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A team of researchers at the Croatian pharmaceutical company Pliva, Gabrijela Kobrehel, Gorjana Radobolja-Lazarevski and Zrinka Tamburasev led by Dr.
Potentially preneoplastic (pre-cancer) lesions were also observed in the brain and heart of male rats exposed to RFR, with higher confidence in the association with neoplastic lesions in the heart than the brain. No biologically significant effects were observed in the brain or heart of female rats regardless of type of radiation.
The supervised deep-learning drug-discovery engine used the properties of small molecules, transcriptional data, and literature to predict efficacy, toxicity, tissue-specificity, and heterogeneity of response. The research is described in a paper in the upcoming issue of the journal Molecular Pharmaceutics. Alex Zhavoronkov, PhD, Insilico Medicine CEO, who coordinated the study, said the initial goal of their research was to help pharmaceutical companies significantly accelerate their R&D and increase the number of approved drugs. Despite the commercial orientation of the companies, the authors agreed not to file for intellectual property on these methods and to publish the proof of concept. Insilico Medicine is located in the Emerging Technology Centers at Johns Hopkins University in Baltimore, Maryland, in collaboration with Datalytic Solutions and Mind Research Network. To train the DNN, scientists utilized both gene level transcriptomic data and transcriptomic data processed using a pathway activation scoring algorithm, for a pooled dataset of samples perturbed with different concentrations of the drug for 6 and 24 hours. One peculiar finding of this experiment was that a large number of drugs misclassified by the DNNs had dual use, suggesting possible application of DNN confusion matrices in drug repurposing. Deep learning is rapidly advancing many areas of science and technology with multiple success stories in image, text, voice and video recognition, robotics and autonomous driving.
Researchers at the Walter and Eliza Hall Institute in Australia have discovered a new way to trigger cell death that could lead to drugs to treat cancer and autoimmune disease. Institute researchers Sweta Iyer, PhD, Ruth Kluck, PhD, and colleagues unexpectedly discovered that an antibody they had produced to study Bak actually bound to the Bak protein and triggered its activation. The researchers used information about Bak’s three-dimensional structure to find out precisely how the antibody activated Bak. Drugs that target this new activation site could be useful in combination with other therapies that promote cell death by mimicking the BH3-only proteins. During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the ?2–?5 hydrophobic groove; Bax is also activated via a rear pocket. As it seeks to modernize its nuclear arsenal, the United States faces a big choice, one which Barack Obama should ponder before his upcoming Hiroshima speech. Should we spend a trillion dollars to replace each of our thousands of nuclear warheads with a more sophisticated substitute attached to a more lethal delivery system?
As physicists who have studied nuclear reactions and cataclysmic explosions, we are acutely aware that nuclear weapons are so devastating that merely a hundred could annihilate the major population centers of any potential state enemy. In today’s world, with nuclear technology more widely accessible, compellance is no longer straightforward.
These considerations raise the question of whether we might actually improve our national security by forswearing compellance and committing to “No First Use.” That is, committing to using nuclear weapons only in response to their use by others.
This deterrence-only approach is already the policy of two other major nuclear powers, China and India. Indeed, hundreds of warheads may be a more convincing deterrent than thousands, because use of the latter might be an act of self destruction, triggering a decade-long global nuclear winter that would kill most Americans, even if no nuclear explosions occurred on U.S.
Whatever one’s opinion on No First Use, it is a question with huge implications for military spending. We urge debate moderators, town hall participants and anyone else who gets the opportunity to ask our presidential candidates this crucial question. Researchers have developed a new method for doping (integrating elements to change a semiconductor’s properties) single crystals of diamond with boron at relatively low temperatures, without degradation. Zhengqiang (Jack) Ma, a University of Wisconsin-Madison electrical and computer engineering professor, and his colleagues describe a solution in the Journal of Applied Physics, from AIP Publishing.
