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Best resultat er ifolge nyere resultater en holistisk behandlingsmetode basert pa nyere medisinsk forskning i samrad med leger og helsepersonell. Behandlingsmetoden fra Tinnitus Miracle har dokumentert effekt, og har sa langt helbredet tusener av mennesker som tidligere led av tinnitus.
I tillegg til den holistiske behandlingsmetoden, finnes det ogsa andre alternative behandlinger. A behandle tinnitus med medisiner krever langvarig bruk av disse medisinene, og effekten opphorer sa snart man avslutter medisinering.
Kirurgiske inngrep i det indre oret har ogsa blitt provd i behandling av oresus, uten at man har lykkes. Kamuflerende lyder (lydterapi) gir et lindrende resulatat som varer sa lenge den kamuflerende lyden er aktiv.
Kognitiv terapi og konsultasjon med psykolog helbreder ikke tilstanden, men behandler kun symptomer. En spesiell ulempe ved sistnevnte tiln?rmingen e at man risikerer a ignorere en forverring av oresusen, og dermed vil tilstanden forverres uten at man soker en mer helbredende losning pa problemet.
Nar man skal behandle en sykdom eller kronisk tilstand, bor man vurdere hvilke alternativer som gir onskelig resultat. Tinnitus Miracle er en holistisk tiln?rming med dokumentert effekt og hvor vi har observert en formidabel suksessrate, spesielt i forhold til flere andre behandlingsmetoder av tinnitus. En metode som fokuserer pa a eliminerer selve problemet, har potensiale til a gi langt bedre resultat enn behandlinger som kun fokuserer pa a behandle symptomene.
Human Pheromones: Can You Really Attract People Through You Nose?Have you ever wondered why you are attracted to certain people yet, others just don't do it for you. Human Sex Pheromones, Does It Really Work ?Technically speaking, a pheromone is an odorous chemical produced by an animal that affects the behavior of another animal. Do Pheromones Play Role In Your Sexual LifeIf you've never heard of pheromones it is time to learn about the part they play in your sex life. How to Select the Right Perfume or Scent for yourselfPerfumes and special scents are often the first things that will be noticed when people walk into the room, so it's best to make sure you are wearing the perfume that best reflects the kind of attention your wanting, e.g. Giving Compliments to WomenCompliments are a simple but effective way to make a woman you are interested in feel special. The Human Pheromones PhenomenomHave you ever considered what role human pheromones play in our day-to-day lives.
How Perfumes Make you SexyThis article seeks to give you a solid knowledge base regarding the subject matter at hand, no matter what your previous experience on the topic. Human Pheromones And Sexual Attraction: Not So Strange BedfellowsMuch of life is governed by what we cannot see. Stress kann viele Probleme verursachen und andere verscharfen – einschlie?lich des Tinnitus – einem Klingeln in den Ohren. We will be provided with an authorization token (please note: passwords are not shared with us) and will sync your accounts for you. The aim of this review is to focus the attention of clinicians and basic researchers on the association between psycho-social stress and tinnitus. Stress stimulates neuroendocrine axes such as hypothalamus-pituitary-thyroid axis (Mebis and van den Berghe, 2009), hypothalamus-pituitary-gonadal axis (Whirledge and Cidlowski, 2010) and hypothalamus-pituitary-adrenal axis (HPA axis) (Lupien et al., 2007). Tinnitus is a subjective perception of sound without external acoustic signal caused by inappropriate activation of auditory cortex. In this review, we will describe some of HPA axis-mediated effects induced by stress and will discuss their possible influence on the auditory system with special focus on tinnitus. HPA-induced steroids signal trough their respective receptors: glucocorticoid and mineralcorticoid receptors.
Glutamate is an abandoned neurotransmitter in CNS and is involved in the process of memory, learning, and also in the auditory processing.
