Product Description: D' Trim is 100% natural, comprising of herbal vitamin, minerals and plant extract dietary supplements.
General information: Quality products D'TRIM core tasks, and constantly improve the quality and nutritional needs. Ingredients: Mannitol, Grape Juice Powder, Blueberry Juice Powder, Inulin, Garcinia Cambogia, Guarana Extract, Bitter Orange Extract and Alfalfa Extract. Our main hot selling products include: Acai Berry Soft gel, Best Slim, P57 Hoodia, Lida Daidaihua, Slim-Vie, Meiitang Botanical Slimming, 1 Day Diet, Jadera, Lipro Diet Pills, Fruits and Vegetables Waist and Abdomen Slimming, Natural Lose Weight Coffee, etc. Controlling Weight Loss NaturallyGlucomannan (Phytomannan) helps reduce coloric absorption from the gastrointestinal tract (EFSA 2009, Sood et al. Glucomannan helps to lower cholesterol levels by reducing cholesterol absorption from the gastrointestinal tract.
Glucomannan is a water soluble fiber that provides many health-promoting benefits because of its ability to form a soft gel when exposed to water. Glucomannan creates a feeling of satiety or fullness through its water-binding effects – it absorbs up to 200 times its weight. Incorporating increased fiber intake into a daily plan for healthy living can help you lower your risk of heart attack and cancer, as well as prevent or manage such common conditions as hypertension and diabetes mellitus. Glucomannan reduces blood fats, discourages weight gain, helps to keep blood sugar levels normal, and relieves constipation. Cuban-manufactured policosanol is a mixture of alcohols isolated and purified from sugar cane.
Policosanol appears to cause decreased synthesis and increased degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA), the rate-limiting step in cholesterol synthesis.
Policosanol decreases platelet aggregation by decreasing the synthesis of platelet-aggregating thromboxame B2 (TXB2), with no effect on prostacyclin (PGI2). Policosanol was effective in three studies on patients with type 2 diabetes mellitus and hypercholesterolemia. Two studies with a total of 300 patients indicate policosanol is effective in post-menopausal women with hypererlipidemia.
In comparative trials policosanol generated lipid profiles similar to simvastatin, pravastatin, lovastatin, probucol, acipimox, and atorvastatin. Two studies demonstrated positive results using policosanol for patients with intermittent claudication.
Recently, intermittent claudication was investigated in comparative double-blind studies with lovastatin or ticlopidine. Forty-five patients with documented ischemic heart disease were placed an 5 mg policosanol twice daily, 5 mg policosanol twice daily phis 125 mg aspirin (ASA), or 125 mg ASA for 20 months °’ The policosanol groups showed an insignificantly lower percentage of patients with functional progression of ischemia and a significantly greater partial regression of ischemia.
Furthermore, exercise capacity and left ventricular function improved significantly in the policosanol groups compared to the ASA-only group. A follow-up study on the same patients examined treadmill exercise ECG-testing performance. Carotid-vertebral atherosclerosis assessed using Doppler-ultrasound showed progression of disease in three of 11 patients on placebo and no patients on policosanol. Berardi RR, DeSimone EM, Newton GD, Oszko MA, Popovich NG, Rollins CJ, Shimp LA, Tietze KJ, editors. Vuksan V, Sievenpiper JL, Xu Z, Wong EYY, Jenkins AL, Beljan-Zdravkovic U, Leiter LA, Josse RG, Stavro M.P.
Vuksan V, Jenkins DJA, Spadafora P, Sievenpiper JL, Owen R, Vidgen E, Brighenti F, Josse R, Leiter LA, Thompson CB.
Vuksan V, Sievenpiper JL, Owen R, Swilley JA, Spadafora P, Jenkins FJA, Vidgen E, Brighenti F, Josse RG, Leiter LA, Xu Z, Novokmet R. Menendez R, Amor AM, Gonzalez R, et al_Effect of policosanol on the hepatic cholesterol biosynthesis of normocholesterolemic rats.
Menendez lc Fernandez SL Del Rio A, et at Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein process-ing in cultured human fibroblasts. Menendez Mas E., Amor MA, at aL Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vifro. Castano G, Mas R Arruzazabala M, at at Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older ItyperchoIesterolemic patients. Arnizazabala ML, Mas lt, Molina V, et al Effect of policosanol on platelet aggregation in type II bypercholesterolemic patients.
Canetti M, Moreira M, Ilinait F, et aL One-year study of the effect of policosanol on lipid profile in patients with.
Aneiros E, Mas R, Calderon B, et at Effect of policosanol in lowering cholesterol levels in patients with type 11 hyperclaolesterolemia.
