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Description: This podcast covers several new topics, including celebrities who are convinced the earth is flat, the growing threat that is Zika virus, and how HIV is eluding CRISPR treatments.
Keywords: glycans, glycobiology, podcast, Pascal Gagneux, sperm, evolution, biolegend, science, chimpanzees, non-human primates, Neanderthal, pathogen, Ajit Varki Having difficulty playing this episode? Description: In this episode, we discuss some a variety of current scientific news, including the discovery of woman who can smell Parkinson's disease, a correlation between bovine leukemia virus and breast cancer, using an individual's microbial cloud to identify them, and how we're using specialized antibodies to combat both HIV and cancer.
Keywords: immunology, comics, cancer, chimeric antigen receptor, T cells, gene therapy, hypoxia, immune checkpoints, goinvivo, tumors, podcast, pedromics, pedro velica Having difficulty playing this episode? Keywords: neuroscience, neurodegeneration, Parkinson's disease, microbes, microbial, gut microbiome, bacteria, asthma, allergy, leukemia, cancer, AML, antibody, virus, cow, bovine, breast cancer, HIV, AIDS Having difficulty playing this episode? Description: Special guest and global health scientist Jessica Taaffe joins us to discuss educating the public, funding research, and the passion needed in scientific role models. Keywords: global health, Jessica Taaffe, HIV, ebola, education, Bill Nye, Neil degrasse Tyson, vaccines, anti-vaxxers, world bank, funding, research, NIH, primates, biolegend, podcast Having difficulty playing this episode? Description: The podcast team discusses the potential anti-venom shortage, a wasp-venom derived protein for cancer therapy, 30,000 year-old viruses, and a new hominid species discovered in South Africa. Keywords: venom, anti-venom, snakebites, wasp venom, Fav-Afrique, MP1, Polybia-MP1, Polybia paulista, phosphatidylserine, annexin V, cancer cells, homo naledi, fossils, Mollivirus sibericum, viruses, Siberia, giant viruses Having difficulty playing this episode? Description: On this podcast, we discuss current events in science, including recent outbreaks of polio in the Ukraine and Legionnaire's disease in California and Illinois.
Keywords: polio, Legionnaire's disease, outbreaks, virus, bacteria, saturated fats, obesity, microbiome, mice, inflammation, leptin, neurons, brain, exercise, neutrophils, T cells, infection, lungs, influenza, open-access, journal, the wall of polio, science, podcast, virology, immunology Having difficulty playing this episode? Description: Glioblastomas and medulloblastomas are two common forms of brain cancer that afflicts thousands of people a year.
Description: We cover the latest science current events, including the new Ebola vaccine, limb regeneration, being hangry, and Kim K's flub with the FDA. Keywords: Kim Kardashian, ebola, vaccines, anti-vaxxers, current events, limb regeneration, repair, hangry, science, podcast, food and drug administration, morning sickness, FDA Having difficulty playing this episode? Description: In our latest podcast, we talk about narcolepsy and the fight between local colleges for the rights to an Alzheimer's disease database.
Keywords: UCSD, USC, University of Southern California, University of California San Diego, Alzheimer's disease, Pandemrix, narcolepsy, sleep, Paul Aisen, BioLegend, science, podcast Having difficulty playing this episode? Description: Ed Chen and Rea Dabelic, two members of the BioLegend Technical Team, take over the podcast this week to discuss Selman Waksman (the Father of Antibiotics), tuberculosis, and giving credit where its due. Keywords: Selman Waksman, Albert Schatz, streptomycin, neomycin, antibiotics, Neosporin, tuberculosis, granulomas, macrophage, biolegend, immunology, mycobacterium tuberculosis, podcast, patents, inventions, royalties, tuberculin skin test, lab assistants, consumption, avastin, microbiology, birthday blog, controversy, Nobel prize Having difficulty playing this episode? Description: We welcome Chris Gould to discuss neuroscience, protein misfolding, aggregation, and prion-like proteins in neurodegenerative diseases.
