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At least 85% of the world population have serological evidence of having had a herpes simplex infection. Herpes simplex infections can be primary- the first infection in a previously seronegative patient – or recurrent. Follows direct contact with an infected individual, either with active disease or shedding viral particles during a latent phase. Trigger factors include minor trauma, febrile illnesses, ultraviolet light and possibly stress. Complications include: Erythema multiforme (65% of attacks are triggered by a herpes simplex recurrence within the preceding two weeks), eczema herpeticum, persistent ulceration in the immunocompromised and keratoconjuctivitis. These are transmitted sexually, and begin to appear at puberty or are spread from a mother’s genital tract infection to a newborn child.
The median recurrence rate is about one attack every 3 months for HSV-2 infections (and far less often for genital HSV-1 infections). Prevention is difficult because the virus is ubiquitous and spread by people with no obvious active infection.
Those looking after patients with atopic eczema should stay away if they have cold sores because eczema herpeticum is so serious. Suppressive long-term antiviral therapy may be needed for particularly frequent or severe relapses. The decision to use oral antiviral therapy for recurrent facial herpes simplex depends on the frequency and severity of relapses and the damage being done to the quality of life. Long-term suppressive therapy can be considered in genital herpes relapsing more than 5 times per year. Chapitre 32 Herpesviridae Les virus herpes simplex (type 1 et 2) (HSV) Les virus de la varicelle et du Zona (VZV) Le cytomegalovirus (CMV) Le virus dEpstein-Barr(EBV) Lherpesvirus humain 6 et 7 Le virus B du singe memingo-encephalite mortelle. Les virus herpes simplexe(HSV) Morphologie et Structure virus 150-200nm spheriques, icosaedriques enveloppes, ADN bicatenaire acide nucleique deux segments lies de facon covalente. Les virus de la varicelle et du Zona le meme virus un type antigenique reservoir de virus humain.

Zona persister des annees dans les ganglions des racines rachidiennes posterieures reactivation: le virus se propage le long des fibres nerveuses sensitives juaqua la peau, reaction inflammatoire de cette racine rachidienne et des vesicules cutanees sur la zone dinnervation de cette racine. Le virus dEpstein-Barr (Virus EB) agent de la mononucleose infectieuse (MI) lymphome de Burkitt carcinome du rhinopharynx. Suite la lyse cellulaire nintervient que tres rarement, lorsque le cycle de replication du virus aboutit a la production de virion. Infection a herpes virus de l’enfant et de l’adulte : §herpes cutaneomuqueux §varicelle §zona. Chapitre 26 Les virus de la voie respiratoire maladies respiratoiresdes infections generalisees. HEPATITES Hepatites virales Hepatites medicamenteuses Hepatites alcooliques Hepatites toxiques.
Il s'agit d'une maladie contagieuse et il en existe deux types, labial (bouche) et génital (organes sexuels). By age 30, 50% of adults of high economic status in the US are seropositive to HSV-1, in contrast to 80% of those of lower status. The introduction of aciclovir (DNA polymeras inhibitor) was a milestone although it does not eradicate the virus. La primo-infection a HSV-1 transmission entre 1 et 3 ans, contact direct avec le liquide vesiculaire ou la salive. SOUS FAMILLE Espece Alpha-herpesvirinae Herpes simplex type 1 HSV-1 Herpes simplex type 2 HSV-2 Varicelle-zona VZV Beta-herpesvirinae.
DEFINITION: Maladie infectieuse generalement benigne due a une primo-infection par le virus EPSTEIN BARR appartenant. Les virus sont des micro-organismes a parasitisme intracellulaire obligatoire, dotes dun seul type dacide nucleique, ADN ou ARN.
Introduction Homme seul reservoir Virus tres fragile Transmis par contact cutaneomuqueux direct Diffuse par propagation le. Les modes et les voies de transmission Transmission horizontale dun individu a un autre Les voies muqueuses.

Generalites (1) Appartient a la sous famille des Paramyxoviridae, genre Rubulavirus Virus a tropisme glandulaire.
Le VIH Recepteur viral – Gp120 Recepteur cellulaire – CD4 Cellules Ta, monocytes et macrophages Ninfecte pas. They are closely related but differ in their epidemiology, although both are spread by close personal contact. Regular use of condoms helps prevent genital herpes and a high protection factor sunscreen helps to prevent recurrent facial lesions. Sores caused on the genitals are known as genital herpes.Herpes are contracted when kissing someone already having a cold sore. Herpes can occur in the genital area if a person has oral sex with someone who already has cold sores.
SDS-PAGE was performed followed by an in-gel trypsin digest in preparation for high resolution mass spectrometry. Herpes can be passed to a newborn baby if the mother already ahs herpes during her pregnancy period. In comparison with a previous proteomic analysis,4 the Bell group identified 67 out of the predicted 82 proteins, with at least 2 unique peptides discovered. These totals included HSV1 structural proteins consisting of capsid proteins (91%) and tegument proteins (96%) but only 79% consisting of envelope proteins. A partir de ce moment, tout ce qui entre en contact avec la plaie est une potentielle source de transmission.

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