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admin 03.07.2014

Chinese researchers have become the world's fifth most prolific contributors to peer-reviewed scientific literature on clock-reversing regenerative medicine even as a skeptical international research community condemns the practice of Chinese clinics administering unproven stem cell therapies to domestic and foreign patients. The accomplishment is all the more astonishing given that China's international credibility has been and still is severely hindered by global concerns surrounding Chinese clinics, where unproven therapies continue to be administered to thousands of patients.
New rules to govern such treatments were recently instituted but need to be strictly enforced in order to repair China's global reputation, according to MRC authors Dominique S. They drew their conclusions after having gained unprecedented access to almost 50 Chinese researchers, policy makers, clinicians, company executives and regulators for interviews. Regenerative medicine an interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and aging.
MRC researchers report that until May 2009 clinical trials to determine the effectiveness of stem cell therapies were not required.
The change was made after international experts, joined by top Chinese researchers, protested that treatment centers were acting "against commonly accepted principles of modern scientific research" and successfully called on China to regulate new treatments and ensure patient safety.
Despite the new rules, however, stem cell treatments are still available at over 200 hospitals across China to patients of diseases such as ataxia, Lou Gehrig's disease, traumatic brain and spinal cord injury, diabetes, Parkinson's, multiple sclerosis, autism, cerebral palsy, stroke, optic nerve hypoplasia and many others. The Stem Cell Center affiliated with Tiantan Puhua Neuroscience Hospital in Beijing, meanwhile, claims to activate and multiply the body's own neural stem cells through oral and intravenous medications and rehabilitation.
Controversial stem cell therapies provided at Beijing Xishan Institute for Neuroregeneration and Functional Recovery, involve injecting cells from aborted fetuses to treat spinal cord injury and a variety of central nervous system diseases. MRC authors say this latter stem cell therapy is the only one discussed in high-impact peer-reviewed academic journals. Despite the absence of randomized clinical trial evidence that these stem cell therapies work, an "increasingly popular but controversial" tourism industry has grown up around them. As for advice to last-resort patients considering Chinese clinic stem cell treatments: "This is not a medical study," says Dr. While unorthodox activities at Chinese clinics and controversial drug approvals have raised eyebrows both in and outside China, dedicated researchers in the country's labs have been making remarkable contributions to the field.
By transferring the nucleus of a human skin cell into the immature ovum cell of a rabbit, researchers from a Shanghai hospital successfully produced embryonic human cells (a finding popular scientific journals held off publishing for two years due to skepticism and of mistrust Chinese scientific integrity). A Shanghai hospital cultivated and reintroduced human brain tissue in 2002 after taking a sample from the end of a chopstick implanted in a patient's frontal lobe following a disagreement at a restaurant. Several human tissue types created artificially include blood vessel, tendon, bone, cartilage, skin, cornea and muscle fiber.
Current research of note includes the efforts of ChinaSCINet, a consortium of 27 medical facilities, starting phase 2 clinical trials to test the efficacy and safety of using cord blood stem cells and oral lithium to treat about 40 patients with spinal cord injuries.
Other clinical trials are underway on the use of stem cell therapies to treat patients of heart attacks, artery obstruction, and liver and neural diseases. Elsewhere in China, studies are underway on the potential use of stem cells to treat Type 1 diabetes, Parkinson's disease, heart, liver and blood diseases, eye cataracts, and to combat aging.
Chinese regulations prohibit reproductive cloning, the use of human embryos past 14 days post-fertilization, the fusion of human and non-human gametes (cells that fuse during fertilization), or the implantation of research embryos into human or animal uterus. Researchers are required to obtain informed consent from subjects and institutes must have an ethics review board to approve research involving human embryonic stem cells. Chinese fertility clinics serve as a source of discarded embryonic stem cells for some research, and cord blood banks may serve as a source of stem cells for clinical applications.
Therapeutic cloning is allowed, as is the use of surplus embryos or discarded fetal cells from abortions as well as embryos created with artificial help. As well, the rules for embryonic stem cell research in China are criticized internationally as having limited authority over researchers because they are not legally binding. MRC authors say that while there is no indication embryonic stem cell research rules are being broken, greater regulatory oversight would help ease international concerns.
Chinese data show the country now generates 400,000 graduates in science and medicine each year and recruits many high caliber scientists from abroad.
According to the MRC, China's push for clinical applications, which has allowed it to produce new scientific knowledge quickly, has come at the expense of basic research aimed at, for example, overcoming technical challenges such as controlling how stem cells behave and differentiate. Only 5.2% of China's budget for research and development is allocated to basic research, compared with 13 to 19% in Japan, Korea and the USA. The McLaughlin-Rotman Centre for Global Health, is based at the University Health Network and the University of Toronto.
