If these foods are not a part of your regular diet, you may benefit from adding a regimen if vitamins and minerals supplement to your diet. Consulting with your health care professional will help you decide which dietary supplements are right for you, as well as any potential adverse reactions. Carlson Super Daily D3 is a natural vitamin D3 supplement for those who don't get enough from food or the sun. Please view our Full Terms of Use Agreement for more information and the terms and conditions governing your use of the VDC Site. Super Daily D3 provides concentrated liquid vitamin D3 with added vitamin E in a single drop. Adults take 1 drop daily or as directed by your health care professional May be put on food or mixed in other liquids, such as water or juice.
This product and statements about this product have not been evaluated by the United States Food and Drug Administration. Vitamin D deficiency is a re-emerging global health problem, which is primarily due to inadequate vitamin D synthesis in the skin.
Affiliation: Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstra?e 11, 32545 Bad Oeynhausen, Germany.
Vitamin D is unique among vitamins in that humans can produce it themselves in their skin provided they have sufficient exposure to ultraviolet (UV) B radiation (290-315 nm).
For a better understanding of toxic vitamin D effects, the following paragraph will briefly highlight some aspects of vitamin D metabolism: Usually, skin synthesis contributes to approximately 80-90% to human vitamin D status.
Once in the circulation, vitamin D is converted by a hepatic hydroxylase into 25-hyroxyvitamin D (25[OH]D). In contrast to renal 1 a-hydroxylation, hepatic 25-hydroxylation of vitamin D is not homeostatically regulated. It is however noteworthy that vitamin D intoxication is rarely seen in the general population. Cases of vitamin D intoxication have been described (i) in patients with established osteoporosis after prescription of excessive therapeutic vitamin D doses [10,11], (ii) in individuals who took over-the-counter supplements that accidently contained vitamin D amounts which were several hundred-fold higher than declared [12,13], and (iii) in persons who drank milk from a home-delivery dairy, which was accidently overfortificated with vitamin D [14,15].
The hallmark of vitamin D intoxication is hypercalcemia, which is due to intestinal calcium hyperabsorption and above all to calcium resorption from bone.
Three major theories about the mechanism of vitamin D intoxication have been proposed [22]. Taken together, available data indicate that all three mechanisms discussed above may exist in parallel and may contribute to toxic vitamin D effects. Vitamin D safety consists of two concepts: One idea of risk assessment of vitamin D is based on the safe tolerable upper intake level (UL) method (Fig. Dose-response evaluation includes the characterization of the dose-response between vitamin D intake and adverse effects.
The circulating 25(OH)D concentration is accepted as the most appropriate indicator of vitamin D status.
Based on the aforementioned associations of circulating 25(OH)D levels with potentially harmful effects, the IOM followed an approach that should maximize public health protection with respect to adverse vitamin D effects. After oral vitamin D intake, the increment in 25(OH)D is remarkably similar in different age groups if the oral vitamin D3 dose is expressed per kilogram body weight.
For the improvement of circulating 25(OH)D levels, different types of vitamin D such as vitamin D2, vitamin D3 and also 25(OH)D3 are available. The concept of vitamin D safety consists of a UL and an adequate circulating 25(OH)D level.
However, this depends on initial levels, the lower the initial level the longer the half-life. Vitamin D toxicity is probably caused by the effects of elevated 25(OH)D itself, not by elevated 1,25(OH)D levels.
A high initial serum 25(OH)D level somehow allows the body to rid itself of most of an additional dose of vitamin D.
However, according to Dr Zimmermann, this recommendation “is not well documented.” Certainly, much higher levels are seen with sun exposure alone.
Notably, intestinal absorption of orally ingested vitamin D is quantitative, even after ingestion of high doses. In contrast, vitamin D deficiency is widespread and a re-emerging global health problem [9].
All involve increased blood concentrations of a vitamin D metabolite reaching the VDR of a target cell. However, evidence that excess circulating 1,25(OH)2D plays a major role in vitamin D intoxication in humans is limited to specific conditions. However, the most important mechanism is probably the toxic effect of 25(OH)D itself at supraphysiological concentrations in the circulation.
