Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The PGM3 gene is located on chromosome 6q14.1-q15 and is composed of 19 exons that generate three alternatively spliced mRNA and three isoforms of this enzyme.
The transferase activity of debranching enzyme removes the terminal three glucose residues of one branch and attaches them to a free C-4 end of a second branch. Once released the catalytic subunits of PKA phosphorylate numerous substrate using ATP as the phosphate donor.
This is accomplished by the binding of PP-1 to phosphoprotein phosphatase inhibitor-1 (PPI-1).


The PGM2 gene is located on chromosome 4p14 and is composed of 15 exons that encode a protein of 612 amino acids.
The PGM5 gene is located on chromosome 9q13 and is composed of 14 exons that encode a protein of 567 amino acids. It consists of soluble factors, such as complement proteins, and diverse cellular components including granulocytes (basophils, eosinophils and neutrophils), mast cells, macrophages, dendritic cells and natural killer cells. The human UDP-glucose pyrophosphorylase 2 enzyme is encoded by the UGP2 gene that is located on chromosome 2p14–p13 and is composed of 13 exons that generate two alternatively spliced mRNAs. The adaptive immune response is slower to develop, but manifests as increased antigenic specificity and memory.


These two mRNAs encode two different isoforms of the enzyme, isoform a (508 amino acids) and isoform b (497 amino acids).



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