They discovered that if you bond a single-crystal diamond with a piece of silicon doped with boron, and heat it to 800 degrees Celsius (low compared to conventional techniques), the boron atoms will migrate from the silicon to the diamond. This technique also allows for selective doping, which means more control when making devices. The new method currently only works for P-type doping, where the semiconductor is doped with an element that provides positive charge carriers (in this case, the absence of electrons, called holes). But to make electronic devices like transistors, you need N-type doping, which gives the semiconductor negative charge carriers (electrons). Still, Ma says, achieving P-type doping is an important step, and might inspire others to find solutions for the remaining challenges. With the best overall electronic and thermal properties, single crystal diamond (SCD) is the extreme wide bandgap material that is expected to revolutionize power electronics and radio-frequency electronics in the future. Consider steps that we can all take to increase the chance of us living long enough to be able to reach the point of wide availability of these therapies.
There will be plenty of change for audience members to ask questions and to raise alternative points of view. Room TBA is on the TBAth level in the main Birkbeck College building, in Torrington Square (which is a pedestrian-only square).
Coffee and other light refreshments can be purchased from the Costa Coffee shop in the reception area of the building, either ahead of or after the meeting.
This will be refunded if the meeting is cancelled or rearranged, or if the attendee cancels at least 2 days before the meetup. In case of difficulty using the meetup app to RSVP and pay, please use a laptop or desktop web browser.
Alternatively, if there are still seats available, payment of ?10 in that case can be made in cash at the door on the day. Journalists are welcome to attend the meeting free-of-charge – please contact the organiser, notifying us in advance of your plans to attend. We are going to try to pick up where Hank Pellissier left off and will be having another transhumanist debate and futurist salon on May 28th at the Octopus. Please bring your curiosity and your insights, we will set aside a good portion of time for questions and answers.
Josh Whiton is an entrepreneur working to enhance human life and support Earth’s ecological flourishing.
But our progress in understanding these molecules has been slow because of the lack of technologies that allow for systematic mapping of their functions.
The study, described in Molecular Cell, was published on May 19, along with two other papers, in Molecular Cell and Cell, respectively, from Yue Wan’s group at the Genome Institute of Singapore and Howard Chang’s group at Stanford University in California, who developed similar methods to study RNAs in different organisms.
Of the 3 billion letters in the human genome, only two per cent make up the protein-coding genes. But the majority of available data has trickled in piecemeal or through serendipitous discovery. The new ‘‘LIGation of interacting RNA and high-throughput sequencing’’ (LIGR-seq) tool captures interactions between different RNA molecules. Not having to rely on pre-existing knowledge will boost the discovery of RNA pairs that have never been seen before. Nonetheless, the new technology developed by Blencowe’s group has been able to pick up new interactions involving all classes of RNAs and has already revealed some unexpected findings. The team discovered new roles for small nucleolar RNAs (snoRNAs), which normally guide chemical modifications of other ncRNAs. And this is only the tip of the iceberg; the researchers plan to further develop and apply their technology to investigate the ncRNAs in different settings. The majority of the human genome is transcribed into non-coding (nc)RNAs that lack known biological functions or else are only partially characterized. Sharing genetic information from millions of cancer patients around the world could revolutionize cancer prevention and care, according to a paper in Nature Medicine by the Cancer Task Team of the Global Alliance for Genomics and Health (GA4GH). GA4GH acknowledges that there are security issues, and has created a Security Working Group and a policy paper that documents the standards and implementation practices for protecting the privacy and security of shared genomic and clinical data. Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A novel nanoscale organic transistor-based biosensor that can detect molecules associated with neurodegenerative diseases and some types of cancer has been developed by researchers at the National Nanotechnology Laboratory (LNNano) in Brazil. The transistor, mounted on a glass slide, contains the reduced form of the peptide glutathione (GSH), which reacts in a specific way when it comes into contact with the enzyme glutathione S-transferase (GST), linked to Parkinson’s, Alzheimer’s and breast cancer, among other diseases. Bufon said the system can be adapted to detect other substances by replacing the analytes (detection compounds).
The use of aqueous solutions as the gate medium is an attractive strategy to obtain high charge carrier density (1012 cm?2) and low operational voltages (<1 V) in organic transistors. The researchers found that Oct4 controls the conversion of smooth muscle cells into protective fibrous “caps” inside plaques, making the plaques less likely to rupture. The researchers are also currently testing Oct4′s possible role in repairing cellular damage and healing wounds, which would make it useful for regenerative medicine.
Oct4 is one of the “stem cell pluripotency factors” described by Shinya Yamanaka, PhD, of Kyoto University, for which he received the 2012 Nobel Prize.
