Cancer cells warburg effect,herpes testing timeline,homeopathic remedies for cancer pain treatment,naturopathic doctor uk - Good Point

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In his work The Metabolism of Tumors, he demonstrated that all forms of cancer are characterized by two basic conditions: acidosis and hypoxia (lack of oxygen).
Whereas, acidosis and a lack of oxygen are two sides of the same coin: where you have one, you have the other. Otto studied chemistry under the great Emil Fischer, and gained the degree, Doctor of Chemistry (Berlin), in 1906. Warburg was never a teacher, and he has always been grateful for his opportunities to devote his whole time to scientific research. This free report covers the health aspects of drinking ionized water from the expertice and opinions of some of today's top holistic doctors and authors. Modulation of ?-catenin signaling by natural agents induces apoptotic cell death in many common cancers, including colon cancer, breast cancer and prostate cancer.
Cancer cells are characterized by self-sufficiency in the absence of growth signals, their ability to evade apoptosis, resistance to anti-growth signals, sustained angiogenesis, uncontrolled proliferation, and invasion and metastasis. Genome instability, leading to increased mutability, was considered the essential enabling characteristic for manifesting the hallmarks. It is critical that cell metabolism be closely linked to cellular energetic and biosynthetic demands.
The mitochondrion is the major organelle implicated in the cellular bioenergetic and biosynthetic changes accompanying cancer. Targeting the fundamental metabolic abnormalities in cancer provides a unique opportunity for the development of more-effective forms of therapy for this disease.
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression.
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism.
Carbohydrate metabolism via glycolysis and the TCA (tricarboxylic acid) cycle is pivotal for cancer growth, and increased refined carbohydrate consumption adversely affects cancer survival. Traditionally, glucose and fructose have been considered as interchangeable monosaccharide substrates that are similarly metabolized, and little attention has been given to sugars other than glucose. Consumption of sugar and sugar-sweetened foods and the risk of pancreatic cancer in a prospective study. Sugar, in the form of glucose, activates the IKK beta enzyme and promotes the development of diabetes via an enhanced inflammatory response. High glucose alone, as well as in combination with proinflammatory cytokines, stimulates nuclear factor kappa-B-mediated transcription in hepatocytes in vitro.
Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells. Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo. Sulfasalazine is the only drug that was developed specifically for arthritis and combines a sulfa drug with acetylsalicylic acid. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.
Sulfasalazine inhibits activation of nuclear factor-kappaB in patients with ulcerative colitis. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus. Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug. Chapter 8: Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer? No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470, or on the web at .
For general information on our other products and services or for technical support, please contact our Customer Care Department within the United States at (800) 762-2974, outside the United States at (317) 572-3993 or fax (317) 572-4002. Cancer persists as a major disease of mortality and is afflicting more people today than ever before. The cancer field went seriously off course during the mid-1970s when many investigators began considering cancer as primarily a genetic disease rather than as a metabolic disease. Seyfried's treatise refocuses attention on the central issue of cancer as a metabolic disease according to Warburg's original theory.
In recognizing cancer as a metabolic disease, it gradually became clear to me why so many people die from the disease. I would like to thank my many students and colleagues for helping me in producing the data and in developing the concepts for this treatise. I would like to thank faculty colleagues in the Boston College Biology Department, including Drs.
Cancer is a devastating disease both physically and emotionally and is projected to overtake heart disease as the leading killer of people in industrialized societies.
How is it possible that we are not winning the cancer war when this disease is under constant investigation in many major pharmaceutical companies and in most leading medical centers throughout the world? Angiogenesis involves the production of new blood vessels from existing blood vessels and involves interactions among numerous signaling molecules ().
I think the artwork of Robert Pope, who died from the adverse effects of chemotherapy and radiation, is especially powerful in conveying the image of cancer from the perspective of the patient, the family, and the physician [19, 20]. The image in is an acrylic on canvas depicting a man lying underneath a radiation machine. The ink on paper image in depicts the suffering of a woman receiving her scheduled chemotherapy. Another ink on paper image in conveys a woman's emotional trauma associated with mastectomy, which involves the surgical removal of a breast to prevent the spread of cancer. A major impediment in the effort to defeat cancer has been due, in large part, to the confusion surrounding the origin of the disease.
Currently, most researchers consider cancer as a type of genetic disease where damage to a cell's DNA underlies the transformation of a normal cell into a potentially lethal cancer cell.
The somatic mutation theory, which has guided cancer research and drug development for over half a century, is now under attack.
While the cancer genome projects are commendable for their technical achievement and have advanced the field of molecular biology, they have done little to defeat cancer [17–19]. The information collected from the large cancer genome projects has done more to confuse than to clarify the nature of the cancer [13, 15, 20]. In my opinion, it is wishful thinking that the vast information generated from the cancer genome atlas will someday serve as a foundation for the development of new and more effective cancer therapies despite recent arguments to the contrary [22].
It is my opinion that most genetic changes in tumors are largely irrelevant to the origin or treatment of cancer. Emerging evidence suggests that cancer is primarily a metabolic disease rather than a genetic disease [24]. Regardless of cell type or tissue origin, the vast majority of cancer cells share a singular problem involving abnormal energy metabolism. Although very specific processes underlie malignant transformation, a large number of unspecific influences can initiate the disease including radiation, chemicals, viruses, and inflammation. According to Hanahan and Weinberg, genome instability is considered to be the essential enabling characteristic for manifesting the six major hallmarks of cancer [5, 32]. The loss of genomic a€?caretakersa€? or a€?guardiansa€?, involved in sensing and repairing DNA damage, was proposed to explain the increased mutability of tumor cells [26, 37–39].
It appears that the route taken by the driver genes and their passengers to explain cancer seems more circular than straight with neither the drivers nor the passengers knowing the final destination. In addition to the six recognized hallmarks of cancer, aerobic fermentation or the Warburg effect is also a robust metabolic hallmark of most tumors whether they are solid or blood born [42–47]. In newly formed cells, low levels of oxygen damage respiration enzymes so that the cells cannot produce energy using oxygen. Poor oxygenation comes from a buildup of carcinogens and other toxins within and around cells, which blocks and then damages the cellular oxygen respiration mechanism. Warburg and other scientists found that the respiratory enzymes in cells, which make energy aerobically using oxygen, die when cellular oxygen levels drop to. When the mitochondrial enzymes get destroyed, they're host cell can no longer produce all its energy using oxygen. The cells that cannot produce energy aerobically, cannot produce enough energy to maintain their ability to function properly. Fermentation allows these cells to survive, but they can no longer perform any functions in the body or communicate effectively with the body. Decades ago, two researchers at the National Cancer Institute, Dean Burn and Mark Woods, (Dean translated some of Warburg's speeches) conducted a series of experiments where they measured the fermentation rate of cancers that grew at different speeds. Naturally Warburg's contention about oxygen and cancer was challenged and tested by other scientists. Some researchers claimed his theory was not valid after they had measured a particularly slow growing cancer, and found no fermentation at all.
Using more sophisticated equipment, they determined that the equipment these researchers used to measure fermentation levels was not accurate enough to detect fermentation at low levels. Pietro Gullino, also at the National Cancer Institute, devised a test which showed that this slow growing cancer always produced fermentation lactic acid. Further research into Warburg's theory showed that when oxygen levels were turned down, cells began to produce energy anaerobically. Chemotherapy and radiation are used because cancer cells are weaker than normal cells and therefore may die first.
However, chemo and radiation damage respiratory enzymes in healthy cells, and overload them with toxins, so they become more likely to develop into cancer. The implication of this research is that an effective way to support the body's fight against cancer would be to get as much oxygen as you can into healthy cells, and improving their ability to utilize oxygen.
And increasing oxygen levels in cancer cells to high levels could help kill those cancer cells.
