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PDF access policyFull text access is free in HTML pages; however the journal allows PDF access only to users from INDIA and paid subscribers. Aims: To determine the immunohistochemical profile of clinically suspected cases of inflammatory myopathies, using monoclonal antibodies to HLA-1 and membrane attack complex (MAC), and to correlate the clinical, serological, and electromyographic profile and the histopathological picture, with the immunohistochemical profile. This study addressed the association of HLA-DR gene with atherosclerotic cerebral infarction (ACI) in a North Chinese Han population. The combination of sarcolemmal depolarization and hypokalemia has been attributed to abnormalities of the potassium conductance governing the membrane potential; however, the molecular mechanism that causes hypokalemia has not yet been determined. Patients and Methods: All patients who underwent surgery for prolactinomas, between December 2002 and December 2009, were analyzed retrospectively. Aim: To investigate the safety, usefulness, and perioperative complications of RAGs for symptomatic cavernous carotid aneurysms in elderly patients.
Transcallosal, transforaminal approach is a safe route and the most direct path to excise third ventricular colloid cyst, without dependence on hydrocephalus. Material and Methods: Forty-six patients with 50 wide-necked and fusiform aneurysms (19 aneurysms with dissections), admitted between June 2009 and December 2010, were treated using Enterprise stents.
Induced pluripotent stem cells are produced by nuclear reprogramming technology and they resemble embryonic stem cells (ES) in key elements; they possess the potentiality to differentiate into any type of cell in the body. Aim: To evaluate the role of intralesional transplant of mouse MSC following coldinduced cerebral cortical injury in mouse in improving neurological function.
We hypothesize that combining NEP1-40 with another promising therapy, neural stem cell transplantation, might further improve the degree of locomotor recovery. Of the 97 patients, 78 (80%) had idiopathic hypoparathyroidism and 19 (20%) had pseudohypoparathyroidism. The O-arm® is the next-generation spinal navigation tool that provides intraoperative 3-D imaging for complex spine surgeries. Before the era of magnetic resonance imaging (MRI), most cases of BCS were diagnosed on postmortem examination.
We report a patient who had functional hemispherectomy for intractable seizures secondary to right hemispheric cortical dysplasia. Spontaneous intracranial hypotension occurs due to reduced CSF pressure usually as a result of a spontaneous dural tear. Settings and Design: This was a retrospective study analyzing the clinical and histopathological features in muscle of clinically suspected cases of inflammatory myopathy and correlating it to their HLA-1 and MAC immunostaining profiles. Material and Methods: The genotyping of HLA-DRB1 was determined by standard techniques based on polymerase chain reaction and sequence-specific oligonucleotides hybridization in a gene chip. Aim: To test the hypothesis that the expression patterns of delayed rectifier potassium channel genes in the skeletal muscle cells of patients with familial hypokalemic periodic paralysis differ from those in normal cells.
The study group consisted of patients who were either intolerant or noncompliant to dopamine agonist (DA) therapy or those in whom medical treatment could not be given due to various reasons. Material and Methods: Of the 74 consecutive patients, in whom RAGs were used, we retrospectively investigated the postoperative outcomes and complications in eight elderly patients aged over 70 years with symptomatic internal carotid artery aneurysms in cavernous sinus.
Aim: To assess the surgical outcome of patients with colloid cysts of the anterior third ventricle treated by the transcallosal, transforaminal approach. Aim: This study was undertaken to evaluate the therapeutic effect of OEC in rat models using different cell dosages. In the present study, we examined whether NEP1-40 combined with bone marrow stromal cells-derived neurospheres (BMSC-NSs) transplantation would produce synergistic effects on recovery.
MRI allows for noninvasive diagnosis by demonstrating characteristic changes which closely parallels the histopathological features of BCS. Preoperatively, the patient had mild left hemiparesis and functional magnetic resonance imaging (fMRI) showed bilateral motor function lateralization to normal left hemisphere. Idiopathic intracranial hypertension (IIH) is a syndrome of elevated intracranial tension without hydrocephalus or mass lesions and with normal CSF composition.
Material and Methods: The study subjects included 33 cases with suspected inflammatory myopathy and 59 with non-inflammatory muscle disease, as controls.
Material and Methods: We examined both mRNA and protein levels of two major delayed rectifier potassium channel genes KCNQ3 and KCNQ5 in the skeletal muscle cells from three patients with familial hypokalemic periodic paralysis and three healthy controls. Results: Postoperative complications included one case of cerebral infarction, one case of symptomatic seizures, and one case of delayed cranial nerve palsy. Patients and Methods: Seventy-eight patients operated by the above approach over a period of 20 years were analyzed.


