National Breast Cancer Awareness Month is in full swing, and Westchester has loaded up their calender to raise money and spread the cause. Join the cause by participating in this 3-mile walkathon presented by Support Connection to bring awareness and support to the needs of individuals affected by ovarian and breast cancer. As the largest network of breast cancer events in the nation, Making Strides Against Breast Cancer unites nearly 300 communities to finish the fight. Hemoglobin is a iron containing protein in the red blood cells that carries oxygen in the blood from the lungs to the rest of the body tissues. Here we will discuss the brief physiology of hemoglobin in the human body which helps in understanding the diseases related to abnormal hemoglobin. The mitochondria of the developing erythroblast are the main sites for the sythesis of haem. A tetramer of four globin chains, each with its own haem group attached, is formed to make a molecule of hemoglobin. Hemoglobin has a quaternary structure characteristic of many multi-subunit globular proteins.
HbA: In adult humans, the most common hemoglobin type is a tetramer (which contains 4 subunit proteins) called hemoglobin A, consisting of two alpha and beta subunits non-covalently bound, each made of 141 and 146 amino acid residues, respectively. HbF: In human infants, the hemoglobin molecule is made up of 2 alpha chains and 2 gamma chains. Hemoglobin H (beta4) – A variant form of hemoglobin, formed by a tetramer of beta chains, which may be present in variants of alpha thalassemia. Hemoglobin Barts (gamma4) – A variant form of hemoglobin, formed by a tetramer of gamma chains, which may be present in variants of alpha thalassemia. Hemoglobin S (alpha2betaS2) – A variant form of hemoglobin found in people with sickle cell disease. Hemoglobin C (alpha2betaC2) – Another variant due to a variation in the beta-chain gene. Hemoglobin E (alpha2betaE2) – Another variant due to a variation in thebeta-chain gene.

Hemoglobin SC disease – A compound heterozygous form with one sickle gene and another encoding hemoglobin C. When oxygen is unloaded from a molecule of oxygenated Hb, the beta-chains open up allowing, 2-3 DPG to enter. Hydropower plants harness water's energy and use simple mechanics to convert that energy into electricity. Dam - Most hydropower plants rely on a dam that holds back water, creating a large reservoir. Use of hydropower peaked in the mid-20th century, but the idea of using water for power generation goes back thousands of years. The Founding Fathers, the framers of the Constitution, wanted to form a government that did not allow one person to have too much authority or control. With this in mind the framers wrote the Constitution to provide for a separation of powers, or three separate branches of government. All proceeds help fund Support Connection’s free support services for people affected with the two forms of cancer. Join the effort and come help the American Cancer Society fight the disease with research, information and services, and access to mamograms for women who need them. There is a variation in the beta-chain gene, causing a change in the properties of hemoglobin, which results in sickling of red blood cells. They lack a cell nucleus and most organelles to accommodate maximum space for haemoglobin. The cells develop in the bone marrow and circulate for about 100–120 days in the body. This results in the deoxygenated Hb having a low affinity for oxygen, preventing haemoglobin from stealing the oxygen back from the tissues. If you have ever been white-water rafting, then you've felt a small part of the river's power. Hydropower plants are actually based on a rather simple concept -- water flowing through a dam turns a turbine, which turns a generator. Often, this reservoir is used as a recreational lake, such as Lake Roosevelt at the Grand Coulee Dam in Washington State.Intake - Gates on the dam open and gravity pulls the water through the penstock, a pipeline that leads to the turbine.

When the gates open, the water flowing through the penstock becomes kinetic energy because it's in motion.
Each has its own responsibilities and at the same time they work together to make the country run smoothly and to assure that the rights of citizens are not ignored or disallowed.
If there is decreased or abnormal hemoglobin synthesis it results in number of different diseases. The subunits are structurally similar and about the same size. Hemoglobin A is the most intensively studied of the hemoglobin molecules.
Hemoglobin F has a higher oxygen affinity and in normal adults  it is restricted to a limited population of red cells called F-cells.
This 2-3 DPG related affinity for the oxygen dissociation curve is sigmoidal in appearance rather than a straight line. White-water rapids are created as a river, carrying a large amount of water downhill, bottlenecks through a narrow passageway. Water builds up pressure as it flows through this pipe.Turbine - The water strikes and turns the large blades of a turbine, which is attached to a generator above it by way of a shaft.
More than 2,000 years ago, the Greeks are said to have used a water wheel for grinding wheat into flour.
However, the level of Hb F can be elevated in certain diseases like sickle cell or thalassaemia.
The most common type of turbine for hydropower plants is the Francis Turbine, which looks like a big disc with curved blades. These ancient water wheels are like the turbines of today, spinning as a stream of water hits the blades. Giant magnets rotate past copper coils, producing alternating current (AC) by moving electrons.

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