Selection of a NOAEL for vitamin D is aided by consideration of how circulating 25(OH)D levels relate to toxicity. However, there is accumulating evidence for a considerably lower efficacy at raising circulating 25(OH)D by vitamin D2 compared with vitamin D3, diminished binding of vitamin D2 metabolites to vitamin D binding protein in plasma, and a nonphysiologic metabolism and shorter shelf life of vitamin D2 [49].
Consequently, bioavailability may be considerably reduced if vitamin D is ingested in the fasting state. It has been shown that the increase in circulating 25(OH)D is similar when oral vitamin D is given daily, weekly or monthly, provided that the total amount of orally ingested vitamin D is identical [52]. However, this upper cut-off value is not well documented and primarily relies on observational studies.
Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health.
Critique of the considerations for establishing the upper tolerable intake level for vitamin D: Critical need for revisionupwards. Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy.
Intermittent high-dose vitamin D prophylaxis during infancy: effect on vitamin D metabolites, calcium, and phosphorus. 1,25-Dihydroxyvitamin D is not responsible for toxicity caused by vitamin D or 25-hydroxyvitamin D. The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.
Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children.
Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects.


Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Circulating 25-hydroxyvitamin d levels in fully breastfed infants on oral vitamin d supplementation. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. That is, it takes about 3 weeks for the body to metabolize one-half of a dose of vitamin D. It is an antioxidant and is essential for normal vision, skin and bone texture and immune function. Fair & lovely Advanced Multivitamin cream promises for the fair and good looking skin with the continuous use for six months.
If you live a busy lifestyle and eating healthy foods is not always convenient, supplementing your diet with a high quality multi vitamin made from natural whole foods can help to keep you in optimal health.It is common sense that dietary supplements cannot replace eating a well balanced diet. What makes it so unique is that it's a vitamin you can get through food and also a hormone your body makes from the sun. The products and the claims made about specific products on or through the Vitamin Discount Center Web Site (a€?VDC Sitea€?) have not been evaluated by the United States Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent disease. However, some safety issues have to be considered, which are highlighted in this review article: The concept of vitamin D safety consists of two models, the safe tolerable upper intake level (UL) method, and the idea of adequate circulating 25-hydroxyvitamin D (25[OH]D) levels. It is assumed that already 10 to 15 minutes of summer sun exposure are sufficient to produce adequate amounts of vitamin D. However, only a few marine foods such as eel, herring and salmon are vitamin D-rich foods, whereas the vitamin D content of the vast majority of other foods is very small or even zero. Therefore, very high circulating 25(OH)D levels can occur after excessive oral vitamin D intake. The main factors being responsible for lower 25(OH)D levels are older age, female sex, higher geographic latitude, winter season, darker skin pigmentation, less sunlight exposure, avoidance of vitamin D-rich foods and absence of effective vitamin D fortification. Moreover, the oral bolus administration in the former German Democratic Republic against rickets with intermittent doses of 15 mg vitamin D2 (600,000 IU) was associated with symptoms of vitamin D intoxications [17,18]. Hypercalcemia and hyperphosphatemia cause mineralization of various soft tissues including kidneys, heart, aorta, other blood vessels, and cutaneous tissue [19]. In most cases, where toxicity due to excessive vitamin D intake is observed, it is rarely accompanied by elevated circulating 1,25(OH)2D levels [22].
This is understandable because the production of 1,25(OH)2D is suppressed by hypercalcemia and hyper-phosphatemia and the absence of PTH. Theoretically, a no observed adverse effect level (NOAEL) and a lowest observed adverse effect level (LOAL) should be established. Since skin synthesis of vitamin D does obviously not lead to intoxication, the IOM's upper limit of the adequate range of circulating 25(OH)D seems to be very conservative. This also implies that compared with lean individuals overweight and obese individuals need considerably higher daily amounts of vitamin D to achieve a similar circulating 25(OH)D level.
Since vitamin D3 is the physiologic form that is produced in human skin following UVB radiation, vitamin D3 supplements should be preferred. In other words, vitamin D should be administered in the non-fasting state, accompanied by a fat-containing meal.
It is noteworthy that in the clinical setting even higher doses than the UL value may be administered if this is necessary and a close-meshed measurement of safety parameters such as circulating 25(OH)D, serum calcium and urinary calcium is guaranteed. It is also of importance that there is no evidence for a reduction in intestinal vitamin D absorption or hepatic conversion of vitamin D into 25(OH)D with advancing age. Fair & Lovely Advanced Multivitamin Cream keeps your skin healthy and the goodness of nature present in the cream makes your skin glow naturally with the healthy skin.
