play a key role in the regulation of lipolysis by inhibiting the release of norepinephrine (NE).
No stranger to inclusion in successful topicals, SesaThin can be found in identical concentrations as is in Lipoderm Ultra.
Interestingly, several of its chemical constituents -- when extracted and isolated -- are found to have medicinal benefits.
Whereas synephrine has been shown to directly bind and activate beta receptors, a quality that RK's lack, their key functional role lies in the potentiation of the rate limiting step in the fat burning process: the hydrolysis of triacylglycerol (TAG).
With caution, we can extend their physical similarity unto the potential for paralleled signaling pathways, and thus observe commonalities in downstream cellular events. The latter, through stimulation of vanilliod receptors prompting the release of Calcitonin Gene Related Peptide (CGRP), another highly potent vasodialator. The Greek physician Theophrastus noted that licorice root granted his patience 'freedom from hunger and thirst'(24), an observation that was reaffirmed in the 1st century BC by Plinius (25).
Expanding upon its predecessor's revolutionary formula, LipoDerm-ULTRA utilizes a number of ancillary fat-fighting ingredients that decrease nutrient uptake and insulin sensitivity in the fat cell, while concurrently increasing leptin expression, leptin sensitivity, and other lipolytic signals such as cAMP and norepinephrine, for maximal fat depletion. I love both of these products on their own, I can't wait to see how applying them stacked will do. I am entering this log with an open mind, always willing to learn, grow, and accel in my workout goals. I will be adding Caffeine to my Napalm in accordance with some anectdotal evidence that it will have a slight diuretic effect in the area of application. For the record, I too have found that heat really aids the absorption of transdermals - I like the idea of the wrap.
The big thing that is great about TKD is it gives you that extra bump of energy when lifting heavy in the gym. La confezione deve essere la stessa che si puA? trovare in negozio, a meno che l'oggetto non sia stato confezionato dal produttore in una confezione anonima, come una busta di plastica o una scatola senza stampa. Contatta il venditore- si apre in una nuova finestra o scheda e chiedi il servizio di spedizione per il tuo indirizzo.
We are run by a Direct Mail Order mega-seller which retails only products that we KNOW and can GUARANTEE work for our valued customers. It's a unique, scientific combination of 8 key ingredients that work synergistically to burn body fat in several different ways. It's the only completely pharmaceutical grade, ephedrine-free, fat burner in the world that will burn fat through several different mechanisms all working together to turn your body into a lean, chiseled masterpiece. You'll be amazed at how fast your body changes and how easy it finally is to get the lean, ripped physique you've always wanted…but couldn't have…until Tight arrived to save the day.
Proprietary Thermogenic Complex: Caffeine Anhydrous 99%, Green Tea Extract 60% EGCG, Synephrine 96%, Pure Guggulsterones E&Z 99%, Sclareolide 96%, Yohimbe 99%, Vinpocetine 99%, Bioperine 96%. If you reside in an EU member state besides UK, import VAT on this purchase is not recoverable.

Import charges previously quoted are subject to change if you increase you maximum bid amount.
Thus, the necessity for a penetration enhancer emerged to loosen, or ease, the passage of ingredients within the topical matrix through the dermal layers and into the adipose. Finding the ideal combination triumphantly yielded the formulation for the Lipoderm Series, which has been adopted and improved upon by Avant Research to create the most effective all-in-one topical to date- Napalm. Our knowledge of the adrenergic system tells us this is easily achievable by coupling alpha-2 antagonism (yohimbine) and beta-receptor activation (synephrine). This is achieved through a self-generated negative feedback loop following NE binding at the alpha-2 AR. The active ingredient in SesaThin -- sesamin -- acts just like certain fish fats as a ligand for PPARalpha (peroxisome proliferator receptor alpha), a type of ligand-activated transcription factor in human cells which plays an important role in fat-metabolism, fat-storage, and glucose homeostasis(8,9,10). It is an agonist of the alpha-1 adrenoreceptor (16,17) which is involved in variety of roles in adipose tissue, inclusive to modulating intracellular Ca2+ and protein kinase C levels and glycogenolysis(18), as well as serving to increase lipolysis in human adipose tissue (19). This process is mediated by the catalytic protein HSL, or hormone-sensitive lipase, which is recruited to lipid droplets in the cytoplasm in a cAMP-dependent manner (21).
