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To ensure the integrity and highest quality of CytoJournal publications, the review process of this manuscript was conducted under a double-blind model (authors are blinded for reviewers and vice versa) through automatic online system. At Cytocheck Laboratory, we offer, both computer-assisted and non-computer assisted ThinPrep Pap smear screening, as well as conventional Pap smear screening. The ThinPrep Pap screening offers an increase in ASC-US, LSIL, and HSIL detection over the conventional screen, along with a decrease in false-negative and unsatisfactory cases.
The ThinPrep Pap is the only liquid-based pap test with FDA approval to test HPV, Gonorrhea, and Chlamydia straight from the vial, eliminating the need for co-collecting. Cytocheck also offers non-gyn cytology, including brushings, washings, fine needle aspirations, urine specimens, and breast smears. All cytology cases are completed and resulted in 1-2 working days from receipt in the laboratory.
At Cytocheck Laboratory, we take advantage of the most advanced technology available for STD testing. High-risk HPV testing is performed using the Cervista platform, which uses signal amplification and fluorescence detection to detect all 14 oncogenic strains of HPV. Gonorrhea and Chlamydia testing can be ran using the APTIMA COMBO2 ASSAY or the PACE method, both of which are offered through Gen-Probe.
Gonorrhea and Chlamydia results are available 1-2 working days from specimen receipt in the laboratory. Because we specialize in women's health care, the majority of our surgical pathology specimens annually are GYN. Non-GYN surgical pathology is offered through fine needle aspirations, brushings, washings, urine specimens, and breast smears.
Specimens are examined, interpreted, and reported out within 24 hours of receipt in the laboratory. Laboratory has partnered with Labette Health hospital laboratory to provide clinical laboratory testing to our clients. Find a doctor at The Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center or Johns Hopkins Community Physicians. Molluscum contagiosum is characterized by the appearance of squamous cells with molluscum bodies. Although the Pap test is primarily used for detecting cellular and epithelial abnormalities, certain infections are easily detected on the Pap test too. Pemphigus vulgaris of the vagina--its cytomorphologic features on liquid-based cytology and pitfalls: case report and cytological differential diagnosis. Cervical smear with intracellular organisms from a case of granuloma venereum (donovanosis). Concomitant malacoplakia and granuloma inguinale of the cervix in acquired immune deficiency syndrome.
Female genital coccidioidomycosis (FGC), Addison's disease and sigmoid loop abscess due to Coccidioides immites; case report and review of literature on FGC. Paracoccidioides brasiliensis in a liquid-based Papanicolaou test from a pregnant woman: report of a case.


Association of Schistosoma haematobium and human papillomavirus in cervical cancer: a case report. Diagnosis of genital cervical schistosomiasis: comparison of cytological, histopathological and parasitological examination.
A case of Taenia saginata (tape worm) infestation of the uterus presenting with abnormal vaginal bleeding. Intraoral molluscum contagiosum imitating a squamous-cell carcinoma in an immunocompetent person--case report and review of the literature.
Pathology over-reads are performed at no extra charge, along with a 15% quality control rescreening process. We pride ourselves on being a progressive billing service able to stay current with the ever-changing regulations in the healthcare industry while still maximizing reimbursement in a timely manner. Infections such as tuberculosis cervicitis may be erroneously diagnosed as carcinoma, whereas others, such as schistosomiasis, are associated with squamous cell carcinoma. Therefore, various microorganisms that involve the lower female genital tract have been reported in Pap tests.
We have access to a wide array of immunohistochemical stains and specialized cancer testing such as FISH, ISH, IHC, HER2, and Flow Cytometry. By allowing Central Billing Office to handle all of your billing needs, your office staff will have more time to devote to quality patient care and other important day to day tasks.
The two most common methods of removing cervical lesions are by procedures called a LEEP or Cold Knife Cone. These cases include granuloma inguinale (donovanosis), tuberculosis, coccidioidomycosis, schistosomiasis, taeniasis, and molluscum contagiosum diagnosed in Pap tests. Rare entities that include neoplastic and non-neoplastic conditions (see [Table 1] for a list of benign conditions), pose challenges due to the infrequent occurrence of many of these entities in the daily practice of cytology.
Welch, owner and pathologist of Cytocheck Laboratory, is also the Medical Director for Labette Health Laboratory, providing an open and immediate line of communication between the two laboratories. For more information on how Central Billing Office can assist with your billing needs, contact your Cytocheck Laboratory representative or call us at (888) 430-8770. Both procedures are quick and typically have a quick recovery time.The LEEP (Loop Electrosurgical Excision Procedure) can be performed either in the doctor’s office or as an outpatient procedure in the operating room.
Granuloma inguinale shows histiocytes that contain intracytoplasmic bacteria (Donovan bodies). These conditions may also give rise to important diagnostic pitfalls to be aware of in Pap tests.
Cytocheck has an electronic interface with Labette Health to download results in near real-time results.
Tuberculosis is characterized by necrotizing granulomatous inflammation with Langhans-multinucleated giant cells. For example, cases of granulomatous cervicitis due to tuberculosis seen in Pap tests have been erroneously diagnosed clinically and cytologically as squamous cell carcinoma, [1] and cases of pemphigus vulgaris have been mistaken for endocervical adenocarcinoma or squamous cell carcinoma.
Cytocheck representatives remain the contacts for all questions and queries regarding clinical testing, helping to make Cytocheck Laboratory the only laboratory necessary for all of your health care needs.


