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Withanolides are important hormone precursors that can convert into human physiologic hormones as needed and are therefore used to regulate important physiological processes. Anxiety disorders are extremely common in the general population with over 15% of people being affected at some point in their lives. Chronic stress has various negative impacts on the body, including cognitive deficit, sexual dysfunction, gastric ulceration, immunosuppression, abnormal glucose balance, and changes in plasma corticosterone levels [5]. Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder and is characterized by the presence of confusion, mood swings, and memory loss. One theory for its mechanism of action is that when there is an excess of a particular hormone, the plant-based hormone precursor occupies the receptor sites thereby effectively blocking the binding of the actual hormone and preventing it from exerting its effects. In one animal study, an increase in serum T4 concentration was seen following the administration of W. The beta-amyloid peptide (BAP) plays a significant role in the development of AD and is a main target for drug treatment. A Double-blind, Placebo-Controlled Evaluation of the Anxiolytic Efficacy of an Ethanolic Extract of W.
Plant-Based Medicines for Anxiety Disorders, Part 2: A Review of Clinical Studies with Supporting Preclinical Evidence. The important constituents of the root are steroidal alkaloids and steroidal lactones referred to as withanolides.
However, if the hormone level is low, this plant-based hormone can exert a small effect [1,2].

It can reduce leucopenia, enhance bone marrow cellularity, and increase the ratio of normochromatic to polychromatic erythrocytes in mice treated with gamma radiation. Withanamides potently inhibit lipid peroxidation, which is involved in the development of several disease states. Additionally, it has been demonstrated to have anticancer, thyroid stimulating, and potent antioxidant effects that can benefit cognition.
It is used for anxiety, inflammation, Parkinson’s disease, cognitive and neurological disorders, and as a supportive adjunct for people undergoing radiation and chemotherapy. It attenuated the following stress parameters: cortisol levels, mental depression, and sexual dysfunction in a study done on rats [5]. It can also enhance total white blood cell count and bone marrow cellularity in mice treated with cyclophosphamide, a common chemotherapeutic agent. Due to its various benefits, excellent safety profile, and low potential to interact with other drugs and herbs it is used frequently in naturopathic practice.
It is also considered an important adaptogen, an herb that helps manage the body’s response to stress, for people with nervous exhaustion, insomnia, debility due to stress, and as an immune stimulant in people with low white blood cell counts [1]. Since immunity is suppressed in cancer, especially for those undergoing chemotherapy and radiation therapy, it is important to support the immune system [9]. An animal study showed that withanamides reduce reactive free radicals that cause oxidative stress on neuronal cell membranes.
It exhibits both antioxidant and pro-oxidant activity and can repair oxidative damage caused by tumor growth and inflammation thereby reducing disease progression.

This oxidative stress results in the fibrillation of tau proteins within the cells and ultimately leads to cell death.
Its GABA agonism has been linked to the prevention of anxiety and therefore this plant is beneficial in anxiety disorders. It has been proposed that the cholinesterase inhibitory potential along with calcium antagonistic ability could make the use of withanolides a possible treatment for Alzheimer's disease and associated problems. A study in mice found that it enhances total white blood cell count and increases nitric oxide production in macrophages, which is important for people undergoing cancer treatment. Withaferin A has been reported to be an inhibitor of angiogenesis, the generation of new blood vessels, and therefore protective in certain types of cancers. Two glycowithanoloids (sitoindoside IX or sitoindoside X) exhibit antistress activity and have been shown to augment learning acquisition and memory retention in both young and old rats [3]. An in vitro study showed that withanolides inhibited growth of human breast, lung, central nervous system, and colon cancer cell lines comparable to doxorubicin, a chemotherapeutic drug [2].

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05.09.2014, author: admin

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