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Initial tingling, burning, or pain, followed by erythema, edema and possibly vesicles in one area of the lips.
Any of the following are appropriate for treating symptomatic herpes simplex virus (HSV) recurrence in normal hosts. For patients with herpes labialis that is provoked by the sun, sunscreen use is recommended. Sitavig is a new formulation of acyclovir, in a tablet, that contains 50 mg acyclovir in a milk protein formulation. Various topical antiviral agents are available but these are much less effective compared to the oral agents. The other condition which a majority of people think is commonly triggered by HSV-1 is canker sore. According to a recent study that was carried out by the CDC (Center for Disease Control), it was discovered that a majority of people in the US contract Herpes Labialis by the age of 20. In contrast to the Herpes Simplex Virus – Type 2, the condition cannot be transmitted from mother to child during birth.
Inflammation is caused when the virus starts reproducing thus infecting cells and tissues that are situated at the tip of nerve.
Other signs and symptoms associated with Herpes Labialis are sores and blisters on the lips and inside the mouth.
Treatment of the Herpes Labialis is usually completed by administering antiviral medications. For example, penciclovir 1% cream (Denavir in the US) is FDA approved for the treatment of herpes labialis.
An outbreak typically causes small blisters or sores on or around the mouth commonly known as cold sores or fever blisters. This is an infection of the mouth as well as the lips triggered primarily by a particular type of virus known as HSV-1 (Herpes Simplex Virus – Type 1). However, it is important to point out that the condition is quite contagious and can be transmitted from one person to the other through kissing.


This often occurs from mother to child and is a way for the virus to pass from one generation to the next. The virus is known to trigger painful sores not only on the lips, but tongue, cheeks, gums and palate.
Canker sore appears within the mouth, tongue as well as the soft palate and not on the skin. The virus causing the disease is known to remain dormant for several years within the nerve tissues of the face.
So advise patients that when they have an active cold sore, they should abstain from kissing. Even though the condition may recur in some patients after a couple of years, the relapse is not contagious. The virus may reactivate in a number of people, thus reproducing cold sores which tend to occur in the same area. The virus can stay dormant in the body for several years and can be activated by a weakening immune system.
Cold sore has a rate of frequency that varies from rare episodes to 12 or more recurrences per year. Other symptoms commonly associated with the condition, include aching of the muscles plus fever. Then again, the condition can be transmitted to another person through oral sex and contact sport.
The frequency and severity of outbreaks generally decreases over time.The virus is transmitted from cold sores and also when there are no symptoms, as it can make copies of itself on the skin in the absence of a blister. Symptoms typically begin with tingling (itching) and reddening of the skin around the infected site. This stage can last from a few days to a few hours preceding the physical manifestation of an infection and is the best time to start treatment. Inflammation (day 1): Virus begins reproducing and infecting cells at the end of the nerve. The healthy cells react to the invasion with swelling and redness displayed as symptoms of infection.


Pre-sore (day 2-3): This stage is defined by the appearance of tiny, hard, inflamed papules and vesicles that may itch and are painfully sensitive to touch. In time, these fluid-filled blisters form a cluster on the lip (labial) tissue, the area between the lip and skin (vermilion border), and can occur on the nose, chin, and cheeks. This yellowish or brown crust or scab is not made of active virus but from blood serum containing useful proteins such as albumin and globulins. The sore is still painful at this stage, but, more painful, however, is the constant cracking of the scab as one moves or stretches their lips, as in smiling or eating.
Healing (day 9-14): New skin begins to form underneath the scab as the virus retreats into latency. A series of scabs will form over the sore (Called Meier Complex), each one smaller than the last. Post-scab (12a€“14 days): A reddish area may linger at the site of viral infection as the destroyed cells are regenerated.
Rare reinfections occur inside the mouth (''intraoral HSV stomatitis'') affecting the gums, alveolar ridge, hard palate, and the back of the tongue, possibly accompanied by ''herpes labialis''.
The virus moves from the mouth to quietly reside (a€?remain latenta€?) in the central nervous system. In approximately one-third of people, the virus can a€?wake upa€? or reactivate to cause disease. When reactivation occurs, the virus travels down the nerves to the skin where it may cause blisters (cold sores) around the lips, in the mouth or, in about 10% of cases, on the nose, chin, or cheeks.
Cold sore outbreaks may be influenced by stress, menstruation, sunlight, sunburn, fever, or local skin trauma. Surgical procedures such as dental or neural surgery, lip tattooing, or dermabrasion are also common triggers. The duration of symptoms can be reduced by a small amount if a antiviral, anaesthetic or non-treatment cream (such as zinc oxide or zinc sulfate) is applied promptly.



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