Coccidioidomycosis may show large intact or ruptured fungal spherules associated with endospores.
Labette Health is fully accredited and certified by the College of American Pathologists and the American Association of Blood Banks. Next, an instrument called a speculum is inserted into your vagina to hold your vaginal walls open so your physician can view the inside of the vaginal walls and the cervix.
This article reviews and illustrates the cytomorphology of 6 rare infections that may be encountered in Pap tests and focuses on helpful diagnostic criteria and differential diagnoses.
This article reviews the cytomorphology of selected rare infections and focuses on their cytomorphology, differential diagnosis, and role of ancillary diagnostic studies. An electrically charged loop made of thin wire is inserted through the speculum and up to the cervix.
As the loop is passed across the cervix, it cuts away a thin layer of surface tissue, removing the abnormal cells. If all of the abnormal cervical tissue is removed, no further surgery is needed, though abnormal cells may recur in the future.Your doctor will give you instructions for recovering at home, including using pads to collect any discharge, avoiding strenuous activity for 48 hours, and abstaining from sexual intercourse for three to four weeks. Over the counter pain relievers can be used to relieve cramping.The Cold Knife Conization is performed in the operating room, using a scalpel. You will lie on a table and place your feet in stirrups to position your pelvis for examination.
An instrument called a speculum will be inserted into your vagina to hold your vaginal walls open so your physician can view the inside of the vaginal walls and the cervix. Abnormal cells from the cervical canal, including adenocarcinoma in situ, may be diagnosed, and sometimes treated with cold knife conization.Your doctor will give you instructions to prepare for the procedure and recover at home.
For two to three weeks after the procedure, you may have heavy, bloody, or a yellow-colored discharge. Avoid sexual intercourse, douching and use of tampons for about four to six weeks.Therapeutic HPV VaccinesThrough the efforts of a team of investigators in the Johns Hopkins Center for Cervical Dysplasia, several clinical trials testing immune therapies for HPV disease are currently open.
The development of these HPV-targeted immune therapies, chronicled in over 20 publications in leading biomedical research journals, emerged from a team of translational investigators in three different disciplines: immunology, gynecologic pathology, and gynecology.
The initial generation of HPV vaccines involved the use of targeting signals that made HPV antigens more visible to the immune system.
In addition, strategic collaborations with a number of companies are paving the way to the development of combination immunotherapies with even greater potential efficacy. It is our goal to develop a combinatorial HPV immunotherapy approach that could be applied to all women with established HPV infections, that would ultimately eliminate the need for the complex and expensive screening, long-term follow-up, and surgical interventions currently employed to manage HPV disease.



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