The Kinetic Energy Recovery System (KERS) developed by Volvo uses energy created during the braking of the vehicle to spin up a flywheel at speeds of up to 60,000 rpm. With the flywheel spinning at such speeds in a vacuum, energy can be transferred back into the rear wheels when the driver needs to accelerate again, powering the vehicle until it reaches cruising speed.
In Volvo’s system, the flywheel is mechanically coupled and decoupled from the rear axle using a continuously variable transmission.

While most people are familiar with stem cell treatment and degenerative disc disease many are not sure with if stem cells are used for degenerative disc disease.  The most common applications for stem cell therapy today are musculoskeletal in nature, for example osteoarthritis of the knees, hips, and shoulders. At Piedmont Physical Medicine and Rehabilitation, PA in Greenville, South Carolina we offer Platelet Rich Plasma (PRP) Injections for the treatment of musculoskeletal conditions where a regenerative approach makes sense. Sacroiliac low back pain is a common disorder, maybe even more common that degenerative disk disease or sciatica. There are not alot of places in Greenville, Spartanburg, and Anderson that specialize in the treatment of hypermobility and lax ligament but at Piedmont Physical Medicine and Rehabilitation, PA that is exactly what we do. Making use of knee bracing for function can be an important part of any knee regenerative medicine program. It is quite often that someone comes into our office looking for stem cell treatment for musculoskeletal pain. Traditional and pioneering assessments using leading-edge technology help uncover diagnoses faster.
Regenerative furnaces have two chambers, each containing refractory material, called the checker. Side port (cross-fired) and end port configurations are the main types of regenerative furnaces. Multi-pass regenerators, the application of which will only be possible with the construction of a new furnace with the addition of more refractory bricks, recover the energy in the flue gases more efficiently, and can reduce the energy intensity of the furnace (Worrell et al., 2008.
Multi-pass regenerators can reduce the energy intensity of the furnace by 15% (Worrell et al., 2008. The Institute for Industrial Productivity welcomes information on relevant industrial efficiency technologies or measures that are not currently included in the database or if information in this database is incorrect or out-of-date. The Institute for Industrial Productivity acknowledges Fraunhofer ISI, IREES, LBNL-China Energy Group, E3M Inc., ISR-UC, Holtec, Utrecht University, and FAI for their valuable contributions. This web page describes a small, single tuned circuit regenerative receiver primarily for daylight reception in the 16, 19, 22 and 25 meter international shortwave broadcast bands. The use of feedback in the reflex receiver allowed a single transistor to be used simultaneously as an amplifier for both RF and AF signals. The gain produced is directly proportional to the amount of feedback, but a limit is reached where the feedback is too great for the transistor to cope with. A phase changer is used to ensure that the feedback from the collector to base of the detector transistor is positive.
The phase changer in this circuit has been implemented by the additional coil L2, which is inductively linked to the aerial coil L1. The addition of the variable capacitor C4 provides a means of controlling the amount of feedback used.
The simple circuit shown in figure 8 can be easily expanded by the addition of one or more stages of AF amplification following the detector. The regenerative receiver has significantly more sensitivity than the previous receivers which have been studied. According to a study by the Canadian-based McLaughlin-Rotman Centre for Global Health (MRC), published this week by the UK journal Regenerative Medicine, China's government is pouring dollars generously into regenerative medicine (RM) research and aggressively recruiting high-caliber scientists trained abroad in pursuit of its ambition to become a world leader in the field.
It uses a combination of several converging technological approaches, both existing and newly emerging, that moves it beyond traditional transplantation and replacement therapies.
Now proof of safety and efficacy through clinical trials is required by China's Ministry of Health for all stem cell and gene therapies. It also offers a lumbar puncture or brain injection of bone marrow stem cells, fetal neural stem cells, or other stem cell types to allegedly improve symptoms of stroke, cerebral palsy, spinal injury, Parkinson's disease or other neurological diseases. One study documented a spinal cord injury patient's early motor and sensory improvement, another found no improvement in seven spinal cord injury patients. Adherence is enforced only for those who receive government funding, which applies to most researchers, but financially independent researchers or hospitals must simply answer to their own institution's ethical review board. Stem cell research, tissue engineering and gene therapy are key areas receiving priority funding, largely centralized in the universities, hospitals and research institutes of China's main urban centers, especially Beijing and Shanghai. And China has developed large primate colonies for preclinical testing, and begun clinical trials for a number of therapies. Even the funds allocated for basic research favor 'strategic basic research' designed to encourage application.
