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The Secret of Cabot House Quest chain is one of the more interesting side Quests in Fallout 4. Venture to Cabot House (tell the person manning the intercom you're expected), where you'll meet Jack Cabot and listen to his interesting theories. The Bobblehead we want is inside this Asylum, but we can't get to it until the final stage of this quest.
Take out the few Raiders at the Parsons Creamery, then it's off to Cabot House to continue the chain. You can optionally go to Goodneighbor and The Third Rail there to ask around about Emogene, or you can go directly to Charles View Amphitheater, mapped above.
Generally easy raiders, you may bump into a few that are Legendary - they were still quick kills. Anyway, once the room full of Raiders is cleared, you'll go to an unused wing of the Asylum and be on your way to Lorenzo. When you reach this hall, enter the last room on the left (Jack goes right) to find a Syringer Rifle, which you can craft ammo for at the Chemistry Station. Get the Massachusetts Surgical Journal Inside Lorenzo's Chamber when you've chosen to free or kill Lorenzo Cabot based on the outcomes below.
There are numerous options and paths to completing this quest, but two main outcomes that benefit a player. Killing Lorenzo is probably the right thing to do, but if you roleplay an evil character you may want to free him!
Do as Cabot Says - Kill LorenzoKilling Lorenzo results in a 'proper' finish to this quest, I suppose.
After a week in-game, you'll be given the Lorenzo's Artifact gun when you visit Jack (likely back at the Insane Aslyum) - a special modification to a gamma gun, which doesn't deal actual radiation damage in its usual form but rather knocks enemies back (its special modifier) while dealing direct damage.
Freeing Lorenzo and siding with him, while killing the other Cabots will give you unlimited access to the Mysterious Serum.


Should you Betray Jack and Free Lorenzo Cabot?Releasing and siding with Lorenzo will likely require you to kill the entire Cabot family, except Lorenzo.
I took the first route (Kill Lorenzo) and actually later found a Zeta Gun sitting on Jack's table in the lab. Gauss Rifles - one of the highest damage weapons in Fallout 4, with examples showing how to make it truly powerful. Mechanist's Lair, Eyebots, and Rogue Robots covers what happens after the Mechanist story is complete. Now that I've written about all Perks in Fallout 4, I've put them all in a list, with how they work, what you can expect, and my own opinions on them. For players new to the game: Difficulty in Fallout 4 has changed, and my info on survival is outdated.
Completing this chain can net you a Charisma Bobblehead, along with a great radiation weapon known as Lorenzo's Artifact, which excels at killing humans. You'll be instructed to travel to Parsons State Insane Asylum and meet up with the head of the guards there, in order to help locate a missing package. Come here prepared for a fight, though not one as bad as it's made out to be - they're just Raiders, after all. Outside this office in a filing cabinet you can find a Cell Key that may come in handy for you later. Once Jack instructs you to, flip all four of the switches in the room outside Lorenzo's chamber. The weapon can be modified to deal radiation damage directly, but loses its huge knockback - so you made it a gamma gun.
I've also released a page that describes Getting Started in Automatron to accompany the main page about the DLC. Before you leave, head to the upstairs bedrooms where you can find a Massachusetts Surgical Journal lying on a dresser. She'll tell you they know where the package Cabot wants is - of course it's being held by some Raiders.


The most important loot here are a few samples of the Serum, which you can take for yourself, along with the Charisma Bobblehead in Jack's office. There are some side rooms that have some supplies you might need, along with a few locks to pick. It does shine against humans (OK it's novelty, it works on humans), but is useless against most everything else. This covers how to make the Robot Workbench to begin making your own Automatrons, and walks you through the first two quests while providing some tips for fighting the Mechanist's creations.
I will update that page and cover the Wasteland Workshop and Far Harbor DLC as soon as it is possible. Upon one more more trips there, you should meet a man named Edward Deegan in the bar in the back.
For people who wonder, there is no point to joining - he just tells you to get out of his office after taking your gear and leaving you naked, forcing you to kill him bare handed. Maybe the Cabots have lived too long, but Lorenzo does seem the psychopath he is described to be.
What it does is heal radiation over time (like, an hour) while also boosting strength by 5.
You can choose to explore the locations on your own or read descriptions for those I've taken notes about. A Syringer can be found if you search it thoroughly, and I found a Raider with a Deathclaw Gauntlet (melee weapon). Additionally, you can find a Zeta Gun on Jack Cabot's corpse - a crappy model of a normal Gamma Gun, which you can modify back to normal.



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