Post-synaptic neuronal plasticity can be induced by changes in the expression and trafficking of glutamate receptors AMPAR. Taken together, peripheral and central auditory systems express molecules, which are modulated by stress in the limbic, memory, and learning centers of CNS. Extended presence of stressor such as inability to escape from a stressing situation (chronic stress) or a high impact stressor (acute stress) may induce allostatic load reflected by pathological reactions or conditions. Taken together, caution needs to be taken when designing, interpreting, and comparing experiments that use various animal stress models. In the auditory research, influence of stress on the auditory processing was often studied using physical acute stress. Under special circumstances, the administration of corticosteroids can also have adverse effects on the auditory system.
In addition to physical stress, psycho-social stress model was also used in the auditory research.
Interesting for the issue tinnitus and stress is the HPA axis, which seems to be disturbed in tinnitus patients.
The link between tinnitus and negative emotional arousal was proposed many years ago by Jastreboff and Hazell to explain why is tinnitus perceived as unpleasant or even dangerous sound (Jastreboff and Hazell, 1993).
Scientists in the field currently agree that tinnitus may be triggered by an injury to the inner ear causing decreased activity of the auditory nerve and lastly in plastic changes in central auditory system (Kaltenbach, 2011).
Furthermore, information collected here, indirectly implies the requirement for psychological assessment during the diagnosis of tinnitus patients, with focus on perceived stress and psychological comorbidity. Second, stress-activated HPA corticosterone release may affect mineralcorticoid receptor function in cochlea and possibly influence the concentration of potassium secreted by stria vascularis, resulting in tinnitus. Third, stress-induced activation of HPA axis and corticosteroid release could provoke pre- or post-synaptic neuronal plasticity of the auditory system (Figure 5).
Exploring the above models and obtaining a clear-cut animal model, which would combine an appropriate stress type and tinnitus read-out, is a challenging task.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Noen behandlinger er egnet til a l?re pasienten til a leve med stoy i oret (ignorering av lyden), andre behandlinger forsoker a gjennopprette balansen i det indre oret, eller man forsoker holistiske tiln?rminger som har vist seg a kunne helbrede tilstanden helt.
Teorien er at ved a kurere pasienten for tinnitus vil ogsa relaterte symptomer som er vanlig for tilstanden ogsa elimineres.
Bivirkningene er i de aller fleste tilfeller sa uheldige at de fleste velger a avsta fra slik medisinsk beahndling. Ogsa her er bivirkningene omfattende, i tillegg til at det vil kunne skade horsel permanent. Det betyr at hovedproblemet fortsatt vil v?re der, men at man l?rer seg a "leve med problemet". In fact, there have been many people who have wondered what pheromones are, and a lot of research has been done on the topic.
How about obviously attractive people who get plenty of attention from elsewhere however, you can't quite see the attraction. Some of the many behaviors affected by animal pheromones include, attracting or finding a mate, reproduction cycles, marking territory, warning of danger, and showing the way to food. The concept of a human pheromone, or sexual scent of attraction, has been debated and researched for years. Is there an invisible force that attracts humans to one another other than our looks and personalities?
Viele Menschen – in Frankfurt, Deutschland, und auf der ganzen Welt – leiden an dieser Krankheit und ertragen sie auf einer taglichen Basis, genau solange, bis der Stresspegel zu sehr steigt. This means that you will not need to remember your user name and password in the future and you will be able to login with the account you choose to sync, with the click of a button.

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Although tinnitus is an auditory symptom, its onset and progression often associates with emotional strain. Schematic representation of two main types of stress and different stress models used in basic research. Further, stress can also activate sympathetic nervous system (Ulrich-Lai and Herman, 2009). Most representative stress-induced pathways and hypothetical involvement in the induction of allostatic load.
This activation has been documented in tinnitus patients by using either positron emission tomography (PET) or functional magnetic resonance imagining (fMRI) (Lanting et al., 2009). Accumulating evidence suggests that changes induced by these diverse conditions may result in similar phenotype, which is inappropriate activation of the auditory cortex.
In addition, we will attempt to transfer some of the in vitro knowledge into a clinical practice. HPA-induced stress hormone release and their signaling via respective receptors induce genomic (slow) and non-genomic (rapid) changes.
