Herpes simplex first symptoms yahoo,treating blisters toes,metaphysical healing bondi,initial herpes outbreak symptoms - Tips For You

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Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital.
Requests for Reprints: Lawrence Corey, MD, University of Washington, Virology Division, Room 9301, 1200 12th Avenue South, Seattle, WA 98144.
Acknowledgments: The authors thank Michael Remington, PA, Carol Winter, RN, Cathy Critchlow, PhD, Stacy Selke, MA, Joan Dragavon, Colleen Olson, Michele Crist, Judy Zeh, PhD, Paul Van Veldheisen, MS, Carolyn Lapinsky, WHCS, Anita Fahnlander, RN, and others whose collaborative efforts over a 14-year period made possible the establishment of our genital herpes database. Anyone can submit a comment any time after publication, but only those submitted within 4 weeks of an article’s publication will be considered for print publication. The first time someone catches herpes the infection may go completely unnoticed or be asymptomatic. Signs of a recurrent herpes episode might include a little tingling sensation, or perhaps flu-like symptoms with fever and swollen lymph nodes.
The herpes virus comes in many forms and the type that usually causes genital sores is called herpes simplex virus, most frequently type 2 (HSV-2). The initial exposure to herpes may be asymptomatic and precede the eruption by months to years. It has long been thought that oral and facial lesions are caused by type 1 herpes (HSV-1) and genital lesions by type 2. The severity of herpes eruptions varies tremendously among individuals and often represents a relative weakness of the immune system in the face of an emerging expression of the virus. Barleans Omega 3 Swirls are delicious ways to get the essential omega-3 fatty acids: take 1000 mg daily. A moistened black tea bag applied for five minutes twice daily has anesthetic and anti-viral properties. A comprehensive program involves many areas in which action steps can be taken, gradually or all at once.
Eat highly nutritious foods during a herpes outbreak as you would for any viral infection: grass fed meats, wild salmon and other fish, pastured-raised eggs, and dairy from pastured cows.
Avoid foods rich in arginine: gelatin, chocolate, carob, coconut meat, oats, whole wheat, white flour, peanuts, soybeans, wheat germ, walnuts, almonds, cashews, pecans, and sesame seeds. The following can be helpful in shortening an acute herpes attack, or interrupting a pattern of recurring attacks. Honey, aloe vera gel, or calendula ointment can all aid the softening and healing of a crusted lesion. Be sure to use disposable gloves to separate the tissues if urination over an open lesion is unbearable. Herpes is best treated with a constitutional remedy in consultation with a professional homeopath. Lysine can be as miraculous in alternative practice as prescription anti-virals have been for conventional medicine. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Currently, two types of direct methods to characterize and identify single virions are available: electron microscopy (EM) and scanning probe techniques, especially atomic force microscopy (AFM). Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans-Knoll-Str. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Thirty-eight percent had at least 6 recurrences during the first year and 20% had more than 10 recurrences. One month after publication, editors review all posted comments and select some for publication in the Letters section of the print version of Annals. These are followed by a cluster of small fluid-filled blisters that break and leave painful crusted ulcers that seem to heal agonizingly slowly, even if it's only several days. The herpes virus has the unfortunate capacity to live dormant in our system and reappear when it gets a chance as an oral, facial, or genital cold sore.
We now know the herpes neighborhoods are not truly exclusive, and either type can appear as a lesion in either area. The sores may be anywhere from the lower abdomen to the mid thigh, front, back and between the legs, for men or women. Alternative herpes treatments are aimed at enhancing the immune response rather than disabling the viral expression, and are similar for either type of herpes virus in any location. Fish, chicken, beef, lamb, milk, cheese, beans, brewer's yeast, mung bean sprouts, and most fruits and vegetables have more lysine than arginine, except for peas. The helpful extract Monolaurin in coconut oil might act in opposition to the arginine-rich coconut meat.
As you would during any viral infection, avoid immune stressors such as alcohol, processed foods, sodas, white flour products, sugar and other refined carbohydrates, and excessive caffeine, all of which can interfere with immune function.
Start with 2 capsules (500 mg each) three times daily during the outbreak and continue taking 1 capsule daily for three months or even years to prevent recurrences. That same area is likely to be contagious before there are open sores, perhaps even as early as when there is just tingling.
