Yohimbine is a chemical compound commonly extracted from Pausinystalia yohimbe (Yohimbe for short), an African plant, the bark of which is generally standardized for Yohimbine content and sold as an herbal dietary supplement. The primary mechanism by which Yohimbine burns fat is via inhibition of alpha-adrenergic receptors which carry out a regulatory function with regards to lipolysis (fat breakdown). Adrenergic receptors control the sympathetic nervous system and require activation by catecholamine neurotransmitters, particularly adrenaline and noradrenaline. However, for the purpose of this article, we will be using the general terms alpha-receptor and beta-receptor to reference each group of receptors. Because these receptors are designed to keep the fat burning process as a whole in check, adrenergic receptors can be considered regulatory receptors.
As alluded to above, Yohimbine is considered an alpha-adrenergic receptor antagonist, meaning it blocks the action of alpha-receptors (recall that alpha-receptors inhibit lipolysis). This means that for Yohimbine to truly be a truly effective weight-loss agent, it must be accompanied by something that induces lipolysis.
However, it is worth noting that the ability of Yohimbine to release adrenaline (activating beta-receptors) may diminish fairly quickly, as evidenced in 1990 study in which the significant increase of noradrenaline faded within 2 weeks of supplementation while the alpha-receptor inhibition remained constant. A 2006 study, published in “Research in Sports Medicine”, found that 20mg of Yohimbine divided into two daily doses significantly reduced fat mass in male soccer players without significantly effecting lean (muscle mass) or exercise performance. Since Yohimbine’s primary mechanism of action is via inhibition of alpha-adrenergic receptors and its ability to increase adrenaline tends to fade quickly, the fat-burning effects are contingent on some sort of beta-adrenergic receptor activation to facilitate fat loss while the alpha-receptors are being blocked.
Given that Yohimbine effectively increases noradrenaline, the usual negative side-effects can potentially occur if too high a dose is taken in stimulant-sensitive individuals. However, using lower doses of 10-20mg, anxiety is likely only to manifest itself in individuals with some sort of predisposition to anxiety, as demonstrated in a 1997 study in which oral Yohimbine induced panic-attacks in several panic-attack susceptible subjects but not in control subjects (not susceptible to panic attacks). The effects of Yohimbine are quite stimulatory in nature, so individuals who react poorly to other stimulants are more likely to experience similar reactions with Yohimbine. Yohimbine, when combined with regular exercise, can be a highly effective fat-loss supplement.
As we discuss in depth here, Yohimbine is an alpha(2) receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis (breakdown of fat).
As previously stated, Yohimbine directly acts on alpha-2 receptor so for it to be truly effective as a weight-loss agent, it must be combined with something that activates the fat-burning process in the first place (i.e.
Rauwolscine (also known as alpha-yohimbine) is what is known as a ‘stereoisomer’ of Yohimbine, meaning it is chemically similar in structure.
Theobromine belongs to the same class of chemical compounds as Caffeine, known as Methylxanthines.
4-amino-2-methylpentane citrate, also known as 1,3 dimethylbutylamine, bares striking chemical similarities to 1,3 dimethylamylamine (DMAA), the compound that became wildly popular among pre-workouts and fat-burners before being banned by the FDA. Hordenine (chemical name N, N-dimethyltyramine) remains relatively under-researched, despite its escalating popularity in pre-workout and weight-loss supplements. Phenylethylamine (PEA) can induce a short, but somewhat potent release of Catecholamines (Dopamine, Adrenaline, Noradrenaline).
Tyramine is a derivative of the amino acid Tyrosine and is thought to act as a Monoamine Oxidase Inhibitor (MAOI), meaning it blocks the enzyme (Monoamine Oxidase) responsible for the breakdown of certain neurotransmitter (Noradrenaline, Adrenaline, Dopamine, etc.). Higenamine, also known as Norcoclaurine acts as Beta(2)Adrenergic Agonist which, like other Beta Agonists, can increase heart-rate (although the optimal oral dose for achieving this effect is unknown). Synephrine acts as a beta-receptor agonist and an alpha-receptor antagonist, the net effect of which is an increase in lipolysis (fat breakdown).
N-Coumaroyldopamine is a compound found in several species of plant, but most commonly extracted from Cocao.
