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At the center of the hemoglobin molecule is a heme group, with an iron atom at the center of it.
As it goes through the body, hemoglobin gives up its oxygen to the various cells it comes in contact with. When this wonderful oxygen transport from your lungs, through your heart to the rest of your body is messed up for some reason, you have anemia.
I used one of my own prior CBC reports to illustrate white blood cell counts in my last article.
If I were a CLL patient with red blood cell issues, RBC can be much lower than these healthy reference ranges. Anemia is easy to diagnose but not as easy to explain since it can be caused by many different things. Once again, I cannot over emphasize the importance of not getting fixated on any one number but looking for overall trends. MCHC is the average hemoglobin concentration of packed red cells expressed as a percentage. In CLL patients with sharply lower RBC – perhaps because of AIHA or some of the other reasons discussed below, the bone marrow will register this fact and try to compensate by producing more red blood cells to replace the ones being lost. There are specific reasons for anemia in CLL, over and above the general reasons (poor diet, physical blood loss etc) discussed above.
When the problem is too few red blood cells, patients are transfused with “packed red cells” – not whole blood. The risk of infection using standard issue packed red cells is trace levels of viruses (hepatitis is one of the biggest risk factors) that can hide out in the donor white blood cells.
Irradiated and leukoreduced blood products are a tad more expensive than the garden variety blood products, but not prohibitively so, and definitely not as expensive as the complications patients can run into if the wrong products are used. As with most things, too frequent red blood cell transfusions carry the risk of iron overload. You are right that poikilocytosis is the term given to somewhat mis-shapen red blood cells. There are many different reasons why red blood cells can be misshapen, not all of them well understood. I listed Vitamin B1 deficiency in the table under reasons for low hemoglobin, therefore anemia. About two weeks ago my Hemoglobin went rapidly down to 7, so I needed a transfusion to get a better one. I read that erythrocyte concentrates are the better the newer they are and that older ones are from a poorer quality and in so far bad for hosts.
Blood banks have very strict guidelines on how long they can keep blood products before they are past their shelf life, so I would not worry about it.
LynnS: My maternal grandfather died, like your mother, of complications of aplastic anemia after 6 years or so of blood transfusions. Both my primary care and Oncologist recommended low dose asprin therapy for me as a preventative step to future cardiac events. Low dose aspirin is likely a good thing to do except for those with aspirin allergy, very low platelet counts or problematic coagulopathies such as Von Willebrands disease, hemophilia, etc.
I would love to know more about the spleen and liver and how it copes with a huge mount of lymphocytes eg: 200K.
You do a great service in guiding us in the art of knowing when to panic and when to wait out the lower or higher than normal numbers on our blood work and what it all means. CLL Topics Updates does not provide medical advice and its contents are for information only.
HODJAPASHA ART and CULTURE CENTER,RUMI,The name Mevlana Celaleddin-i Rumi stands for Love and ecstatic flight into the infinite. The Mevlevi, or Mevleviye, one of the most well-known of the Sufi orders, was founded in 1273 by Rumi's followers after his death, particularly his son, Sultan Veled Celebi (or A‡elebi, Chelebi) in Konya , from where they gradually spread throughout the Ottoman Empire.
The Mevlevi Order is also linked to other Dervish orders such as the Qadiri (founded in 1165), the Rifa'i (founded in 1182), and the Kalenderis.
Following a recommended fast of several hours, the whirlers begin to rotate on their left feet in short twists, using the right foot to drive their bodies around the left foot.
The Mevlevi Sema Ceremony is proclamated as an INTANGIBLE WORLD HERITAGE in Traditional performing art social practices themes by UNESCO in October 2005. Since anemia is a common side effect of CLL and causes significant loss of quality of life, we need to learn about it.
Over the years I have seen many thousands of patient CBC reports, people seem to like sending me stuff and ask me to read the tea-leaves. Take out all the water in the red blood cells and pretty much the only thing left is hemoglobin.
