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admin 24.08.2014

Intensive care (ICU) patients with co-infections of HHV-6 and CMV are 7.5x more likely to die or have an extended stay in the hospital. Japanese investigators published findings suggesting that HHV-6B plays a pathogenic role in epilepsy by enhancing gene expression that induces neuroinflammation and sclerosis in the temporal lobe.
A pivotal study, led by Michael Boeckh at the Fred Hutchinson Cancer Research Center, has determined that occult infections contribute to 57% of all cases of “idiopathic” pneumonia syndrome (IPS), a condition previously assumed to be non-infectious. Delirium associated with HHV-6B reactivation in cord blood transplant patients: time for an antiviral prophylaxis trial?
A prospective study authored by Joshua Hill and Danielle Zerr determined that higher than average HHV-6B DNA levels increased the odds of developing delirium after cord blood transplantation (CBT) by almost three fold. Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B that infect nearly all human beings, typically before the age of two. Like the other herpesviruses—Epstein Barr virus, varicella zoster virus, etc—HHV-6 establishes life-long latency and can become reactivated later in life.
A growing number of studies also suggest that HHV-6 may play a role in a subset of patients with chronic neurological conditions such as multiple sclerosis, mesial temporal lobe epilepsy, status epilepticus and chronic fatigue syndrome.
ABOUT THE HHV-6 FOUNDATIONThe HHV-6 Foundation in a non-profit entity founded to encourage scientific exchange between investigators and to provide pilot grants for promising scientific and clinical research on the under- appreciated viruses HHV-6A and HHV-6B. The Foundation sponsors international conferences and supports scientists and clinicians seeking to clarify the role of the two HHV-6 viruses in disease.
Roseola is primarily caused by a virus called human herpesvirus 6 (HHV-6) and less commonly by human herpesvirus 7 (HHV-7).

The signs and symptoms of HHV-6 (or HHV-7) infection vary depending upon the age of the patient. If you wish to treat the fever, acetaminophen (Tylenol and others) can be used to lower a fever.
Human herpesvirus 6: A herpes virus that apparently lies dormant in many people, human herpesvirus 6 is most likely to cause problems when the immune system is compromised by disease, as in AIDS patients, or by deliberate immune suppression, as in organ transplant patients.
On the other hand, single infections with either HHV-6 or CMV did not significantly impact outcome.
HHV-6 DNA levels were significantly higher in the resected tissue of epilepsy patients with sclerosis compared to those without it. The acquisition of HHV-6 in infancy is often symptomatic, resulting in childhood fever, diarrhea, and exanthem subitum rash (commonly known as roseola). This reactivation has been associated with many clinical manifestations that can be seen in the “Associated Conditions” section of this site. There is an urgent need for more studies that can prove or disprove the important disease associations that have been suggested.
Since the HHV-6A and HHV-6B can smolder in the brain and other organs without circulating in the peripheral blood or plasma, identifying chronic infection is a challenge. Roseola has a sudden onset and short duration, and it most commonly affects young children. Infants and toddlers routinely will develop sudden symptoms with a sudden onset of a high fever that lasts for three to five days, irritability, bulging "soft spot" on the head (fontanel), swollen glands in the front or back of the neck, runny nose, puffy eyelids (due to swelling with fluid), and mild diarrhea.

It is not necessary to awaken the child to treat a fever unless instructed to do so by a health-care practitioner.
Although rare, this initial infection can also cause febrile seizures, encephalitis or intractable seizures. Reactivation can occur in locations throughout the body, including the brain, lungs, heart, kidney and gastrointestinal tract.
The incubation period between exposure to the virus and onset of symptoms is nine to 10 days.
In some cases, HHV-6 reactivation in the brain tissue can cause cognitive dysfunction, permanent disability and death.
If a child develops shivering during the bath, the temperature of the bath water should be raised.
Unlike other viral infections, roseola occurs throughout the year without seasonal variation. Treatment is experimental at this time, but anti-viral drugs or beta interferon may be tried.

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