In recent years, Yohimbine has been the subject of some heated debates among fitness enthusiasts and industry insiders alike. Recently yohimbe, or more accurately, its active ingredient yohimbine, has been the subject of some heated debates among fitness enthusiasts and industry insiders alike.
With all the claims and hype being thrown around, we asked our own resident supplement expert Dan Gastelu to do a little reading on what the current research says, and shed some light on the subject for us. Yohimbe bark is mostly found being used in male aphrodisiac preparations, but some supplement manufacturers have claimed that it can aid fat loss as well. Currently, yohimbe bark is mostly found being used in male aphrodisiac preparations, but some supplement manufacturers have claimed that it can aid fat loss as well. Medically, yohimbine is a pre-synaptic alpha-2-adrenergic blocking agent, also referred to as an alpha 2-adrenergic antagonist. The main effects epinephrine and norepinephrine have on the body include increasing blood pressure and heart rate. In the 1960's, studies were conducted using a combination supplement called Nux Vomica, which contained yohimbine and methyl testosterone.
Do not use while taking any medications, or if other medical problems exist, such as; angina pectoris, depression, other psychiatric illness, heart disease, high blood pressure, kidney disease, or liver disease.
The use of yohimbine for weight loss is inconclusive, and in this author's opinion not to be recommended due to the potential side effects. Alpha-2 receptors are common in sites of the body that tend to preferentially accumulate fat; abdomen, breasts, buttocks and thighs.
Generally, when fatty acid blood concentration is high, it favors fat storage, which results from over-eating and inactivity.
Hypothetically speaking, blocking the alpha-2 receptors might be useful during weight loss to free up the catecholamines like norepinephrine, making more available to stimulate beta receptor sites, resulting in a higher rate of lipolysis.
Galitzky and coworkers observed during their 14- day study of yohimbine treatment that lipid-mobilizing effects were sustained during this study period. There are other nutritional aids that can result in greater weight loss, with fewer or no side effects. Also, there are other nutritional aids that can result in greater weight loss, with fewer or no side effects. Waluga and coworkers went on to examine what the combined effects of caffeine and yohimbine were on cardiovascular function and rate of weight loss. However, the main aim of the study was to determine adverse effects of the supplement treatment on the cardiovascular system, and in fact, the researchers did determine that the inclusion of yohimbine along with the caffeine, did evoke some potentially dangerous changes in the cardiovascular system.
ISSA was the first organization to recognize the need for specialized levels of education in the fitness field.
Circulation is another issue that comes into play with stubborn fat areas.  Antagonism of alpha-2-receptors likely increases blood flow to these cells. For those wanting to use both in the same day I’d recommend waiting four hours after using yohimbine before taking your first dose of the eca stack. You may want to try half the before-mentioned dosage first to see how well you tolerate this supplement. Please follow me on Facebook, Twitter, or Google+ so you'll be updated when I post an article.
Every now and then a supplement discovery comes along that resets the bar for expectations. ALLMAX Yohimbine + Rauwolscine (Alpha-Yohimbine) are the pure synthetic versions of Pausinystalia Yohimbe and Rauwolfia serpentina; thousands of times more powerful than the original herbal extracts from which they were isolated.
Rauwolscine (or Alpha-Yohimbine), is an extremely rare variation of Yohimbine with a longer half-life and a more powerful ?2-AR affinity. Allergen Information: Produced in a facility that also handles Milk, Soy and Shellfish products. Just in case, let’s kick things off by eliminating any confusion about yohimbine and yohimbe. In this yohimbine alpha receptors guide we’ll cover what yohimbe is, and how it interacts with alpha receptors to enhance fat burning. Put simply, your body has two different types of adrenergic receptors called alpha and beta.

Beta receptors are involved in a number of actions including cardiac output, renin secretion of the kidney and ghrelin secretion from the stomach.
You might have heard yohimbine referred to as an adrenergic receptor antagonist at some point.
Yohimbine alkaloids work by attaching to alpha receptors and exerting an inhibitory effect on it. Just like any other weight loss ingredient or supplement or you will always want to check with your doctor first before using it, especially if you have any history of blood pressure issues, cardiovascular, or heart issues. Potential yohimbine side effects include upset stomach, anxiety, dizziness, vomiting, and diarrhea.