Ma Lan, MD and Joel Wallach DVD, point out that one type of white blood cells kills cancer cells by injecting oxygen creating hydrogen peroxide into the cells. There are several ways to significantly increase oxygen levels in your cells so that you can kill cancer cells and also prevent them from spreading. You can also increase the efficiency of the mitochondria, enabling it to utilize the oxygen to create energy aerobically. And finally, you can enhance circulation so that more oxygen and vital nutrients get to your cells. There is a miracle cure ebook selling like hotcakes talking about all the ways increasing oxygen levels in your body is valuable to you. I first became aware of a problem with this therapy years ago when a naturopath said that he was tired of patching up holes in the stomach of people drinking food grade hydrogen peroxide.
In addition, only a small portion of the oxygen they release gets into cells as there is not a delivery system that naturally takes oxygen from the blood and gets it into cells. Energetic testing for drinking hydrogen peroxide comes in very low, about 25, making it a poor solution to oxygenating your cells. However the best oxygenating supplements make use of deuterium or heavy water to split water molecules into oxygen and hydrogen.
First, though, let's finish up about oxygen and cancer by covering the energetic testing on some oxygenation treatments that are commonly used or recommended by some alternative practitioners.
Hydrogen peroxide baths, check online on how to do them, come in much stronger than drinking hydrogen peroxide, at 233 for cancer. This one ounce bottle of liquid contains an acid based formulation of sea water minerals, dissolved oxygen, plant based amino acids and plant based enzymes. What sets Oxy E apart from your typical oxygen supplement is that this oxygen producing reaction can take place inside the cells. Oxy E is able to supply the body with a steady diet of free oxygen, hydrogen, full spectrum minerals, amino acids, and enzymes ­ all the while cleansing cells of toxins and lactic acid.
Ed McCabe, a noted oxygen researcher, in an article in Well Being Journal gives some examples of how supplements like Oxy E helped some people with cancer.
Suggested Use: Add drops to eight ounces of purified water or juice and take with or after meals. First and foremost, it contains therapeutic levels of DHQ which on its own is a powerful free radical scavenger that also conditions red blood cells so that they are more flexible and work better.
It also has 15% sea ormus - which brings in that healing force of energetic frequencies to OxyDHQ. It’s creation of free oxygen and hydrogen helps to stabilize toxic elements in the body by polar bonding and electrical charge, to create new unharmful elements and leaves the harmful compounds inert or soluble. OxyDHQ, as an electrolyte, has the ability to stimulate healthy cell growth by adding the proper amounts of voltage to the cell. While Oxy E and OxyDHQ work by putting small amounts of deuterium in your body, where it interacts with water molecules and produces oxygen and hydrogen ions, Ronuv works in the opposite way, introducing a water with extremely low levels of deuterium into your body.
Because cancer cells produce most of their energy by fermenting sugar, not with oxygen, they tend to accumulate more deuterium in their cells.
Once Ronuv has entered these cells, the excess deuterium in them moves to the low deuterium water.
The effectives of Ronuv and OxyDHQ becomes much stronger when you add Oxy Life Force Elixir to the mix.
If you have a cancer where you have to avoid swelling of the tumors, limit Ronuv and OxyDHQ to a maximum of 2 bottles a month of each. Oxy Life Force Elixir (and Ronuv) are part of a whole range of energetic elixirs this report will cover.
Oxy Life Force Elixir influences your red blood cells; improving their ability to carry more oxygen to your cells.
It improves the ability of the mitochondria to utilize the oxygen that gets into your cells. Radiant Care is based on a specific ratio of oil and water that worked incredibly well in improving health in many different ways.
Radiant Care is a one of a kind supplement that gives some powerful health improvements no other supplement does. It is one of the most important supplements to use when there is a large amount of inflammation in the body. Radiant Care works even more powerfully internally, working on all the organs in the body and thus helping to increase oxygenation throughout the body.
It is a proprietary blend of structured water, oils and other nutrients that are emulsified in a patent pending process.
2.Radiant Care increases hydration of the spine, and purifies spinal fluid which, in turn, significantly and greatly improves the functioning of the spinal nerves.
Because of this, Radiant Care is one of the best supplements to use for conditions when the immune system is attacking the body, and when there is inflammation of any kind. 3.It significantly improves the performance of the spleen by increasing production of high quality immune cells, and also by improving performance of the lymphatic system. A simple but unique and effective supplement that will increase the amount of oxygen getting into cells is Royal Ling Zhi.
It is a proprietary formulation combining several oils and essential oils with specially processed Ling Zhi mushroom (Ganoderma Lucidum) to deliver unique health benefits. The Ling Zhi mushroom, also known as Reishi mushroom, is commonly used as a natural medicine in Asia and across the globe.
The most important effect of this combination of ingredients is its ability to increase uptake of oxygen into cells. When there is cancer in the lungs, they are not as efficient at getting oxygen into your body.
When addressing the oxygen and cancer link, It is also important to repair the mitochondria in cells, which is the part of the cell that uses oxygen to make energy.
Our energetic testing re-evaluation of how well these supplements actually fight cancer finds that Ge-ProCoQ10 Max works much better than the highly touted ubiquinol.
Interest in coenzyme Q10 as a potential treatment for cancer began in 1961 when a deficiency of the enzyme was noted in the blood of cancer patients.
Most of the original research on CoQ10 centered on the treatment of heart failure, but two older journal articles highlight it's potential in combating cancer and maintaining a cancer free life.
New CoQ10 research in 2005 performed at the University of Miami Medical School is even more impressive, Researchers reported that in laboratory and animal studies where CoQ10 was delivered to cancer cells and tissues, it induced apoptosis, which is the normal programmed cell death that goes awry in the disease process. Scientists made two presentations at the annual meeting of the American Association for Cancer Research in Anaheim, Ca.
In the second presentation, the researchers showed that CoQ10 greatly inhibited the proliferation of breast cancer cells, while providing a stabilizing effect on the normal mammary cells. Human Trials show that at just 30 mg per day, ProCoQ10 reduced daily DNA damage in humans by 51%. Ge-ProCoQ10 contains another powerful oxygenation promoting ingredient, Organic Germanium 132. Germanium132 improves cellular oxygen levels, which is the basis of the oxygen for cancer fighting strategy. It provides a broad range of antioxidants including tocotrienols, which have been found to be six thousand times more effective than vitamin E.
Q RME is one of the more powerful supplements that can be used for fighting cancer when you need to avoid swelling.
Anaerobic glucose fermentation does not produce much energy compared to aerobic energy production, burning oxygen for fuel. Because it has lived longer than its normal life span as a renegade cancer cell, the now functioning cell's internal clock tells it that it has lived too long. Q RME greatly increases the body's ability to repair the damaged mitochondria in cancer cells so that cancer cells can start to function normally again, and thus realize they must die.
Energetic testing for this combination of Q RME, Ge-ProCoQ10 and Oxy Life Force Elixir puts their healing power at 8500. Oxy Life Force Elixir is also valuable for its ability to boost the effectiveness of Q RME and Ge-ProCoQ10. The energies it transfers to your body also stimulate repair of cellular mitochondrial function. When your cell walls are not made with the right fats, they are not able to absorb oxygen efficiently.
The theory was that fish oil enhances the ability of cancer cells to uptake nutrients that can cause rapid cell growth. In the second study fish oil caused a huge increase of cancer infiltration into the spleens of mice, up to 8 fold. As a result of these issues, the functional Omega 6 and Omega 3 content in our foods is low or absent while the consumption of damaged oils is high.