We said if you take a tube of fresh blood and spin it around fast in a centrifuge, the red blood cells will settle to the bottom and that this layer is just under half the volume of blood in the tube. There is a range of sizes in red blood cells, not all of them are exact copies of each other.
It is a derived number, you can calculate MCH by dividing the total amount of hemoglobin by the number of RBC, then multiply by ten to make the units work.
You can calculate it by dividing the total amount of hemoglobin by the hematocrit, multiply by 100 to get percentage.
Many of the chemotherapy drugs used to treat CLL are “myelosuppressive” – meaning they damage or reduce the production capacity of stem cells to produce more myeloid cells – red blood cells are part of the myeloid line.
The only choices at that point are stem cell transplant with healthy stem cells from a willing donor, or a lifetime of blood transfusion dependency. These are chemical messengers that alert the bone marrow to low RBC; marching orders as it were, that tell the marrow to gear up and increase production. One of the most common autoimmune diseases in CLL is AIHA (autoimmune hemolytic anemia), where perfectly good red blood cells are targeted and destroyed by the body’s own immune system gone berserk.
The red blood cells are separated from blood plasma and from the other cells such as platelets, white blood cells etc by simple process of centrifugation. So, most blood banks recommend using irradiated and leukoreduced blood products for transplant patients as well as patients with any level of immune dysfunction.
I had reason to learn all about this while my husband was going through his stem cell transplant and needed frequent transfusions.
Each of those healthy new red blood cells coming into the body carries its own iron atom, and too many transfusions can cause too much accumulation of iron in the body of the patient.
The reason for this low Hemoglobin is not yet identified but some reasons like bone marrow infiltration with CLL or autoimmune disease ore some viruses could be excluded.
I am in W&W but this seems counter intuitive as asprin thins the blood and would seem to impact platlets. I have been anemic and you explanation of causes and the meanings of the CBC has been very helpful. Rumi is one of the great spiritual masters and poetical geniuses of mankind and was the founder of the Mevlevi Sufi order, a leading mystical brotherhood of Islam.


He is the Divine Voice giving the good news to those seeking beauty , truth , goodness , light and Divine Truth. Today, Mevleviye can be found in many Turkish communities throughout the world but the most active and famous places for their activity are still Konya and Istanbul. The Mevlevi Order was outlawed in Turkey at the dawn of the secular revolution by Kemal AtatA?rk in 1923.he Mevlevi Sema Ceremony Mevleviye are known for their famous practice of whirling dances.
The body of the whirler is meant to be supple with eyes open, but unfocused so that images become blurred and flowing. Explore Old Istanbul, from the ancient tradition of the Turkish bath to the mystic Whirling Dervishes, from the Egyptian Spice Market to the trade secrets of the Silk Road linking Europe with China.
Heck, blood is red because it is full of red blood cells.  Next obvious question, what makes red blood cells red?
When hemoglobin comes in contact with oxygen in your lungs, oxygen gets attached to the iron atom. And as you can see from the reference interval given for healthy individuals, I am doing OK on this front.  Reference ranges are even more important in the case of red blood cells because they are different for men and women. Remember, just because you have CLL does not give you a pass, a get-out-of-jail-free card from all the other things that go wrong with people as they age.
Hematocrit is the volume of red blood cells in a sample of blood, reported as a percentage. For example, newly minted red blood cells are just a bit bigger than older RBC that have been around the block more than a few times. If there is a robust number of new red blood cells being made, as well as old ones hanging around, RDW will be a high number because the range of sizes of the cells present is broad.
If there are so many CLL cells in the bone marrow that the ‘factory’ is packed to the rafters with these cancerous cells, there is no room left for healthy production of other cells to make up for losses due to normal wear and tear.