Another yohimbe study took 20 obese females following a calorie-restricted diet showed and gave them either 20 mg of yohimbe or a placebo every day for 3 weeks. Keep in mind that yohimbine, like any other supplement is meant to assist your weight loss efforts.
As the study above suggests, it might be most beneficial to take yohimbine prior to exercise to enhance fat burning during your workout. Rauwolscine (or Alpha-Yohimbine), is an extremely rare variation of Yohimbine with a longer half-life and a more powerful I±2-AR affinity. Adrenergic receptors can be further broken down into two subsets, alpha-receptors and beta-receptors. So, generally speaking, alpha receptors inhibit lipolysis while beta receptors induce lipolysis. By blocking the alpha-receptor, Yohimbine allows lipolysis to continue, assuming it was triggered by something (like exercise).
The neurotransmitters adrenaline and noradrenaline are beta-receptor agonists which induce lipolysis and exercise happens to be a great way of releasing them. So, even in the absence of exercise, Yohimbine still has a mechanism by which fat-loss may be achieved. So, Yohimbine can potentially burn fat by itself in the short term, but must be combined with exercise for significant results. However, as exercise was not part of the protocol for this study (as was the case in the above mentioned study), this actually makes perfect sense.
The most common of these side-effects is anxiety, as demonstrated in a 1983 study in which subjects who received 30mg of Yohimbine reported increased anxiety.
As with any supplement (especially stimulants), it is advised to take smaller doses to assess tolerance and work-up if necessary.
However, it is important understand that Yohimbine’s effects are highly stimulatory, so individuals with certain medical conditions or stimulant-sensitivities should probably avoid it.
By blocking the action of this receptor Yohimbine allows for more fat to be burn during exercise than exercise alone. These results conflicted somewhat with those of an earlier (1991) study from the “International Journal of Obesity” in which Obese men did not benefit from long-term Yohimbine supplementation. Because of this similarity, Rauwolscine produces similar effects, although perhaps to a milder degree. While its CNS stimulant properties are less potent than Caffeine, it is alleged to increase heart rate to a greater degree, potentially enhancing oxygenation. Like DMAA, very little is known about 1,3 dimethylbutylamine, other than that it has a very similar chemical structure so it should have similar effects. Oral doses of Hordenine have been shown (in animals) to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself, indicating that it works as a Monoamine Reuptake Inhibitor. While studies testing the effects of PEA supplementation on exercise performance are limited, a boost in Catecholamines may certainly translate into more focus and energy in the gym, resulting in a more intense workout.
The result is an increase in levels of these neurotransmitters which can induce a state of increased alertness, focus, and perceived energy. Higenamine has also been demonstrated in vitro to increase acetylcholine levels, though these findings have not yet been replicated in humans. A 2005 study, published in “The FASEB Journal”, found that N-Coumaroyldopamine was able to increase cAMP via beta-adrenoceptor agonsim, in vitro. While it was originally considered a flop of a supplement, because it did not increase testosterone levels as first suspected, it had developed a bit of a cult following by some men for its reported ability to increase support sexual health. Typically, these areas are located in the midsection of men, and on the glutes and thighs of women. Yohimbe is a small evergreen tree native to Africa, and the scientific name is Pausinystalia yohimbe. This action increases sympathetic nervous system activity, and can result in increasing the amounts of epinephrine (also known as adrenaline) and norepinephrine in the blood stream. Paradoxically, in low dosages yohimbine may help support healthy blood pressure already in normal range.
Nux Vomica was found to be effective after 2 to 3 weeks of use in most cases, various side effects were observed (see below). Side effects reported using yohimbine include: nervousness, irritability, insomnia, headache, skin flushing, anorexia, nausea, gastric distress, diarrhea, vomiting, palpitations, tachycardia, dysuria, pain, increased blood pressure, dizziness, sweating, weight gain, constipation, and anxiety. Do not exceed the recommended dosage for Yohimbine, as an overdose could, in extreme cases, result in death. When exposed to circulating catecholamines, such as norepinephrine and epinephrine, alpha-2 receptor sites inhibit lipolysis (the release of fatty acids), while the beta receptors stimulate lipolysis.
