ScienceDaily recently published an article about an investigational combination of drugs already approved to treat obesity, migraine and epilepsy that produced up to a 10 percent weight loss in obese individuals participating in a one-year clinical trial.
Currently, there is only one drug on the market for long-term treatment of obesity – orlistat. The participants of this Duke University Medical Center study took a controlled-release combination therapy consisting of phentermine and topiramate. This meeting took place after the agency rejected three weight loss drugs in the past six months.
If we focus more on the complications that we associate with obesity, then the benefits would be clear.


By using or accessing the Doctors of Weight Loss site, you acknowledge and agree to the following terms and conditions. Patients receiving this combination experienced on average 8.6 percent greater weight loss compared to those patients receiving placebo.
According to the article, studies have shown that treatment with orlistat can lead to about seven-pound greater weight loss compared to treatment with placebo after one year, but the combination drug achieves about 19 pounds of weight loss relative to placebo at one year. The FDA requires diet drugs to show in clinical trials that at least 30% of people who took the drug lost at least 5% of their body weight.  Additionally, after one year, the difference in average weight loss between the active and control groups needs to be at least 5%. They also saw reductions in blood pressure and improvements in cholesterol, triglycerides and inflammatory markers.


For obese patients who have failed to achieve meaningful weight loss with diet and exercise, we have just one treatment before jumping to bariatric surgery.



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