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Researchers at MIT’s Lincoln Lab have developed technology that may someday cure the common cold, influenza and other ailments. Most bacterial infections can be treated with antibiotics such as penicillin, discovered decades ago. Now, in a development that could transform how viral infections are treated, a team of researchers at MIT’s Lincoln Laboratory has designed a drug that can identify cells that have been infected by any type of virus, then kill those cells to terminate the infection. In a paper published July 27 in the journal PLoS One, the researchers tested their drug against 15 viruses, and found it was effective against all of them — including rhinoviruses that cause the common cold, H1N1 influenza, a stomach virus, a polio virus, dengue fever and several other types of hemorrhagic fever. The drug works by targeting a type of RNA produced only in cells that have been infected by viruses. Because the technology is so broad-spectrum, it could potentially also be used to combat outbreaks of new viruses, such as the 2003 SARS (severe acute respiratory syndrome) outbreak, Rider says. Other members of the research team are Lincoln Lab staff members Scott Wick, Christina Zook, Tara Boettcher, Jennifer Pancoast and Benjamin Zusman. Rider had the idea to try developing a broad-spectrum antiviral therapy about 11 years ago, after inventing CANARY (Cellular Analysis and Notification of Antigen Risks and Yields), a biosensor that can rapidly identify pathogens. Rider drew inspiration for his therapeutic agents, dubbed DRACOs (Double-stranded RNA Activated Caspase Oligomerizers), from living cells’ own defense systems. When viruses infect a cell, they take over its cellular machinery for their own purpose — that is, creating more copies of the virus. As part of their natural defenses against viral infection, human cells have proteins that latch onto dsRNA, setting off a cascade of reactions that prevents the virus from replicating itself. Rider had the idea to combine a dsRNA-binding protein with another protein that induces cells to undergo apoptosis (programmed cell suicide) — launched, for example, when a cell determines it is en route to becoming cancerous. Combining those two elements is a “great idea” and a very novel approach, says Karla Kirkegaard, professor of microbiology and immunology at Stanford University. Each DRACO also includes a “delivery tag,” taken from naturally occurring proteins, that allows it to cross cell membranes and enter any human or animal cell. Most of the tests reported in this study were done in human and animal cells cultured in the lab, but the researchers also tested DRACO in mice infected with the H1N1 influenza virus.
The researchers are now testing DRACO against more viruses in mice and beginning to get promising results.
This work is funded by a grant from the National Institute of Allergy and Infectious Diseases and the New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, with previous funding from the Defense Advanced Research Projects Agency, Defense Threat Reduction Agency, and Director of Defense Research & Engineering (now the Assistant Secretary of Defense for Research and Engineering).
If there is no adverse effect on pregnancy then this could be as big a discovery as the discovery of penicillin (or even bigger).
What effects, if any, would this have on someone who has undergone gene therapy of the kind based on engineered viruses?
And what if someone has lots of harmless viruses on their body, would this kill otherwise healthy cells potentially threatening the person's life? New York, NY New, Get Introduced parties and get togethers Connecting New York City singles.
New York City (or NYC) -- officially, "City of New York," and affectionately known as "The Big Apple" -- is the largest city of the state of New York and in the United States, and by many measures, one of the most important cities in the world. New York is also the location of what was, according to many experts, the most devastating act of terrorism in modern history: the September 11, 2001 attack that utterly destroyed the twin towers of the World Trade Center and several surrounding buildings.
New York has had a reputation as a crime-ridden city, partly due to the hundreds of TV and cinematic crime dramas set in it. The current mayor of New York City is Michael Bloomberg, elected in 2001 on the Republican ticket.
Although New York's harbour was first discovered by Giovanni da Verrazano during his expedition of 1524, the history of New York City properly begins with the Dutch settlement of 1624. In 1664, British ships captured the city, with minimal resistance: the governor at the time, Peter Stuyvesant, was unpopular with the residents of the city. Several battles were fought in New York during the Revolutionary War; the British defeated George Washington's troops, and held the city until the war ended. New York was briefly the capital of the new United States of America, in 1789 and 1790, and George Washington was inaugurated as President in New York, then the nation's second largest city.
The building of the Erie Canal, in the 1820s, helped the city grow further by increasing river traffic upstate and to the west.
The modern city of New York -- the five boroughs -- was created in 1898, as the merger of the cities of New York (then Manhattan and the Bronx) and Brooklyn with the largely rural areas of Queens and Staten Island. The building of the New York subway, as the separate IRT and BMT systems, and the later IND, was a later force for population growth and development.
