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admin 21.06.2014

A new systematic review has appeared discussing one of the most widely and longest used supplements in small animal medicine, the amino acid lysine, which is used to prevent and treat upper respiratory infections in cats caused by Feline Herpesvirus. Lysine is an amino acid which is hypothesized to be useful in the prevention and treatment of Feline Herpesvirus (FHV-1) infections. Lysine is proposed to interfere with the replication of FHV-1 by blocking the uptake of another amino acid, arginine. Taking all results discussed in this systematic review together, we conclude that lysine supplementation does not have an inhibitory effect on FHV-1 replication in the cat. Interestingly, most systematic reviews are reluctant to make active recommendations even when the lack of evidence is quite clear.
Of course you are inclined to believe your own experience above controlled research done by others. There can be no learning without openness to the possibility that our current beliefs are wrong. For example, herpesvirus cats tend to have flare-ups during times of stress, and most often, those flare-ups are self-limiting, with or without treatment. My anecdotal evidence is just as valid as it yours, which is why I now rely on actual evidence rather than anecdotal reports and testimonies such as yours.
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Shingles, also called herpes zoster, is a viral infection that causes a rash of painful, fluid-filled blisters. Lysine, also called l-lysine, is an essential amino acid that must be obtained from the diet; the body doesn't produce it. Lysine helps make carnitine, which converts fatty acids to energy, and it helps form collagen needed for bones and connective tissue. Shingles can be a painful disease, and it has a nasty habit of descending on you when your life is already stressful. New for fall '11: I've added a second page of presentation backgrounds: download Powerpoint slides!
This virus is extremely common, and many cats will be exposed and become infected as kittens.
There are theoretical concerns that lysine supplementation could make cats arginine deficient, but experimental studies suggest this is unlikely in practice. For once, numerous studies have been done, but there is no clear, consistent pattern of results.
The scientific data do not support lysine supplementation or additional research with cats, as has been advocated by some…Based on the complete lack of scientific evidence for the efficacy of lysine supplementation, we recommend an immediate stop of lysine supplementation for cats.
The general thinking is that one can only prove a therapy does work, one cannot prove it does not. That is both a natural human tendency and the main reason for the persistence of ineffective treatments throughout history. While all of us are predisposed to trust our experiences even when more reliable evidence contradicts them, some of us recognize this bias and attempt to overcome it whereas others embrace the bias and reject the better evidence. I am open to this, I simply require scientific evidence to justify rejecting my beliefs, not merely testimony about the beliefs or personal narratives of others.