They are meant to assist your regular eating habits to ensure you are getting the recommended daily allowances of vitamins, minerals, and nutrients. Despite the multiple ways of getting vitamin D, many are still deficient due to changing seasons, sunscreen, skin color, age, and sun protection.
The information provided on the VDC Site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. Daily full-body exposure to solar UVB-radiation can be equivalent to an oral vitamin D intake of 250 ug (10,000 international units (IU), to convert ug into IU multiply by 40) [1] and probably even more [2]. Therefore, in the absence of effective food fortification programs, dietary vitamin D intake does not exceed 3-5 ug per day in most individuals [5]. Hypercalciuria may occur in the absence of hypercalcemia and is related to either hyperabsorption of calcium in the gut or a renal leak whereby calcium excretion is enhanced. This is understandable, because circulating 1,25(OH)2D is usually tightly regulated by serum levels of PTH and FGF-23, two hormones that respond to variations in serum calcium and phosphate.
25(OH)D can, at high concentrations, become transcriptionally active, leading to excessive bone resorption and intestinal calcium and phosphate hyperabsorption. In case of vitamin D intoxication, overloading by various vitamin D metabolites significantly comprises the capacity of DBP [22]. It has been assumed that individuals with certain conditions, notably sarcoidosis, tuberculosis, and those treated with thiazide diuretics are extremely sensitive to excessive vitamin D. The increment in circulating 25(OH)D depends on various factors including the person's body weight, the initial 25(OH)D level, the administered dose and the type of oral vitamin D. Data indicate that at high initial 25(OH)D levels vitamin D is not quantitatively converted into 25(OH)D. It is also noteworthy that oral 25(OH)D3 is much more effective in increasing circulating 25(OH)D compared with oral vitamin D3. Additional studies are therefore still needed to determine the upper safe level of circulating 25(OH)D more appropriate.
Fair & Lovely Advanced Multivitamin Cream is more of a fairness treatment which treats various skin problems, like dark spots, tanning, aging, and makes sure that your skin is fair and healthy. Get your daily dose of vitamin D3 by placing a drop of Super Daily D3 in your food or drink or directly on your tongue. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any vitamins or herbs, or if you have or suspect you might have a health problem.
It is also noteworthy, that there are no reports of vitamin D intoxications after intensive solar UVB irradiation [3].
This explains why dietary vitamin D intake usually contributes only 10-20% to human vitamin D status. In the granulomatous condition sarcoidosis, however, consistently elevated circulating 1,25(OH)2D have been described [24]. Notably, excess vitamin D intake is equally hypercalcemic in 1 a-hydroxylase-deficient mice. A significant portion of vitamin D is obviously metabolized otherwise and does not reach the circulation.


However, available data indicate that it would be more appropriate to adjust oral daily vitamin D intake according to body weight. Fair & Lovely advanced Multivitamin Cream targets all the women and their problems are effectively solved with the regular usage.
Citrus fruits are rich in Vitamin C, beta carotene, calcium, and other necessary nutrients. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment.
This is due to the fact that daily skin synthesis of vitamin D reaches a plateau when 15% of the vitamin D precursor 7-dehydrocholesterol is converted into vitamin D.
In some populations with a traditionally high intake of specific, vitamin D-rich marine foods, however, daily vitamin D intakes of 54-62 ug (2,160-2,480 IU) have been reported [6]. A high percentage of all vitamin D metabolites circulating in the blood are bound to a vitamin D specific transport protein, which is named vitamin D binding protein (DBP).
Vitamin D intoxicated patients suffer from headache, nausea, vomiting, diarrhea, anorexia, weight loss, polyuria and polydypsia.
This is due to overexpression of unregulated extrarenal 1 ahydroxylase gene expression (CYP27B1) in the face of normal circulating 25(OH)D. This clearly indicates that 1,25(OH)2D is not the toxic agent in case of excessive oral vitamin D intake and that 25(OH)D itself is probably toxicant [8].
This assumption is supported by findings of elevated free 1,25(OH)2D levels in a family accidentally intoxicated with vitamin D [22]. The UL method involves three basic, standardized steps: hazard identification, dose-response evaluation, and derivation of the UL [26].