In contrast to ubiquitously expressed GRs, expression of mineralcorticoid receptors is restricted to selected tissues including brain, eye, intestine, kidney, mammary gland, pancreas, pituitary gland, and the inner ear. Not surprisingly, mineralcorticoid receptor was found to be predominantly localized in stria vascularis and in the spiral ganglion neurons (Furuta et al., 1994).
Special feature of glutamate circuits is their involvement in the process of plasticity, for the reason that glutamate and glutamate receptors NMDAR (N-methyl-D-aspartate receptor) and AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) regulate the strength and function of neuronal synapses. AMPAR are multimers composed of various subunits, quantity, and ratio of which influences the synaptic strength. However, the outcome of allostatic load not only depends on duration and category of stress but also on age, gender and the genetic makeup of stressed organism (Joels and Baram, 2009). Majority of stress research requiring information regarding histology, molecular or cell biology has been preformed with use of different animal stress models.
Physical type of stressor (restraint) in the acute settings (4 h of duration) increased the concentration of corticosterone in blood and as a consequence, protected the animals form the noise-induced trauma. Prenatal, long-term administration of glucocorticoids, increased the susceptibility of the of the Sprague-Dawley offspring rats to noise trauma (Canlon et al., 2003).
However, little is known about the other side of this interaction—that is about stress inducing tinnitus. The first study demonstrated that the probability of developing tinnitus is approximately the same for highly stressed persons as it is for persons exposed to occupational noise (Baigi et al., 2011).
Recent review of Kraus and Canlon delineates known to date anatomical connectivities between the auditory and limbic systems (reviewed in detail by Kraus and Canlon, 2012).
Resulting plastic changes in central auditory activity are coupled with altered attention and negative emotions. Importantly, biomarkers and mechanisms are being indentified in a process of stress definition (Piazza et al., 2010).
Such assessment may be performed in form of a self-filled questionnaire or by a clinical psychologist.
Model of stress-induced neuronal plasticity, which has been accepted in memory, learning, and emotional systems—can it also be truth to explain the induction of auditory pathologies by stress? In addition, designing and conducting large epidemiological studies, where individuals would be monitored for stress parameters and followed audiometrically for decades, would be an expensive and a time-consuming mission.
Eneste mulige bivirkning her er at en permanent kamuflerende lyd vil kunne redusere horsel pa sikt. Dette er ingen perfekt losning, ettersom oresusen fortsatt vil v?re av samme intensitet som den tidligere har v?rt, men man l?rer seg a akseptere lyden. These are usually used to attract a mate, but pheromones have also been found to have an effect in social and business circles.
Is there truth in the rumour that we emit a substance called a pheromone to entice the opposite sex, or for that matter, the same sex in our general direction. Erst dann befassen sie sich mit Tinnitus, weil er deutlich schlechter wird, und die Lebensqualitat vermindert. Recent epidemiological studies have provided evidence for a direct relationship between the emotional status of subjects and tinnitus.
Adaptation of neuronal system to stress-induced condition is reflected by neuronal plasticity. The results of animal and human studies have helped to determine various possible causes of inappropriate activation of auditory cortex leading to neuronal plasticity. Finally, release of ACTH to blood causes secretion of stress hormones from the adrenal glands (Lupien et al., 2007). It consists of locally produced corticotropin-releasing factor (CRF), CRF1-receptor and ACTH. To date, mechanisms determined as responsible for the synaptic plasticity are glutamate receptors (NMDAR)—related long-term potentiation (LTP) and long-term depression (LTD).
The mechanism that mediates HPA-induced changes in AMPA receptors trafficking is attributed to the genomic and non-genomic effects of glucocorticoids (Figure 4).
If stress and activated HPA axis could induce plastic changes in the auditory pathway via modification of glutamate neurotransmission, remains to be established. The goal of animal stress models is to mimic and study stress experienced by people under certain conditions.
Similar protective effects had the administration of glucocorticoid-based drugs prior to acoustic trauma (reviewed in Meltser and Canlon, 2011). However, these findings could not be reproduced by other group in Wistar rats, possibly reflecting inter-strain genetic differences in stress and corticosteroid susceptibility (Hougaard et al., 2007).