Although somatic cell activation of the embryonic stem cell (ESC) pluripotency factor OCT4 has been reported, this previous work has been controversial and has not demonstrated a functional role for OCT4 in somatic cells. Cubimorph is an interactive device made of a chain of reconfigurable modules that shape-shifts into any shape that can be made out of a chain of cubes, such as transforming from a mobile phone to a game console.


British researchers and Google have independently developed revolutionary concepts for Lego-like modular interactive mobile devices. The research team has developed three prototypes demonstrating key aspects — turntable hinges, embedded touchscreens, and miniaturization.
The modular interactive design is a step toward the vision of programmable matter, where interactive devices change their shape to meet specific user needs. The research was presented last week at the International Conference on Robotics and Automation (ICRA). We introduce Cubimorph, a modular interactive device that accommodates touchscreens on each of the six module faces, and that uses a hinge-mounted turntable mechanism to self-reconfigure in the user’s hand. New software developed by Carnegie Mellon University helps mobile robots deal efficiently with clutter, whether it is in the back of a refrigerator or on the surface of the moon. Carnegie Mellon University roboticists have developed an algorithm that helps robots cope with a cluttered world. When a person reaches for a milk carton in a refrigerator, he doesn’t necessarily move every other item out of the way.
The new algorithm was also tested on NASA’s KRex robot, which is being designed to traverse the lunar surface. They researchers presented their work last week (May 19) at the IEEE International Conference on Robotics and Automation in Stockholm, Sweden. Researchers at Washington State University are using ideas from animal training to help non-expert users teach robots how to do desired tasks. As robots become more pervasive in society, humans will want them to do chores like cleaning house or cooking. With Bei Peng, a doctoral student in computer science, and collaborators at Brown University and North Carolina State University, Taylor designed a computer program that lets humans without programming expertise teach a virtual robot that resembles a dog in WSU’s Intelligent Robot Learning Laboratory. The researchers recently presented their work at the international Autonomous Agents and Multiagent Systems conference, a scientific gathering for agents and robotics research.
As robots become pervasive in human environments, it is important to enable users to effectively convey new skills without programming. This escape from the immune response depends upon the ability to express a new surface antigen. National Toxicology Program (NTP) has carried out extensive rodent toxicology and carcinogenesis studies of radiofrequency radiation (RFR) at frequencies and modulations used in the US telecommunications industry. Cross-validation experiments showed that DNNs achieve 54.6% accuracy in correctly predicting one out of 12 therapeutic classes for each drug. In this paper we demonstrate how deep neural networks (DNN) trained on large transcriptional response data sets can classify various drugs to therapeutic categories solely based on their transcriptional profiles. In healthy cells, Bak sits in an inert state but when a cell receives a signal to die, Bak transforms into a killer protein that destroys the cell. The researchers are now working with collaborators to develop their antibody into a drug that can access Bak inside cells.
The research was supported by the National Health and Medical Research Council, the Australian Research Council, the Victorian State Government Operational Infrastructure Support Scheme, and the Victorian Life Science Computation Initiative. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the ?1–?2 loop.
Or should we keep only enough nuclear weapons needed for a devastatingly effective deterrence against any nuclear aggressor, investing the money saved into other means of making our nation more secure?
That prospect is enough to deter any rational leadership while no number of weapons could deter a mad one. But other arguments for maintaining the ability to initiate nuclear war remain, positing the utility of “compellance” (also known as “nuclear blackmail”) or using the threat of nuclear attack to extract concessions. If a nonnuclear nation feels it is subject to nuclear bullying, it can counter by developing its own nuclear deterrent, or enlisting nuclear allies. It is a mission we could fulfill with a much smaller and cheaper arsenal, freeing up money for other investments in our national security.
But one crucial question is beautifully simple: is our aim strictly to deter nuclear war, or should we invest the additional resources needed to maintain our ability to initiate it?
They can handle high voltages and power, and electrical currents also flow through diamonds quickly, meaning the material would make for energy-efficient devices. It turns out that the boron-doped silicon has defects such as vacancies, where an atom is missing in the lattice structure. You can choose where to dope a single-crystal diamond simply by bonding the silicon to that spot. The researchers are already working on a simple device using P-type single-crystal diamond semiconductors.
