Oral herpes scar treatment,energy increasing medicine homeopathy,herpes sore mouth pictures toddler - You Shoud Know

admin 15.11.2013

Sir,The term "isotopic response" describes the occurrence of a new unrelated skin disorder at the site of another, already healed skin disease. Irritation fibroma is also called as traumatic fibroma, focal fibrous hyperplasia, fibrous nodule or oral polyp a kind of scar soft tissue. The color of the fibroma will be same as the mouth liner there are cases where it may be dark if it has a bled. The proposed etiologies of isotopic response are viral, immunological, neural, vascular and locus minoris resistentiae (a site of lessened resistance).
Isomorphic and isotopic phenomenon occurring simultaneously in a case of granuloma annulare.
Antisense oligonucleotide against collagen-specific molecular chaperone 47-kDa heat shock protein suppresses scar formation in rat wounds.
Usually this tissue grows in buccal mucosa rarely it starts to grow in lips and tongue which causes irritation. Most cases of isotopic response have been described in healed lesions (scars) of herpes zoster (HZ). Granuloma annulare, lichen planus, granulomatous folliculitis, tinea, multiple epidermoid cysts, morphea, rosacea, erythema annulare cetrifugum, Kaposi's sarcoma, leukemia cutis, metastasis, acne, verrucae plana, molluscum contagiosum, squamous cell carcinoma, basal cell carcinoma and sarcoidosis have been reported as second disease as part of an isotopic response.


She was a known diabetic on oral hypoglycemic agents and presented with an occasionally itchy skin lesion over the gluteal area since approximately four months duration. She gave a past history of intramuscular injection and HZ over the same site five years ago.
A general practitioner had administered an injection for preherpetic pain and the puncture site took a long time to heal. On examination, she had an irregular pigmented, thick plaque over the left gluteal region with areas of depigmentation, erosion, and adherent scale.
A similar but smaller pigmented plaque with an adherent scale was seen above the large plaque. A small pigmented scar was present on the left side close to the midline [Figure 1] and [Figure 2]. Her hemogram was normal except for a low hemoglobin level and she was negative for antinuclear antibody. Her blood sugar was raised; urine was positive for sugar, but negative for albumin and deposits. H and E, ×100Click here to viewDiscoid lupus erythematosis likely occurs in genetically predisposed individuals, but the exact genetic connection has not been determined.


It has been suggested that a heat-shock protein (HSP) is induced in the keratinocyte, which can act as a target for T-cell-mediated epidermal cell cytotoxicity. Injury to cutaneous nerve fibers, may alter the secretion of neuropeptides, impairing the immune response.
Whether the occurrence of DLE over the HZ scar was because of alteration in the local skin immunity due to herpes virus infection or local injection could not be delineated. The role of HSP and the TLR in preparing a bed for a second lesion to appear over scar tissues needs further elucidation.
To the best of the author's knowledge, DLE occurring as an isotopic response over a HZ scar has so far not been reported.



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