It is also noteworthy that due to insufficient data, at present it is not possible to determine a LOAEL.
Therefore, it may sometimes be that even higher oral doses than the UL may be given to increase circulating 25(OH)D levels into the adequate range, e.g. The instructions are to use it twice a day on clean skin, and you can expect the results within 4 to 12 weeks.
Higher concentrations of vitamin D in the blood have been associated with strong bones and good health. Thereafter, vitamin D-inactive substances such as lumisterol and tachysterol are produced [4]. In clinical practise, there is also a widespread use of 1,25(OH)2D or other active forms of vitamin D to treat secondary hyperparathyroidism in chronic kidney disease. Since 1,25(OH)2D has a high affinity for the VDR in its target cells, 1,25(OH)2D is transcriptionally very active and may thus, at high cellular levels, lead to toxic vitamin D effects. Hazard identification includes the collection, organization, and evaluation of all information pertaining to the adverse effects of vitamin D. Before an UL can be determined, uncertainties should be estimated and an uncertainty factor (UF) should be established.
Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. If you wish to maintain your results, then continue using Fair and Lovely Advanced Multivitamin Cream. Fiber: Natural Fiber can help avoid certain conditions, such as diabetes, heart disease, and constipation. In clinical practice, oral vitamin D dosing has to consider that the increment in circulating 25(OH)D depends on baseline 25(OH)D levels and the person's body weight. Data on skin synthesis of vitamin D are thus a first indication that in apparently healthy free-living individuals a daily amount of up to 250 ug (10,000 IU) is safe. Only a small portion of vitamin D metabolites circulate in the blood in a "free" biologically active form. Vitamin D intoxication has been widely used as an experimental model for vascular disease [21].
Occasionally, symptoms such as hypercalcemia, hyperphoshaturia and soft tissue calcification occur, which are most certainly the result of overexposure of target cells to these physiologically active vitamin D substances [22].
In clinical practise, the oral daily vitamin D dose should be determined and adjusted, if necessary, by measuring circulating 25(OH)D before and 3-6 months after dosing.
Fair & Lovely Advanced Multivitamin Cream gives you the best effect within six months of its usage. This amazing vitamin supports healthy immune system function, supports a healthy mood and promotes muscle strength.
It is reasonable to assess 25(OH)D before and 3-6 months after initiation of oral vitamin D administration and to adjust the dose, if necessary. Cellular vitamin D actions are mediated by a membrane-bound and a cytosolic vitamin D receptor (VDR). However, one should clearly distinguish between the oral intake of these substances and native vitamin D. Animal studies can be neglected, since there is sufficient evidence from healthy adults for establishing a safe upper limit for oral intake [26]. This statement is based on several observational findings indicating that values above this level are associated with an elevated risk of all-cause mortality and specific types of cancer [20].
Fair & Lovely Advanced Multivitamin Cream has to be used twice in a day for the best and effective result to get a good and fair looking skin. Fresh fruits and vegetables contain phytochemicals that can help protect against cancer, heart disease, diabetes, and hypertension. In future, two issues have to be clarified: First, would it be more appropriate to define instead of a fixed UL a variable UL, based on the individual's body weight?
The VDR is nearly ubiquitously expressed, and almost all cells respond to vitamin D exposure. Therefore, some safety issues have to be considered, which are highlighted in this article. They also are antioxidant rich, which help protect the body against cell and tissue damage.
Whereas classical vitamin D actions are related to an improvement in intestinal calcium and phosphate absorption, nonclassical actions include important functions in the regulation of cell metabolism, differentiation, and communication. Who should take vitamin and mineral supplements?If you are healthy and eat a variety of natural whole foods, you most likely will not need to take vitamin supplements.
High 25(OH)D levels may sometimes occur as a result of low 1,25(OH)2D levels, probably indicating deficient vitamin D actions at the cellular level [31]. In a randomized controlled trial [32], an oral bolus of 12,500 ng (500,000 IU) each autumn to winter for 3 to 5 years resulted in an increased risk of falls and fractures among older community-dwelling women. The risk was especially elevated in the first 3 months following dosing and not in the remaining 9 months of the year.
However, if the half-life of 25(OH)D in the circulation is considered, it can reliable be assumed that 25(OH)D levels were considerably higher immediately after dosing.



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