Eventually, he said, single-crystal diamond could be useful everywhere — perfect, for instance, for controlling power in the electrical grid. However, turning SCD into useful semiconductors requires overcoming doping challenges, as conventional substitutional doping techniques, such as thermal diffusion and ion implantation, are not easily applicable to SCD. Torrington Square is about 10 minutes walk from either Russell Square or Goodge St tube stations. He is currently writing a book on the role of human intelligence in the global history of economic growth and technological development.
He is interested in embodied cognition, Effective Altruism, and the evolution of cooperation. Born on a farm in Minnesota and raised on science fiction & Wittgenstein, his work now focuses on problems in the philosophy of physics, the problem of Qualia, and existential risk. The genes are copied, or transcribed, into messenger RNA (mRNA) molecules, which provide templates for building proteins that do most of the work in the cell. And with emerging evidence that ncRNAs could drive disease progression, such as cancer metastasis, there was a great need for a technology that would allow a systematic functional analysis of ncRNAs. The power of our method is that you don’t need to preselect your candidates; you can see what’s occurring globally in cells, and use that information to look at interesting things we have not seen before and how they are affecting biology,” says Eesha Sharma, a PhD candidate in Blencowe’s group who, along with postdoctoral fellow Tim Sterne-Weiler, co-developed the method. This technology will open the door to developing a new understanding of ncRNA function,” says Blencowe, who is also a professor in the Department of Molecular Genetics. Scientists can also, for the first time, look at RNA interactions as they occur in living cells, in all their complexity, unlike in the juices of mashed up cells that they had to rely on before. But the truth is that no one really knows the extent to which these ncRNAs control what goes on in the cell, or how they do this.
It turns out that some snoRNAs can also regulate stability of a set of protein-coding mRNAs.
Numerous characterized ncRNAs function via base pairing with target RNA sequences to direct their biological activities, which include critical roles in RNA processing, modification, turnover, and translation. GA4GH intends to provide a common framework for the responsible, voluntary and secure sharing of patients’ clinical and genomic data. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care.
The team is working on paper-based biosensors to further lower the cost, improve portability, and facilitate fabrication and disposal. Additionally, it provides a simple and favorable architecture to couple both ionic and electronic domains in a single device, which is crucial for the development of novel technologies in bioelectronics. They also discovered that the gene promotes many changes in gene expression that are beneficial in stabilizing the plaques. His lab and many others have shown that artificial over-expression of Oct4 within somatic cells grown in a lab dish is essential for reprogramming these cells into induced pluripotential stem cells, which can then develop into any cell type in the body or even an entire organism.
The work was funded by the National Institutes of Health, the Russian Science Foundation, the Russian Federal Agency of Scientific Organization, and the U.S. It has touchscreens on each of the six module faces and uses a hinge-mounted turntable mechanism to self-reconfigure in the user’s hand. Cubimorph contributes toward the vision of programmable matter where interactive devices reconfigure in any shape that can be made out of a chain of cubes in order to fit a myriad of functionalities, e.g.
Rather, a person might move an item or two, while shoving others out of the way as the carton is pulled out.
While HERB focused on clutter typical of a home, KRex used the software to find traversable paths across an obstacle-filled landscape while pushing an object. NASA, the National Science Foundation, Toyota Motor Engineering and Manufacturing, and the Office of Naval Research supported this research. But to get a robot started on a task, people who aren’t computer programmers will have to give it instructions.
As when somebody is teaching a new skill to a real animal, the slower movements let the trainer know that the virtual dog was unsure of how to behave, so trainers could provide clearer guidance to help the robot learn better. They also hope to eventually also use the program to help people learn to be more effective animal trainers. Most existing work on Interactive Reinforcement Learning focuses on interpreting and incorporating non-expert human feedback to speed up learning; we aim to design a better representation of the learning agent that is able to elicit more natural and effective communication between the human trainer and the learner, while treating human feedback as discrete communication that depends probabilistically on the trainer’s target policy.
It was patented in 1981, and was later found by Pfizer's scientists while going through patent documents.
The glioma lesions occurred in 2 to 3 percent of the rats and the schwannomas occurred in 1 to 6 percent of the rats.
We used the perturbation samples of 678 drugs across A549, MCF-7 and PC-3 cell lines from the LINCS project and linked those to 12 therapeutic use categories derived from MeSH.


