Magnesium is present in all cells of the body and is involved in over 300 enzymatic processes, including energy production. Research has shown that 68% of individuals in the US do not consume the daily recommended amount of dietary magnesium and 19% do not even consume half of the RDA levels (310-420mg daily) (3).
This elevated calcium to magnesium ratio is a major player in conditions such as mitral valve prolapse, migraines, attention deficit disorder, autism, fibromyalgia, anxiety, asthma and allergies.  Wherever there is elevated calcium and insufficient magnesium inside of cells the effects are muscle contractions, spasms, twitches and even convulsions (6).
Specifically, the hippocampus region of the brain is the primary location for retaining long term memories. Associated with decision making, the prefrontal cortex area of the brain aids in the retrieval of short-term memories. As a result of increased long-term potentiation, resulting from the repetitive stimulation of a nerve, as well as the ability for nerves to transmit signals more effectively, magnesium better enables an individual to improve their ability to learn.
Researchers looked to test rats using Magnesium threonate (MgT) supplementation and look at their ability to swim and find a submerged platform on which to rest. Amazingly, the supplemented group was able to retain their memory of where the submerged platform was hidden after 24 hours. This meant that older MgT supplemented rats showed significantly better memory and recall than young rats who didn’t get MgT. With the deteriorating health habits of our modern culture, it is not a surprise that Alzheimer’s disease is associated with decreased levels of magnesium.  Toxic plaque buildup is evident in patients with declining cognitive abilities symptomatic of the pathogenesis of Alzheimer’s disease. Restoring adequate levels of brain magnesium has been found to prevent the further decline of cognitive function. Case studies show that treating magnesium deficiency has helped patients struggling with anxiety, irritability, confusion, hyperexcitability, postpartum depression, drug and alcohol abuse, as well as traumatic brain injuries. Known as an anti-stress mineral, cellular magnesium levels stimulate serotonin production which improves mood. Have you ever experienced instances when you were highly reactive towards situations or people for minimal or no apparent reason? Magnesium therapy can treat symptoms of anxiety by relaxing nerves, assisting in digestion, relieving muscle tension, and conducting healthy nerve responses (5).
A healthy sleep cycle is important to promoting overall health and the production of hormones which are synthesized during sleep. Primarily reliant on the same factors which regulate mood and manage stress, a healthy night’s sleep is dependent on cellular magnesium concentrations. Magnesium is a critical component involved in the regulation and maintenance of regulating blood glucose levels. Many studies conducted show that supplementing diet with magnesium via food or oral supplementation improves insulin secretion and response in type-2 diabetic patients (6).
However, clinical testing has yet to determine if the magnesium alone is solely responsible for improved glucose control.
Regardless of the lack of scientists to directly correlate magnesium to the healthy balance of blood sugar, a decreased risk factor for developing diabetes is not to be overlooked following dietary magnesium supplementation.
Up to 60% of magnesium is concentrated in bones and the remaining is found in soft tissue and blood. Limited clinical trials have found that when magnesium citrate is taken daily over long periods may prevent and possibly reverse osteoporosis (7). Magnesium assists in detoxifying the body’s tissue of acids, toxins, gasses, poisons and other impurities.
Magnesium improves the motility of the gastrointestinal tract and colon and thereby stimulating the removal of contaminants by promoting a laxative effect.
Individuals at greatest risk of magnesium deficiency should pay special attention to health problems they are experiencing.
Crohn’s disease, Celiac disease and patients with other gastrointestinal diseases– These individuals are less able to absorb nutrients from dietary intake.
Type-2 diabetics- A high concentration of blood glucose leads to increased urination and a higher risk of kidney damage.
Alcoholics- Chronic alcohol abuse is likely to cause gastrointestinal problems which further promote the removal of magnesium in urine. Elderly- As the body ages, the gastrointestinal tract becomes less efficient at absorbing minerals. Most magnesium supplements are most efficiently absorbed by the gastrointestinal tract and limited quantities are able to cross the blood brain barrier where it can penetrate into cells.
Magnesium mineral sprays can temporarily reduce pain by becoming directly absorbed through the skin and alleviate pain entirely when used over long term periods. Commonly used forms of magnesium supplements include magnesium oxide, magnesium citrate and magnesium chloride.
Researchers suggest that magnesium citrate, lactate and chloride are most readily available forms of magnesium for the body to use (7). The latest research indicates that magnesium L-threonate is the best form of magnesium which you could take.


