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Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two strains of the Herpes virus family, Herpesviridae, which cause infections in humans.
After an initial, or primary, infection, HSV establishes latency, during which the virus is present in the cell bodies of nerves which innervate the area of original outbreak. Herpes infections are marked by painful, watery blisters in the skin or mucous membranes (such as the mouth or lips) or on the genitals. HSV is generally transmitted by direct contact of lips or genitals when the sores are present, or just before they appear (known as shedding). Entry and replication of the HSV involves interactions of several viral glycoproteins with cell surface receptors or particles. Once bound to the HVEM, glycoprotein D changes its conformation and interacts with glycoproteins H and L, which form a complex.
The packaging of the viral particles, which include the genome, core and the capsid, occur in the nucleus.
About Me“The master in the art of living makes little distinction between his work and his play, his labor and his leisure, his mind and his body, his information and his recreation, his love and his religion. This journal is a member of and subscribes to the principles of the Committee on Publication Ethics. The varicella zoster virus is a type of herpes simplex virus (HSV) but is not the same as the herpes simplex virus that causes genital herpes. Herpes zoster is not a virus but a syndrome that arises with reactivation of the varicella zoster virus (VZV) years or even decades after chickenpox. Herpes zoster is the same as shingles, an alternative and commonly used name for this condition.
Herpes zoster is more likely to occur in a person with a depressed immune system and the elderly. Herpes zoster, commonly known as just zoster or shingles, is a condition caused by the reactivation of the varicella zoster virus (VZV).
Shingles is the syndrome where a painful skin rash marked by the presence of tiny blisters usually forms on a dermarcated area on the skin surface of the head or trunk. Once the virus reactivates, it causes inflammation of the nerves and is therefore also known as acute posterior ganglionitis. However, shingles often arises for no known reason even in a person without any of these contributing factors. Images from CDC (1)The main symptoms of herpes zoster (shingles) is an itchy skin rash and pain which has been discussed in detail below. Herpes zoster mainly affects sensory nerves but motor nerves that control muscles may also be affected.
Pain that lasts for longer than a month, even after the rash clears, is most likely a complication of shingles known as post-herpetic neuralgia.
All images have been sourced from the Dermatology Atlas (2) courtesy of Samuel Freire da Silva, M.D.


Tricyclic antidepressants, anticonvulsants and corticosteroids along with anesthetics may be needed for post-herpetic neuralgia. Treatment should be commenced immediately once a diagnosis of shingles is made, preferably within the first few days of the onset of the rash. Zoster vaccine to prevent shingles and should be considered only for a person older than 60 years of age.
Ask a Doctor Online Now!Please note that any information or feedback on this website is not intended to replace a consultation with a health care professional and will not constitute a medical diagnosis. Immunocompromised patients may have marked necrosis of the epidermis and widespread involvement of adnexal structures. Herpes simplex and herpes zoster virus do not typically involve the hair follicles, but may occasionally do so, particularly in early infection.
Viral cytopathic effects may be seen within the hair follicles: dysmaturation, acantholysis, dyskeratosis, multinucleate keratinocytes.
The dermis shows dense perivascular and sometimes perineural lymphocytic infiltrates, in some cases with atypia that may mimic lymphoma. Please respect the Terms of use of Dermpedia and consider patient privacy when contributing material to Dermpedia.
During reactivation, virus is produced in the cell and transported outwardly via the nerve cell’s axon to the skin. The blisters resemble those seen in Chickenpox — an infection caused by a third member of the alpha-Herpesviridae subfamily, Varicella Zoster Virus (VZV), also known as Human Herpes Virus 3 (HHV-3). In addition, herpes may be transmitted during childbirth, which can be fatal to the infant. The virus particle contains an envelope which, when bound to specific receptors on the cell surface, will fuse with the cell membrane. Glycoprotein B interaction with the glycoprotein H and L complex allows the virus to enter into the cell. In the nucleus, cleavage of genome concatemers occurs and these are placed into pre-formed capsids. Intracavernous pressure (ICP) and simultaneous arterial pressure (AP) of the normal group (a), HSV-untreated nerve-injured group (b), nerve-injured HSV-LacZ control vector group (c) and nerve-injured HSV-NTN 2 107 group (d). After the active phase of the infection resolves, the virus stays dormant at the spinal nerve root, specifically the dorsal root ganglion. It mainly affects the sensory nerves but can sometimes involve the motor nerves – those nerves that control muscles in the body. These symptoms usually settle after 10 to 15 days but can take up to one month to resolve completely. This gives rise to symptoms such as paralysis of the diaphragm, bladder and bowel problems, cranial nerve palsies and muscle weakness. A dermatome is an area of the skin which is innervated by nerves from a single spinal root.
However, if the infection occurs in a vaccinated person it is usually less severe and shorter in duration. The ability of Herpes virus to establish latency leads to the chronic nature of Herpes infection; after the initial infection subsides, Herpes symptoms may periodically recur in the form of outbreaks of herpetic sores near the site of original infection.
The immature immune system of the child is unable to defend against the virus and even if treated, infection can result in brain damage. The viral particle migrates to the nucleus, where the genome is replicated using enzymes from the host cell.


The viral envelope is acquired from the nuclear envelope, more specifically the inner lamellae of the membrane. He simply pursues his vision of excellence at whatever he does, leaving others to decide whether he is working or playing. Shingles can affect any age group but is more commonly seen in the elderly and those with depressed immune defenses. Although the peripheral nerves to the trunk is commonly affected, the virus may cause inflammation of any part of the nervous system, even the brain (encephalitis), meninges (meningitis) or both (meningoencephalitis).
Transmission occurs while passing through the birth canal and the risk of infection is minimal if there are no symptoms or exposed blisters during delivery.
Initially, glycoprotein C, on the surface of the viral envelope, targets and binds to a cell surface particle, heparan sulfate. Upon entering the cell, an ?-TIF protein also joins the viral particle and aids in immediate early Transcription. The varicella zoster virus causes the common childhood infection known as chickenpox which resolves after a few weeks.
The virus targets certain nerves with symptoms such as the rash and pain being isolated to those areas of the skin supplied by a single spinal nerve. If permission is granted, you must credit me for the use of the material and link to this website prominently from your own. This is particularly likely during an outbreak, although individuals may shed virus between outbreaks. The first outbreak after exposure to HSV is commonly more severe than future outbreaks, as the body has not had a chance to produce antibodies; this first outbreak also carries the risk of developing meningitis. However, the virus remains dormant for long periods of time in the body and may sometimes reactivate to cause inflammation of the nerve roots. Although shingles resolves within a month, it can sometimes lead to complications or the pain can persist for months thereafter (post-herpetic neuralgia). Although no cure is yet available, treatments exist which reduce the likelihood of viral shedding.
Two major glycoproteins, glycoprotein B and glycoprotein D, also associate with the cell membrane. This enzyme shuts off protein synthesis in the host, degrades host mRNA, helps in viral replication, and regulates gene expression of viral proteins.
This does not happen in every person who had chickenpox and is more frequently seen in diminished immune states.
Vaccines provide an effective albeit not guaranteed protection against developing shingles.
No website is a substitute for a visit to a living, breathing dentist or physician who can deal with you personally. Glycoprotein D binds specifically to the herpesvirus entry mediator receptor (HVEM), thus providing a strong, fixed attachment to the host cell. While the viral genome immediately travels to the nucleus, the VHF protein remains in the cytoplasm.



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