If the damage is temporary in nature, production will gradually recover and RBC counts will head back up gradually. AIHA can be detected by Direct Coombs test and looking for antibodies targeting red blood cells. While getting any blood product carries some risk of infection, this risk can be minimized by taking proper precautions. Leukoreduced means they put the packed red blood cells through another step of purification, where the last remnants of white blood cells (“leukocytes”) are removed, since viruses hang out in white blood cells. You can read the details by visiting “Harvey’s Journal”, the on-line blog we maintained so others can learn from our experience through this difficult period of our lives. But this is not something to worry about unless we are talking of patients who are chronically transfusion dependant. I will pass this on to my family as well.I tell them knowledge is wisdom and we need all the wisdom we can muster with this disease. It has been one of the most useful aids in helping me and my Doctors see trends in the progression of my disease.
Rumi was born on 30 September 1207 in Balkh in present day Afghanistan to a family of learned theologians. The Mevlevi were a well established Sufi Order in the Ottoman Empire, and many of the members of the order served in various official positions of the Caliphate. At their dancing ceremonies, or Sema, a particular musical repertoire called ayin is played. The Sema takes place in a large circular-shaped room that is part of the mevlevihane building. Each of these intimate half-day and full-day tours will immerse you in a unique aspect of Turkish history and culture.Get expert help choosing the best hotels for yor needs and budget for your stay in A°stanbul and Turkey, Fethiye, Antalya, Marmaris, Bodrum, A°zmir, Gaziantep, Canakkale, Cappadocia, Black Sea, Gallipoli, Ephesus, East Turkey.
Answer: because red blood cells have a molecule in them called hemoglobin (also spelled as haemoglobin if you are Brit, and abbreviated to Hb, Hgb or Hg) and hemoglobin is colored a bright cherry red when it is rich in oxygen, but more bluish red in color when it has been stripped of its oxygen.
After picking up this precious hitchhiker in the lungs the blood next goes to the heart – the pumping station which circulates blood throughout your body.
In my case, the hemoglobin level is a tad low, below the reference range for my lab and hence it is flagged. A low hematocrit usually indicates decreased production, excessive loss, or destruction of red blood cells. Cell size can also change depending on dietary issues – B12 and folic acid deficient red blood cells are larger than iron deficient cells. A small RDW number suggests there is no extraordinary amount of red blood cells being made in the bone marrow. This may suggest that in spite of the obvious and  crying need for increased production of red blood cells, the bone marrow is not able to oblige. The remedy is to clean out the bone marrow with appropriate therapy to kill the CLL cells there.
Treatment options include prednisone, Rituxan, chemotherapy drugs, spleen removal – some or all of the above, as it becomes necessary. It can also be caused by a digestive disease, such as celiac disease, in which case the treatment may be treating the underlying celiac disease. I have used multiple institutions, some of which still log in values by hand on crude charts. Escaping the Mongol invasion and destruction, Rumi and his family traveled extensively in the Muslim lands, performed pilgrimage to Mecca and finally settled in Konya, Anatolia, then part of Seljuk Empire. This is based on four sections of both vocal and instrumental compositions using contrasting rhythmic cycles and is performed by at least one singer, a flute-player (neyzen), a kettledrummer and a cymbal player. In all those areas in Turkey you can find different variations of tour programmes from walking tour to Full package tours according to our all budget guests. Did you know hemoglobin is present to the tune of 95-97% by dry weight of red blood cells (if water is counted, then the weight percentage of hemoglobin is around 35%). This oxygenated version of hemoglobin is bright red – which is why arterial blood leaving the heart is bright red. I am a bit anemic, possibly due to low level of iron in my food (I am a vegetarian) and poor absorption of what iron there is in my diet due to early stage Crohn’s disease. Perhaps the marrow is choke full of CLL cells and with the best of intentions the marrow cannot produce new red blood cells because of the infiltration, or perhaps the bone marrow is just not getting the message.  More about this further down. I too have a mild case of poikilocytosis, because of underlying Crohn’s disease (a kind of autoimmune ulceration of the GI tract). When his father Bahaduddin Valad passed away, Rumi succeeded his father in 1231 as professor in religious sciences. There is also a Mevlevi monastery or dergah in Istanbul, near the Galata Tower, where the sema ceremony is performed and accessible to the public.During Ottoman Empire era, the Mevlevi order produced a number of famous poets and musicians such as Sheikh Ghalib, Ismail Ankaravi (both buried at the Galata Mevlevi-Hane) and Abdullah Sari. The oldest musical compositions stem from the mid-sixteenth century combining Persian and Turkish musical traditions.
