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Aciclovir, and check out Aciclovir on Wikipedia, Youtube, Google News, Google Books, and Twitter on Digplanet. Aciclovir (ACV), also known as acyclovir, is an antiviral medication.[3] It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Intravenous aciclovir is effective to treat severe medical conditions caused by different species of the herpes virus family, including severe localized infections of herpes virus, severe genital herpes, chickenpox and herpetic encephalitis. Aciclovir is excreted in the breast milk, therefore it is recommended that caution should be used in breast-feeding women. Common adverse drug reactions (a‰?1% of patients) associated with systemic aciclovir therapy (oral or IV) include: nausea, vomiting, diarrhea, encephalopathy (with IV use only), injection site reactions (with IV use only) and headache. Intravenous aciclovir may cause reversible nephrotoxicity in up to 5% to 10% of patients because of precipitation of aciclovir crystals in the kidney. Ketoconazole: In-vitro replication studies have found a synergistic, dose-dependent antiviral activity against HSV-1 and HSV-2 when given with aciclovir. Resistance to aciclovir is rare in people with healthy immune systems, but is more common (up to 10%) in people with immunodeficiencies on chronic antiviral prophylaxis (transplant recipients, people with acquired immunodeficiency syndrome due to HIV infection). Acyclovir is poorly water-soluble and has poor oral bioavailability (15a€“30%), hence intravenous administration is necessary if high concentrations are required.
Vince later went on to invent abacavir, an nRTI drug for HIV patients.[46] Elion was awarded the 1988 Nobel Prize in Medicine, partly for the development of aciclovir. Herpes simplex is an infection that mainly affects the mouth resulting in cold sores or fever blisters. Herpes test are often done for sores in and around the genital areas, and not so much for oral herpes.


Cells from a fresh sore are scraped off and then smeared onto a microscope slide to identify if the herpes virus is present. Acyclovir, Famciclovir and valacyclovir are all antiviral drugs which help prevent the herpes virus from multiplying thereby reducing the frequency of outbreaks. Povidone-iodine is available in an ointment and helps herpes sores dry out quickly and weeping, thereby preventing the sores from becoming infected by bacteria. This cream needs to be applied regularly through out the day and may cause irritation to sensitive vaginal and anal area. A person’s diet and lifestyle can have a role to play in herpes outbreaks and should be looked as a way to help lessen outbreaks. When one has active herpes lesions, avoid contact with newborns as children have low immune systems which may make them more susceptible to developing herpes. There are no known cures for herpes but are several safe medications and treatments available to help reduce outbreaks for herpes. Studies show people with a diet high in lysine and low in arginine helps them reduce the number of herpes outbreaks.
There have also been some studies regarding the effectiveness of Honey, Zinc and Echinacea when treating herpes. Try avoiding citrus fruits as well as citrusy juices should you have the herpes virus. Please note: We understand that outbreaks are a very sensitive subject and we will protect your privacy. Other uses include prevention of cytomegalovirus infections following transplant and infections due to Epstein-Barr virus.


It is also effective in systemic or traumatic herpes infections, eczema herpeticum and Herpes simplex meningitis. Aciclovir crystalline nephropathy is more common when aciclovir is given as a rapid infusion and in patients with dehydration and preexisting renal impairment.
Infrequent adverse effects include erythema or itch.[12] When applied to the eye, aciclovir is commonly associated (a‰?1% of patients) with transient mild stinging.
Nucleosides isolated from a Caribbean sponge, Cryptotethya crypta, were the basis for the synthesis of aciclovir.[40][41][42] It was codiscovered by Howard Schaffer following his work with Robert Vince, S.
These appear as small and painful blisters that usually show up on or around a person's lips and are caused by the (HSV-1) virus.
These treatments work on already present outbreaks, shortening their duration and severity. That is, we do not indicate that this remedy is for herpes on the label, ensuring your privacy. Gurwara on the adenosine analog acycloadenosine which showed promising antiviral activity.[43] Later, Schaffer joined Burroughs Wellcome and continued the development of aciclovir with pharmacologist Gertrude B.



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