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admin 22.03.2016

According to a study reported in the Journal of Infectious Diseases, a new gonorrhea treatment has successfully eliminated gonococcal infection from female mice and prevented reinfection. More than 100 million new gonococcal infections occur each year around the globe, according to the World Health Organization. In considering how to modify the immune response to gonococcal infection, Prof Russell became intrigued with an anti-cancer therapy being developed by Prof Nejat Egilmez, also from the University at Buffalo.
Prof Egilmez, co-author of the current study, developed a sustained-release nanoparticle treatment that uses Interleukin-12, a cytokine or protein that helps stimulate an immune response against tumors that normally suppress immunity.
One month later, attempts to reinfect these mice with the bacterium failed, demonstrating that the animals had retained the ability to fight reinfection. An antibiotic-resistant strain of gonorrhea—now considered a superbug—has some analysts saying that the bacteria’s effects could match those of AIDS, reports CNBC.
Because the disease resists antibiotics it’s being considered a superbug and is in the same category as MRCA and CRE, which are both resistant bacteria. Conspiracy Theory: Mary J Blige Hints That R&B Singer Aaliyah Was Set Up To Be Murdered? Researchers are warning that the sexually transmitted disease gonorrhea is becoming increasingly resistant to antibiotics.
The only effective antibiotics recommended by the CDC may soon become ineffective in the fight against gonorrhea infections. However, not to worried about much, because there is a hope that vaccine for may be possible. Vaccines have been our best weapon against the world’s deadliest infectious diseases such as smallpox, polio, measles, and yellow fever etc.
Potential candidates for HIV antibodies and HIV early stage result are selected and then accounted for clinical trials. Moreover, the candidate having HIV infection that is experimented, some of them showed some efficacy and some do not. The already developed vaccines, namely ALVAC-HIV and AIDSVAX, were used in combination in these trials. The possible approach for the HIV vaccine covers all the seven phases from Free State phase to Releasing phase.


Moreover, blocking the replication in phase-l and damaging the virion or its parts in phase-l to Vll are also possible approaches for the HIV vaccine. Researchers in the Pacific Northwest have discovered a new line of attack against gonorrhea, the dreaded venereal disease that can cause searing sensations in one’s nether regions, swollen testicles and vaginal discharge.
A strain of gonhorrea is one of several infections that current drugs can't treat, according to CDC officials. The potential breakthrough comes as the sexually transmitted scourge continues to run circles around antibiotic treatments, causing a surge in cases across the United States.
Hopefully, that could soon be a thing of your parents’ (and maybe best friend’s) past. In a study published in Molecular and Cellular Protometrics, scientists at Oregon State University and the University of Washington identified a pocket of previously unidentified proteins that act as a shield against the interior of the gonorrhea bacteria. These proteins protect the bacteria from toxic molecules and are essential for its survival.
These findings offer scientists a brand-new avenue from which to attack the survival and spread of gonorrhea, says Aleksandra Sikora, the pharmacy researcher at OSU who spearheaded the study. The timing of these findings could not be better, as health officials continue to fearfully monitor the rise of drug-resistant strains. The infection can be asymptomatic but it also can cause extremely painful urination in men and pelvic inflammatory disease, which can lead to infertility and ectopic pregnancy, in women. It turns out that gonococcal infection very cleverly controls the immune system, inducing responses the bacterium can fight and suppressing the responses that it cannot fight,” said study senior author Prof Michael Russell of the University at Buffalo.
It could be argued that when the IL-12 microspheres are administered this way, they serve as an adjuvant that, in effect, converts the gonococcal infection into a live vaccine, thus essentially vaccinating the very population that is at risk for repeat infections,” Prof Russell said. Enhancement of Adaptive Immunity to Neisseria gonorrhoeae by Local Intravaginal Administration of Microencapsulated Interleukin 12.
It’s being reported that the HO41 gonorrhea strain was discovered in Japan two years ago from a 31 year old female sex worker.
These superbugs kill about half the people they attack, and nearly one in 20 hospital patients become infected with one, according to the Centers for Disease Control and Prevention.
These researches and programs are based on managing clinical trials seek to create one good HIV vaccine that can work, but unfortunately, there is no effective HIV vaccine yet discovered to deal this deadly virus, because HIV has unique ways of evading the immune system and human body is failed of mounting an effective immune response.


As there has been no vaccine discovered to protect human body from HIV virus, trials have been made to experiment medicine on potential candidates time to time. The first vaccine prim an immune response against HIV and the second used as a booster once the immunity waned.
These classifications are theoretical as none of the vaccines proven to be working against HIV virus. Filtering virions from blood, catching the virion and destroying or damaging the virion or its parts are exercised as possible approaches for the HIV vaccine. To block the replication, Insertion into blood chemical or organic compounds take place in that binds to the gp120. Doctors have deemed these new drug-resistant strains of the clap, frequently called super gonorrhea, a looming public health crisis. In 2012, The New Yorker reported on the possibility of a super clap becoming a global epidemic. Centers for Disease Control that showed how patients with the disease were finding fewer and fewer options for treatment.
One of the evidence is that monoclonal antibodies (MAb) proven that the human body can defend itself against HIV after experiments. And another positive thing about these trials was that first time ever any trial showed positive results. Whereas, to destroying or damaging the virion or its parts have different classification of methods.
Doctors here now treat approximately 300,000 patients a year, and health officials believe that just as many cases go unreported. However, there were many trials which showed no efficacy, such as the STEP study and HVTN 505 trials etc.



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