In addition, iPS research obviates the political and ethical quandary associated with embryo destruction and ES research. Material and Methods: OECs harvested from the olfactory mucosa of adult white Albino rats were cultured.
Material and Methods: Adult Sprague-Dawley rats were subjected to spinal cord injury (SCI) at the T10 vertebral level. We report a case of 26-year-old female with BCS involving bilateral thalami, with typical MRI appearance.
The patient remains seizure free at 1-year follow-up, with no deterioration of motor power on left side.
Neuroimaging plays an important role in excluding secondary causes of raised intracranial tension. Clinical data, electromyographic findings, serological profile, and details of therapy were obtained from patient records.
Results: When normal cells were exposed to 50 mM potassium buffer, which was used to induce depolarization, the KCNQ3 protein level significantly increased in the membrane fraction but decreased in the cytosolic fraction, whereas the opposite was true in patient cells.
Results: Stent deployment was successful in all the 50 lesions, and additional coil embolization was performed in 48. Spinal cord injury (SCI) was inflicted at the lower thoracic segment in a control and test group of rats. Neurological severity score (NSS) and rotarod treadmill test were used to perform serial assessments. The most common presenting manifestation was carpopedal spasm in 68 (70%) patients, followed by paresthesia and seizures in 52 (54%) patients. This report reviews physiology of neural plasticity for motor function lateralization and also reliability of fMRI in determining the functional shift. As the clinical presentation is varied, imaging may also help the clinician in arriving at the diagnosis of IIH with the help of a few specific signs. Statistical Analysis: Student 'T' test, Pearson's Chi square test, and Kappa statistics were used appropriately.
Conclusions: These data indicate that the polymorphisms in HLA-DRB1 may influence the risk of ACI in the North Han population of China. Conclusion: Abnormal subcellular distribution of the KCNQ3 protein was observed in patient cells. Postoperatively there was improvement in cranial nerve palsy in seven patients and the patients who had symptoms for one year and eight months had residual deficits. Complete or near-complete occlusion immediately after stent deployment was achieved in 44 aneurysms, whereas, no immediate coil embolization was chosen in two cases. This brief review summarizes currently available stem cell platforms, with emphasis on cellular reprogramming and iPS technology and its application in disease modeling and cell replacement therapy in neurodegenerative diseases.
However, the use of this therapy in the treatment of these neurological diseases is highly restricted, mainly owing to several technical difficulties and limitations. Two weeks later, OECs were delivered in and around the injured spinal cord segment of the test group of the rats.
BrdU-labeled BMSC-NSs (2×105 ) were transplanted into the injured site 7 days after SCI. In this review, we attempt to compile the salient magnetic resonance imaging findings in these two conditions. Our results suggest that the altered expression of KCNQ3 in patient cells exposed to high extracellular potassium levels could possibly hinder normal function of the channel protein.
Overall, at last follow-up, hormonal remission could be achieved in 44% patients (83% microadenomas, 48% macroadenomas, and 16% of giant adenomas).
Although it cannot be stated that the frequency of perioperative complications was low, the final outcomes were favorable.
The strategy of isolation and characterization of neural stem cells from various sources will probably provide a major impetus and open up an interesting, novel therapeutic modality for several neurodegenerative disorders. The outcome in terms of locomotor recovery of limb muscles was assessed on a standard rating scale and by recording the motor-evoked potentials from the muscles during transcranial electrical stimulation.
The most common imaging abnormality noted was basal ganglia calcification followed by cerebral cortex and cerebellum calcification. Ten patients (40%) had American Spinal Injury Association (ASIA) grade A injuries, two patients (8%) had grade B, five patients (20%) had grade C, four patients (16%) each had grade D, and grade E injuries.


Careful observation of these findings may help in early accurate diagnosis and to provide appropriate early treatment. Conclusions: A combination of clinical presentation, serological profile, electromyographic and histopathological features, together with the immunoprofile for HLA-1 and MAC, contribute toward making a diagnosis of inflammatory myopathy. These findings may provide an important clue to understanding the molecular mechanism of familial hypokalemic periodic paralysis. Conclusion: Even in carotid disease that is difficult to treat among the elderly, RAG would appear to be a useful and safe treatment. This difference was not found to be statistically significant when subgroup analysis of animals, where the assessments were blinded, was performed.
Animals were perfused transcardially 10 weeks after contusion, and histological examinations were performed. 59% of those patients, who did not achieve remission after surgery, finally attained normoprolactinemia with either DA therapy or radiotherapy, at last follow-up. Statistical Analysis: Wilcoxon signed rank test and Mann-Whitney U-test were used to compare the data in the control and the test group of animals. There was no significant difference in the rotarod treadmill scores between the control and the MSC group at any time point.
Results: The combined therapy group showed statistically better locomotor recovery than the control group at 7 weeks of contusion. In addition to oral calcium and active vitamin D (calcitriol), twenty-six patients (27%) also required hydrochlorothiazide.
Of these, 113 (81%) were dorsolumbar pedicle screws, 2 were odontoid screws, 12 were anterior cervical screws, and 12 screws (48%) were lateral mass screws. Conclusions: Medical treatment of prolactinomas with DA should be considered as treatment of choice for these tumors. All patients underwent the transcallosal, transforaminal approach, and total excision of the lesion was achieved in 77 patients and subtotal in 1.
Conclusions: The Enterprise stent is very useful for endovascular embolization of wide-necked intracranial aneurysms, because it is easy to navigate and place precisely. Few BrdU-positive cells could be identified in the periphery of the contusion up to day 10 posttransplant. The important finding in our study was long lag time from the first reported symptom to diagnosis. However, there is a major subgroup of patients who respond better to surgery rather than protracted medical therapy. Conclusions: Transplanted MSCs were shown to survive for at least 10 days after intralesional transplant in the cryoinjury model of the mouse cerebral cortex but the functional recovery observed in the experimental group was not statistically different from the controls. The average area of the cystic cavity was significantly smaller in the combined therapy group than in the control group. Conclusion: Transplantation of OECs along with olfactory nerve fibroblasts improved the motor recovery in rat models with SCI. Fluorescence microscopic analysis showed that NEP1-40 dramatically inhibited the formation of glial scar and promoted the axons penetration into the scar barrier.
Practicing clinicians should have high index of suspicion of diagnosis hypoparathyroidism in the appropriate clinical states to avoid the morbidity associated with hypoparathyroidism. Conclusion: This study revealed that BMSC-NSs and NEP 1-40 exhibit synergistic effects on recovery in rat SCI. Accurate screw placement provides better patient safety and reduces the in hospital stay thereby leading early patient mobilization and may reduce the cost incurred in patient management. Early detection and total excision of the lesion can be a permanent cure with low mortality and minimum morbidity, when compared to the natural history of the disease.
The limited anterior callosotomy does not result in disconnection syndromes or behavioral disturbance.



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