The living culture present in yogurt, is reported to help alleviate the symptoms of a herpes outbreak. One study showed that sores healed faster for people using the ointment containing propolis than in those using ointments containing the antiviral drug acyclovir or a placebo. Both can be found as an ointment in health food stores and may be applied three times daily.
Avoiding contact with the skin or membranes at or around the outbreak area is the only sure protection whether that is from refraining from touch or inserting a barrier (condom) between yourself and the lesion. Many exposures do not result in herpes transmission, when the outbreak is minor and the unaffected person's immune system is strong and able to respond vigorously to the herpes virus. I first learned about using lysine from a patient, close to 20 years ago, when homeopathic treatment had lessened the intensity and frequency of the herpes outbreaks but not eradicated them. Is there a health tip - for herpes or anything else - that you've always wanted to share with your physician? It doesn’t change my mind, but if you are still getting routine mammograms, it might change yours. Friends, television ads, and even your physician have probably told you that probiotics are part of a healthy life. Robert Lustig from the University of California, San Francisco (my alma mater!) is gaining notoriety this week for calling attention to the serious health hazards of sugar. Possible reasons include loss of sunlight enriched vitamin D levels, exposure to cold and damp, indoor air quality, and greater indoor crowding. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions.
AFM in particular provides morphologic information even of the ultrastructure of viral specimens without the need to cultivate the virus and to invasively alter the sample prior to the measurements. HSV-1 can also cause genital herpes. Herpes simplex virus 2 (HSV-2) is the most common cause of genital herpes, but it can also cause oral herpes. Continue taking 1 capsule daily for at least three months, and possibly for years, to prevent recurrences. Monolaurin, found naturally in coconut oil and breast milk, has anti-viral effects against all types of herpes viruses. To alleviate stress, relaxing therapies such as meditation and guided imagery are recommended.
Open herpes sores inside the vagina are often silent and painless; sores on the cervix are often painless.
For extremely painful initial outbreak unresponsive to above measures, one may wish to use an analgesic topically such as lidocaine gel, which requires a prescription. Lysine ointment at the spot of the “tingle” and oral capsules in high doses are often adequate to reverse an emerging herpes outbreak. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
Trends in HSV Types and Genital Herpes Genital herpes can be caused by either HSV-2 or HSV-1. Twenty-six percent of women and 8% of men had no or 1 recurrence in year 1 of follow-up, whereas 14% of women and 26% of men had more than 10 recurrences.
If coconut is important to your diet, test it on yourself to see its personal effect on your tendency to herpes.
If you are symptom-free, re-introduce foods one at a time to identify which foods might need a permanent boot off your plate! We may sleep through a fire siren or the alarm clock, but we can be awakened with enough effort. Interestingly, varying morphological parameters for virions of the same type can be found in the literature, depending on whether AFM or EM was employed and according to the respective experimental conditions during the AFM measurements.
Genital herpes' little blisters become bigger, and eventually break to leave ulcers, scabs, and sores that heal slowly over days to weeks. And then, we return to life with our brains and attitudes refreshed.The world is a sunnier place, jokes are funnier, and everything falls into place.
Here, an inter-methodological proof of principle is presented, in which the same single virions of herpes simplex virus 1 were probed by AFM previously and after they were measured by scanning electron microscopy (SEM).
In recent years, HSV-1 has become a significant cause in developed countries, including the United States. Turns out that inside your body everything is just as happy, and it’s primarily the work of the melatonin that made your sleep so restful.
Sophisticated chemometric analyses then allowed a calculation of morphological parameters of the ensemble of single virions and a comparison thereof. Recurrence rates are especially high in persons with an extended first episode of infection, regardless of whether they receive antiviral chemotherapy with acyclovir.
A distinct decrease in the virions’ dimensions was found during as well as after the SEM analyses and could be attributed to the sample preparation for the SEM measurements.


Men with genital HSV-2 infection have about 20% more recurrences than do women, a factor that may contribute to the higher rate of HSV-2 transmission from men to women than from women to men and to the continuing epidemic of genital herpes in the United States.
The risk of infection is highest during outbreak periods when there are visible sores and lesions.