Keywords: neuroscience, tau, a-synuclein, alzheimer's disease, parkinson's disease, neuroinflammation, prions, Creutzfeldt-Jakob disease, mad cow disease, kuru, cannibalism, brain, aggregation, protein misfolding, blood brain barrier, lymphatic system, chris gould, biolegend, immunology, podcast, neurofibrillary tangles, lewy bodies, inclusion, Lou Gehrig's disease, ALS, amyotrophic lateral sclerosis, neurodegeneration, microglia Having difficulty playing this episode? Description: Neuroinflammation can be beneficial in some instances, but too much of it can cause any number of neurological diseases. Keywords: Kenya Cohane, neuroinflammation, neuroscience, alzheimer's disease, parkinson's disease, multiple sclerosis, tau protein, a-synuclein, aggregation, immunology, podcast, biolegend Having difficulty playing this episode? Description: Antibody therapies have become incredibly popular for the treatment of diseases, including cancer. Keywords: cancer, tumor, antibody therapy, therapeutics, immune checkpoints, PD1, PDL1, LAG3, TIM3, CD80, CD86, Galectin 9, MHC II, CTLA4, Pembrolizumab, Ipilimumab, Nivolumab, nanobody, melanoma, carcinoma, biolegend, science, podcast, merck, amgen Having difficulty playing this episode?
Description: CRISPR is an amazing technology originally discovered in bacteria as a defense mechanism against invading foreign genetic material. Description: Despite our advances in science and technology, it seems like more and more people are outright denying scientific principles and concepts like evolution and climate change. Keywords: podcast, biolegend, immunology, biology, climate change, ted cruz, NASA, jim inholfe, brain, neuroscience, music, ignorance, science, education, ivory tower, spock, star trek, leonard nimoy, evolution, fluorine, fluoridination, fanta, Tourette Syndrome, nerdy, nerds, nerd, fandom Having difficulty playing this episode? Description: In this podcast, we discuss bacterial hot spots in New York, a brand new antibiotic found in dirt, telomeres and aging, and an interesting article published in 17 scientific journals about Cocoa Puffs. Keywords: podcast, podcasts, New York, subways, bacteria, antibiotics, MRSA, antibiotic resistance, telomeres, cocoa puffs, teixobactin, beer, alzheimer’s disease, parkinson’s disease, aging, BioLegend, immunology, biology, science, grad school, scientific journals Having difficulty playing this episode? Description: In this podcast, we take a look at how a lack of vaccinations has once again caused an outbreak of a once-controlled disease, the efficacy of the flu vaccine this year, and why people are clamoring to know if their food contains DNA.
Keywords: podcast, science, measles, vaccinations, vaccines, anti-vaxxers, Jenny McCarthy, research, cures, Disney, Disneyland, outbreak, flu vaccine, influenza, flu, dna, food, GMO, genetically modified organism, antibiotics, virus, viruses Having difficulty playing this episode?
Description: In this podcast, we examine why it’s so hard to transition from animal research into human cures and Obama’s latest visit to the NIH.
Keywords: podcast, president, Obama, Barack Obama, BioLegend, NIH, National Institutes of Health, science, Ebola, HIV, Human immunodeficiency virus, AIDS, acquired immune deficiency syndrome, translational models, animal models, translation, research, bench to bedside, cures, vaccines Having difficulty playing this episode?
As most of the people are using Smartphone’s to capture pictures, here I have shortlisted you some of best photo editing app, which you can make use of to take the photography towards next level.
For the desktop photo editing knowledge within palms of your hands, you have need of Adobe Photoshop Touch. Do you need a stunning method to organize and edit your photos along with flawless Creative Cloud sync, you should get Adobe Lightroom.
Pixlr Express is the next good photo editing apps on this list, which was developed via Autodesk Inc.
Photo Aviary by Aviary has located their place on the list of cool photo editing apps, since it contains a slightly additional composed set of real editing features. The Photo Editor Pro is extremely hard photo editor app though there is nothing histrionic about it.
Facebook is the owner of Instagram and most recently it has grown-up to above 90 million of users. In the list of best photo editing apps, here occupies Picture Effect Magic and it is the best one to edit all your photos through great photo effects. Retro Camera app provides you with simple and quick way of providing your photos with vintage look.
With above 10 million downloads, here it is very clear that PicSay app is one of the most popular best free photo editing app in the list.