Working at the nexus of science, entrepreneurship, and the developing world, the Centre conducts translational research on malaria, on ethics and on commercialization in global health to help researchers and companies get life sciences technologies (such as diagnostics, drugs, and vaccines) to those who need them in developing countries. The CVT engages the flywheel as the car slows, spinning it to up to 60,000 rpm, then decouples the flywheel as the car comes to a halt, finally re-coupling the spinning flywheel to the rear wheels when the car accelerates from a stop. Schwartz and Piedmont Physical Medicine and Rehabilitation, PA (PPMR)  have been featured in a PR Web news release on stem cell for the treatment of osteoarthritis of the knee.

While in one chamber the combustion gases pass through the checker and enter the furnace in the other chamber the checker is heated, or regenerated, with the outgoing hot exhaust gas.
Side ports are most common and offer good flexibility for adjusting the furnace temperature profile.
I have attempted to incorporate every improvement I have thought of into this receiver, including maximum mechanical rigidity and electrical shielding. The regenerative circuit however takes the RF output of a transistor detector (which would normally be disregarded) and returns part of it to the input to boost the incoming signal. The RF current and its corresponding voltage appearing at the collector of the transistor will be out 180 degrees out of phase with the input to the base. If the coil is connected to the collector one way around it will tend to produce cancellation with the input; and connected the other way around it will tend to boost the input signal.
By varying this capacitor, the maximum gain attainable before sending the transistor into oscillation can be found.
Sufficient output power is provided by these circuits to drive a high impedance loudspeaker direct without the need for an output transformer.
Volvo’s mechanical, motorless rear-axle-mounted setup is unique from Porsche’s approach to KERS, which relies on motor-generators to spin up the flywheel, recover its energy, and transfer that energy back to the car’s forward motion. The furnace operates in two cycles, where about every 20 minutes, the flow is reversed so that the new combustion air can be heated by the checker. This receiver is suited for reception of AM signals with the regenerative stage not oscillating.
The transistor detector combines the RF amplifier stage with the diode detector by utilising the base - emitter junction of a suitable transistor. Thus maximum gain is achieved by designing the feedback circuit so that the point of oscillation is approached as nearly as possible without the transistor actually going into oscillation. This will tend to cancel rather than boost the RF input which is applied directly to the base. These approaches may include the use of soluble molecules, gene therapy, stem cell transplants, tissue engineering, and the reprogramming of cell and tissue types. We provide a comprehensive regenerative and rehabilitative knee program for Greenville, Spartanburg, Anderson and surrounding areas. The actual gain which may be obtained can be as great as 100:1, thus vastly improving the sensitivity of the receiver.
Thus the phase changer is necessary to reverse the phase of the feedback, so that it is applied to the input in the same phase. The RF stage immediately following the antenna has an input impedance high enough so that the signal voltage on the antenna is essentially transferred to the gate of the first stage over the tuning range of the receiver without antenna tuning. I know from my reading that the maximum impedance the antenna will present to the receiver is about 2,000 Ohms. At Piedmont Physical Medicine and Rehabilitation, PA we offer a full line of services to diagnose, treat and reverse peripheral neuropathy. The only way I can get away with that in the presence of the ever-present 60 Hz fields is to couple the antenna to the jfet gate with a small capacitance. Regenerative Pump (XGB-8) - China Regenerative Pump regenerative braking Principle function for the Ljungstrom regenerative preheater. In this regenerative receiver I have installed ten capacitors ranging from three turns of hookup wire to 100 pF. Let's further say that you have advanced the VERY FINE REGENERATION CONTROL as far clockwise as possible short of oscillation and that you have the signal tuned to the center of its carrier.
You will notice an immediate drop in received signal level, but you can then advance the VERY FINE REGENERATION CONTROL further clockwise, and you will find you have somewhat greater signal strength than you did at 8pF. You will also notice that tuning with the FINE TUNING CONTROL is slightly broader than it was at 8 pF.
You have slightly increased loading of the tuned circuit by the antenna(even though there is a jfet stage between the antenna and the regenerative stage). How far you carry this process depends on the proximity of powerful stations to the station you want to hear.
There is a SPST toggle switch which connects a 33 pF capacitor across the tuned circuit to allow 25 meter band reception.
The connections from the 140 pF tuning capacitor and the tuning coil to the RF circuit board below the chassis deck are made with AWG number 14 solid insulated wire.

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