Rapid visualization at high resolution of pathogens by atomic force microscopy—structural studies of herpes simplex virus-1. Symptoms When genital herpes symptoms do appear, they are usually worse during the first outbreak than during recurring attacks.
Viral capsomere structure, surface processes and growth kinetics in the crystallization of macromolecular crystals visualized by in situ atomic force microscopy.
Herpes, Pregnancy, and Newborn Infants Herpes can pose serious risks for a pregnant woman and her baby. The risk is greatest for mothers with a first-time infection, because the virus can be transmitted to the infant during childbirth. Guidelines from the American Academy of Pediatrics recommend using specific diagnostic tests for women in labor to determine the risk of transmission. Babies born to mothers infected with genital herpes are treated with the antiviral drug acyclovir, which can help suppress the virus. They include human herpes virus 8 (the cause of Kaposi sarcoma) and varicella-zoster virus (also known as herpes zoster, the virus responsible for shingles and chickenpox).
The word "herpes" comes from the Greek word "herpein," meaning "to creep." This refers to the unique characteristic pattern of all herpes viruses to creep along local nerve pathways to the nerve clusters at the end, where they remain in an inactive (dormant) state for variable periods of time. Localization and force analysis at the single virus particle level using atomic force microscopy. HSV-1 can also cause genital herpes, which is a sexually transmitted disease (STD). Herpes simplex virus 2 (HSV-2) is the usual cause of genital herpes, but it can also cause oral herpes. Resolving structure and mechanical properties at the nanoscale of viruses with frequency modulation atomic force microscopy.
Until recently, the general rule was to assume that HSV-1 caused oral herpes and HSV-2 caused genital herpes. It is now clear, however, that either type of herpes virus can be found in the genital or oral areas (or other sites).
In fact, HSV-1 is now responsible for more than half of all new cases of genital herpes in developed countries. The Disease ProcessHerpes is transmitted through close skin-to-skin contact. Comprehensive size-determination of whole virus vaccine particles using gas-phase electrophoretic mobility macromolecular analyzer, atomic force microscopy, and transmission electron microscopy. To infect people, the herpes simplex viruses (both HSV-1 and HSV-2) must get into the body through tiny injuries in the skin or through a mucous membrane, such as inside the mouth or on the genital or anal areas.
The risk for infection is highest with direct contact of blisters or sores during an outbreak.
But the infection can also develop from contact with an infected partner who does not have visible sores or other symptoms. Once the virus has contact with the mucous membranes or skin wounds, it enters the nuclei of skin tissue cells and begins to replicate.
Single virus detection by means of atomic force microscopy in combination with advanced image analysis. The virus is then transported from the nerve endings of the skin to clusters of nerve cells (ganglia) where it remains inactive (latent) for some period of time. However, at some point, the virus wakes up and travels along nerve pathways to the surface the skin where it begins to multiply again. During this time, the virus can infect other people if it is passed along in body fluids or secretions. Akima, R port by Albrecht Gebhardt aspline function by Thomas Petzoldt enhancements and corrections by Martin Maechler. Viral shedding may be accompanied by noticeable symptoms (outbreak) but it can also occur without causing symptoms (asymptomatic shedding). In either case, a person is infectious during periods of viral shedding. Symptoms may appear as multiple small red bumps or patches that develop blisters. Certain triggers can wake up the virus from its dormant state and cause it to become active again.
In general, recurrent episodes of herpes cause less severe symptoms than the primary outbreak. HSV-1 is the most prevalent form of herpes simplex virus, and infection is most likely to occur during preschool years. People can get HSV-2 through genital contact or HSV-1 through mouth-to-genital contact with an infected partner. Structure of the herpes simplex virus capsid: effects of extraction with guanidine hydrochloride and partial reconstitution of extracted capsids. People with active symptoms of genital herpes are at very high risk for transmitting the infection. Unfortunately, most cases of genital herpes infections occur when the virus is shedding but producing no symptoms.
Most people either have no symptoms or do not recognize them when they appear. In the past, genital herpes was mostly caused by HSV-2, but HSV-1 genital infection is increasing.