It means fairly and thoughtfully considering the arguments and evidence before judging a claim. Taking offense when you can’t convince someone who disagrees with you is just a way of abandoning reasonable debate. Acyclovir, an antiviral drug, is the usual treatment, but there is solid evidence that the amino acid lysine is also helpful in treating the virus.
It usually affects only one side of the body and commonly appears in a band, called a dermatone, that wraps around one side of the chest, waist or neck. Because it is found in so many foods--red meat, poultry, eggs, fish, soy--deficiencies are usually found only among strict vegans. Lysine prevents herpes from spreading because it competes with arginine, another amino acid that helps the herpes virus replicate. Clinical symptoms include sneezing, nasal congestion, and conjunctivitis, and they range from mild and self-limiting to very severe. Lysine supplementation is not effective for the prevention or treatment of feline herpesvirus 1 infection in cats: a systematic review.
Lysine supplementation is not effective to prevent cats from becoming infected with FHV-1, it does not decrease the chance of developing clinical signs related to active FHV-1 infection, and it does not have a positive effect on the clinical course of its disease manifestations. Certainly, additional evidence can always appear that shifts the probabilistic conclusions of science in one direction or another. Thousands of people have been just as certain of the effectiveness of bloodletting, homeopathy, Lourdes water, and every other treatment imaginable, yet those don’t work either. Homeopathy works as well, and I could cite you many instances in my own life and the lives of my animals wherein it has proven to be amazingly successful when all modern medicine had failed miserably in treating the condition over some period of time.
Homeopathy is a wonderful example, but not in the sense you intend, because in fact it clearly does not work and cannot work, yet personal anecdotes are used to suggest it does despite the powerful evidence to the contrary. You appear unwilling to consider the possibility you might be wrong at all, and unconvinced that any scientific evidence could justify changing your mind. OI have done this for homeopathy (as you can see by the extensive literature search and analysis I have published here on the subject).
According to the University of Maryland Medical Center, lysine treats shingles by speeding recovery time, as well as reducing the chance of recurrence. The first symptom you will feel is usually pain, accompanied by burning, numbness or tingling, then a red rash that develops into blisters. For this reason, lysine also helps treat mouth and genital lesions caused by the herpes simplex virus.
Huemer, a holistic practitioner in Lancaster, California, the optimal dose for lysine is 500 to 1,000 mgs three times a day during an outbreak, and 1,000 mgs daily for prevention. In fact, results from two clinical trials with cats even suggest that excess dietary lysine may have an enhancing effect on FHV-1 replication.
However, we must make practical decisions about the risks and benefits of treatments based on the evidence we have, and at a certain point we must be willing to decide that enough is enough, that adequate negative evidence has accumulated to merit rejecting a therapy. He was very ill until I started treating him with lysine, and the improvement was very rapid with lysine treatment.
I suggest you are clinging a bit more tightly to your beliefs than I am, and it is your mind that is closed.

Because lysine can increase the toxicity of certain antibiotics, you must consult with your doctor before taking it. With suppression of immune function from stress, medication, or disease, the virus can re-emerge and cause symptoms again. So while lysine supplementation appears to be safe and there is a plausible rationale for its use, no definitive conclusion about its efficacy is justified. Positive findings, either for HHV-1 or FHV-1, were the result of poor study design and could not be replicated in well-controlled, larger studies.
The disease went into remission for several months, then symptoms reappeared, and again I treated with lysine, and the symptoms vanished quickly. It is ironic that you can accuse me of this when you clearly believe your observations are unchallengeable, but I see this type of irony a lot when discussing these things.
A small subset of cats may develop chronic, ongoing symptoms associated with this infection. Furthermore, the proposed mechanism of action of lysine-arginine antagonism does not work in cats and its result, lowering arginine levels, would be highly undesirable. But since it works equally well or better on my animals as on me, I rather doubt that it is placebo, since the animals do not even know they are getting a remedy. You have committed firmly to unshakeable faith in your personal experiences, so nothing anyone else can say is likely to matter. Once again, I do not argue with success, and I don’t care how it works if it works and does no harm. Two or three weeks after the blisters develop, they fill with pus, break open and start to crust over. The research may not support it scientifically, but I for one do not argue with success, and it has proven to me that it works. Shingles can take four or five weeks to clear up, and some people experience lingering pain, called postherpetic neuralgia, at the site of the blisters long after they have healed. I feel sorry for those who are more concerned with clinging to their current beliefs than with learning. According to the National Institute of Neurological Disorders, you must first have had an outbreak of chickenpox in order to develop shingles, which is triggered by residual virus particles in the nervous system. Roughly 20 percent of people who have had chickenpox will eventually develop shingles, usually at a time of great stress. Shingles is more common in older people--about half of the people over 80 will develop it--and people with weakened immune systems. If you're infected with shingles, you can pass the virus to anyone who hasn't had chickenpox, but that individual will develop chickenpox at that time, not shingles.

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  • wise, 21.06.2014 at 18:11:18
    Vera and minimize it into two the vaccine is being conducted.
  • unforgettable_girl, 21.06.2014 at 13:55:29
    For HSV-1, the period of time between contact with the.
  • farida, 21.06.2014 at 21:57:58
    Your body could make antibodies and all you'll have about herpes.
  • kursant007, 21.06.2014 at 11:27:26
    Not go on with life just accepting that we each details about.