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Ek was so tien jaar terug gediagnoseer met depressie en angs en het medikasie daarvoor ontvang vir omtrent so jaar lank. Ever wonder how many mice have to die to produce one peer-reviewed medical journal article? Daniel Engber has authored an excellent, three-part expose at Slate that answers these and other questions about the animal research industry. Additionally, Slate put together this excellent slide show, where you can meet the 10 most common lab rodents. An excerpt from part one follows. Twenty miles away in Bethesda, though, where Barry serves as chief of the Tuberculosis Research Section at the National Institute of Allergy and Infectious Diseases, a single animal has taken over the ecosystem.
By clicking and submitting a comment I acknowledge the Science Progress Privacy Policy and agree to the Science Progress Terms of Use. Part One, "The Mouse Trap," looks at the realities and dangers of our dependence on cheap, couch-potato mice for medical research. Part Two, "The Trouble With Black-6," examines the peculiarities of the world's largest research mouse supplier's best-selling mouse, an inbred, alcoholic critter called Black-6. Part Three, "The Anti-Mouse,"  looks at recent research using a hairless African rodent called the Naked Mole Rat. The government's top researcher on tuberculosis—still one of the world's most deadly infections—seems to be running a midsized wildlife park out of his Maryland home.
Each step leads to the next: No drug can be tested in man until it's been shown to work in mice, and no drug is tested in mice until it's been shown to have a reasonable effect in the dish.
Science Progress proceeds from the propositions that scientific inquiry is among the finest expressions of human excellence, that it is a crucial source of human flourishing, a critical engine of economic growth, and must be dedicated to the common good.


The cold truth: Every single person listed as a co-author is responsible for everything in a paper, by virtue of his or her name appearing there! Robotics and automation research projects on perception and cognition to improve artificial intelligences for medical applications. In a modest house on a tree-lined street in Germantown, Clif Barry keeps two kinds of turtles, three veiled chameleons, two Jackson’s chameleons, six species of frogs, half a dozen fish tanks (filled with cichlids, goldfish, and piranhas, kept separately), two dogs (named Jacques and Gillian), and an Australian tree python. It has infested every paper and conference, and formed a living, writhing barrier to new drugs on their way to clinical trials. In a modest house on a tree-lined street in Germantown, Clif Barry keeps two kinds of turtles, three veiled chameleons, two Jackson's chameleons, six species of frogs, half a dozen fish tanks (filled with cichlids, goldfish, and piranhas, kept separately), two dogs (named Jacques and Gillian), and an Australian tree python. If anything is fraudulent or more than trivially erroneous anywhere in a paper, the scientific integrity of every author (not just whichever unrecorded one who actually handled the bad portion) is at stake.
Inform all prospective authors, right at the start, that you expect their substantive contribution to the process all the way through the end of formal reviews. If you’re the lead author, clearly implore every single co-author, individually, to proofread the entire paper (not just their contribution) at least once before submission, and during each state of revision. Provide all reviews of the paper to all authors, along with your proposed replies, before sending back the revision. And how much can we really learn about human physiology from mice or other animal experiments anyway?
And how much can we really learn about human physiology from  mice or other animal experiments anyway?
Researchers have found that it seems to be completely immune to cancer, no matter how many carcinogens it is exposed to.


You start by testing a new compound in a Petri dish, to find out whether it can slow the growth of a particular bacterium in culture. The GMC panel was clear that it was Wakefield alone who wrote the final version of the paper. That gives you the smallest dose that has an effect, known as the minimum inhibitory concentration, or "MIC"—the first M.
His coauthors seem to have been unaware of what he was doing under the cover of their names and reputations. Then you move to a living animal: Does the compound have any effect on the course of disease in a lab mouse? As the GMC panel heard, they did not even know which child was which in the paper’s patient anonymised text and tables.
If so, you've cleared the second M, and you're ready to test the compound in the third M, man.
Although only two (John Walker-Smith and Simon Murch) were charged by the GMC, and only one, the paper’s senior author Walker-Smith, was found guilty of misconduct, they all failed in their duties as authors.
The satisfaction of adding to one’s CV must never detract from the responsibility to ensure that one has been neither party to nor duped by a fraud.
This means that coauthors will have to check the source data of studies more thoroughly than many do at present—or alternatively describe in a contributor’s statement precisely which bits of the source data they take responsibility for.



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