Although, keeping in mind that fatty acids are always used for energy, it is the balance between the amount of fatty acids ingested versus their use for energy that determines how much ends up stored as fat. Also, yohimbine, through its alpha 2-adrenergic receptor antagonist activity, has been shown to increase levels of norepinephrine in the blood stream.
This research collaborated their earlier observations found using yohimbine as a lipid-mobilizing agent, as well as from the research of Lafontan and coworkers.
In their research report, titled, "Does yohimbine act as a slimming drug?" they found an interesting answer.
However, there was not a significant effect on lipolysis observed, nor did treatment with yohimbine delay the gastric emptying rate.
The researchers concluded that further research is warranted to determine the applicability of using alpha 2-receptor inhibitory supplements as supplementary management in the treatment of obesity.
They concluded that the addition of yohimbine should be treated with caution, and must be excluded in particular obese individuals with cardiovascular complications. This is the main reason I don’t recommend using supplements that contain both ephedra and yohimbe. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder, or stroke. Yohimbine + Rauwolscine effectively shuts down fat storage and increases lipolysis; the release of fatty acids within stored fat. This means you need less of it to create a greater effect; it lasts longer and is the perfect complement to Yohimbine. Widely praised for its unique MOA (Mechanism Of Action) Yohimbine + Rauwolscine is radically different than caffeine. These receptors secrete the neurotransmitter norepinephrine, which is then binds to the receptor. This just means it acts on alpha receptors to stimulate an increase in the amount of norepinephrine in the blood stream. Blocking alpha-2 receptors in this way frees up neurotransmitters such as norepinephrine, which stimulates lipolysis (fat burning) by antagonizing beta receptors. What’s more, taking high doses of yohimbine can cause extremely low blood pressure, difficulty breathing, and heart problems. This means that you should be doing everything in your power to eat healthy and follow an exercise program to maximize yohimbine’s fat burning effects.

Because yohimbine has side effects if too much is consumed, be sure to accurately check the supplement label for the proper dosage procedure. It’s worth mentioning that alpha receptors can be further divided into the subsets ?1 and ?2, whereas beta receptors can be divided into the subsets ? 1,?2, and ?3.
It’s important to understand that by blocking the alpha-receptor, Yohimbine is not directly burning fat, it is simply ALLOWING the process to go on. When combined with exercise, Yohimbine allows significantly more fat to be burned than just exercise alone.
By increasing the actions of beta-receptors while simultaneously decreasing the action of alpha receptors, Yohimbine is able to burn fat with remarkable efficacy. Furthermore, because Yohimbine interacts with neurotransmitters, it is ill-advised to combine it with other medication. Like most Yohimbine supplements, PrimaForce Yohimbine comes in 2.5mg capsules, so multiple capsules a day may be necessary depending on desired effects.
Currently Yohimbine is available in hundreds of fat-burner supplements alongside other stimulants, or by itself as Yohimbine HCl.
However, the obvious difference between these two studies was that in the failed study the subjects did not exercise.
Rauwolscine functions as an Alpha-Receptor Antagonist which may enhance the fat-burning induced by other stimulants (Beta-Receptor Agonists). Unlike Caffeine, Theobromine has not been extensively studied with regards to its effect on physical performance or fat-burning so its true efficacy is tough to gauge, and no optimal dose has been established. Anecdotal reports of 1,3 dimethylbutylamine indicate the effects are similar, though perhaps not as overwhelmingly potent, as 1,3 dimethylamylamine and many are calling it “the next 1,3”.
Unfortunately, the effects of PEA tend to degrade very quickly as it is rapidly metabolized upon reaching the brain. Human research on Tyramine is somewhat scarce and the combined effect of the Tyramine and the other stimulants present in the formula has not been the subject of any published study. Like many of the stimulants mentioned earlier, Higenamine remains under-researched, despite its implications as a performance enhancing stimulant and fat-loss agent. Although these findings should be viewed as strictly preliminary, they do suggest that N-coumaroyldopamine has the potential to be used as a fat-burner in humans, sharing the same mechanism of action as such compounds as Synephrine. Chemically, Yohimbe bark contains a substance called yohimbine, plus additional similar compounds, known as indole alkaloids.
The sympathetic nervous system is involved in controlling the body's response to stress, and also triggers the fight or flight response.
