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Carotenoids, isoflavones, zinc, selenium, and folic acid are among the cancer preventing compounds found in vegetables and fruits, says Dr. He was the first to report the sensitization of prostate cancer cells to chemotherapy and radiation therapy by soy isoflavones and the first to report that soy isoflavones prevent the adverse effects of radiation in prostate cancer patients. These studies were done in collaboration with other investigators at Karmanos Cancer Institute and Wayne State University, Detroit, Michigan. He has also been very active internationally with collaborative research projects and international conferences conducted with scientists in Turkey, Israel, Brazil and Norway. Seren S, Mutchnick M, Hutchinson D, Harmanci O, Bayraktar Y, Mutchnick S, Sahin K, Kucuk O. Hussain M, Banerjee M, Sarkar FH, Djuric Z, Pollak MN, Doerge D, Fontana J, Chinni S, Davis J, Forman J, Wood DP, and Kucuk O. Hillman GG, Yu Wang, Kucuk O, Che M, Doerge DR, Yudelev M, Joiner MC, Marples B, Forman JD, Sarkar FH. Kucuk brings to Emory an impressive track record of groundbreaking research in cancer prevention through nutritional components. Kucuk conducted the first clinical trials with lycopene and soy isoflavones in prostate cancer and was the first to report the benefits of lycopene and soy isoflavones in treatment of prostate cancer patients. Future studies at Emory Winship Cancer Institute will continue to investigate the role of soy isoflavones and other nutritional compounds alone or in combination with chemotherapy and radiation in the treatment of prostate cancer. Kucuk is conducting innovative clinical trials to investigate new approaches to prostate and bladder cancer therapy using combinations of chemotherapy, radiation therapy and nutritional agents.
He organized the First International Congress on Nutrition and Cancer in Antalya, Turkey in May 2008. Kucuk comes to Emory from the Karmanos Cancer Center at Wayne State University in Detroit, where he was a professor and co-leader of the population sciences and prevention program and member of genitourinary and head and neck cancer multidisciplinary groups. Kucuk has more than 150 peer-reviewed publications, review articles and book chapters to his credit, and he is on the editorial boards of numerous publications, including the Cancer Detection and Prevention and Cancer Epidemiology, Biomarkers and Prevention.


Kucuk, who speaks Turkish, was the only child of a family of tobacco farmers from a small town, Akhisar, in Western Turkey. Kucuk moved to the United States in 1975 after graduating from Hacettepe University Medical School in Ankara, Turkey. Also, Emory Healthcare does not endorse or recommend any specific commercial product or service.
He has been conducting clinical trials with lycopene and soy isoflavones in combination with standard therapy for prostate cancer since 1996. Our current investigations focus on the effects of micronutrients and phytochemicals on biomarkers of cell growth, differentiation, inflammation and oxidative stress in a variety of cancers. He reported that lycopene and soy isoflavones have efficacy in patients with hormone-naïve as well as hormone-refractory prostate cancer. He was also the first to report that dietary lycopene intake prevents leiomyoma in the Japanese quail in collaboration with veterinary researchers at Firat University, Elazig, Turkey.
He has published extensively on various nutrients in combination with chemotherapy and radiation. His grandparents, also tobacco farmers, came to Akhisar from Drama, Greece, after the First World War. He became interested in cancer prevention in 1984, when he first discovered that oxidation products of cholesterol have profound effects in cell mediated immunity, at Northwestern University Medical School in Chicago, Illinois. This Web site is provided solely for personal and private use of individuals accessing this information, and no part of it may be used for any other purpose. Burns School of Medicine in Honolulu between 1991 and 1995 where he continued to work on diet and cancer and reported for the first time that dietary intake of antioxidant micronutrients prevent mutagen sensitivity of blood lymphocytes.



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