Failure of apoptosis can allow cancer cells to grow unchecked or immune cells to inappropriately attack the body. A monoclonal antibody (clone 7D10) binds close to ?1 in non-activated Bak to induce conformational change, oligomerization, and cytochrome c release. Waging nuclear warfare could involve using vastly more warheads to strike diverse military and industrial targets. By easing fear of our intentions, this could also reduce further nuclear proliferation — so far, eight other nations have developed nukes after we bombed Hiroshima, and all except Russia have concluded that deterrence requires fewer than a few hundred nuclear weapons. And they are thermally conductive, which means diamond-based devices would dissipate heat quickly and easily (no need for bulky, expensive cooling methods). Carbon atoms from the diamond will fill those vacancies, leaving empty spots for boron atoms.
Here we report a simple and easily accessible doping strategy demonstrating that electrically activated, substitutional doping in SCD without inducing graphitization transition or lattice damage can be readily realized with thermal diffusion at relatively low temperatures by using heavily dopedSi nanomembranes as a unique dopant carrying medium. Much of the remaining 98 per cent of the genome was initially considered by some as lacking in functional importance. Some researchers believe that most ncRNAs have no function, that they are just a by-product of the genome’s powerful transcription machinery that makes mRNA. With LIGR-seq, the paired RNA structures are removed from cells and analyzed by state-of-the-art sequencing methods to precisely identify the RNAs that are stuck together. This is a bit like moving on to explore marine biology from collecting shells on the beach to scuba-diving among the coral reefs, where the scope for discovery is so much bigger. In this way, snoRNAs can also directly influence which proteins are made, as well as their abundance, adding a new level of control in cell biology. But we will also use our method to discover and map changes in RNA-RNA interactions in the context of human diseases,” says Blencowe. To define roles for ncRNAs, we have developed a method enabling the global-scale mapping of RNA-RNA duplexes crosslinked in vivo, “LIGation of interacting RNA followed by high-throughput sequencing” (LIGR-seq).
Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing.
In addition, the researchers believe it may be possible to develop drugs or other therapeutic agents that target the Oct4 pathway as a way to reduce the incidence of heart attacks or stroke.
Results of SMC-lineage-tracing studies showed that these effects were probably the result of marked reductions in SMC numbers within lesions and SMC investment within the fibrous cap, which may result from impaired SMC migration.
Powering this is Greybus, a new bit of software deep in the Android stack that supports instantaneous connections, power efficiency, and data-transfer rates of up to 11.9 Gbps. The robot is programmed to understand the basic physics of its world, so it has some idea of what can be pushed, lifted, or stepped on. We propose a planner to solve the rearrangement planning problem by considering two different types of actions: robot-centric and object-centric. The occurrences of two tumor types in male Harlan Sprague Dawley rats exposed to RFR, malignant gliomas in the brain and schwannomas of the heart, were considered of particular interest, and are the subject of this report. To train the DNN, we utilized both gene level transcriptomic data and transcriptomic data processed using a pathway activation scoring algorithm, for a pooled dataset of samples perturbed with different concentrations of the drug for 6 and 24 hours. When the Soviet Union was perceived to be a threat to Europe with its numerically superior conventional forces, the U.S. For example, when President Eisenhower threatened the use of nuclear weapons to compel negotiations ending the Korean War. We could save ourselves four million dollars per hour for the next 30 years, according to government estimates. Because such polydiamonds have irregularities between the crystals, single crystals would be superior semiconductors.
Atomistic simulations elucidate a vacancyexchange boron doping mechanism that occurs at the bonded interface between Si and diamond. We further demonstrate selectively doped high voltage diodes and half-wave rectifier circuits using such dopedSCD. Applying this method in human cells reveals a remarkable landscape of RNA-RNA interactions involving all major classes of ncRNA and mRNA. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. We present a design rationale that exposes user requirements to consider when designing homogeneous modular interactive devices. We present results from 60 participants to show how a learner can ground natural language commands and adapt its action execution speed to learn more efficiently from human trainers. The findings in this report were reviewed by expert peer reviewers selected by the NTP and National Institutes of Health (NIH). An antibody (clone 3C10) to the Bax ?1–?2 loop activates mitochondrial Bax, but blocks translocation of cytosolic Bax.