Photosynth for Windows Mobile is the scenery app, which makes it fun and easy to capture as well as share interactive scenery of people, events and places that are essential for you. Pixlr-O-Matic app is somewhat different from other apps because it focuses mainly in enhancing the photos without lots of hassles. But even the best photos — and the best camera phone photographers — sometimes need a bit of TLC. This well-rounded photography app includes a timer, multi-shot bursts, stability mode, brightness and contrast adjustment, zoom features and photo filters. Android apps are coming to chromebooks this year, The same apps that run on phones and tablets can now run on chromebooks without compromising their speed, simplicity or security. The best video editing apps for android, Odds are your android phone is pretty good at recording videos wait to transfer a video to the desktop for editing with movie-making software. Google announces android instant apps, use applications without installing them, Chrome os works great for most of google's services, but it falls flat on its face when it comes to video and photo editing android apps from the google play store, or an operating system that just runs android apps well, chrome os looks pretty good..
Android app support coming to some chrome os devices - As for video editing deliver a good enough experience to meet the minimum performance and compatibility standards we have for our users", he said. Android apps are coming to chromebooks this year - The same apps that run on phones and tablets can now run on chromebooks without compromising their speed, simplicity or security. The best video editing apps for android - Odds are your android phone is pretty good at recording videos wait to transfer a video to the desktop for editing with movie-making software. Google announces android instant apps, use applications without installing them - Chrome os works great for most of google's services, but it falls flat on its face when it comes to video and photo editing android apps from the google play store, or an operating system that just runs android apps well, chrome os looks pretty good..
Google play bringing android apps to newer chromebooks - As liu demonstrated the system by editing a photo in an android app, integrating it into a document in another, and sending it on via gmail in chrome os.
Google play is coming to chromebooks - It's also potentially good news for app developers who will be able to limitations preventing at least some older chromebooks from running android apps.
ANDROIDTODAY – While carrier availability of the Sony Xperia Z3 Compact might not stack up to the flagship bigger brother, you still won’t have much issue getting one if you’re prepared to pay full price.
ANDROIDTODAY – Android fans are eagerly anticipating the launch of the Nexus 6, Google’s latest Nexus smartphone, which is expected to be officially announced tomorrow, October 15th. SubscribeEnter your email address below to receive updates each time we publish new content. We examine increasing cases of diabetes and how finding the "secret sauce" for beta cells might fight this trend. BioLegend is working with Sean Parker and the Parker Institute’s collaboration in fighting back against cancer.
Recent studies have reported a link between Herpes Simplex Virus 1 (HSV-1) and increased AD risk.
This blog will cover the major apps provided by BioLegend relevant to research steps from conceptualization to discovery, as well as a few useful apps not from BioLegend. Look back at this year’s most popular posts and find out which blogs our writers enjoyed composing.
Our latest podcast invites guest Pascal Gagneux to discuss his thoughts on glycans, evolution, and sex cells! Learn what makes this virus dangerous and why some countries are advising women to avoid pregnancy.


Although respiration is considered the more efficient pathway because it has more ATP output per molecule of pyruvate, rapidly-dividing cells sometimes choose fermentation instead.
Almost 50 BioLegend employees took part is this fun race which supports awareness for local charities trying to bring about positive change in San Diego. By controlling key molecules involved in regulating the immune response, researchers have obtained very promising results in the treatment of certain cancers.
Read this blog to learn more about Mazumdar-Shaw’s humble beginnings and how she built her empire by literally starting in her garage. Scientists would like to reanimate this virus to learn more about its origins and the evolution of giant viruses.
We also cover recent research linking high-fat diets with a change in the gut microbiome and obesity-linked inflammation, as well as the role that leptin plays in the rewarding effects of exercise. Immunotherapy is a groundbreaking option because it can hypothetically target cancer cells specifically while leaving healthy cells intact, which can decrease the number of adverse effects associated with current treatment options.
Some may notice a modest decline in their mental abilities, including memory function, while some may develop neurodegenerative diseases as they age. Tune in to hear our guest Mohar Chattopadhyay discuss its symptoms, treatments, and research. Using bioinformatics methods, they reconstructed the evolutionary tree of AAV and made viruses that represent different branching points.
Resistance to anti-microbial drugs occurs naturally, however, the misuse of these drugs, among other factors, is helping the spread of multidrug resistant microbes.
However, communication between the CNS and the periphery occurs through unknown mechanisms.