Castano Or Mas R, Nodarse M, et al One-year study of the efficacy and safety of policosanol (5 mg twice daily) in the treatment of type 11 hypercholesterolemia’ _ Cie?.
Castano 0: Canetti M, Moreira M, et al Efficacy and tolerability of policosanol iii elderly patients with type II hyperclialester-olemix a 1 2-montla stut. Mas R, Cassano G, ItIttait J, et al Effects of policosanol in patients with type II hypercho-lesterolemia and additional coronary risk factors. Crespo N, Alvarez R, Mas R, et aL Effects of policosanol on patients with non-insulin-dependent diabetes mellitus and hypercholes¬terolemia. Crespo N, Illnait 3, Mas It et al Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and monin.culin depen-dent diabetes mellitus.
Castano G, Mas R, Fernandez L, et aL Effects of policosanol on postmenopamal W01111E21 with type It hypercholesterolemia_ Gynecol Ertdocrirtoi 2000;14187-195.

Zardoya B, MAIL, Castano G, et aL Effects of policosanol on hype rcholesterolemic patients with abnormal serum biochemivil.
Stusser R, Batista I Padron Let 21 Long-term therapy with policosanol improves treadmill exercise-ECG testing performance of coronary heart disease patients. Aleman CI, Nita rd, Elias EC, et at Carcinoge-nicity of policosanol in mice: an 18-month study-. Rodriguez MD, Sanchez Ni, Garcia R Muhigeneration reproduction study of policosanol in rats.
Is used in Herbal Medicine to) promote(s) bowel movements by increasing bulk volume and water content Chua et al.
Helps to lower cholesterol levels: In addition to improving serum lipids, policosanol reduces LDL oxidation, decreases platelet aggregation, decreases smooth muscle proliferation, and improves symptoms of cardiovascular disease. Slim trim 2000 is a weight loss formula carefully developed for delivering the exact results. D' Trim is taken orally and produces thermogenisis in the stomach and lower intestines, which suppresses the appetite and heightens the metabolism.
In addition to the constant innovation, D'TRIM also will create the high-quality products to meet the needs of all types of consumers. Research indicates that soluble fibers help lower blood cholesterol, slows glucose absorption, lowers the Glycemic index and promotes regular bowel movements.
By creating a thick gel, Glucomannan delays gastric emptying and slows the release of sugar into the bloodstream, which helps to lower levels of insulin and blood glucose. Moreover, because soluble fibers form a gel with water, it is important to drink plenty of water with fiber supplements.
When ingested, it takes on a jelly-like consistency and expands to make the stomach feel full.
Policosanol, an extract from sugar cane (Saccharum officinarum L.), has been heavily researched in Cuba in several human populations for its cholesterol-lowering properties.
This is different than the mechanism of action of statin drugs, which work by competitively inhibiting HMG-CoA. Studies on humans and rats show policosanol decreases in vitro LDL oxidation using multiple oxidation models. Both studies started with 5 mg daily, which was later bummed (at week 8 in one study and week 12 in the other) to 10 mg daily for a period of eight or 12 more weeks. Both 5 and 10 mg policosanol significantly lowered lipids and reduced serum levels of ALT, suggesting improvement in liver function. Policosanol significantly increased the initial and absolute claudication distances in both studies, surpassing ticlopidine (a platelet-aggregation inhibitor) in one study, while significantly out-competing lovastatin (which had minimal effect) in the other study. Both policosanol groups were more effective than ASA alone, but policosanol plus aspirin therapy was more effective than policosanol alone.
Those taking policosanol demonstrated decreases in cardiovascular functional class, rest and exercise-induced angina cardiac events, and ischemic ST-segment response.
In addition, policosanol showed an increase in maximum oxygen uptake, a decline in double product (peak heart rate times peak systolic blood pressure), and an increase in aerobic functional capacity compared to placebo. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial.
Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children. Brussels (LU): Office for Official Publications of the European Communities [Accessed 2009-12-23].
Reports of the Scientific Committee for Food (forty-first series): Opinion on the safety in use of konjac gum as a food additive.
Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes.
Arruzazabala MI, Fernandez L, et at Effect of policosanol on platelet aggregation in healthy vohmteers. L et at Effects of policosanol 20 versus 40 nagday in the treatment of patients with type II hy-percholes¬terolemia: a 6-mouth double-blind study. Mas R, et at Effects of policosariol chronically administered in male monkeys (ifrocarcr oierroidei). In modern days being being fit and healthy holds a greater significance than any other aspect.
