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admin | Category: Phone Number By Address | 01.05.2015
The membrane-trafficking system is a key characteristic of eukaryotes (humans, plants, yeast, etc.) and one of the defining features that separates us from bacteria at a cellular level. Evidence suggests that the membrane-trafficking system arose early on in eukaryotic evolution, with the major protein families involved likely having been already present in our ancestors over one billion years ago.
Although evolutionary in nature, my research also provides insight into basic cell biology, parasitism and pathogenesis. We use genomics and molecular evolutionary tools such as phylogenetics and homology searching to address our questions. Some of the world’s most significant infectious diseases are caused by microbial eukaryotes. Furthermore, I am the co-founder and co-director of the (UAlberta) Biomedical Global Health Research Network. The Northern Alberta oil sands are one of the biggest deposits of bitumen in the world, extending over 77,000 km2 and are a reserve of comparable magnitude to the world’s reserves of conventional petroleum. Several strategies for conversion of the tailings ponds and soils into viable landscapes have been proposed, with microbial communities playing a biological role in establishing ecosystem health.
We have recently launched investigations into the potential role of microbial eukaryotes in tailings ponds and oil sand associated soils. Hirst J*, Schlacht A*, Norcott JP, Traynor D, Bloomfield G, Antrobus R, Kay RR, Dacks JB**, Robinson MS. Klinger CM, Klute MJ, Dacks JB** Comparative Genomic Analysis of Multi-subunit Tethering Complexes Demonstrates an Ancient Pan-Eukaryotic Complement and Sculpting in Apicomplexa. Fritz-Laylin LK, Prochnik SE, Ginger ML, Dacks JB, Carpenter ML, Field MC, Kuo A, Paredez A, Chapman J, Pham J, Shu S, Neupane R, Cipriano M, Mancuso J, Tu H, Salamov A, Lindquist E, Shapiro H, Lucas S, Grigoriev IV, Cande WZ, Fulton C, Rokhsar DS, Dawson SC.
Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR, Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Müller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM Jr, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ. CPR Etobicoke is authorized to provide warranty repair services for Samsung phones and tablets. Here at Etobicoke Cell Phone Repair shop, we can reduce separation anxiety with walk-in repairs.  Our gadget tech team has the experience and knowledge to repair a wide variety of tech problems. When your iPhone or iPad is not functioning correctly, you cannot be as connected as you want to be. All CPR Stores are independently owned and operated and may not offer all of the repair and warranty types listed on this website. It is responsible for the proper movement and final location of most of the material in our cells. The innovation of an endomembrane system would have been crucial for early eukaryotes, allowing predation, surface remodelling and increased cell size.


By comparative genomics and evolutionary cell biology addressing organisms from across the taxonomic breadth of eukaryotes (beyond yeast to man), core components of eukaryotic cellular systems are identified.
SNAREs, vesicle coats) can reveal important information about the specific history of that membrane-trafficking machinery and about the membrane-trafficking system in general.
Our work investigates the ways in which the cell biology of membrane-trafficking, as we understand it primarily from studies in animal and yeast models, applies to that of organisms that cause significant mortality and poverty across the world. The goal of the network is to facilitate interaction between UAlberta researchers doing biomedical work with relevance to, and in aid of, Global Health. Over 120 000 Albertans are directly employed in mining and oil extraction sectors, not to mention the industries supporting these jobs. Compounds such as naphthenic acids, and polyaromatic hydrocarbons are known components of the ponds and have toxic effects, while experimental exposure to oilsands process-affected water has been shown to be directly toxic in mouse models. There has been extensive study of the prokaryotic communities of the tailings ponds, showing both beneficial and adverse effects in situ.
This work has implications for environmental reclamation, and for organism discovery in anthropogenically disturbed environments. Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases. First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes. Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution. Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology. The mitochondrial genome and a 60-kb nuclear DNA segment from Naegleria fowleri, the causative agent of primary amoebic meningoencephalitis. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. This allows us to provide many same-day warranty services using authentic Samsung parts during your tablet or cell phone repair in Etobicoke. Our rates are competitive, and you can let us take an external look at your device without a fee or commitment to our service. The professional technicians of CPR Etobicoke can fix your device the very same day you drop it off, even while you wait. It underlies not only brain activity, and hormone secretion in humans, but healthy plant growth, as well as normal cellular activity in a diverse array of single-celled organisms important for our economy, our environment and our health. This allows the development of models of cell biological mechanism that are valid for all eukaryotic cells.


Additionally, the lab is currently involved in several international sequencing projects of protist genomes to examine their membrane trafficking machinery (Monocercomonoides sp., Trimastix pyriformis, Blastocystis homonis and more), having just been involved in the successful publication of the Emiliania huxleyi, Guillardia theta, Bigelowiella natans, and Naegleria gruberi genomes.
Such studies have thus far demonstrated ancient complexity in the trafficking system and the proposal of an evolutionary mechanism for non-endosymbiotic organelle evolution. We often collaboratively pair our in silico work with molecular cell biology to test hypotheses.
Soils overlying bitumen deposits are also disrupted during surface mining and so restoring them to functioning ecosystems is also important.
However, little work has been done on the microbial eukaryotic communities and none using modern molecular methods. If we can diagnose the problem, we will give you a free estimate so that you can know the cost before we get to work. Services include iPhone screen repair, iPad screen repair, water damage, audio-sound problems, buttons malfunction and fixes for most common issues. The pathogenic mechanisms of many parasites, such as the organisms causing malaria, primary amoebic meningoencephalitis and African sleeping sickness, are all underpinned by action of the membrane-trafficking system. It is also possible to place in context some aspects that are unique to a particular model system. As a by-product of these investigations, we have uncovered new protein complexes and trafficking pathways, even in human cells and revealed the cryptic origin of others relevant to neurodegenerative diseases. Current work includes molecular evolutionary work on Trypanosoma brucei (African Sleeping Sickness) and evolution of invasion organelles in Apicomplexa (malaria, toxoplasmosis). This despite the influence in all other environments tested for microbial eukaryotes in food webs impacting both the prokaryotic communities and upwards into animals and plants. Features that are unique, when found in parasitic protistan pathogens, may represent potential therapeutic targets.
We continue to investigate the evolution of protein families involved in membrane-trafficking, with the goal of understanding the emergence of specificity and organelle identity in the eukaryotic cell. We are also among research groups leading the genome sequencing project of Naegleria fowleri (the brain-eating amoeba). Additionally, work in other petrochemical-impacted environments has shown changes in both the community structure (who and how many) and in the cell biology of individual microbial eukaryotic organisms. Bring your shattered screen in today, and leave with a clear view back into your digital world.




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