One of the leaders in the emerging field of PEO research is Professor Brian Peskin, chief research scientist at the Cambridge International Institute for Medical Science. A Parent Essential Oil (PEO) is a natural cold pressed organic oil that has NOT been heated, NOT been chemically processed AND retains enough naturally occurring antioxidants to remain fresh and physiologically active. The ratio of Omega-6 to Omega-3 fatty acids healthy humans require to function optimally has been subject to much debate. Professor Peskin and his colleagues hold that the body needs a supply of GOOD Omega-6 to regain health and undo much of the damage already caused to the cells. Peskina€™s experimental results have led him to use an Omega-6 to Omega-3 ratio of 3 to 1 to enable the best wellness recovery.
NINE year decrease in biological arterial age: In a study of 35 subjects, 13 male and 22 female, aged 35-75, all were supplemented with the a€?plant-based Parent Essential Oilsa€? for between 3 months and 4 years.
Cancer, Oxygenation and Omega-6 Oils: Research shows that parent Omega-6 oils increases oxygen transfer into cells.
Regardless of where the cancer occurs, the prime cause is always the same a€“ the cancerous tissue is the most oxygen impaired.
So the Budwig diet, which focuses on Omega-3 essential fatty acids is missing a crucial component. The Good News: Fortunately, consuming relatively small amounts of high quality Omega-6 can reverse this issue. Weight Loss: Another major benefit from consuming these oils, in just the right ratio, is weight normalization. Headache Relief: Simultaneously, fatigue, chronic weakness and pain levels fade away as oxygen gets to work again sparking the cells and organs back to better function. Natural Inflammation Relief: Providing the body with the highest quality plant oils and a correct ratio of omega-6 to Omega-3 fatty acids brings the body back to balance, supporting the elimination of free-radicals, decreasing inflammation and encouraging healthy metabolism. Fish Oil Overdose: The Budwig diet is correct in recommending use of Flax Oil as an Omega-3 Parent Essential Oil instead of fish oil.
First, research shows that your body mostly needs and uses Parent Essential Oils and not it's derivatives, EPA and DHA. However, the best testing 3 to 1 formulation by far makes use of eight specialty oils and essential oils that provide a host of health benefits in addition to the correct ratio of Omega-6 to Omega-3 essential fatty acids.
Super PEO is a proprietary, nutrient dense, organically crafted, Parent Essential Oil blend. Each bottle represents the healing force of literally hundreds of pounds of organic and wild crafted fruits and vegetables. A report from the American Association of Anti-aging Medicine states that black currant seed oil works against inflammation by stimulating the production of prostaglandin-1, an anti-inflammatory hormone.
Its special formulation of magnesium dioxide and citric acid interact with the acids in the intestinal tract to release oxygen. Otto Warburg was director of the Kaiser Wilhelm Institute (now Max Planck Institute) for cell physiology at Berlin.
Warburg is accredited to discovering that all normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation and ideally the fernantation of sugars. He then studied under von Krehl and obtained the degree, Doctor of Medicine (Heidelberg), in 1911. His later researches at the Kaiser Wilhelm Institute have led to the discovery that the flavins and the nicotinamide were the active groups of the hydrogen-transferring enzymes. If at the same time exogenous carcinogens are excluded rigorously, then much of the endogenous cancer may be prevented today.
Topics include how ionized alkaline water plays an important role in maintaning a healthy lifestyle, and The Application of Ionized Alkaline Water Associated With Today's Ailments. However, the mutation rate for most genes is low making it unlikely that the numerous pathogenic mutations found in cancer cells would occur sporadically within a normal human lifespan.
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. These bioenergetic modifications contribute to the invasive, metastatic and adaptive properties typical in most tumors. We know that glucose is the primary substrate for aerobic glycolysis, the primary metabolic pathway in cancer cells. While sugar of any kind offered sustenance, fructose played a key role in the proliferation of cancer cells.
However, fructose intake has increased dramatically in recent decades and cellular uptake of glucose and fructose uses distinct transporters.
IKK beta is required for activation of a protein called nuclear factor kappa B (NF-kB), that acts as a master switch to turn on inflammation in response to bacterial or viral infections.
When a person undergoes chemo or radiation and consumes a carbohydrate rich diet, there is a strong probability that this diet will contribute to the failure of their treatment protocol. Sulfasalazine is used primarily as an anti-inflammatory agent in the treatment of inflammatory bowel disease (IBD) as well as for rheumatoid arthritis.
No warranty may be created or extended by sales representatives or written sales materials. The metabolic defects in cancer cells were thought to arise as secondary consequences of genomic instability. The book is unique in linking nearly all aspects of the disease to respiratory insufficiency with compensatory fermentation.
The lack of progress in either managing or preventing cancer motivated me to write this treatise.
Many of the current cancer treatments exacerbate tumor cell energy metabolism, thus allowing the disease to progress and eventually become unmanageable.


One would think that effective nontoxic therapies would be readily available from all this attention.
It depends on whether you are a cancer patient, a friend or family member of a patient, an oncologist, a pathologist, a statistician, or a person who does basic research on the disease. According to the figure, point mutations are more common in pancreatic cancer than are larger deletions or amplifications. I also think the Commentary by Donald Cohodes on the experience of chemotherapy should be read as a supplement to Pope's book [21]. The doctors talk among themselves about cancer differently than they do to the patient or to the patient's family so as not to alarm the sensitivity of the layperson. The chemical in the syringe is Adriamycin (doxorubicin), which Pope received along with other drugs during his battle with cancer. She gently touches the instrument of her suffering, while her doll in the background and the metal pan in foreground are reminders of the comfort and pain in her life.
The finding of hundreds and thousands of gene changes in different cancers has led to the idea that cancer is not a single disease, but is a collection of many different diseases. To make matters worse, there are now suggestions for an international effort to identify all abnormal proteins in tumors, that is, a cancer proteome project [21]. According to Serge Koscielny, the gene microarray bioinformatics literature is polluted with many gene expression signatures that have inadequate validation or no validation at all.
While gene-based targeted therapies could be effective against those few cancers that are inherited and where all cells within the tumor have a common genetic defect, most cancers are not inherited through the germ line and few cancer cells have gene defects that are expressed in all cells of the tumor [1, 8, 11, 14, 16, 17, 20]. The types of mutations found in one tumor cell will differ from those found in another tumor cell within the same tumor [7, 15, 23]. I will present evidence showing how cancer is a disease of defective cellular energy metabolism and that most of the genomic defects found in cancer cells arise as secondary downstream effects of defective energy metabolism. While many in the cancer field consider gene defects as being responsible for the metabolic abnormalities in cancer cells, I do not share this view.
Indeed, it appears that prolonged exposure to almost any provocative agent in the environment can potentially cause cancer [26, 27].
Hanahan and Weinberg suggested that six essential alterations in cell physiology were largely responsible for malignant cell growth [5]. Self-Sufficiency in Growth Signals This process involves the uncontrolled proliferation of cells owing to self-induced expression of molecular growth factors. Insensitivity to Growth-Inhibitory (Antigrowth) Signals In order to carry out specific functions in mature differentiated tissues, most cells must remain quiescent or nonproliferative. Evasion of Programmed Cell Death (Apoptosis) Programmed cell death is an effective means of eliminating damaged or dysfunctional cells.
Limitless Replicative Potential All cells of a given species possess a finite number of divisions before they reach mortality.
Sustained Vascularity (Angiogenesis) Angiogenesis involves neovascularization or the formation of new blood capillaries from existing blood vessels and is associated with the processes of tissue inflammation and wound healing.
Tissue Invasion and Metastasis Invasion of tumor cells into local tissue and their spread to distant organs underlies the phenomenon of metastasis.
Genome instability was assumed to elicit the large numbers of mutations found in tumor cells, supporting the idea that cancer is a type of genetic disease. The loss of these caretaker systems would allow genomic instability, thus enabling premalignant cells to reach the six essential hallmarks of cancer [5, 32].
