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Novel Treatments for Chronic Viral InfectionsContraVir seeks to develop and commercialize novel drug treatments to improve the lives of patients suffering from chronic viral infections, with an initial focus on herpes zoster, or shingles, and hepatitis B.
A Novel Drug Candidate for Hepatitis BCMX157 has completed a Phase 1 clinical trial in healthy volunteers, demonstrating a favorable safety, tolerability and drug distribution profile. A Shingles Treatment with Best in Class PotentialOur lead candidate is FV-100, a potent oral antiviral being developed for the treatment of herpes zoster, commonly known as shingles.
ContraVir is developing targeted antiviral therapies with two drug candidates in clinical studies.
CMX157 is a novel, highly potent lipid conjugate of the successful antiviral drug tenofovir, marketed by Gilead as Viread®.

We are developing FV-100 as a fast-acting, low-dose, once-daily, oral antiviral therapy for the treatment of herpes zoster, or shingles, an infection caused by the reactivation of the varicella zoster (chicken pox) virus.
FV-100, now in Phase 3 trials, is being developed for the treatment of herpes zoster, or shingles, and shingle pain.
CMX157 has completed a Phase 1 clinical trial in healthy volunteers with positive initial results. ContraVir intends to develop CMX157 for Hepatitis B in Phase 2 clinical studies. In addition to its potent antiviral activity, FV-100 has demonstrated an ability to reduce shingles-associated pain, known as post-herpetic neuralgia, or PHN. ContraVir is also developing CMX157, a highly potent analog of the successful antiviral drug tenofovir DF (Viread®).

Patients with mild to moderate pain may respond to conventional analgesics (paracetamol, ibuprofen, acetyl salicylic etc.), but if the pain is severe may also require drug treatment. In the use of narcotic analgesics with or without carrying a regular dosing schedule is most appropriate for pain control. Studies are underway to evaluate the effectiveness of a vaccine against varicella-zoster in the prevention or control of herpes zoster in the elderly.

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