The cause of this disease is unknown, and although there is presently no cure, there are some treatment options such as medication and surgery to manage its symptoms. Learn more about neuroinflammation and the newly discovered central nervous system lymphatic system with our special guest, Kenya Cohane. They are highly similar to peripheral macrophages and respond to pathogens and injury by becoming activated. But, how does this peer review work and why have so many controversies sprung up recently about this system? The Neuroinflammation page shows how neuronal injury can lead to immune infiltration, and how differential activation of microglia can be either neuroprotective or neurotoxic. This versatile system can accommodate your experimental needs, whether you are doing positive or negative selection. In cancer, it may be beneficial to prevent interaction of "immune checkpoints", which can inactivate T cells. This time we contribute to science enrichment classes in elementary schools throughout San Diego. In this blog, we discuss the potential impact of sequencing or genotyping individuals and why the FDA temporarily shutdown one company for marketing their kit as a medical device. Quite often, they manage to subvert a highly evolved immune system and proliferate inside a host. It allows researchers to listen to important talks, collaborate, and see what companies have to offer. Researchers are now repurposing this for useful applications in like increasing crop size and treating diseases like HIV and cancer. With open source sharing of 3D models, anyone with access to a 3D printer can print tube racks, 96 well plates, gel combs, and many other things. We also take a look at some of the inner workings of the brain including synchronization, implanting false memories, and how it blocks distractions. In this blog, we discuss one of the biggest scientific scandals in recent memory: The publication of high-profile stem cell papers in one of the most reputable journals that was riddled with errors, and, in at least a couple of spots, obvious data manipulation. Depending on the requirements of your assays, as well as your equipment at hand, you may need to use a colorimetric assay.
This blog discusses the implications of red meat consumption in humans and the characterization Neu5Gc as a xeno-autoantigen capable of inducing low level inflammation leading to cancer. These are called plantibodies, and in fact, there are already companies developing therapeutic antibodies using them. There we showcased some of our newly released products, such as LEGENDplex and newly aquired NeoClone antibodies. Our blog examines possible causes, treatments, and mechanisms of action for food allergens. Keywords: BioLegend, science, podcast, podcasts, immunology, neuroscience, memory, alcohol, beer, neurons, ion channels, NMDA receptor, redox, oxidation, reduction, calcium, potassium, sodium, hippocampus, GIRK receptor, addiction, Karthik Bodhinathan, Stuart Lipton Having difficulty playing this episode?
Here is a post to show some of the cool costumes and pumpkin carving contest we had this year. Photographs frequently never look as fine as they can unless you apply the finishing touch in them. Whether you are looking for inclusive editing power, arty effects, ease of use or simply a quick method to spice up your picture before posting it on social networks, there is something interesting for you here.
It brings you the actual Photoshop experience to mobile devices as well as it is almost certainly the most highly developed image editing tool on iPad.
This app is questionably one amongst the best ways to allow you in editing RAW files from DSLR camera, sync your entire edits, creating stunning galleries and changing rights to Creative Cloud account and a lot more.
Not like Instagram, but Flickr contains advanced editing tools that are superior for enthusiasts. Photo Editor by Aviary will be a great choice when you look for large variety of tools as well as willing to sacrifice lots of advanced editing tools for convenient sake. Photo Editor Pro features the one-touch enhancing feature, frames, filters as well as fundamental photo improvement tools such as rotate, crop and color balance.
It is one amongst the good photo editing apps in Android and IOS, also offers different photo editing tools that allow you to fully customize and edit your photos. It comes packed with quite a few beautiful linear, filters and radial tilt-move smudge effects as well as an auto enhancement feature name as Lux, which permits you to balance color, contrast and tone of your pictures with single tap. There are several types of effects like: Neon, Bump, Negative, Light, Stamp, Bend, Snow, Sepia, Engrave, Oil Paint, Noise, Emboss, Marble, Gray scale image, etc. It is powerful and fun photo editor where you can quickly rotate, fine tune and crop any picture, everything in wholly ad-free experience. Not like other panoramic photo apps, this allows you to capture 360 degree scenery on both horizontal and vertical access, permitting user to capture all environment about a point.
They've got great movie-making capabilities, killer flashes, and the megapixels are on the rise with each new Android device that hits the market. Whether your latest snap needs a little Lomo touch or you need to crop a stranger out of an otherwise perfect party pic, you could use a few good Android apps for taking and editing perfect photos.