This is further highlighted with suggestions that some cancer genes, such as the isocitrate dehydrogenase gene 1 (IDH1), can act as either a tumor-provoking oncogene or as a tumor-inhibiting suppressor gene (reference IDH1) [41].
Aerobic fermentation involves elevated glucose uptake with lactic acid production in the presence of oxygen.
Warburg won his first Nobel Prize for proving cancer is caused by a lack of oxygen respiration in cells.
Clumping up of red blood cells slows down the bloodstream, and restricts flow into capillaries. And if cancer could grow with no fermentation, then fermentation, or lack of oxygen respiration, was not the cause of cancer. Their testing, using newer and more accurate equipment, showed that even in those very slow growing cancer cells, fermentation was still taking place, at very low levels.
Silvio Fiala, a biochemist from the University of Southern California, also confirmed that this slow growing cancer produced lactic acid, and that it's oxygen respiration was reduced. Lactic acid is toxic, and tends to prevent the transport of oxygen into neighboring normal cells. And though the typical oxygen supplement gets oxygen into the blood, that doesn't mean it gets into the cells.
The most effective way is to take an oxygen supplement that will literally produce much more oxygen in your cells. The mitochondria that become damaged by lack of oxygen cannot produce energy using oxygen, leading to the development of cancerous cells. By increasing oxygen in your cells, and its utilization, you will go a long way towards eliminating cancer. Another drawback is that oxygen released by hydrogen peroxide treatment and also oxygen salt supplements that release oxygen when they are ingested, tend to cause free radical damage. The most heavily marketed one, found in most health food stores, energetically is much stronger than the aerobic oxygen salts at 214.
Hydrogen peroxide IV's if you can find a practitioner to give you them, are just a hair better, at 246. But it also acts as a free radical scavenger, and produces extra hydrogen to increase pH levels and combat free radicals.
The ionic trace mineral blend in Oxy E carries it into your cells, where it then makes oxygen. Throat Cancer and surgery combined with 40 radiation treatments left him burnt and scarred inside. It uses at its foundation the same type of oxygen producing formulation as Oxy E, a deuterium fortified water with 84 minerals, 39 enzymes, 19 amino acids.
While it is acidic in the stomach, just like lemon juice, it works to increase pH levels in your body. The mechanism that causes Ronuv to be one of the most powerful cancer fighters there is, is the following. Use 3 bottles a month for early stage cancers, 4 per month for advanced cancers, and 6 bottles a month for very advanced cancers.
Because the low deuterium water in Ronuv is attracted to cancer cells, OxyDHQ is also attracted to cancer cells when Ronuv is used because OxyDHQ is attracted to Ronuv.
Reported on below, Oxy Life Force Elixir will increase the amount of Ronuv and oxygen from OxyDHQ that will get into cancer cells.
For over 200 years homeopathy has used water in this fashion to store and transmit particular energetic frequencies that act in and on the body in a variety of ways. So that they are more receptive to allowing the oxygen that is available to it to be taken into the cells.
It stimulates the efficiency of the red blood cells ability to pick up oxygen in the lungs, and helps more of it get delivered to your cells.
It worked so impressively that Radiant Care was made, based on this ratio, to give even more benefits through internal or external use. More important to someone fighting cancer is to use it topically on the skin over the liver if the liver is damaged and inflamed. This increase in hydration leads to an improvement in the ability of the organs to function at optimal levels, and to create radiant health. This action enables these nerves to better control the functioning of all organs in your body, and also improves the ability of your body to control and improve immune system function. For healing cancer and supporting overall health with there is inflammation, Radiant Care tests at 11,300.
Ingredients include a Proprietary Nutrient Blend all Organic, cold pressed, full spectrum, non GMO: Sesame Seed Oil, Grape Seed Oil, Black Cumin Seed Oil, and Black Currant Seed Oil.
Each oil has unique properties working synergistically to promote excellent health and increase energy.
Its use in Chinese medicine dates back over 2000 years, which makes it one of the oldest mushrooms to be used medicinally.
Cancer, at the most fundamental level, develops in cells that cannot produce energy using oxygen because their mitochondria is not working properly. It works to reactivate mitochondria function and has been the subject of a bit of research. It tests at 830 when therapeutic doses of 6 bottles a month are used to fight early stage cancer and 7 bottles a month are used for advanced stage cancer. Low blood levels of coenzyme Q10 have been found in patients with myeloma, lymphoma, and cancers of the breast, lung, prostate, pancreas, colon, kidney, head and neck. It is an oxygen-rich organic form of germanium which has been studied for its antiviral, immuno-stimulative and free-radical scavenging actions, and for supporting improved oxygen utilization. Increase to 7 bottles a month for advanced cancers and 8 bottles per month for very advanced cancers.
Warburg's Nobel Prize winning research, cells fundamentally turn cancerous when their mitochondria, the energy factory of the cell, becomes damaged. In fact the cells using glucose fermentation to produce energy do not function well enough to do their work. Use 3 bottles a month for early stage cancers and 4 bottles a month for advanced or very advanced cancers.
This combination supplies the hard nutrients that your cells need, a bioavailable CoQ10, germanium and support nutrients, and instructions from each elixir prompting mitochondrial repair in different ways.
The mitochondria are the energy producing factories in your cells, converting oxygen to energy when working properly. For decades the Budwig diet, focusing on a blend of flax oil and cottage cheese has been used to fight cancer and cardiovascular disease in this way. Lack of the proper ratio of high quality Omega 6 oils to the Omega 3 oils supplied by flax oil. Rats feed fish oil had an 85% loss of mitochondrial enzymes because the mitochondria were far more susceptible to oxidative stress damage. Grazing animals are fed poor quality grains they cannot digest leading to poor quality meat full of poor quality omega 6 oils from grains. Thus, it is essential to supplement our diets with high quality fresh omega oils to recover optimal health.
In general, todaya€™s western diet provides far more Omega-6 fatty acids than necessary, but the vast majority of these are damaged to the degree that they no longer function.
The average improvement was a 9 year decrease in biological arterial age, making their effective age younger than their physical age.
Relieved users consistently report dropping pounds and pounds effortlessly a€“ and keeping them off as their overall health comes into balance. Fish, especially farmed fish, contain almost entirely the Omega-3 derivatives, Eicosapentaenioc acid (EPA) and Docosahexaenoic acid (DHA) which are crucial to every body function, from skin health to cancer resistance. The truth is that the body requires very little of these compounds a€“ and can produce the amounts needed from fresh parent oils. Because of this, fish oil supplements originally thought to help prevent cancer have been called into question. It has a history of being vital for cancer prevention, and improves a host of other health issues too. Plus it has been frequency enhanced to make it even more useful and bio-available in the body. It comes in a 8oz bottle which provides a montha€™s supply (6 grams daily) of the most biologically active PEO's that you could find anywhere.
This oxygen becomes a powerful colon cleanser as it softens and loosens the hardened matter in the colon. The products and information contained herein are not intended to diagnose, treat, cure, or prevent any diseases or, medical problems.
He investigated the metabolism of tumors and the respiration of cells, particularly cancer cells.
His father, the physicist Emil Warburg, was President of the Physikalische Reichsanstalt, Wirklicher Geheimer Oberregierungsrat. His special interest in the investigation of vital processes by physical and chemical methods led to attempts to relate these processes to phenomena of the inorganic world. This, together with the iron-oxygenase discovered earlier, has given a complete account of the oxidations and reductions in the living world.
In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Several TCA cycle and oxidative phosphorylation inhibitors are being tested for their anticancer potential. The intake of sugar and sweetened foods was clearly linked to the development of pancreatic and other cancers.
In epithelial cells, NF-kB promotes the development of cancer not through inflammation, but through inhibition of a cell-killing process called apoptosis. The followings are excellent studies which explain, in detail, how glucose increases NF-kB activity. Fortunately, salicylates and sulfasalazine bind directly to the IKK beta enzyme thereby inhibiting its ability to activate NF-kB signaling.