The world-famous Grand Central Terminal[?] opened as the world's largest train station on February 1, 1913. As of the census of 2000, there are 8,008,278 people, 3,021,588 households, and 1,852,233 families residing in the city.
The median income for a household in the city is $38,293, and the median income for a family is $41,887.
I invite people using message boards saying that I prefer my guests to be 30 - 50 years old but everyone is welcome.
Lebera€™s Hereditary Optic Neuropathy (LHON) symptoms usually begin as sudden, painless loss of central vision. A brief, basic medical overview of LHON is provided in this video by another US LHON Expert, Dr. About 100 people in the United States lose central vision due to LHON each year, joining the 4,000 or so Americans who are already vision impaired due to LHON. LHON is a genetic disorder that can cause the optic nerve to atrophy but does not always do so. Because there is a clear pattern of LHON inheritance, those with a family member on the maternal inheritance chain with LHON should expect that any sudden, painless central vision loss is caused by LHON.
Those who are not aware of any family members with LHON are taken by surprise when they suddenly lose central vision.
It is important to find a medical professional who is aware of the most current research regarding LHON, as there has been much new learning in recent years and the condition is so rare that most medical professionals are not up-to-date on recent developments. Another option is to use the Register tab above, and request a referral to an experienced LHON doctor.
Since LHON is a rare disorder, it may be helpful to discuss these reports with your ophthalmologist, neuro-ophthalmologist or other health professional to determine if this supplement may be right for you, as well as possible side effects. Many LHON specialists suggest that people carrying a LHON mutation, both carriers and affecteds, should avoid environmental factors that could create additional stress on the mitochondria. Having a discussion with your own LHON medical professional about these factors is encouraged. It is important to avoid getting caught up in the hype of for-profit organizations located in China and other countries who offer a€?stem cell treatmentsa€? to a€?curea€? LHON and other disorders. Making new RCGa€™s means nothing if they dona€™t know where their axons need to connect to. This website should be considered general information only and should not be considered medical guidance or professional advice. 3.Making new RCGa€™s means nothing if they dona€™t know where their axons need to connect to. However, such drugs are useless against viral infections, including influenza, the common cold, and deadly hemorrhagic fevers such as Ebola. In the left set of four photos, rhinovirus (the common cold virus) kills untreated human cells (lower left), whereas DRACO has no toxicity in uninfected cells (upper right) and cures an infected cell population (lower right). During this process, the viruses create long strings of double-stranded RNA (dsRNA), which is not found in human or other animal cells. However, many viruses can outsmart that system by blocking one of the steps further down the cascade.


Therefore, when one end of the DRACO binds to dsRNA, it signals the other end of the DRACO to initiate cell suicide. Rider says he hopes to license the technology for trials in larger animals and for eventual human clinical trials.
The new drug from MIT Researches will be a breakthrough in curing ailments like common cold, influenza and others. Are any double stranded RNA particles produced during the early stages of pregnancy with its immune system suppression ? But success as an Rx is less certain, since the presumably costly drug non-selectively enters every cell in the body: "Each DRACO also includes a “delivery tag,” taken from naturally occurring proteins, that allows it to cross cell membranes and enter ANY human or animal cell.
To target cells containing dsRNA and then combining a dsRNA-binding protein with another protein that induces cells to undergo apoptosis.
Is there a way to identify cancer cells and employ the similar mechanism to induce apoptosis?
The city is probably the world's most important financial center, and one of the most important cultural centers of the Western world. Each borough elects a Borough President, but under the current city charter, the Borough President's powers are limited--he or she has a small discretionary budget to spend on projects within the borough. The population of the City of New York is more than eight million (2000 US Census), with the population of the entire metropolitan area at around 20 million. Residents generally refer to New York City (or just Manhattan) as "New York" or "the city". In fact, the city has a high crime rate compared to the United States of America at large, but a relatively low rate compared to other North American cities.
Bloomberg had come to prominence as an expert on Wall Street, which had brought him great wealth, but the mayoralty is his first political office.
