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admin 04.02.2014

For a long time, scientists have sought to take islet cells from people or even from pigs and place them inside another person. The mice were given white blood cells from a rat’s spleen, which is part of the immune system.
With type 2 diabetes treatment the goal is to get and keep your blood sugar in normal ranges. Of the hundreds of doctors that I have worked with, their approach is always lifestyle modification through diet and exercise as well as prescribing medications when necessary. If a healthy diet and regular exercises are not effective, physicians use medicine to help treat type 2 diabetes. These drugs have received bad press in recent years because of serious side effects and aren’t used as much as they used to be.
Nearly 24 million Americansa€”or 1 in 10 adultsa€”have diabetes, according to the Centers for Disease Control and Prevention, which projects that by 2050, as many as 1 in 3 adults will have the disease. Once people are diagnosed, the primary goals of type 2 diabetes treatments are to control glucose levels and to reduce other conditions that put patients at risk for major complications.
Some people find changes to diet and exercise sufficient treatments for type 2 diabetes, but many others require medication and insulin therapy. When scientist Douglas Melton at Harvard University Department of Stem Cell and Regenerative Biology set out to find a cure for type 1 diabetes, he was driven by a personal motive: both of his children have the disease. When they transplanted the cells to mice with compromised immune system, the mice were cured of type 1 diabetes in 10 days. But, as it usually happens when new medical drugs or procedures are discovered, it will take years until we will see an actual diabetes treatment. Enter your email address to subscribe to this blog and receive notifications of new posts by email.
They have successfully placed insulin-producing islet cells from one animal species into another without using anti-rejection medicines. Insulin exchanges from human remains have proved difficult, while animal-to-human transplants have been almost impossible.
Researchers at Northwestern University have carried out an islet cell transplant from rats to mice without the use of anti-rejection medicines. They were bathed in chemicals that put the cells into a sleeping condition known as programmed cell death.


They entered the spleen and liver of the mice, but soon after, they were destroyed by cells called macrophages. In that process, small pieces of the rat spleen cell ended up on the surface of the macrophages. She also wants to use what is almost an unlimited supply of pig islet cells for transplants into patients with type 1 diabetes. This allows more glucose to be absorbed into the cells of your body.  They work in combination with sulphonylureas and metformin or both.
Diabetes is one of the major causes of heart disease, stroke, new cases of adult blindness, and leg and foot amputations not caused by injury. Sue McLaughlin, former president of healthcare and education at the American Diabetes Association, offered her opinion of what she says are the six most common myths and misconceptions about diabetes, based on an ADA survey of more than 2,000 Americans released in 2009. Generally, the goal is to keep one's blood sugar stable and doctors may set levels specific to each person.
While there is no one diabetes diet, patients are encouraged to eat nutritious, low-calorie foods.
Medication regimes are individual, based on each person's medical history, other diseases, and individual factors. Fifteen years later, he says he is on the right track and trials on humans should begin soon, according to the article he co-authored, published on the Thursday edition of journal Cell.
Insulin is an essential hormone, as it transforms sugar and starch into the energy we need.
In the future, the transplant operation could provide an unlimited supply of tissue to treat people whose bodies cannot produce insulin. Xunrong Luo is the head of the Northwestern medical school’s human islet cell transplantation program. This taught the mouse’s immune-system T cells to accept islet cells, which researchers transplanted seven days later. Treatments for type 2 diabetes are life-long – there is no pill to cure this chronic disease.
Yet metformin (Glucophage) is often prescribed; this diabetes medication lowers glucose production in the liver. There are many different types of insulin and doctors may prescribe a mixture based on individual factors.


Doctors may recommend regular exercise, limiting alcohol, the cessation of smoking, among others. Those who suffer from type 1 diabetes lack beta cells in their pancreas, the cells needed to produce insulin.
So far, patients would have been satisfied if the daily insulin shots could be replaced by a less invasive procedure. American scientists are turning their attention to all the information it has gathered over the past four years.
In most patients, the immune system attacks and destroys the islet cells that produce insulin. These side effects are less likely to appear if you start with a small dose and gradually increase.
Doctors may have people check their blood sugar daily or several times a week; it varies by individual.
They may also prescribe certain medications like ACE inhibitors and diuretics to lower blood pressure, statins and fibrates to lower cholesterol, or aspirin and clopidogrel to control clotting.
But Metlon says that by using stem cells, his team managed to create the needed beta cells. We could soon see other organs being repaired or replaced with stem cells as part of a new wave called regenerative medicine. Some people can manage their diabetes with changes to diet and exercise, while others require medication. If patients are conscientious, they can still enjoy active, healthy lives, even with the disease. Always consult a doctor before beginning an exercise regime, but for most people, 30 minutes of aerobic exercise combined with strength training, most days of the week, is ideal.



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