The following studies identify sulfasalazine as a direct inhibitor of IKK-alpha and -beta by antagonizing adenosine triphosphate binding.
In fact, cancer is predicted to overtake heart disease as the prime cause of death in industrialized societies during this century. Seyfried provides substantial evidence documenting the inconsistencies of the gene a€?onlya€? theory. Cancer has remained incurable for many due largely to a general misunderstanding of its origin, biology, and metabolism.
I am a biochemical geneticist and have worked on the lipid biochemistry of cancer since the early 1980s. Most cancer patients do not battle their disease but are offered toxic concoctions that can eventually undermine their physiological strength and their will to resist. I would also like to acknowledge my current students Linh Ta and Zeynep Akgoc for their continued productivity. The disease involves multiple time- and space-dependent changes in the health status of cells, which ultimately lead to malignant tumors.
We constantly hear in the media of new breakthroughs in the fight against cancer, yet high profile celebrities and politicians continue to die from the disease. The authors of this study, and of many similar studies, believe that the cataloguing of mutations found in various tumors will be important for disease identification and management. Although targeting of Akt-related pathways is part of cancer drug development, the simple restriction of calorie intake will reduce Akt expression in tumors [14]. Besides expensive antiangiogenic cancer drugs such as bevacizumab (Avastin) [15], simple calorie restriction effectively targets angiogenesis in tumors [16, 17]. In the hallway, the communication is considered scientific, blunt, and factual, while in the room it is considered more nurturing and emotional. In this painting, Pope depicts an older woman with lymphatic cancer who is getting chemotherapy. Indeed, these sufferings have become even worse with some of the newer drugs available [15, 22]. The data in show that we are not winning the war on cancer, regardless of what the pundits say [8]. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?
Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: case report.
Much of the confusion surrounding the origin of cancer arises from the absence of a unifying theory that can integrate the diverse observations on the nature of the disease. Consideration of cancer as a a€?disease complexa€? rather than as a single disease has contributed to the notion that management of various forms of the disease will require individual or a€?personalizeda€? drug therapies [6–8].
Despite these concerns, the cancer field slogs forward with massive genome-based projects to identify all gene defects that occur in various tumor types [13–16]. Linda Chin mentioned in her plenary lecture that improved genomic sequencing speed was a major beneficiary of the cancer genome projects. If the ratio of a€?information in to useful information outa€? was so low for the cancer genome projects (), what is the justification that the ratio would be better for a cancer proteome project? Even if the expression signatures were adequately validated, the information would have little impact on the daily cancer death rate.
Although almost 700 targeted therapies have been developed from the cancer genome projects, no patients with solid tumor have been cured from this strategy [19]. Genetic heterogeneity and randomness is the norm rather than the exception for mutations found in most sporadic cancers. While genomic changes might participate in disease progression, they do not cause the disease. Most genetic defects found in tumors are a€?red herringsa€? that have diverted attention away from mitochondrial respiratory insufficiency, the central feature of the disease. In fact, I will present evidence showing how the gene defects in cancer cells can arise following damage to respiration. That a very specific process could be initiated in very unspecific ways was considered a€?the oncogenic paradoxa€? by Albert Szent-Gyorgyi, a leading cancer researcher of his day [27, 28]. In other words, dysregulated growth would arise through abnormal expression of genes that encode growth factors. A complex signaling circuitry involving the action of tumor-suppressor genes is necessary to maintain the quiescent state. Elimination of damaged cells is necessary in order to maintain tissue homeostasis and health. Many solid tumors have difficulty growing unless enervated with blood vessels, which can deliver nutrients while removing metabolic waste products (Fig. Metastasis or complications of metastasis is associated with about 90% of all cancer deaths [32, 35]. In addition to the prototypical growth signaling circuit centered around Ras and coupled to a spectrum of extracellular cues, other component circuits transmit antigrowth and differentiation signals or mediate commands to live or die by apoptosis.
However, the mutation rate for most genes is low, making it unlikely that the thousands and even millions of pathogenic mutations found in cancer cells would occur sporadically within a normal human lifespan [15, 26, 36]. Attempts to classify cancer mutations as either a€?driversa€? or a€?passengersa€? have done little to clarify the situation [13, 15, 22, 40].
The situation is even more confusing with suggestions that IDH1 is both an oncogene and a tumor-suppressor gene! Elevated glucose uptake and lactic acid production is a defining characteristic of most tumors and is the basis for tumor imaging using labeled glucose analogs [48–50]. For a short period of time, like when running a race, this anaerobic fermentation of sugar is okay. Kizer, a biochemist and physicist at Gungnir Research in Portsmith, Ohio explains, "Since Warburg's discovery, this difference in respiration has remained the most fundamental (and some say, only) physiological difference consistently found between normal and cancer cells. An overload of toxins clogging up the cells, poor quality cell walls that don't allow nutrients into the cells, the lack of nutrients needed for respiration, poor circulation and perhaps even low levels of oxygen in the air we breathe. Over time as these cells replicate, the cancer may spread if not destroyed by the immune system. And the cancer usually returns quickly a second time unless you make changes to support the health of your body. When we're working with cell cultures in the lab, if we want the cells to mutate, we turn down the oxygen. In fact our new top suggestion in this field may be the best cancer fighting supplement there is.
Unfortunately, their low cost solution is a bit dangerous and not all that effective for cancer.
However a different oxygen supplement from an MLM company is even higher, coming in at 320. And ends up creating hydrogen and oxygen as it splits the chemical bonds in water molecules. Many oxygen producing products like hydrogen peroxide, vitamin O (energetic testing a 30), or Aerobic 7- there's a whole slew of them - get oxygen into the blood. As maximum oxygen creation from Oxy E occurs 6 to 8 hours after ingesting, there is plenty of time to be taken into cells.
He heard about and started taking the supplement, and when I interviewed him he was working out at the gym 4 hours a day, and considers himself way ahead of others who had the same surgery and radiation a year ago.
Enough oxygen is released that the cancer cells are killed, or the viruses in the cells are destroyed. There have been reports of people beating cancer drinking about a liter a day of plain low deuterium water for months and months. This makes OxyDHQ even more effective because it is producing more oxygen near to cancer cells as Ronuv is able to target these cancer cells for OxyDHQ. They are all frequency enhanced water, water that has been imbued with particular vibrational energy messages that stimulate or instruct your cells to act or respond in specific ways. The energies in the elixirs covered in this report are much stronger than homeopathic remedies as they tell the body what to do.
If you remember, one of the issues with lack of oxygen in cells is that the cells are not taking it in efficiently. Radiant Care is an oil and water formulation that will thus improve oxygenation while benefiting health in many other ways.
This action makes Royal Ling Zhi one of the more valuable supplements to use with lung cancers. Energetic testing puts it at 230 for fighting cancer so it is not that good compared to the supplements we recommend here.
One example is a 48-year-old man started taking daily CoQ10 17 years before after a diagnosis of inoperable lung cancer.
The researchers showed that adding CoQ10 to the cells in vitro, or in the laboratory, there was a 70 percent inhibition of cell growth over 48 hours.
Human trials show that taking it results in 18 times higher serum levels of CoQ10 than the same amount of standard CoQ10. It is completely digestible because only the soluble part of the stabilized rice germ and bran is used.