His bid for United States Senator from New York State was aborted by treatment for cancer and controversy over his affair with Judith Nathan. That town, at the southern tip of Manhattan, was called New Amsterdam (Nieuw Amsterdam), and was the main city of the Dutch colony of New Netherlands. The British renamed the colony New York, after James II of England, who sponsored the takeover and who was at that time the Duke of York. Patrick's Day was celebrated in New York City for the first time at the Crown and Thistle Tavern on March 17, 1756. By 1835 Manhattan overtook Philadelphia as the most populous city and established itself as the financial and mercantile capital of the western hemisphere. The song gave its name to a film directed by Martin Scorsese (see New York, New York (film)[?]). LeeAnne Homsey Get Introduced! Scientific Confidence Model for Origins’ Beliefs Harold R. The classic pattern is for one eye to suddenly lose central vision, then on average 8 weeks later the other eye also loses central vision, though many variations on this pattern are possible. Similarly, in the right set of four photos, dengue hemorrhagic fever virus kills untreated monkey cells (lower left), whereas DRACO has no toxicity in uninfected cells (upper right) and cures an infected cell population (lower right). The United Nations headquarters is in New York City, giving some credence to the city's self-designation as "capital of the world". In addition, New York has been growing safer for most of the last decade--FBI data indicate that the murder rate in 2000 was the lowest since 1967. Bloomberg had been a Democrat until only a short time earlier, but switched to the Republican Party to run for mayor, in order to avoid a crowded Democratic primary. He handled the aftermath of the World Trade Center disaster well, providing much-needed leadership, and greatly increased his popularity.
The Dutch origins can still be seen in many names in New York City, such as Brooklyn (from Breukelen), Harlem (from Haarlem), The Bronx (from Pieter Bronck) and Staten Island. The city grew northward, and remained the largest and most important city in the colony of New York. This holiday has since become a yearly city-wide celebration that is famous around the world as the St. A nearly pure form of capitalism created a large upper-middle and upper class, but its need for manpower encouraged immigration on an unprecedented scale, with mixed results. Valerio Carelli made very informative presentations about the LHON clinical profile and therapeutic options.
Valerio Carelli made very informative presentations about the LHON clinical profile and therapeutic options.A  Click on the photos below to watch their presentations. Holiday Party, Office Party, Christmas Party, Divorce Party, Cast Party, Many Types Of Events And Parties.
The island of Manhattan was in some measure self-selected as a future metropolis by its extraordinary natural harbor formed by New York Bay (actually an arm of the Atlantic Ocean), the East River (actually a tidal strait) and the Hudson River, all of which are confluent at the southern tip, from which all later development spread. The famed melting pot was brought into being, from which multitudes have since arisen in the successful pursuit of the "American Dream". Have The Jellin Girls Introduce You To Other Great People In New York City's Top Night Clubs. Also of prime importance was the presence of deep fresh water aquifers near the southern tip, especially the Collect Pond[?]. But countless others failed to rise, or entire generations were forced to plough themselves under for their children or grandchildren to rise. Holiday Party, Office Party, Christmas Party, Divorce Party, Cast Party, Many Types Of Events And N.Y. In the mid-1800s these antipodes could be found in the fabulously rich stretches of lower Broadway (wealth that would later take up residence on Fifth Avenue[?]) and the almost unbelievably squalid enclave of Five Points (abject poverty later to take up residence in the Lower East Side[?]). The Best Singles events in New York City Now internet Audio Personals Help Make Connections 24 hrs A Day!
Because of this there is a tendency to err in thinking all statements of science on any topic have greater weight than non-scientific statements.
Ideas can initially appear in any stage, move between stages or skip stages in either direction.
To be investigated in any particular stage, however, they must meet the minimal criteria for the stage. Questions may feedback, but hypotheses are attempts to progress to higher levels of confidence.
Independent findings may strengthen confidence within a stage of examination but do not in themselves increase confidence beyond the stage of examination.
The stage of examination does not necessarily reflect the level of scientific confidence that will ultimately be determined. The confidence that can be attributed to any idea capable of being investigated by the scientific method varies from low to high. When theistic scientists develop simulations or models that meet the criteria of stage II, they too need to present independent methods of verification. For example when creationist Gerald Aardsma wished to verify his model for radiometric time dating based on a catastrophic flood model, he used the independent method of tree rings for correlation. Since the result was highly correlated, he provided a model that was of greater scientific confidence than those based on stage I speculations.20 Although greater scientific confidence can be established at the analytical stage than the creativity one, the situation can arise where more than one model is offered to explain the same process. This is particularly troublesome, as in origins science, where the underlying assumptions differ considerably.
The distinguishing feature in both categories is that the scientist actually sees (directly with the senses or with instruments) something that can be recorded for others to verify independently. In the case of theories, confirmation depends primarily on controlled experiment and direct observation of predictions. Evolution NA NA 2.


Creation NA NA 3. Theistic Evolution x x 5. Intelligent Design x x 6.
Darwinism x x (or eliminated ?) 8.
Lamarckism x x (or eliminated ?) 9.
Abrupt Appearance Evolution x x (or eliminated ?) 10. Genetics x x 11. Thermodynamics x x 12. Gravity x x 13. Big Bang x x? Flat Earth x (eliminated) 18. Sun revolves around Earth x (eliminated) Table 1 illustrates how the author would judge some grand ideas using the Scientific Confidence Model.