A transport process makes the absorption of magnesium into cells extremely difficult and can often lead to inaccurate blood tests results suggesting healthy levels of magnesium.
Brain calm magnesium contains magnesium L-threonate along with other magnesium compounds designed to promote optimal magnesium support. Before taking on a magnesium supplementation regimen, you should first consult your doctor to see if any medications may interact with magnesium.
Magnesium is a naturally present mineral found in many of the foods we should be eating which are farmed from the Earth. The following lists of foods are excellent sources of achieving the recommended dietary dose of magnesium (1, 8). International Shipping - items may be subject to customs processing depending on the item's declared value. Your country's customs office can offer more details, or visit eBay's page on international trade.
Estimated delivery dates - opens in a new window or tab include seller's handling time, origin ZIP Code, destination ZIP Code and time of acceptance and will depend on shipping service selected and receipt of cleared payment - opens in a new window or tab. This item will be shipped through the Global Shipping Program and includes international tracking. Will usually ship within same business day if paid before 14:00 PDT (excludes weekends and holidays).
By submitting your bid, you are committing to buy this item from the seller if you are the winning bidder. By clicking Confirm, you commit to buy this item from the seller if you are the winning bidder. By clicking Confirm, you are committing to buy this item from the seller if you are the winning bidder and have read and agree to the Global Shipping Program terms and conditions - opens in a new window or tab. Over 300 enzymes require magnesium to perform biological reactions essential to tissue and organ function (2). Studies show that low levels of brain magnesium directly correlate to poor memory function (4).
Magnesium is known to strengthen the function of synapses in the hippocampus thus improving long-term potentiation.
One study found that the supplemental treatment of magnesium over a 17 month period reduced amyloid plaque accumulation in the hipocampus region of the brain by 35.8% and by 36% in the prefrontal cortex.
Damage to the nervous system has been implicated as the cause of numerous health concerns including dementia and depression (5). Magnesium has also been reported by the American Academy of Neurology and the American Headache Society as a “probably effective” treatment for preventing migraines and headaches which can be associated with stress (7). Clinical studies have found that 125-300 mg of supplemental magnesium is effective at treating symptoms of depression after just one week (5). Unhealthy nerve impulses in the hippocampus can cause factors conducive to stimulating fear and anxiety (3).
A healthy magnesium balance is needed to regulate hormones such as melatonin which in turn helps to induce sleep and decreases cortisol. Deficiencies in magnesium impair insulin secretion and the ability of glucose to be transported into cells (7). It is this increased concentration of glucose in the kidneys that leads to frequent urination and further promotes magnesium deficiency (7). Physicians speculate whether the improved health benefits are a result of another vitamin or mineral commonly found in food sources high in magnesium. When magnesium supply is deficient in cells, the body has to search for magnesium which can affect overall health.
Magnesium has to be in a proper balance with calcium in order to maintain healthy bone density and is essential to bone health as we age. Women who supplemented their diets with enriched magnesium food sources over a 2 year period reportedly had fewer fractures and a decreased rate of bone loss (1). In combination with these other minerals, magnesium is responsible for the function of muscle contraction and heart rhythm.
Aside from alleviating symptoms of anxiety, relieving the restriction around blood vessels and regulating a healthy contraction of the heart may lower blood pressure (2, 7). Lower doses of magnesium supplementation was found to reduce the risk of stroke by 8% requiring further studies to analyze the link between dose dependency and results. Environmental contaminants in our food expose our bodies to a higher amount of toxins and impurities than in the past. For this reason, magnesium is a primary ingredient in most laxatives used to relieve constipation. Only 32% of Americans are believed to meet the recommended daily requirements for magnesium (2).
Older adults are more likely to be taking medications which can interfere with the absorption of magnesium.


The body filters out up to 90% of magnesium before it reaches the cells of the body where it is needed most (7). People experiencing symptoms of osteoarthritis can benefit from these mineral oil sprays by improving the balance of magnesium to the affected area. Anecdotal evidence suggests that spraying magnesium oil over extended time duration can alleviate cramping during menstruation. Be sure to buy a pure magnesium supplement product free of other elemental compounds which may adversely affect the body. Unlike other magnesium compounds, magnesium threonate is capable of passing the blood brain barrier and becoming absorbed into cells (2, 3, 4). The dietary supplementation of magnesium threonate is the most highly bioavailable magnesium compound effective at increasing the concentration of magnesium inside cells.
Only magnesium L-threonate has the highest absorption rate of magnesium available for cells and may be the best form of a magnesium supplement that you could buy. For instance, some antibiotics have compounds in which magnesium can bind with and become insoluble (7). Without a constant replenishment of this mineral, the brain and nervous system loses ability to function properly. Be sure to purchase organic and non-GMO farmed foods to receive the maximum benefit from these sources. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. If you'd like to get the additional items you've selected to qualify for this offer, close this window and add these items to your cart. Contact the seller- opens in a new window or tab and request a shipping method to your location. You have read and agree to the Global Shipping Program terms and conditions - opens in a new window or tab.
Import charges previously quoted are subject to change if you increase you maximum bid amount. Magnesium supports optimal cognitive health by maximizing the various intricate functions of the brain. In other words, magnesium better equips the brain with the ability to retain memories over long term periods. Magnesium also strengthens the synaptic nerve endings responsible for transmitting a response (2, 3). Some researchers even propose that the development of the disease may even be reversed following magnesium therapy. Remember, magnesium is used by our cells as a type of fuel source for biological processes to function. Magnesium therapy is not only found to strengthen the ability of nerves in the brain to function properly, but magnesium treatment also increases the selectivity of nerves to fire which reduces one’s risk of excitability and agitation (2). Magnesium is also needed for a restful night’s sleep because it promotes muscle relaxation ensuring less of your night is spent counting sheep. Other reports found that there was a 15%-23% reduction in the risk of developing diabetes following different doses of magnesium supplements. Low levels of blood magnesium affects heart rate, nervous function, and can lead to chronic headaches. When magnesium is pulled from the bones resulting from cellular magnesium deficiency, the concentration of calcium to magnesium becomes too imbalanced leading to the calcification of bones and joints. As previously mentioned, magnesium assists in regulating nerve impulses and is perhaps most important in maintaining cardiovascular health. If you reside in an EU member state besides UK, import VAT on this purchase is not recoverable. The higher amount of both physical and mental demands in our lives, the higher the rate our bodies deplete magnesium sources. As a result of their magnesium hunt, cells are forced to pull what limited magnesium concentration is found in a delicate balance out of bone formations.



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