This powerful photo editor lets users correct color, crop images, add text in word balloons or as titles, and apply special effects. 40 photo effects, zoom functions, photo bursts, timers, stable shot, white balance, grids and sound activation will help the serious Android photog up his or her game, and social media mavens will appreciate the app's Twitter and Facebook integration and geotagging capabilites. It's a touchscreen interface that allows the user to color and draw over photos or other images or on a blank canvas. Powered by its own proprietary technology, Mashable is the go-to source for tech, digital culture and entertainment content for its dedicated and influential audience around the globe. Whether you’re a fan of the massive screen or not, the Nexus 6 is going to be one of the best Android phones of the year. And, we talk about Sean Parker's new $250 million grant to establish the Parker Institute for Cancer Immunotherapy. In this blog, we discuss a landmark case study, and human trial, in which gene editing was successfully used in the treatment of leukemia. As hard as it is to secure funding, prioritizing how to stay within the lab’s budget is an equally daunting task. The use of monoclonal antibodies against some of these molecules, called immune checkpoint receptors, have provided some answers and hope in the search for a cure.
Tune in to hear our discussion on the release of an open-access journal that will publish ideas as well as data and results, and other exciting research on influenza infection.
In this blog, read about adoptive cell transfer, the process of training and expanding a patient's own immune cells and placing it back into the patient to fight the cancer with their own cells. Scientists are increasingly interested to understand the factors and mechanisms that may impact brain health. These viruses were used to circumvent detection by the immune system to successfully deliver genes to various mammalian tissues.
This is a serious public health issue at the moment, and if we don’t act with energy, there can be hard consequences.
In this blog, we discuss a recent paper published in Nature that discovered that the CNS does, in fact, have a lymphatic system that can be used to communicate with immune cells in the periphery. Read our blog to learn more about Selman Waksman, his work in antibiotics, and the controversy over streptomycin. Read our blog to learn more about the correlation between the flu vaccine and narcolepsy, and the evidence to support or refute the hypothesis. Read our blog to learn about the work being done to uncover how bacteria can influence the mental state.


This blog discusses the blood-brain barrier, which can be compromised under certain conditions, leading to immune cell infiltration and chronic neuroinflammation. As part of their response, they secrete cytokines and chemokines, which help in the resolution of the inflammatory response. The page also features IHC reagents for detection of neuroinflammation and a list of our neuroinflammation products. Learn more with our podcast about some of the more popular antibody and nanobody treatments.
Read about BioLegend at IMMUNOLOGY 2015™ in this blog, and we’re excited for next year's AAI Annual Meeting! Check out our blog to learn how Joseph Lister turned it all around and why he is now known as "the father of modern surgery". In this post, we comment on the number of mechanisms that HIV, a retrovirus, has to escape the immune system. Learn about BioLegend's involvement in scholarships, talks, and interesting facts about this year's host city, New Orleans. There's a battle brewing over the CRISPR patents with millions in funds (and profit) at stake. This allows for on-the-fly access to lab goods, and also nearly infinite customizability for lab supplies in your experiments.
The fallout after the retraction of these papers just goes to show that scientific misconduct is not worth the risk. Luckily, our immune system has also “learned” how to deal with most of these pathogens, so we can eliminate most of these infections.
Read through our blog to learn more about the logistics of picking out the right animal for you. Looking for a best photo editing apps to help you in editing and tweaking your photos to the perfection whereas on the go?
You will require Creative Cloud subscription for using the Lightroom, however if you are not prepared to bite bullet yet, then sign up for the trial and  have the benefit of 30 days free before deciding. For fast editing in app that is easy to understand and use, Pixlr Express will suit the invoice for most people. It combines the basic editing like saturation, brightness, sharpness and warmth with many additional for you to play around with. Some of the VSCS Cam editing tools are rotate, brightness, crop, saturation, shadows, contrast, brightness, sharpness and much more.
Instagram is a simple technique to capture or detain and share world’s exciting moments at your Android phone.
Retro Camera permits the users to choose from a set of retro cameras, changing the appearance of capturing interface consequently. Also, you can apply artistic effects, contrast, exposure, temperature and brightness as well. Capturing procedure is very simple and results are normally without many blemishes otherwise flawless. It's not as highly rated as similar free apps, however, and users have noted that the app is a bit slow and lacks important features like photo filters and a wide range of visual effects.