We also cover Q RME in the immune system section where the reason for avoiding swelling is explained. Usually this damage results from lack of oxygen caused by toxins, or by lack of CoQ10 in the cell. Co Enzyme Q10 is responsible for transporting oxygen from one of the steps in the Krebs cycle to the next step. Once a cancer cell is able to produce energy normally again, with oxygen, it produces enough energy to begin to function again. Damage to the mitochondria caused by low oxygen levels, stops the cell's ability to produce energy aerobically using oxygen. They found that the rats feed fish oil had seven times more cancer tumors than the other groups. Omega-6 is also known as linoleic acid (LA), and Omega-3 is known as alpha-linoleic acid (ALA). Fish oil, on the other hand, dramatically overloads the system with EPA and DHA, at 20 to 100 times our bodya€™s requirements per dose. Included are therapeutic levels of the following PEOa€™s, combined to provide you with the perfect Peskin PEO 3 to 1 ratio. In 1918 he was appointed Professor at the Kaiser Wilhelm Institute for Biology, Berlin-Dahlem. His methods involved detailed studies on the assimilation of carbon dioxide in plants, the metabolism of tumors, and the chemical constituent of the oxygen transferring respiratory ferment. For his discovery of the nature and mode of action of the respiratory enzyme, the Nobel Prize has been awarded to him in 1931. If mutations are such rare events, then how is it possible that cancer cells express so many different types and kinds of mutations?
Several cancer management therapies have been proposed that target tumor cell metabolism and mitochondria. In myeloid cells, NF-kB causes the expression of pro-inflammatory molecules that stimulate the division of genetically altered epithelial cells and thereby increase tumor size.
The study shows how a mixed meal stimulates ROS (reactive oxygen species) generation and increases NF-kB activity. The suppression of NF-kB activation by inhibition of the IKKs contributes to the well-known anti-inflammatory and immunosuppressive effects of sulfasalazine.
These effects were shown to result primarily from inhibition of cystine uptake mediated by the x(c) (-) cystine transporter and not from inhibition of NF-kB (nuclear factor kappaB) activation, another anticancer property of sulfasalazine. I have worked in the cancer metabolism field since the late 1960s and have extensively published works on the metabolic basis and properties of cancer.
He critically reevaluates the evidence linking cancer progression to a Darwinian process and raises the intriguing possibility that cancer progression is an example of Lamarckian evolution.


Hopefully, Seyfried's thoughtful analysis of the a€?cancer problema€? will change our understanding of the disease and move the field in the right direction toward solutions and therapies, such as 3BP, that act much faster and more effectively than those currently available. I have developed numerous mouse models for brain tumors and for systemic metastatic cancer. I would also like to thank the following undergraduate students for their input and help, including Katherine Holthause, Jeremy Marsh, Jeffery Ling, Will Markis, Tiernan Mulrooney, Todd Sanderson, Todd Theman, Lisa Mahoney, Michelle Levine, Emily Coggins, Erin Wolfe, Ivan Urits, Taryn LeRoy, and Emily Gaudiano. If the breakthroughs are real or meaningful, shouldnt the wealthy and powerful have access to any potential life-saving therapy? While cataloguing cancer genetic defects is interesting, it is important to recognize that the defects often vary from one neoplastic cell to another within the same tumor [12]. The different shades of gray are indicative of different degrees of genetic alteration [13]. Although many patients view cancer doctors as secular priests in today's society, the toxic therapies doctors use to treat cancer are often counterproductive to the long-term well-being of cancer patients.
Some normal cells that are not killed outright can be metabolically transformed into tumor cells. In contrast to the treated patient, the mask and gloves protect the nurse from the toxic effects of the chemotherapy.
The promises of new drugs based on improved understanding of cancer genetics and biology have not materialized [26–28].
Without a clear idea on cancer origins, it becomes difficult to formulate a clear strategy for effective management and prevention. This therapeutic strategy would certainly be logical if, in fact, most cancers were of genetic origin. Gabor Miklos provided a compelling argument for the unlikelihood that data generated from cancer genome projects will provide effective cures for the disease [14]. Another benefit has been the increased number of jobs created in the biotechnology sector as a result of the genome projects. If technology improvement and new jobs creation is the justification, then this should be clearly stated, as a cure for cancer will not likely be the ultimate outcome. How many times must we beat the dead horse before we realize that it will not get up and walk?
We have recently shown how the majority of cancer gene defects could arise as downstream epiphenomena of tumor progression rather than as cancer causes [24]. If my prognosis is accurate, then where should one look for real solutions to the cancer problem? I trained in classical genetics with Herman Brockman at Illinois State University and in biochemical genetics with William Daniel at the University of Illinois. I predict that targeting the defective energy metabolism of tumors will eventually become the most cost-effective, nontoxic approach to cancer prevention and management. Oncogenesis is the term used to describe the biological process leading to tumor formation.
These six alterations were described as the hallmarks of nearly all cancers and have guided research in the field for the last decade [32].
The released growth factors would then bind to receptors on the surface of the same cell (autocrine stimulation) or bind to receptors on other nearby tumor cells (paracrine stimulation), thereby locking-in signaling circuits that perpetuate continuous replication. In addition to these internal signals, interactions with other cells (cella€“cell) and the external environment (cella€“matrix) also act to maintain quiescence.
Cell damage can initiate the release of mitochondrial cytochrome c, a protein of the mitochondrial electron transport chain, which is a potent inducer of apoptosis in normal cells. The prevention of metastasis remains the single most important challenge for cancer management. As for the genetic reprogramming of this integrated circuit in cancer cells, some of the genes known to be functionally altered are given in gray.
Pathogenic mutations are those that disrupt normal cell physiology and differ from nonpathogenic mutations, which generally do not have any physiological effect on cell homeostasis.
The view of cancer as a genetic disease reminds me of a traffic jam in Calcutta, India, where passengers direct drivers onto sidewalks and into opposite lanes of traffic in order to arrive at their destination. Labeled glucose analogs have become an important diagnostic tool for cancer detection and management using positron emission tomography (PET).
Even lack of the proper building blocks for cell walls, Omega 3 essential fatty acids, restricts oxygen exchange.
Your legs build up lactic acid from this fermentation process and burn, and you stop running. Using cell culture studies, I decided to examine the differential responses of normal and cancer cells to changes in the oxygen environment. And then you'll learn about a completely unique and different type of oxygenation supplement, Ronuv, that is testing as one of the best cancer fighters, 7000. Hyperbaric chamber treatments where high pressure drives oxygen into cells, comes in at 312. It forms an O- molecule with a negative ionic charge, which eliminates an O+ free radical by combining with it. The amount of deuterium in this water has been reduced to 25 parts per million of deuterium. What makes Ronuv such a powerful cancer fighter is this targeting of cancer cells caused by the attraction of its energized low deuterium water to those cells. The use of the specific elixirs and energetic vibrational frequencies in Ronuv makes a huge improvement in effectiveness. The combination of using equal amount of bottles of Ronuv, OxyDHQ, and Oxy Life Force Elixir, 3 of each for early stages, 4 of each for advanced stage cancers, and 5 of each for very advanced cancers tests energetically at 9800.
As the one of a kind technologies used to make these elixirs have improved, their effectiveness has become increasing powerful.
Usually because of too many toxins and also cells walls constructed of the wrong kinds of fats that are not as permeable as properly constructed cell walls are.
For an inflamed brain, Radiant Cane can be put topically on the crown and the nape of the neck. Since radiation damage is oxidative, this protection suggests it has strong anti-oxidative activity. When taking just one capsule you receive the equivalent nutrition of a pound of ordinary brown rice, without all the starch. Once the mitochondrial enzymes have been damaged, the cell principally produces energy anaerobically by fermenting glucose or sugar. If your cell lacks CoQ10, the Krebs cycle breaks down as the oxygen molecule can't be transferred from one step to another step, and the cell can only produce energy anaerobically. After three weeks the fish oil fed rats had 10 times more tumors than animals on the low fat diet. This is because they count the omega-6 you are currently eating as useful, which, according to Peskin, it is not. This study used photoplethysmography to detail the differences in arterial flexibility between subjects taking PEO's and those taking fish oil.