This is thought to occur by causing dilation of blood vessels, thereby reducing vascular resistance. Keep in mind, however, no conclusive studies using the botanical Yohimbe have been published which show the same effects. Generally, yohimbine is not recommended for use by females for libido enhancement, and certainly is not to be used during pregnancy. Keep in mind, though, that just because investigators have conducted research on using the supplement yohimbine, does not mean that such studies should automatically be used to endorse the self-prescribed use of this supplement. Generally speaking, epinephrine, norepinephrine, glucagon, adrenocorticotropic hormone (ACTH), and growth hormone stimulate the release of fatty acids from adipose tissue into the blood stream. In this study, twenty female subjects were first subject to a 3 week 1,000 Calorie per day diet. Keep in mind that while over two pounds more weight was lost by the yohimbine taking group, there were no measurements of where the weight was lost, body fat or muscle, and that these results were observed in sedentary females, eating 1000 Calories per day.
The first group received only a very low calorie diet (400 Calories per day) and a placebo.
Although no significant results were seen between the groups, the researchers pointed out that this study was only 10 days long, and that the subjects were on a very low calorie diet, which may have distorted any weight loss effects of the supplements, or was too short to distinguish the real effects reported by other researchers. The YOHIMBINE HCL product is a pinnacle product in the premium line up of hardcore 4DN supplements! Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors, or any other prescription drugs.
Although yohimbine is sometimes used as an aphrodisiac, it also has powerful fat burning capabilities. It is possible that individuals taking Yohimbine may experience some mild fat burning effects without exercise in the short term, but to experience the complete effects, regular exercise is required. Unfortunately, until more studies are published, we really won’t know too much about this compound, the benefits or the pitfalls. For this reason, it is generally seen alongside Monoamine Reuptake Inhibitors (such as the above mentioned Hordenine) which block the enzymes that break down PEA. However, given its mechanism of action, it stands to reason that Tyramine can synergistically enhance the effects of other catecholamine-releasing stimulants. A 2011 study, published in the “International Journal of Medicinal Sciences”, found that supplementation of 50mg Syneprhine increased the metabolic rate in human subjects without affecting blood pressure or heart rate. Once in the blood stream, fatty acids are usually rapidly oxidized if the fatty acid blood concentration is not elevated from fatty acid input resulting from a meal. After this 3 week period, 10 subjects were given yohimbine and the other 10 were given a placebo for three additional weeks, in addition to the 1000 Calorie per day diet. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Engineered to be nothing less than extreme, the 4DN YOHIMBINE HCL formula works on a number of levels to crank up energy and accelerate fat loss!* Each dose delivers a highly stimulating hit of Yohimbine HCL to increase fatty acid mobilization to be burned as energy.* This formula is so powerful in fact that users should never exceed the recommended dosage!
Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Consult a medical doctor before use if you have been treated for, or diagnosed with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. We hope this article was helpful in developing a better understanding of what Yohimbine does and its potential role as a fat-burner. The combination of Hordenine and PEA tends to produce entirely different results than PEA by itself, so these compounds are believed to be very synergistic (and rightfully so). This makes Synephrine an attractive option for weight-loss, while maintaining a strong safety profile.
The third group received the same diet, and caffeine treatment used in group 2, plus yohimbine. Yohimbine and Methyl Testosterone in the treatment of impotence.", Current Therapeutic Research, Vol. To add to the already kick-ass energy enhancing and fat burning effects of this 4DN formula, you can expect intense muscle pumps every time you take it!* Every athlete who has ever lifted a weight in the gym knows that therea€™s no better feeling on earth than a vein-popping pump! Do not use this product if you are at risk of or are being treated for high blood pressure, heart, kidney, thyroid or psychiatric disease, anxiety, depression, seizure disorder or stroke.
Pittler recently reviewed several studies concerning the use of the supplement yohimbine for erectile dysfunction. 4DN YOHIMBINE HCL delivers on so many levels and thata€™s why it stands among the greatest, most hardcore supplements of all time! Consult your health care professional before us if you are taking anti-depressants, MAO inhibitor or any other prescription drug.
If youa€™re serious about your business in the gym then you must make this formula a staple in your program! Improper use of this product will not improve results, is not advised and may cause adverse reactions listed in the warning.

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