Effects include Lomo and toy camera filters, Polaroid-style effects, cross-processing and tilt-shift. Some users complain the app runs slow, but for a fun, free app, Camera Illusion is worth a look. It’ll certainly put up a very good fight against our current reigning champ, the LG G3. Read this blog to get an idea about how much it costs to run an academic research lab in the U.S. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
If you're able to score a perfect 100%, you'll win a goodie bag filled with BioLegend prizes. But these cells are also known for their harmful roles in neurodegenerative diseases and brain injuries, such as Alzheimer’s and Parkinson’s disease. In this post, we comment on a number of mechanisms that Salmonella has to escape the immune system.
In this post, we comment on a number of mechanisms that Listeria has to escape the immune system.
Snapseed is a brilliant app, which will automatically adjust all your photos for creating an extremely best final image. This app sports necessary image styling and editing options, such as color adjustments (like Saturation, Exposure and contrast), basic editing tools (like Rotate, Flip, Straighten and Crop), filters (like Sharpen, Reduce noise and sketch), borders and filters, giving you with fast, no-fuss technique for enhancing your pictures before you share with your friends.
Add filters, change the focus, eliminate blemishes, experiment with frames, whiten teeth and a lot more. This is a powerful and fun photo editor, which allows you fast to be pro, though you have never edited any picture before. It also contains many excellent filters to enhance and improve the loveliness of your photos.
Customize your videos and photos with one of numerous beautiful and custom-made filter effects. With above 30 frames and graffiti, color adjustments, basic image editing tools, 95 inspiring image effects, Picture Effect Magic app is one of most inclusive image styling apps on IOS. Selection of 12 various retro style frames, which can be applied to the Retro photos using buttons or swipe signs in top app bar region. It has 3 categories of light filters, photo frames and photo filters that allow you to transform your images completely. If you've got faves we didn't mention here, be sure to let us know about them in the comments.
You can easily create photo collage using lots of cool effects like denoise, focal blur and more.
The only main negative is that its Window Phone app is not equal to Android and IOS variants. Aviary is fun, fast and powerful photo editor that is created for the effortless way to edit your pictures on move with no commotion or fuss. Make over everyday’s moments into artistic works that you need to share with family and friends. In paid version, you will get extra content such as more filters and actual features (like removing red eye, pressure sensitive drawing and others). In addition, experiments through fun effects, such as Vintage Drama, Films, Organic Frames and Center Focus.
Pixlr Express Auto Fix feature is said to be more interesting and just one click on app will automatically adjusts color, contrast, brightness, exposure, etc. Snapseed makes it easier to compare the edited photo to your original as well as share through Facebook, Flickr, Email or print it directly from app. PicFX has many options like film filters, retro filters, vintage style filters as well as light leak overlays.Most importantly I find it easy and logical to navigate in.
What makes me go back to PicFX again and again is that I can control how much or how little of the filter effect I want to add. It makes it easy to see how your image will look in the end.I like the filters faded memory, snap shot and sx-70 8 (polaroid). Wood CameraJust like PicFX, Wood Camera let?s you control how much filter effect you want on your photo. You can add filters, grunge textures and frames one at a time, so it?s possible to make your own style.Controlling the filters are a little bit more advanced in Snapseed because you get to control several options within each filter. Snapseed stores your photos in the app itself so even if you delete your photo from the camera roll it will still be available in the app.5.
He is into videography and Kitcam is a super video app – even in low light situations.
What?s fantastic about this app is that you get to set your settings before you take the photo or record a video.What I love about kitcam is that I can easily set the white balance + it has exposure-control, so you can add more light to your photos in low light or lower it in bright sunlight. VSCOcamVSCO is a wonderful editing app with a great camera. I love the VSCO app mainly for it?s filters. I?m especially a fan of their fade effect, which I use to create a matte effect in my photos.What about you, do you have a favorite photo editing app you recommend? She is known for her elegant and bright photography and draw much of her inspiration from the Nordic countryside, travels, food and still life.
After a decade of working with psychology and coaching, Christina?s passion for photography evolved into a full-time photography business. Today she runs a thriving + fast growing business specializing in professional, motivating and engaging training for female photographers + creative souls.



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