There is also evidence that children today are less likely to get cold sores and become exposed to HSV-1 during childhood. Centers for Disease Control and Prevention (CDC), about 1 in 6 Americans ages 14 to 49 years have genital herpes. While HSV-2 remains the main cause of genital herpes, HSV-1 has significantly increased as a cause, most likely because of oral-genital sex. Scaffold expulsion and genome packaging trigger stabilization of herpes simplex virus capsids.
African-American women are at particularly high risk. People with compromised immune systems, such as those who have HIV, are at very high risk for genital herpes. Drugs that suppress the immune system, and organ transplantation, can also weaken the immune system and increase the risk for contracting genital herpes. Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy. It is almost impossible to defend against the transmission of oral herpes, because it can be transmitted by very casual contact, including kissing. Comparison of electrical properties of viruses studied by AC capacitance scanning probe microscopy. Still, you can help reduce the risk of transmitting oral herpes by not sharing objects that touch the mouth, such as eating and drinking utensils, toothbrushes, and towels. It is best to refrain from any type of sex (vaginal, anal, or oral) during periods of active outbreak. However, herpes can also be transmitted when symptoms are not present (asymptomatic shedding). Only water-based lubricants (K-Y Jelly, Astroglide, AquaLube, and glycerin) should be used. It is very unlikely to transmit or contract genital herpes from a toilet seat or bath towel. Studies suggest that male circumcision may help reduce the risk of HSV-2, as well as human papillomavirus (HPV) and HIV infections.
However, herpes can cause significant and widespread complications in people who don't have a fully functioning immune system. The CDC recommends that all people diagnosed with herpes simplex virus 2 (HSV-2) get tested for HIV. Most people with HIV are co-infected with HSV-2 and are particularly vulnerable to its complications.
HSV-2 infection increases HIV levels in the genital tract, which makes it easier for the HIV virus to be spread to sexual partners. Herpes and PregnancyPregnant women who have genital herpes due to either HSV-2 or HSV-1 have an increased risk for miscarriage, premature labor, inhibited fetal growth, or transmission of the herpes infection to the infant in the uterus or at the time of delivery. Herpes in newborn babies (herpes neonatalis) can be a very serious condition. Fortunately, neonatal herpes is rare.
Although about 25 to 30% of pregnant women have genital herpes, less than 0.1% of babies are born with neonatal herpes. The baby is at greatest risk during a vaginal delivery, especially if the mother has an asymptomatic infection that was first introduced late in the pregnancy.
The risk for transmission also increases if infants with infected mothers are born prematurely, there is invasive monitoring, or instruments are used during vaginal delivery. Transmission can occur if the amniotic membrane of an infected woman ruptures prematurely, or as the infant passes through an infected birth canal. This risk is increased if the woman is having or has recently had an active herpes outbreak in the genital area. Very rarely, the virus is transmitted across the placenta, a form of the infection known as congenital herpes. Also rarely, newborns may contract herpes during the first weeks of life from being kissed by someone with a herpes cold sore. Infants may get congenital herpes from a mother with an active herpes infection at the time of birth.
Aggressive treatment with antiviral medication is required. Most infected pregnant women do not have a history of symptoms, so herpes infection is often not suspected or detected at the time of delivery. Fortunately, if a woman does have genital lesions, rapid diagnostic blood tests can quickly determine her chances of transmitting the virus to her baby during delivery.
Some women with new or recurrent herpes may also be prescribed antiviral medication during pregnancy.
A woman with herpes can usually safely breastfeed her baby, as long as she does not have a lesion on her breast or nipple. Neonatal herpes can spread to the brain and central nervous system, causing encephalitis and meningitis.
Herpes can also spread to internal organs, such as the liver and lungs. Infants infected with herpes are treated with acyclovir, an antiviral drug. They usually receive several weeks of intravenous acyclovir treatment, followed by several months of oral acyclovir. It is important to treat babies quickly, before the infection spreads to the brain and other organs.
Fortunately, rapid diagnostic tests and treatment with acyclovir have significantly improved survival rates and reduced complication rates. Nearly all who recover have some impairment, ranging from very mild neurological changes to paralysis. Like encephalitis, meningitis symptoms include headache, fever, stiff neck, vomiting, and sensitivity to light.