The ratio of Omega-6 to Omega-3 supplementation of 3 to 1, does take into account that we do get some healthy Omega-6 EFA's in our diet. Agency for Healthcare Research and Quality (AHRQ) performed an exhaustive search and analysis of the Omega-3 related research papers in 3 of the top medical databases over 30 years. Hundreds of medical studies have been published in the Middle East, Asia and Europe focusing on its immune strengthening, anti-histamine, anti-tumor, anti-microbial, and anti-inflammatory activity. Like Black Cumin Seed Oil, Evening Primrose and Borage seed oil, it is an excellent source of GLA (gamma-linoleic acid), which is an essential fatty acid used to treat a variety of ailments, from diabetes and ulcers to allergies and cancer. They have been recognized as a super-food for hundreds of years, and these nutrients are absorbed by the body in oil form. These oils derived from the fruit peel are antiseptic, anti-depressant, antispasmodic, anti-inflammatory, add delicious flavor and protect the blenda€™s freshness and stability.
For the digestive system, peppermint oil is effective for a range of ailments, as it stimulates the gall bladder and the secretion of bile. Since 1931 he is Director of the Kaiser Wilhelm Institute for Cell Physiology, there, a donation of the Rockefeller Foundation to the Kaiser Wilhelm Gesellschaft, founded the previous year. This discovery has opened up new ways in the fields of cellular metabolism and cellular respiration. Mutations in each of cancer genes result in dysregulation of metabolic pathways involved in oxygen, iron, energy or nutrient sensing, suggesting that cancer is a disease of cell metabolism. Targeting of the apoptotic regulatory machinery of mitochondria is another potential anticancer field in need of exploration.
Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages. When viewed collectively, the documented inconsistencies of the gene a€?onlya€? theory make it clear why little progress has been made in the cancer war and in the development of effective nontoxic therapies. The view of cancer as a genetic disease has confounded the problem and is largely responsible for the failure to develop effective therapies. I would like to thank those students from my BI503 class on Current Topics in Cancer Research for their input. Tumor cell invasion of surrounding tissues and spread to distant organs is the primary cause of morbidity and mortality in most cancer patients. That these folks are just as vulnerable as the rest of us to the ravages of the disease clearly indicates that the war is not won. For each altered component of a particular pathway, the nature of the alteration and the percentage of tumors affected are indicated. Moreover, those tumor cells that survive the radiation treatment will sometimes grow back as more aggressive and less manageable cancers in the future. As each new a€?miraclea€? cancer drug is discontinued due to no efficacy or unacceptable toxicity, a new a€?miraclea€? drug with similar disappointing effects quickly takes its place [15, 29]. The failure to clearly define the origin of cancer is responsible in large part for the failure to significantly reduce the death rate from the disease. A recent commentary in Science supports Miklos' argument in mentioning that little new information was uncovered from a comprehensive analysis of the ovarian cancer genome (Jocelyn Kaiser, 333:397, 2011).
In light of these findings, it is not likely that gene-based targeting strategies will be useful for managing most advanced cancers.
Moreover, the therapeutic efficacy of molecularly a€?targeteda€? therapies could be enhanced if combined with therapies that target energy metabolism. John Cairns also struggled with this paradox in his essay on The Origins of Human Cancers [29]. Damage to suppressor genes or the microenvironment is assumed to dampen growth inhibition and provoke proliferation, as the cell no longer responds appropriately to the growth-inhibitory actions of these genes or molecules. In contrast to normal cells, however, tumor cells lose their sensitivity to apoptotic death signals. The phenomenon of limitless replicative potential is closely connected to the first three acquired capabilities. The dissemination of tumor cells throughout the body is assumed to depend in part on the degree of tumor vascularization. If the genome guardians are so essential for maintaining genomic integrity, then why are these guardians prone to such high mutability? The attempt to link the six hallmarks of cancer to genomic instability is like a Calcutta traffic jam, but without a clear destination.
The radiolabeled glucose collects in the tumor tissue because nearly all tumors depend heavily on glucose for survival. Whittaker points out, quite rightly, that liquid oxygen supplements that release oxygen into the blood, which most of them only do, can't get oxygen into the cells. And the oxygen therapy where you breath oxygen while exercising on a treadmill, where the increased circulation from exercising carries the oxygen to more parts of your body, comes in at 314. Whittaker points out, what they can't do though, is to actually get the oxygen into the cells. Just remember, Oxy E is a detoxifier so you may experience detoxification symptoms like headaches, fatigue, nausea and diarrhea if you increase the amounts rapidly, and thus detoxify faster than your body can comfortably handle.
This low deuterium water has small amounts of a number of frequency enhanced elixirs added to it to greatly enhance its actions. In fact, any cells with damaged mitochondrial function, such as cells infected by viruses and other pathogens which damage their ability to produce energy aerobically, will have more deuterium in them, and thus will act as a magnet, attracting deuterium to them.
Oxy Life Force Elixir turns on your cells hunger for oxygen so that they will uptake more of them, even if there are more toxins than ideal, and even if the cell walls still are not made of the right Omega 3 fatty acids.
Germanium 132 also increases the production of interferon, which helps activate immune system macrophages and T-suppressor cells, and enhances Natural Killer Cell activity. This nutritious Rice Complex strongly supports maximum absorption of ProCoQ10 - and further enhances its far ranging benefits. This damages these heat sensitive omega 3 and 6 oils, which when consumed, causes harm in the body and leads to cancer and cardiovascular disease. But the Omega-6 has been damaged by heat, solvents, exposed to sunlight, contaminated -- all of which destroy its benefits.
Adding this to your diet provides a host of health benefits in addition to cancer and cardiovascular protection.
Parent Essential Oils provide the body with fatty acids in their whole, parent form, so the body can utilize exactly the nutrients it needs. They came to the conclusion that a€?Omega-3 fatty acids do not appear to decrease overall cancer risk.a€? This calls into question the effectiveness of the Omega-3 supplements most popularly used a€“ which are distilled fish-oil based a€“ not fats from fresh fish or fresh pressed seed oils. And then it is energy infused with frequency vibrations to tell the body to improve cellular respiration. This cold pressed oil is exceptionally high in antioxidants and contains thymoquinone, nigellone and beta-sitosterol, a plant sterol known to lower serum cholesterol. GLA is also powerful anti-inflammatory, which can be used to treat the swelling and pain associated with arthritis, as well as gastritis, which is inflammation of the stomach.
Organic Cold Pressed Camelina Seed Oil and Cold Pressed Flax Seed Oil have among the highest (quality) omega-3 contents of any plant.
Sunflower seed oil has higher vitamin E content than many vegetable oils with high levels of unsaturated fat.
It is also useful for other cancer near the colon where the oxygen released by O3Right will easily travel to.
He has shown, among other things, that cancerous cells can live and develop, even in the absence of oxygen.
Additionally, oxidative phosphorylation uncouplers, potassium channel modulators, and mitochondrial redox are under investigation for their anticancer potential. Seyfried personally, I am very impressed with the excellent job he has done in highlighting abnormal energy metabolism as the central issue of the cancer problem. A key point made by Seyfried is that most of the genomic instability seen in cancer likely arises as a consequence rather than as the cause of the disease. First, it became clear to me that the therapeutic action of some anticancer drugs operated largely through reduced caloric intake. The view of cancer as a genetic disease is based on the flawed notion that somatic mutations cause cancer.
The road to the cancer front is littered with major breakthroughs that never materialized into effective solutions.
Boxes contain the final percentages of glioblastomas containing alterations in at least one known component gene of the designated pathway. What if most of the gene changes identified in tumor tissue arise as secondary downstream epiphenomena of tumor progression?
While enhanced sequencing speed and creation of new jobs are certainly important and noteworthy, these achievements are not connected to curing cancer. Unfortunately, much of my original enthusiasm for the genetic origin of cancer has given way to skepticism and frank disbelief.