It is an amazing product that works great for burning calories and shedding excess of stored fat. The official website contains additional detailed info about the product with customer reviews and expert views. Our products are convenient and effective, and have helped countless people achieve a healthy and slim figure. Additionally, Glucomannan improves blood-lipid profiles and can lower systolic blood pressure. People are therefore sated more quickly and are less likely to overeat, according to results of trials in which obese patients were put on calorie-restricted diets and Glucomannan. In addition to improving serum lipids, policosanol reduces LDL oxidation, decreases platelet aggregation, decreases smooth muscle proliferation, and improves symptoms of cardiovascular disease Side erects are virtually non-existent.
Policosanol has also demonstrated improvement in LDL metabolism by increasing LDL binding, uptake, and degradation in human fibriablasts. Another step in the formation of atherosclerotic plaques is an increase in smooth muscle proliferation_ In rabbits, policosanol decreased neointimal formation, indicating decreased smooth muscle cell proliferation.

Policosanol also improved lower extremity symptoms of coldness and pain compared to placebo.
There were four vascular events in ASA alone (1 fatal myocardial infarction, 2 unstable angina, 1 cardiac failure), one in the group taking policosanol alone (non-fatal myocardial infarction), and none in the combined group.
Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults. Supplementation of konjac glucomannan into a low-fibre Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet controlled trial.
Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Konjac-mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitus. Glucomannan, The Official American Nutraceutical Association Guide, Nutraceuticals The Complete Encyclopedia of Supplements, Herbs, Vitamins, and Healing Foods. Evaluation of the pharmacotherapeutic efficacy of Garcia cambogia plus Amorphophallus konjac for the treatment of obesity. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (Amorphophallus konjac).
Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. Beneficial effects of viscous dietary fibre from konjac-mannan in subjects with the insulin resistance syndrome.
Effect of policosanol on hyperlipidemia and coronary heart disease in middle-aged patients_ A 14-month pilot study. The pressures of work and life connections have grown manifold and so has the demand for performance. This is one unique formula that comprises of all natural ingredients that contribute to the natural fat brining capacity while energizing your body in every manner. Besides being a slimming agent it can also used as a natural health supplement for boosting up work and life.
Also, on the official website you can avail numerous on product discounts and offers that further make your buy a joyful experience.
Glucomannan has an extraordinary water-holding capacity and is the most viscous of all known dietary fibers.
Because of these effects, Glucomannan can greatly benefit individuals with metabolic syndrome or diabetes. In a comparative study, policosanol demonstrated a greater effect than lovastatin on neointimal formation. Of the 13 trials measuring HDL, seven showed significant increases and in six HDL was unchanged.
Warning Statements Required for Over-the-Counter Drugs Containing Water-soluble Gums as Active Ingredients. As such, it serves the purposes of a total health supplement that simply revitalizes your life. The average American currently consumes only 12-17 grams of fiber a day from dietary sources, far below the 20-35 grams recommended by the American Dietetic Association and the 30 grams or more suggested by both the American Heart Association and the National Cancer Institute. Absolute walking distance increased 81 percent after six months and 249 percent after 24 months. Of the many obesity holds the maximum points for cutting down our achievement and experience possibilities. This amazing ingredient works great in supplementing the fat burning process in a quick fashion. When consumed upon recommended dosages it simply provides visible results within the shortest possible time frame without comprising to any health factor. Glucomannan is used in Herbal Medicine to) promote(s) bowel movements by increasing bulk volume and water content (Chua et al.
Being obese not slows us down but it also contributes to numerous other ailments that may affect us in a severe manner in the long run.
While burning the fat it being rich in nutrition and antioxidant nourishes the body ensuring total health. Even more impressive, significantly more patients in the placebo group experienced serious vascular events (8 patients with 10 total serious adverse events), while none were experienced laced in the policosanol group.
Being the most of problem to millions around the globe the issue of obesity has been well studied and researched.
It also helps improve the signaling molecule in our body named cyclic adenosine monophosphate that simply makes us feel supercharged while also activating our metabolism rates. Policosanol (5 mg twice daily) also compared favorably to probrucol (500 mg twice daily) at reducing TC, LDL, and TG in patients with type II hypercholesterolemia. As for solutions the most popular one counts being the slimming pills that work straight towards burning the fat. Lastly, policosanol was significantly less effective than atorvastatin (Lipitor) in reducing both LDL and TC, although it was similar in reducing both atherogenic ratios and TG.
These studies suggest a therapeutic benefit to policosanol in type II hypercholesterolemia, while presenting no adverse effects on the liver.

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