Fortunately, herpes meningitis usually resolves after about a week without complications, although symptoms can recur. Herpes Eye ComplicationsOcular herpes is a recurrent infection that affects the eyes. Herpes Skin ComplicationsEczema Herpeticum: A rare form of herpes infection called eczema herpeticum, also known as Kaposi varicelliform eruption, can affect people with skin disorders and those with a weakened immune system.
In children, this is often caused by thumb sucking or finger sucking while they have a cold sore. It can also occur in adult health care workers, such as dentists, because of increased exposure to the herpes virus. The use of latex or polyurethane gloves prevents herpes whitlow in health care workers. SymptomsHerpes symptoms vary depending on whether the outbreak is initial or recurrent.
The primary outbreak is usually worse than recurrent outbreaks, with more severe and prolonged symptoms. In fact, studies indicate that 10 to 25% of people infected with HSV-2 are unaware that they have genital herpes.
The first signs are a tingling sensation in the affected areas (genitalia, buttocks, and thighs) and groups of small red bumps that develop into blisters. The sores may sometimes itch, but itching decreases as they heal. About 40% of men and 70% of women develop other symptoms during initial outbreaks of genital herpes, such as flu-like discomfort, headache, muscle aches, and fever.
Some women may have difficulty urinating and may, occasionally, require a urinary catheter. The virus sheds for a much shorter period of time (about 3 days) compared to an initial outbreak of 3 weeks. Women may have only minor itching, and the symptoms may be even milder in men. On average, people have about four recurrences during the first year, although this varies widely.
There are some differences in frequency of recurrence depending on whether HSV-2 or HSV-1 caused genital herpes. HSV-2 genital infection is more likely to cause recurrences than HSV-1. Symptoms of Oral Herpes Oral herpes (herpes labialis) is most often caused by HSV-1, but it can also be caused by HSV-2. It usually affects the lips and, in some primary attacks, the mucus membranes in the mouth. The sores last 10 to 14 days and can be very uncomfortable. Blisters that may be preceded or accompanied by sore throat, fever, swollen glands, and painful swallowing. Recurrent Oral Herpes Infection: A recurrent oral herpes infection is much milder than the primary outbreak. It usually manifests as a single sore, commonly called a cold sore or fever blister (because it may arise during a bout of cold or flu). The sore usually shows up on the outer edge of the lips and rarely affects the gums or throat. Recurrences of genital herpes are more likely with HSV-2 infection than with HSV-1 infection.
Occasionally, the symptoms may not resemble those of the primary episode, but appear as fissures and scrapes in the skin or as general inflammation around the affected area. They include sunlight, wind, fever, physical injury, surgery, menstruation, suppression of the immune system, and emotional stress.
For most people, outbreaks recur with more frequency during the first year after an initial attack. The good news is that in most healthy people, recurring infections tend to become progressively less frequent, and less severe, over time. However, other conditions can resemble herpes, and doctors cannot base a herpes diagnosis on visual inspection alone. These tests include: Virologic tests (viral culture of the lesion) Serologic tests (blood tests that detect antibodies) The CDC recommends that both virologic and serologic tests be used for diagnosing genital herpes. People diagnosed with genital herpes should also be tested for other sexually transmitted diseases. At this time, experts do not recommend screening for HSV-1 or HSV-2 in the general population. Genital herpes can be caused by either HSV-1 or HSV-2.
It is important to determine which virus is involved, as the type of herpes infection influences prognosis and treatment recommendations. Recurrences of genital herpes, and viral shedding without overt symptoms, are much less frequent with HSV-1 infection than with HSV-2. False-negative (testing negative when herpes infection is actually present) or false-positive (testing positive when herpes infection is not actually present) results can occur.
Your health care provider may recommend that you have a test repeated. Virologic TestsViral culture tests are made by taking a fluid sample, or culture, from the lesions as early as possible, ideally within the first 48 hours of the outbreak. PCR tests are much faster and more accurate than viral cultures, and the CDC recommends PCR for detecting herpes in spinal fluid when diagnosing herpes encephalitis.
PCR can make many copies of the virus' DNA, so that even small amounts of DNA in the sample can be detected. However, many labs now use PCR for herpes testing because it is highly accurate. An older type of virologic testing, the Tzanck smear test, uses scrapings from herpes lesions.