This has been done with Intelligent Design for a scientific theory of origin of life.21 With the notable exception of Intelligent Design all of the grand ideas on origins that currently compete with Darwin or Lamarck are stuck in stage I. However tests at the highest confidence level have routinely shown neither idea to be true (at least for macro evolution; which is essential for a grand idea).
In fact, one might consider these ideas to have been falsified by experiment; therefore should be eliminated.
They might have some value on a more limited scale, but not as grand theories that naturalistically explain origins.
Grand ideas like genetics, thermodynamics, gravity, and electromagnetics (10, 11, 12,13) that are neutral toward origins not only had the highest potential for confidence, but are now established at the highest scientific confidence level.
They do however have the potential for model verification, and in the case of Big Bang and Age of the Earth have been independently corroborated with different models. When we look at theories that have been tested at the highest level, Darwinism actually ranks closer to Flat Earth. Intelligent design scientific researchers have successfully specified testable models and simulations clearly distinct from Darwinian models.
The reader may find considerable disagreement with these classifications, but the primary purpose of both tables is to illustrate how the scientific confidence model may be exercised in developing one’s personal confidence in scientific statements. It would appear that experts in the various fields could use the model to build greater consensus on origins issues and scientific relevance, with greater independence from philosophical or religious preferences.
Darwinian Models of Fossil Origins x x 9.
Geological Stratification of Fossils x x 11. Recent Universal Flood x x 17. Catastrophic Models of Geology xx 18.
Uniformitarian Theory of Geology x x 19.
Earth Age Dating Methods x x 20. DNA identification of individuals x x 21. This shows Intelligent Design is fully scientific since it is capable of generating unique scientific hypotheses and models capable of corroboration.
Even most analytical representation methods that could at least give moderate confidence of what happened in prehistory are poorly constructed, primarily ad hoc rather than predictive. Origins science can illustrate well how a scientific contribution can be independent of the scientist’s philosophical or religious interpretation. The model would support, however, those who resist attempts to constrain educators from teaching science to the best of their ability and understanding.
As we have seen, both Darwinism and Intelligent Design have some explanatory value for science. Non-Darwinian scientific models can, however, help teach the benefits of properly applying the scientific method to acquire a high level of scientific confidence in the findings of scientists.
The actual status of discovered transitional fossils is so small that the inference of Darwinian gradualism is no longer held by paleontologists. See for example, typical comments of members of the American Scientific Affiliation in Perspectives on Science and Christian Faith. 150-162) while not opposed to theistic interpretations of the evidence for evolution is critical of Alvin Plantinga’s proposal for a theistic science, being dubious about the benefits to either Christianity or natural science. No Darwinist has ever built a detailed model down to the biochemical level connecting a precursor system to a supposed evolved system. Within non-theist scientific forums, the strongest model presented for biological evolution is modern Darwinism (natural selection as modified with genetics) with no scientific role seen for intelligent design. For example, Darwinian gradualism says nothing scientific about the thermodynamic interface of precursors to the origins of life, species, and the human mind.
In order to qualify as science, intelligent design must do more than find fault with Darwinism; it must suggest scientific research on questions that are distinct from those suggested by evolution. Although pure mathematics is a very exact discipline, it is still a tool, no better no worse at providing answers to philosophical questions than the mind that employs it.
But until the mathematical nicety is verified by sky, field or laboratory observation, its underlying assumptions are still considered on weak foundation. The highest stage of confidence is established by reality testing. That is, there is no testable hypothesis that can be stated to test either Grand Idea when stated so broadly.
They might have some value on a more limited scale, but not as grand theories that naturalistically explain origins. Grand ideas like genetics, thermodynamics, gravity, and electromagnetics (10, 11, 12,13) that are neutral toward origins not only had the highest potential for confidence, but are now established at the highest scientific confidence level. It would appear that experts in the various fields could use the model to build greater consensus on origins issues and scientific relevance, with greater independence from philosophical or religious preferences. Implications for Research and Education Many of the limited scientific ideas regarding origins and biological change have suggested hypotheses that have either been verified or rejected in the reality verification activities.
From evolution the idea of natural selection for species variation has been demonstrated in micro and population biology. It can however conduct experiments that give results that support intelligent design over Darwinism as best explanation of results. Most importantly however, intelligent design has met the criteria for advancing in the confidence process. For a good presentation of the concerns that Intelligent Design is primarily religion see: Barbara Forrest and Paul R. Evolution requires intermediate forms between species and paleontology does not provide them. Darwinism could be proven at the reality verification stage if three forms of evidence were produced.



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