In the 1950s, the Turkish government, began allowing the Whirling Dervishes to perform annually in Konya on the Urs of Mevlana, December 17, the anniversary of Rumi's death.
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Think of red blood cells as little sacks full of water and hemoglobin and you will be right on the mark. Depleted oxygen supply to the cells is slow suffocation, and that is exactly what it feels like.
Rumi 24 years old, was an already accomplished scholar in religious and positive sciences.The mevlevi brotherhood is founded completely on love and tolerance. He teaches that every thing is within the human being and that the whole universe is under man's command.Mevlana is a great lover of the Divine Truth.
Music, especially the ney, play an important part in the Mevelevi order and thus much of the traditional "oriental" music that Westerners associate with Turkey originates with the Mevlevi order.
The repertoire was continuously broadened, and the first notations were made from the early twentieth century onwards. Once the hemoglobin has given up its oxygen to the cells it picks up the waste byproduct of cellular breathing, namely carbon dioxide.
Indeed, if one buys a CD of Turkish Sufi music, chances are it will be Mevlevi religious music. They performed in France, for Pope Paul VI, and at the Brooklyn Academy of Music and other venues in the United States and Canada - under the direction of the late Mevlevi Shaikh Suleyman Hayati Dede. Venous blood returning to the lungs and heart is bluish red in color because hemoglobin with carbon dioxide attached to it is bluish red in color. None of the hemotologists I see or my primary MD seem concerned and I have not gotten much of an explanation for it. During the Ottoman period, the Mevlevi order spread into the Balkans, Syria, and Egypt (and is still practiced in both countries where they are known as the Mawlawi order). Many practitioners kept their tradition alive in private gatherings, and thirty years later, the Turkish government began to allow performances again, though only in public.
The Bosnian writer Mesa Selimovic wrote the book Death and the Dervish about a Mevlevi dergah in Sarajevo. From the 1990s, restrictions were eased and private groups re-emerged who try to re-establish the original spiritual and intimate character of the Sema ceremony. Calligraphy Lesson in Istanbul,Ottoman - Turkish Calligraphy, also known as Arabic calligraphy, is the art of writing, and by extension, of bookmaking. He is prejudiced toward none because he knows that everything is the manifestation and actualization of God and he reflects this as a spritual state to the mind and heart of man Mevlana is asuperior and saintly master . Just as the ocean can only fill the jug to its capacity , so mevlana can only fit into words and our perception in proportion to our capacity .
He is a monument to spritually who , through his sublimity , displayed his moral values , his knowledge , wisdom love , intelligence , perception of God , behaviour , everything . His is the true representative of the prophets , the highest element and realization of love and intelligence. Choose love that you might be a chosen one."To give up one's own existence and become non-existent in God , th is , to bind ones's heart completely to God , is shortest way to God .
Photo Safari Tour in Istanbul ,Istanbul is an enchanting city of ancient beauty and modern charm . In this way that person no longer acts in accordance with his ego , doing the bad things that would cause harm to others. Each year thousands of people from the far corners of the world, travel to Konya in response to Mevlana's call of 735 years ago: "Come, come again, whoever you are, come!Heathen, fire worshipper or idolatrous, come!
Real Whirling Dervish Ceremony in Istanbul,We will take you Fatih and Silivrikapi Monestries in Istanbul , Sufism Speech with Dervish EROLKnown to the west as Whirling Dervishes, the Mevlevi Order was founded by Mevlana Rumi in the 13th century.