The scrapings are stained and examined under a microscope for the presence of giant cells with many nuclei or distinctive particles that carry the virus (called inclusion bodies). The Tzanck test is not reliable for providing a conclusive diagnosis of herpes infection and is not recommended by the CDC. Serologic TestsSerologic (blood) tests can identify antibodies that are specific for either HSV-1 or HSV-2. When the herpes virus infects you, your body's immune system produces specific antibodies to fight off the infection. If a blood test detects antibodies to herpes, it is evidence that you have been infected with the virus, even if the virus is in a non-active (dormant) state. The presence of antibodies to herpes also indicates that you are a carrier of the virus and might transmit it to others. Serologic tests can be especially useful for people who do not have active symptoms, but who have other risk factors for herpes (such as other STDs, multiple sex partners, or a monogamous partner who has genital herpes). Although glycoprotein (gG) type-specific tests have been available for many years, many of the older nontype-specific tests that cannot distinguish HSV-1 from HSV-2 are still on the market.
Canker sores frequently crop up singly or in groups on the inside of the mouth, or on or underneath the tongue. They usually heal within 2 weeks without treatment. Canker sores (Aphthous ulcers) are very common. The drugs are used initially to treat a first attack of herpes, and then afterward to either treat recurrent outbreaks (episodic therapy) or reduce frequency of recurrences (suppressive therapy). Drugs can, however, reduce the severity of symptoms, improve healing times, and prevent recurrences.
If people experience very severe disease or complications, they need to be hospitalized and receive an antiviral drug intravenously. Your health care provider will prescribe one of the three antiviral medications, which you will take for 7 to 10 days. You should begin the medication as soon as you notice any signs or symptoms of herpes, preferably during the prodrome stage that precedes the outbreak of lesions. If taken during prodrome, episodic therapy may help prevent an outbreak from occurring or reduce its severity. Valacyclovir is taken once a day. Suppressive treatment can reduce the frequency of outbreak recurrences by 70 to 80%.
It is generally recommended for people who have frequent recurrences (6 or more outbreaks per year).
Because herpes recurrences often diminish over time, you should discuss annually with your health care provider whether you should stay with drug therapy or discontinue it. While taking any suppressive therapy for genital herpes, it is still important to regularly use latex condoms and to avoid any sexual activity during recurrences. A new form of acyclovir (Sitavig) is administered orally as an adhesive tablet; it is applied to the gum region of the mouth, where it dissolves during the course of the day.
In addition, acyclovir is available in topical form, as is the related drug penciclovir (Denavir). Topical TreatmentsThese ointments or creams can help shorten healing time and duration of symptoms.
However, none are truly effective at eliminating outbreaks. Penciclovir (Denavir) heals HSV-1 sores on average about half a day faster than without treatment, stops viral shedding, and reduces the duration of pain. Ideally, you should apply the cream within the first hour of symptoms, although the medication can still help if applied later. Apply the cream 5 times a day, beginning at the first sign of tingling or pain. Over-the-counter topical ointments may provide modest relief. They include Anbesol gel, Blistex lip ointment, Camphophenique, Herpecin-L, Viractin, and Zilactin. Some contain a topical anesthetic such as benzocaine, tetracaine, or phenol. Lip balm that contains sunblock, or sunscreen applied around the lips may help prevent sun-triggered outbreaks. Herbs and SupplementsGenerally, manufacturers of herbal remedies and dietary supplements do not need FDA approval to sell their products. Just like a drug, herbs and supplements can affect the body's chemistry, and therefore have the potential to produce side effects that may be harmful. There have been several reported cases of serious and even lethal side effects from herbal products. Always check with your provider before using any herbal remedies or dietary supplements. Many herbal and dietary supplement products claim to help fight herpes infection by boosting the immune system.
There has been little research on these products, and little evidence to show that they really work. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Seroprevalence of herpes simplex virus type 2 among persons aged 14 - 49 years -- United States, 2005-2008. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Epub 2013 Jan 28. Martin ET, Krantz E, Gottlieb SL, Magaret AS, Langenberg A, Stanberry L, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection.



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