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Changes in white blood cells, leukogram patterns, the positive acute-phase protein (APP) fibrinogen and negative APPs (albumin and arylesterase) were monitored to evaluate their potential as sensitive indicators throughout the course of therapy in canine skin Pseudomonas aeruginosa infection.
ReferencesAndonova M, Urumova V (2013) Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa—review. Bass DA, Gonwa TA, Szejda P, Cousart MC, DeChatelet LR, McCall CE (1980) Eosinopenia of acute infection: production of eosinopenia by chemotactic factors of acute inflammation.
Linch SN, Kelly AM, Danielson ET, Pero R, Lee JJ, Gold JA (2009) Mouse eosinophils possess potent antibacterial properties in vivo. Oran M, Tulubas F, Mete R, Aydin M, Sarikaya HG, Gurel A (2014) Evaluation of paraoxonase and arylesterase activities in patients with irritable bowel syndrome. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser.
The study was performed on 15 male mixed-breed dogs, divided in three groups of 5 dogs each.


Bulg J Vet Med 17:32–41Bardoel BW, Kenny EF, Sollberger G, Zychlinsky A (2014) The balancing act of neutrophils.
Intl Res J Pharm 3:69–73Georgieva TM, Georgiev IP, Petrov VS, Vachkov A, Tanev SI, Pavlov AI, Eskersall D (2009) Variations of acute phase proteins in weaning rabbits experimentally infected with E.
Bioformation 7:59–63Sureshkumar V, Sarathechandra G, Ramesh J, Vairamuthu S, Thejomoorthy P, Hariharan P (2012) The effect of enrofloxacin administration on haematological profile in broiler chicken—a safety pharmacology study.
Indian J Field Vet 8:20–24Taceetti G, Campana S, Neri A, Boni V, Festini F (2008) Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis. Dogs from group B were infected and treated with a combination of enrofloxacin (at above-mentioned dose and intervals) and parthenolide (feverfew extract 90 mg, 0.7 % parthenolide). Rev Med Vet 160:133–139Gregory AD, Hogue LA, Ferkol TW, Link DC (2007) Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
The schedule consisted of daily oral intake of two capsules of feverfew beginning on post infection hour 4 and continued for 6 days.


ISBN 0781768500Toker A, Kadi M, Yildirim AK, Askoy H, Akcay F (2009) Serum lipid profile paraoxonase and arylesterase activities in psoriasis.
The haematological indices and APPs were assayed before infection and on 4th, 24th, 48th and 72nd hours and on 7th, 10th and 14th days after infection.
Eur Colloquium Report 1:1–3Tras B, Maden A, Bas L, Elmas M, Yazar E, Civelek T (2001) Investigation of biochemical side-effects on enrofloxacin in dogs.
Infected and antibiotic-treated dogs responded with significant leukocytosis, left shift, eosinopaenia and lymphopaenia between hours 24 and 72. The combination of enrofloxacin and parthenolide modified, at a significant extent, the deviations in studied parameters except for eosinophil percentage, which persisted low.



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