Mevlana's books are translated to many languages and are among the best selling books of their sort all over the world.
At present, Mevlana, better known there as Rumi, is the "best selling poet" in United States of America. The Essential Rumi by Coleman Barks has sold more than a quarter of a million copies and is one of the top 1000 best selling books at Amazon. It is by far the largest selling poem book ever!Sufism is a mystical Muslim school of thought and aims to find love and knowledge through direct personal experience of Allah. Sufism, often referred to as the mystical dimension of Islam, was formerly understood in Orientalist scholarship as a spiritual movement that reached its apogee during the medieval period of Islamic history, with its crowning achievement being the brilliant literary productions in Arabic and Persian that became the classics of the Sufi tradition. Some Sufis (primarily in "the West") are involved with other religions, or no formal religion -- as directed by the higher source of wisdom within the human heart. Shopping Tour in Istanbul,Shopping Tour is one of our most requested tours for the people who wants to nice & unique things for themselves or for the friends, relatives etc. Graveyard ( Cemetary ) Tours in Istanbul,Cemeteries in Turkish cities were originally made on the outskirts of the cities, so that as cities expanded, the grave yards became part of the inner city landscape. Sufism Speech with Dervish EROL,Known to the west as Whirling Dervishes, the Mevlevi Order was founded by Mevlana Rumi in the 13th century.
The Order wrote of tolerance, forgiveness, and enlightenment.Istanbul Day Tours, Istanbul city tours, Sultanahmet Tours, Walkig Tours in istanbul, Art Tours in istanbul, walking tours in istanbul, group tours in istanbul, private tours in istanbul, hire a guide in istanbul, off the paths tour in istanbul, excursions in istanbul, ottoman tour, byzantine tour in istanbul, classical sightseeing tours in istanbul Swimming Tour in Istanbul,Kilyos is a small Black Sea village which is surrounded by green forests. The village is just a forty five minutes drive from Istanbul.Turkish Music Lesson in Istanbul,The last august 2004 I stayed in Istanbul, during a holiday trip. Yoga Lesson in Istanbul,Yoga is a group of ancient spiritual practices originating in India. Jewish community have lived in the geographic area of Asia Minor for more than 2,400 years. In the later Middle Ages, Ashkenazi Jews migrating to the Byzantine Empire and Ottoman Empire supplemented the original Jewish population of Asia Minor. At the end of the 15th century, a large number of Sephardic Jews fleeing persecution in Spain and Portugal settled in Asia Minor on the invitation of the Ottoman Empire. Despite emigration during the 20th century, modern day Turkey continues a Jewish population.The present size of the Jewish Community is estimated at around 26,000 according to the Jewish Virtual Library. The vast majority live in Istanbul, with a community of about 2,500 in A°zmir and other smaller groups located in the rest of Turkey. We can show you the photogenic side of Istanbul - the mesmerizing blur of dervishes in their whirling dance, the dazzle of the wares of the bazaar, the delicate beauty of long-forgotten gems of classical architecture hidden in the maze of city streets, the serene faces of old men relaxing in the smoke-filled haze of a teahouse, birds-eye views of Istanbula€™s scenic panoramas. Calligraphy is especially revered among Islamic arts since it was the primary means for the preservation of the Qur'an.Ottoman Turkish calligraphy is associated with geometric Islamic art on the walls and ceilings of mosques as well as on the page. It was invented by Housam Roumi and reached its height of popularity under SA?leyman I the Magnificent. We will transfer to your hotel MINA Hotel, 3 Days Special Hotel and Tour Reservation in Istanbul,4 Days Special Hotel and Tour Reservation in Istanbul,3 Days Yoga Tour in Istanbul,You will be able to learn the basic or advance techniques about yoga and have a nice time during your visit in istanbul .



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