This implies that chronic, psycho-social stress may influence the function of auditory pathway. It has been a frequent observation made by otologists and audiologists that many tinnitus patients complain of psycho-social distress prior to or during the onset and progression of tinnitus.
Importantly, the authors also have noticed that psycho-social stress contributes to worsening of tinnitus symptoms. In addition, patients who had disturbing tinnitus for a longer time (on average 14.7 years) were shown to develop improper HPA responses to an experimental, psycho-social stress (Hebert and Lupien, 2007).
In addition, this important work collected evidence supporting the notion of noise generating synaptic plasticity in the limbic structures. Can stress induce such critical injury to the inner ear or induce plasticity in higher auditory structures?
This provides the researchers and clinicians not only with more basic knowledge about stress-induced processes but also with more diagnostic power.
Psychological intervention with a goal of stress-management strategies appears to be an indispensable element in tinnitus treatment, especially important to use in very early stages of tinnitus, before the chronification of plastic changes has taken place. Nevertheless, step-by step understanding of how and to what degree the psycho-social or physical stress could affect our peripheral and central auditory system should become a goal in the basic and clinical auditory research. The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis. Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inflammatory action. Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: a PET study with [18F]deoxyglucose. Dette kan brukes som en del av behandlingsopplegget, men alene er det ingen fullstendig losning.

In addition, studies of function, morphology, and gene and protein expression in the auditory system of animals exposed to stress support the notion that the emotional status can influence the auditory system. Generally speaking, stress is a positive reaction because it increases the chance of survival by initiating adaptation and coping with new situation (Lupien et al., 2009).
These causes include changes in spontaneous firing rate, increased gamma band reflecting synchronous firing of auditory cortex and tonotopic reorganization (Nava and Roder, 2011). Stress hormones comprise glucocorticoids (corticosterone, cortisol) and mineralocorticoids (aldosterone) (de Kloet et al., 2005). Interestingly, deletion of CRF1-receptor gene resulted in auditory impairment of knock-out animals (Graham and Vetter, 2011).
In addition, changes in AMPAR composition and density on the synapses were shown to be essential for the plasticity process.
In the prefrontal cortex, stress has been demonstrated to activate in a non-genomic way the glucocorticoid-inducible kinase SGK (Popoli et al., 2011). From the perspective of allostatic model, one could hypothesize that the acute physical stress is unable to induce allostatic load in auditory pathway. One of the earliest published observations connecting the onset of tinnitus with psycho-social distress was made by John Harrison Curtis, the surgeon of the Royal Dispensary for Diseases of the Ear in London (the first hospital in England offering specialized care for ear diseases, est. Interestingly, exposure to high level of stress and occupational noise doubles the probability of developing tinnitus. HPA axis in tinnitus patients under stress seems to be activated later and to a lesser extend than in the healthy controls, consistent with glucocorticoid inefficiency (Yehuda et al., 1996). Induction of limbic plasticity is possible due to multi-level projections of the auditory system to the limbic structures. An important hint was recently delivered by a group studying mild stress model of depression in Sprague-Dawley rat with PET imaging technique.
Stress is no longer an undefined, sad state of mind but an important, distinct factor in precipitation and amplification of mental and mood disorders (Holsboer and Ising, 2010). A pheromone is a substance that is secreted by the body primarily for the purpose of mating.
The data provided by clinical and basic research with use of animal stress models offers valuable clues for an improvement in diagnosis and more effective treatment of tinnitus. The process of coping with conditions altered by stress is called allostasis and means a change from the usual, homeostatic status into a status, in which the organism can adapt to changes (McEwen and Gianaros, 2011). This impairment was accompanied by reduced expression of glutamine synthetase together with abnormal innervation features and was attributed to the developmental role that CRFR1 potentially plays in the inner ear.
SGK1 is also expressed in stria vascularis, spiral ligament, spiral limbus, organ of Corti, Reissner's membrane and in the spiral ganglion of rats (Zhong and Liu, 2009) but role of SGK1 in the inner ear has not yet been experimentally addressed. To the physical stress models belongs between many others the immersion in cold water, restrain, cold-water restrain, electric foot shock, and food deprivation.