You can dope single crystals by injecting boron atoms while growing the crystals artificially. Our new doping strategy has established a reachable path toward using SCDs for future high voltage power conversion systems and for other novel diamond based electronic devices. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture. Several device characteristics such as moderate switching speeds and hysteresis, associated with high capacitances at low frequencies upon bias application (3.4–12 ?F cm?2), indicate the occurrence of interfacial ion doping.
These results provide the first direct evidence that OCT4 has a functional role in somatic cells, and they highlight the potential role of OCT4 in normal and diseased somatic cells.
We present our Cubimorph mechanical design, three prototypes demonstrating key aspects (turntable hinges, embedded touchscreens and miniaturization), and an adaptation of the probabilistic roadmap algorithm for the reconfiguration. Robot-centric actions move the robot without object relevant intent, easily allowing simultaneous object contact and whole arm interaction. The agent’s action execution speed can be successfully modulated to encourage more explicit feedback from a human trainer in areas of the state space where there is high uncertainty. These reviews and responses to comments are included as appendices to this report, and revisions to the current document have incorporated and addressed these comments. Tethers within Bak show that 7D10 binding directly extricates ?1; a structural model of the 7D10 Fab bound to Bak reveals the formation of a cavity under ?1.
We were prepared not only to deter the use of nuclear weapons by others, but also possibly to initiate nuclear warfare, and to use nuclear weapons in battle.
The problem is the process requires powerful microwaves that can degrade the quality of the crystal.
LIGR-seq thus represents a powerful approach for illuminating the functions of the myriad of uncharacterized RNAs that act via base-pairing interactions.
Finally, water-gated CuPc OTFTs were employed in the transduction of the biospecific interaction between tripeptide reduced glutathione (GSH) and glutathione S-transferase (GST) enzyme, taking advantage of the device sensitivity and multiparametricity. Our results show that our novel adaptive speed agent dominates different fixed speed agents on several measures of performance. Supplemental information in the form of 4 additional manuscripts has or will soon be submitted for publication. In both gene and pathway level classification, DNN convincingly outperformed support vector machine (SVM) model on every multiclass classification problem.
Our identification of the ?1–?2 loop as an activation site in Bak paves the way to develop intrabodies or small molecules that directly and selectively regulate these proteins. Additionally, we investigate the impact of instructions on user performance and user preference in training conditions. These manuscripts describe in detail the designs and performance of the RFR exposure system, the dosimetry of RFR exposures in rats and mice, the results to a series of pilot studies establishing the ability of the animals to thermoregulate during RFR exposures, and studies of DNA damage. For the first time we demonstrate a deep learning neural net trained on transcriptomic data to recognize pharmacological properties of multiple drugs across different biological systems and conditions.
Capstick M, Kuster N, Kuhn S, Berdinas-Torres V, Wilson P, Ladbury J, Koepke G, McCormick D, Gauger J, Melnick R. A radio frequency radiation reverberation chamber exposure system for rodents Yijian G, Capstick M, McCormick D, Gauger J, Horn T, Wilson P, Melnick RL and Kuster N. This work is a proof of principle for applying deep learning to drug discovery and development. Life time dosimetric assessment for mice and rats exposed to cell phone radiation Wyde ME, Horn TL, Capstick M, Ladbury J, Koepke G, Wilson P, Stout MD, Kuster N, Melnick R, Bucher JR, and McCormick D. Pilot studies of the National Toxicology Program’s cell phone radiofrequency radiation reverberation chamber exposure system Smith-Roe SL, Wyde ME, Stout MD, Winters J, Hobbs CA, Shepard KG, Green A, Kissling GE, Tice RR, Bucher JR, Witt KL. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Acupuncture , heat , electrical stimulation channels of energy , body's internal organs, correct imbalances digestion, absorption, and energy production activities, circulation of their energy . Specialization, Materia Medica, internal medicine, diagnosis , examine, refer ,investigations .health shops, pharmacies, prescription, complex remedies, labelled ,individualized ,mental, migraines, asthma, eczema, hay fever, glandular fever, chronic fatigue syndrome. Free-radical, toxin-, inflammatory, degenerative diseases, Nutrients, minerals, enzymes, vitamins, amino acids.



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