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Scientists at the Institut Pasteur, Inserm, the CollA?ge de France and Pierre & Marie Curie University, working closely with scientists at the University of Auvergne, have recently discovered the function of pejvakin, a molecule that plays a vital role in the hearing system. In 2006, the team led by Christine Petit in the Institut Pasteur's Genetics & Physiology of Hearing Unit, especially Sedigheh Delmaghani, working in cooperation with Paul Avan's team at the University of Auvergne's Laboratory of Sensory Biophysics, identified a new gene that was responsible for early-onset sensorineural hearing loss. The scientists, particularly Sedigheh Delmaghani, studied young mice whose pejvakin gene had been inactivated. The auditory sensory cells in people with impaired pejvakin were observed to be extremely vulnerable to noise.
The scientists will now look into possible techniques to restore the function of pejvakin, particularly using gene therapy, which has already proved successful in conserving hearing in mice lacking in pejvakin, even when they are overexposed to noise.
Hypervulnerability to sound-exposure through impaired adaptive proliferation of peroxisomes, Cell, November 5, 2015. If you're concerned about losing your hearing because of noise exposure (earbud deafness syndrome), a new discovery published online in the FASEB Journal offers some hope. A specific protein found in the bridge-like structures that make up part of the auditory machinery of the inner ear is essential for hearing.
UNSW researchers have answered the longstanding question of how the brain balances hearing between our ears, which is essential for localising sound, hearing in noisy conditions and for protection from noise damage. Hearing loss is linked with accelerated cognitive decline in older adults, but the use of hearing aids may help safeguard seniors' memory and thinking skills. Dandruff is not caused by a fungus, as many believe, but by an imbalance between two competing bacteria that naturally colonise the human scalp, according to a study released Thursday. It's rare for scientists to get what they describe as "clean" results without spending a lot of time repeating the same experiment over and over again. Synthetic sugar-based molecule activates the immune system and could serve as a vaccine against C. One of the most complex human organs is the digestive tract: Here, the body comes into contact with all manner of diet-derived compounds and with countless bacteria.
Tinnitus is the perception of sound within the human ear not including the perception of sound outside the ear. Tinnitus is not a disease, but a condition that can result from a wide range of underlying causes: neurological damage multiple sclerosis, ear infections, oxidative stress, foreign objects in the ear, nasal allergies that prevent (or induce) fluid drain, wax build-up, and exposure to loud sounds. Tinnitus may be an accompaniment of sensorineural hearing loss or congenital hearing loss, or it may be observed as a side effect of certain medications (ototoxic tinnitus). The most common cause of deafness is damage to the sensitive hair cells of the inner ear (cochlea), known as sensorineural hearing loss.


For people with the most severe hearing loss, the only therapeutic intervention available is the cochlear implant.
Research at the Bionics Institute is aimed at improving the performance of the cochlear implant through developing techniques to improve the function of the hearing nerve, sound processing research to enhance the perception of speech, and investigation of how the brain responds to long-term artificial stimulation.
Meningitis is an inflammation of the meninges, which are the layers that surround the brain and spinal cord. Normal hearing happens because nerve cells in the cochlea send sound signals along the auditory nerve to the brain. A cochlear implant reproduces sound in ears that don’t work for certain reasons, including meningitis-related ossification.
It does this with what’s called an electrode array, a thin and flexible piece of silicone that’s inserted into the cochlea.
MED-EL has the largest range of electrode arrays, even special electrode arrays specifically for ossified cochleae, and if you’re considering a cochlear implant then your surgeon will pick out the right electrode array. About this blog:This is the official blog of MED-EL, a leader in implantable hearing loss solutions.
The absence of this molecule appears to be responsible for noise-induced hearing loss, one of the most common causes of deafness. This gene codes for a protein which was given the name "pejvakin" (which means "echo" in Persan).
Their observations revealed an astonishing variation in hearing impairments from one mouse to the next, ranging from mild to profound hearing loss. They observed that in mice without pejvakin, the auditory sensory cells are damaged as soon as they are exposed to even seemingly harmless sounds - the equivalent of a minute spent in a nightclub for humans. When a standard hearing test was performed on these hearing-impaired individuals, the responses of their auditory sensory cells and neurons, although normal to begin with, gradually worsened as the test went on as a result of the sounds used.
Urban crowding means that large cities are getting noisier, particularly in developing countries.
You have menges because they’re supposed to protect your nervous system, but unfortunately sometimes they can do the exact opposite: inflame and damage your nerves. This inflammation can destroy parts of the cochlea, which is the tiny organ responsible for sending sound signals to your brain. If the meningitis causes hearing loss, hearing normally doesn’t come back because the soft tissues inside the cochlea start to turn to bone, and the nerve cells start to die. The electrode array sits in the cochlea, so every time it sends a tiny electrical pulse this pulse is sent through the living nerve cells so they are ‘heard’ by your brain.


It is a place where you can connect with MED-EL and learn all about hearing and hearing implants. The scientists' discovery, which was published on November 5 in the journal Cell, offers new prospects for the treatment of this condition.
Audiometric tests performed on individuals with mutations in this gene subsequently revealed an unusually high level of diversity in hearing impairments, in terms of both severity and characteristics.
Young mice are highly vocal for the first three weeks after they are born, particularly when feeding.
WHO predicts that by 2030, one billion people will be at risk of noise-induced hearing loss. In-ear earphones, whose sound enters directly into the ear canal without any opportunity to be deflected or absorbed elsewhere, are a common cause of tinnitus when volume is set beyond moderate levels.
As tinnitus is usually a subjective phenomenon, it is difficult to measure using objective tests, such as by comparison with noise of known frequency and intensity, as in an audiometric test. Once this inflammation happens the cochlea can’t respond to sound waves and therefore the ear can’t hear. A cochlear implant can stimulate these nerve cells with electrical pulses, keeping them alive, and sends a signal along the auditory nerve in a way that’s similar to normal hearing. It doesn’t matter if you’re a 2 year old or 102; a shorter time between hearing loss and cochlear implantation can lead to better hearing with the cochlear implant.
Cochlear osteoneogenesis after meningitis in cochlear implant patients: a retrospective analysis. This latest study, carried out by scientists from the Institut Pasteur, Inserm, the CollA?ge de France, Pierre & Marie Curie University and the University of Auvergne, aimed to clarify the reasons for this heterogeneity. The scientists observed that as the number of mice in the cage increased, so did their hearing threshold - the minimum sound level at which they are able to hear sounds.
The scientists also identified the noise-sensitive element in the cell as being the peroxisome, a small organelle involved in detoxification. Using direct, controlled acoustic stimulation, the scientists were able to prove that the auditory system of mice lacking in pejvakin is affected by their acoustic environment.
However, we don't yet know what percentage of the population is either lacking in pejvakin or has a less effective form of the protein.



Objective tinnitus 2014
Pressure in one ear ringing noise




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