From the perspective of allostatic model, one could postulate that chronic physical stress may induce the allostatic load in auditory pathway. On the contrary, activation of HPA axis resulting in the production of corticosteroids protects the auditory system against the noise trauma. In the second study, a self-completion questionnaire was used to inquire about work- and health-related stressors and hearing problems, such as tinnitus. Recent research has implicated that living in a city affects stress processing and may be responsible for increased incidence of anxiety disorders in the cities, as opposed to rural communities (Lederbogen et al., 2011). Tinnitus in the general population with a focus on noise and stress: a public health study.
The female attracts the male of the same species by putting out just the right pheromones to bring him to her. It would have been too confusing and way too funny had this been not the case. This is nature's way of making sure that the right kind of animal mates with another of its own species and that the line of that animal can continue to reproduce.
Es ist deshalb entscheidend, dass Personen mit Tinnitus den Versuch unternehmen, Stress in ihrem Alltagsleben zu kontrollieren und zu reduzieren, um die Auswirkungen des Tinnitus zu minimieren. Abuse or chronic deregulation of allostatic processes (such as prolonged or repeated stress) may lead to so-called allostatic load, which is a negative physiological and behavioral effect of stress (Figure 2) (McEwen and Wingfield, 2003). Future experiments should determine the connection between cochlear and systemic HPA systems. Lastly, there are models that mix different types of acute and chronic stress in an unpredictable way (Jaggi et al., 2011). This endogenous corticosteroid protection is comparable to the application of synthetic corticosteroids, used in therapy of acute hearing loss (Meltser and Canlon, 2011). If these projections are activated by stress and if this activation could induce plastic changes in the auditory system, remains to be determined.
After 4 weeks of random mixed stressing, brain PET analysis revealed the activation of left auditory cortex and deactivation of left inferior colliculus in stressed animals. It also is a way of making sure that nothing has to force certain animals to breed; they simply will when the time is right. Allostatic load can affect various tissues and organs and include neuronal atrophy, impaired immunity, atherosclerosis, obesity, bone demineralization and mood disorders (McEwen, 2003). The genomic reactions occur due to the fact that both GRs and mineralcorticoid receptors are cytoplasmic, ligand-activated transcription factors (Funder, 1997). Curtis has noticed that in two of five cases, affected patients attributed the beginning of tinnitus to a psycho-social strain caused by death in immediate family (Curtis, 1841). In addition, prevalence of sleeping problems was significantly higher in subjects with tinnitus, than in the tinnitus-free subjects. It is, however, possible that the observed changes in HPA axis of tinnitus patients may be a result and not a cause of tinnitus.
Changes in the auditory system correlated significantly with the depressive symptoms of experimental animals (Hu et al., 2010). Including stress as factor of future investigations in the auditory, tinnitus-related research seems to be a logical consequence of above observations. This can happen in any kind of living creature -- people, animals and insects -- because all living things need a mate in order to reproduce. Binding of steroids to GRs or mineralcorticoid receptors induces translocation of the ligand-receptor complex to the nucleus, where the transcription of selected genes is either induced or suppressed (Datson et al., 2008). Importantly, the authors found linear association between tinnitus and the magnitude and duration of stress, such as for instance occupational stress (Hasson et al., 2011).
Both studies were performed with more than 10,000 subjects each, thus, providing statistical strength. Non-genomic responses induced by corticosteroids and mineralocorticoids are extremely rapid (seconds to minutes) and are not mediated by a cytoplasmic but by a minor, membrane-bound form of GRs or mineralcorticoid receptors (Groeneweg et al., 2012).
Both receptors were shown to be localized to the lipid rafts—more precisely to caveolae on a cell surface. Caveolae are rich in signaling proteins such as G-proteins and kinases, thus, they support formation of various signalosomes. The precise signaling pathways induced by corticosteroids and mineralocorticoids remain to be confirmed but it is already apparent that the kinase pathways are predominant (Groeneweg et al., 2012).

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