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AbstractCo-signaling molecules have been demonstrated to regulate regulatory T cells’ (Tregs) function during human immunodeficiency virus (HIV) infection. This is a very serious condition which can cause long term damage to some cats such as blindness. A recently reported co-signaling molecule called herpes virus entry mediator (HVEM), a member of the tumor necrosis factor receptor family, can both enhance and inhibit the immune response.
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However, it remains unknown whether HVEM can regulate Treg function in HIV-infected patients or whether HVEM affects HIV disease progression. The use of household bleach mixed with water is advisable on washable items.The Spread of the virus needs to be contained. In this study, we found that the blockage of the HVEM could weaken Tregs’ suppressive activity to effector T cells (Teffs). HVEM expression is reduced during the asymptomatic phase of HIV infection and fairly predictive of the recovery of CD4+T-cells in response to highly active anti-retroviral therapy (HAART), more so than nadir CD4+T-cell count or viral load. It is important that we do not handle the sick cat often and always thoroughly wash our hands when we do.


Taken together, these findings demonstrate the importance of HVEM in relation to Treg function and HIV disease progression, which would have therapeutic implications and provide insight into the pathogenesis of acquired immune deficiency syndrome (AIDS).



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