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Even for people with severe obsessive-compulsive disorder (OCD), cognitive-behavioral therapy outperforms anti-psychotic medication in some hard-to-treat patients, finds a recent study by researchers at Columbia University Medical Center and New York State Psychiatric Institute.
More than 6 million Americans are affected by OCD, which causes intrusive thoughts, images or urges (obsessions) as well as repetitive behaviors or mental acts (compulsions). OCD patients are often treated first with serotonin reuptake inhibitors (SRIs), but most will continue to have significant residual symptoms. Choosing which treatment is best for each individual patient, however, can be a complicated decision for clinicians to make.


This study was funded by National Institute of Mental Health Grants K24 MH091555 , R01 MH045436 and R01 MH45404.
Blair Simpson, MD, PhD, professor of psychiatry at Columbia University Medical Center and director of the Center for Obsessive-Compulsive and Related Disorders. Wheaton (New York State Psychiatric Institute), David Rosenfield (Southern Methodist University), Edna B.
Blair Simpson received research funds for clinical trials from Janssen Pharmaceuticals (2006 –2012), Transcept Pharmaceuticals (2011–2013), and Neuropharm Ltd.


Blair Simpson (New York State Psychiatric Institute and Columbia University Medical Center).
Foa was a consultant to Jazz Pharmaceuticals (for Acetelion) and received royalties from Bantam and Oxford University Press for book sales, including a manual of cognitive-behavioral therapy for OCD.



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