Cybernetics is generally viewed as the study of goal-directed control and communication systems [33].
Tumor cells are known to express multiple defects in tumor-suppressor genes and in cella€“cell or cella€“matrix interactions. Consequently, tumor cells continue to live and proliferate despite damage to their nuclear DNA and respiration. The more blood vessels in tumors, the greater will be the potential to invade and metastasize. If mutations are such rare events, then how is it possible that cancer cells can express so many different types and kinds of mutations during the development of a malignant tumor?
Indeed, the p53 genome guardian is one of the most commonly mutated genes found in tumors [38]. Consequently, it is easy to detect many tumor types based on their requirement for glucose as shown in . However the problem comes when your cells cannot produce energy using oxygen because of this damage to the respiratory enzymes.
OxyDHQ tests energetically at 1350, making it easily the second best oxygenation supplement to use after Ronuv, covered below. Then to make these actions even more powerful, it is frequency enhanced with numerous subtle vibrational energies -- again all working to make Ronuv work more powerfully. Plain low deuterium water tests energetically at 360, which is good compared to some of the common cancer fighting supplements and oxygenators, but not nearly as good as Ronuv testing at 7000. Its frequencies also work to increase efficiency of oxygen exchange, helping move oxygen to enter cells. This damage turns Omega-6 into health destroying EFA's that cause inflammation in your body, decrease the ability of your cells to absorb oxygen, thus the oxygenation and cancer connection, and greatly increase cardiovascular damage.
And a major issue would be the rancidity of fish oils given the sensitivity of EPA and DHA.
The oil is more than 80% unsaturated essential fatty acids with abundant nutrient cofactors that protect the oil and those who consume it. Cleaning the colon is also quite valuable in the fight against cancer as it will enable your body to better detoxify. I recognized long ago the pivotal role of mitochondria and of aerobic glycolysis in sustaining and promoting cancer growth. When viewed more as a metabolic disease, many cost effective therapeutic strategies become recognized for cancer management. Substantial evidence indicates that genomic instability is linked to protracted respiratory insufficiency.
The biological process by which normal cells are transformed into malignant cancer cells has been the subject of an enormous research effort in the biomedical sciences for more than a century. A plateau in overall death rates for some cancers has been due more to better awareness and avoidance of risk factors, for example, smoking for lung cancer, than to any real advances in the management of systemic metastasis, the most deadly feature of the disease [6, 7]. It is also interesting to note that no alterations in any of the pathways occur in about 15% of glioblastomas despite similarity in histological presentation. SABiosciences is a QIAGEN company specializing in molecular array technologies that can help analyze gene expression changes, epigenomic patterns, microRNA expressions, and so on.
According to Pope, the painting shows the human encounter with poisonous drug therapy, an all-too-familiar scene for the cancer patient.
The abnormal circuitry in tumor cells is assumed to result in large part from the dominant expression of cancer-causing oncogenes. Loss of tumor-suppressor genes, which sense cell damage and initiate cell death, is responsible in part for resistance of tumor cells to programmed cell death.
Tumor cells release growth factors that stimulate nearby host stromal cells (vascular endothelial cells and macrophages) to proliferate, thus providing the tumor with a vasculature and the means for more rapid growth. Most genes necessary for survival, for example, ubiquitin, histones etc., show little mutability across species.
In addition to improving glucose metabolism, salicylates also prevent fat induced insulin resistance. The Nobel laureate, Otto Warburg, was the first to provide evidence during the early part of the last century for the involvement of disturbed respiration with compensatory fermentation (glycolysis) as a common property of cancer, thus perceived to be related to its uncontrolled growth and progression. I know this first hand from our studies of 3-bromopyruvate (3BP), discovered in my laboratory by Dr.
Third, that ketone bodies can serve as an alternative fuel to glucose in most cells with normal respiratory function. Once cancer becomes recognized as a metabolic disease with metabolic solutions, more humane and effective treatment strategies will emerge. Despite this effort, cures or long-term management strategies for metastatic cancers are as challenging today as they were 40 years ago when President Richard M.
It remains unclear how these genomic alterations relate to the origin or progression of the disease. It will end, in my opinion, only after we come to recognize cancer as a metabolic disease that can be effectively managed with nontoxic metabolic therapies [31]. We have a financial crisis in the federal government and yet we are wasting enormous resources on genome projects that provide little useful information for cancer patients. The endothelial cells form the vessel walls, while the local macrophages and other stromal cells degrade the microenvironment facilitating neovascularization. It is difficult for me to see how natural selection would select high mutability genes as a€?guardians of the genome.a€? This would be like bank owners hiring tellers who are highly prone to corruption! Use 3 bottles a month for early stage cancer and 4 bottles a month for advanced or very advanced cancers. Start out taking just 1 capsule at bedtime and gradually work up to taking 6 capsules nightly. Few subjects have been as controversial in the cancer field as Otto Warburg and his theory of cancer. My treatise highlights cancer as a metabolic disease and identifies the inconsistencies of the gene theory of cancer. A switch from low vascularization to high vascularization is considered to be an essential acquired capability for tumor progression [5, 32, 34]. It is nice to see how Seyfried shows that Warburg was largely correct in defining the nature of the disease as involving insufficient respiration with compensatory fermentation. This is a low cost drug with powerful and quick antitumor effects against multiple cancers in animal models and in cancer patients.
Fifth, that all cancer cells regardless of tissue origin express a general defect in mitochondrial energy metabolism.
Moreover, my treatise addresses most of the so-called provocative questions raised by the National Cancer Institute regarding outstanding issues in cancer research. According to the American Cancer Society, 569,490 people died in the United States from cancer in 2010 [4]. Borage oil, taken internally and used topically, has been used for soothing these and other inflammatory skin conditions. I knew personally many of the key figures and their research mentioned in Seyfried's book, including Dean Burk, Peter Mitchell, Sidney Weinhouse, and my former Department Chair, Albert Lehninger, among others. 3BP works primarily by targeting tumor cell energy metabolism, thus depleting the energy-rich compound a€?ATPa€? essential for growth.
Finally, that cancer can be effectively managed and prevented once it becomes recognized as a metabolic disease. Nevertheless, there were times in my early career when I felt almost alone in considering energy metabolism as important to the cancer problem. Remarkably, the number of deaths in 2002 was 555,500 providing quantitative evidence of no real progress in management over a 8-year period [5].
I even remember one of my colleagues, an expert in DNA technology, dumping Lehninger's a€?Warburg Flasksa€? in the trash as relics of a bygone era in cancer research.
Seyfried's book provides substantial evidence showing how cancer can be managed using various other drugs and diets that target energy metabolism.
All one needs to do is read the obituary pages from any local newspaper to know that the a€?cancer wara€? is not going well. Fortunately for him, Lehninger was no longer the Department Chair, and fortunately for me, I salvaged many of these flasks and am now glad I did. In addition, the restriction of glucose and glutamine, which drive cancer energy metabolism, cripples the ability of cancer cells to replicate and disseminate. After reading Seyfried's book, I think these flasks will become valuable as collector items.
Purna was the first to make me aware of the powerful therapeutic action of calorie restriction.
She is superbly trained in the areas of angiogenesis and inflammation and her work provided seminal information on the mechanisms by which dietary energy reduction can both treat and prevent cancer. Nevertheless, cancer is a singular disease involving aberrant energy metabolism as Warburg originally showed and as I, and more recently many others, have documented in biochemical studies.
Roberto Flores is exceptional in his dedication to finding the truth underlying the metabolic origin of cancer and in questioning the metabolic origin of cancer. Finally, I would like to thank my institution, Boston College, for providing animal care support over the first 23 years of my employment there (1985a€“2008). The data collected supporting my treatise would not have been possible without this invaluable institutional support.



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