In this vein, the warming sensation observed in our beta testing suggests that RK's do have similar metabolic consequences when administered in a topical matrix.
CGRP is highly instrumental in reducing the capacity of the adipocyte to absorb glucose through the insensitivity alluded to above. It wasn't until modern technological advancements allowed us to characterize the licorice root in order to reveal the main active ingredient: glycyrrhetinic acid (GA). 11HSD1 is found in subcutaneous adipocytes in a relatively lesser abundance than it's visceral counterpart (27). By reducing the local availability of cortisol via 11HSD-1 inhibition (28), GA causes a reduction in the concentration of intracellular triglycerides (29), in addition to impeding the differentiation preadipocytes(30).
In addition, this new formula modestly facilitates increased utilization of fatty acids in muscle while sparing glycogen. In total I have lost about 75lbs, and I have been making huge strides in adding as much muscle and strength as I can. Se sei residente in uno stato membro dell'Unione Europea eccetto il Regno Unito, non puoi recuperare l'IVA per questo oggetto. We want to ensure that you are 100% satisfied with your purchase and experience with us, so please contact us with any questions, concerns or suggestions to help make us a better seller. And the beauty of Tight is that it doesn't require ephedrine to accomplish this amazing feat. Pioneering scientific literature using common therapeutic drugs (1,2,3,4,5) proved that skin penetration and local deliver is attainable and feasible for certain compounds. The role of yohimbine here is to bind selectively at the alpha-2 AR and inhibit the stimulatory actions of circulating catecholamines, such as NE, and its mimetics, such as ephedrine.
Moreover, studies have shown that sesamin-induced PPAR-alpha activation elevates fatty acid oxidation as much as 10-fold over normal levels (11,12,13). Without getting overly technical, this creates a significant degree of synergism between cAMP-inducing mechanisms offered by other component of Napalm (see below & RK's). RK's have been shown to sufficiently enhance the localization of HSL within the cell to dramatically increase the rate of this crucial reaction (22). Offering support are the observations made by Kawada et al (1986) whose group documented comparable increases in oxygen consumption following ingestion of either capcaisin, or RK's (23). While this property is unfavorable in other tissues, starving adipocytes of the necessary energy supply is a novel mechanism to induce apoptosis and consequently lose fat!
However, 11HSB-1 is sufficiently concentrated to perform its primary function and influence the level of cortisol by reactivating the inactive cortisone. Lastly, Lipoderm-ULTRA incorporates a local diuretic that neutralizes water retention, making it easier to evaluate progress during use.
This is staggering news…it's like a one-legged man winning an ass-kicking contest against a prize mule. An adequate dosage of topical yohimbine will concomitantly increase blood flow in adipose tissue (at the site of application) (6), and ensure liberated fat will not be retained(7) – all without the deleterious and unwanted effects in the CNS and cardiovascular systems.
Couple its ability to increase fatty acid utilization while suppressing fat-storage (8,13,14,15) and it's clear to see why it works so well with the other active ingredients in Napalm. Additional synergism lies in synephrines' ability to stimulate beta receptors, albeit to a lesser degree than other more specific beta-1 and beta-2 agonists (20).
Researchers were curious to contrast its affects to structurally similar drugs: synephrine and capsaicin. Additionally, unpublished data recorded the ability for RK's to enhance a critical marker of mitochondrial activity, cytochrome C oxidase, demonstrating RK's ability to increase cellular metabolism, albeit in a mouse model. This brilliant hypothesis brought us SpookyDerm, a vicious blend of Lipoderm Ultra, pain-inducing capsaicin, and nicotine. A hyperactive mutant form of 11HSD-1 is observed in cases of the pathologically obese, suggesting that inhibition of this enzyme will facilitate reduction in adipocytic mass. Here is where it gets interesting, Ive discovered a way (at least I personally feel) to make the Lipoderm more effective and to get it to absorb better. Furthermore, the negative feedback loop alluded to earlier is now essentially 'short circuited' allowing hyperactivation of Beta receptors and potentiation of downstream lipolytic effectors, namely cAMP and adenosine antagonism.
While we have Spook to thank for the original concept, we have RK's to thank for the widespread popularity of this pain-free approach to unsurpassed topical fat loss.
Moving forward we'll see the critical interplay between these processes and those incited by other actives found in Napalm. I purchased mine for a few bucks at Dunhams, but I tell you, you can DEFINETLEY feel the Lipoderm working more when it is on then when it is not.

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