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Himalaya's phytochemistry team studies the geographical and seasonal variations of marker profile of these herbs.
With a focus on taking herbal research to new levels, Himalaya's scientists have adopted bioassay guided fractionation and purification technology to identify the active fractions.
Super Critical Fluid (SCF) extraction is one of the fast growing technologies for extracting herbal materials without using chemical solvents. Extracts from single herb or a combination of herbs are initially tested on disease models of cell lines to evaluate the efficacy of the drug. We have conducted clinical trials for our products in leading hospitals in India and worldwide including the All India Institute of Medical Sciences (Delhi), Apollo Hospitals (Chennai), St.
Phase IV studies are also conducted by Himalaya, which involve the safety surveillance (pharmacovigilance) and ongoing technical support of a drug after it receives permission to be sold.
A team of botanists and Ayurveda experts at our R&D center review these scholarly texts and shortlist suitable herbs for further research.

Active markers within these herbs, which are responsible for its therapeutic property, may vary depending on whether they are cultivated or sourced from the wild. Himalaya’s scientists are leveraging this technology during research and development for the extraction of beneficial bioactive compounds. Once efficacy is confirmed, these extracts undergo rigorous toxicity tests and mutagen studies to ensure that it is safe to test on humans.
The numbers of patients increase in each phase before the drug is launched into the market.
Phytochemical profiling is established from different seasons and geographical locations to ensure batch-to-batch consistency, good quality and standardization. This ensures no solvent residues in herbal preparation while delivering to the safety and efficacy of the products.
The extracts are formulated into the desired dosage forms (capsules, tablets, etc) and then enter human clinical trials.

In Phase 1, the drug is administered to a small number of healthy human subjects to assess safety of the formulation. Himalaya has over 1,200 published clinical trials in leading international journals including Journal of the American Medical Association (JAMA), Alternative Medicine, Indian Journal of Pharmaceutical Sciences, The British Journal of Radiology and Journal of Ethnopharmacology. The quality of herbs is further maintained either by cultivating herbs under supervision of agricultural scientists or by practicing sustainable collection and harvesting practices under the supervision of trained botanists (in case of herbs sourced from the wild). Both Phase II and Phase III studies are conducted to assess the true efficacy in patients suffering from the disease.

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