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But larger, longer trials are needed, experts say By Amy Norton HealthDay Reporter WEDNESDAY, Jan. New York NYC Crime Bronx Brooklyn Manhattan Queens Education Obituaries Sports Yankees Mets Giants Jets Knicks Nets Rangers Islanders Football Basketball Baseball Hockey Soccer College High School The Score News Crime U.S. Follow Us Facebook Twitter Instagram Pinterest YouTube Subscribe Follow UsNewsletter App Subscriptions Subscribe Get Our Newsletter A daily blend of the most need-to-know Daily News stories, delivered right to your inbox.
Women who used tenofovir gel were better protected against genital herpes than those who took it orally.
An experimental vaginal gel containing a drug used to treat the AIDS virus could prevent half of cases of genital herpes, according to a study done in South Africa. Among women who used tenofovir gel, the annual rate of infection with the genital herpes virus, known as herpes simplex virus type 2 or HSV-2, was 10.2 percent versus a rate of 21 percent for women who used a placebo gel. HSV-2 virus infects about one in five sexually active adults worldwide, or about 417 million people aged 15 to 49 years old, the study team writes in the New England Journal of Medicine.
Condoms provide the best protection, but even that is limited because the virus can be shed and acquired by other parts of the groin not shielded by a condom, Abdool Karim said. Among the 422 women enrolled in the herpes study, half were given applicators with the drug-infused gel and the rest were given a placebo gel. The study results indicate that topical tenofovir can reduce HSV-2 acquisition by almost half, said Dr. The study did not detail side effects, although an earlier report available online says the drug can increase the risk of mild diarrhea. Send a Letter to the Editor Join the Conversation: facebook Tweet Get Daily News stories, delivered to your inbox. Researchers may just have come one step closer to finding a possible cure for genital herpes, a common yet incurable sexually transmitted infection. The drug, called pritelivir, curbs "viral shedding," or the amount of time the virus was active and potentially transmissible to the sexual partners of people with genital herpes.
This was discovered in a small preliminary study, which was funded by AiCuris, the pharmaceutical company that is developing pritelivir. At the end of four weeks, researchers found that patients who were on a daily dose of 75 milligrams of pritelivir demonstrated the biggest response to the medication. The occurrence of genital lesions also decreased to 1.2 percent of days among those who took pritelivir, compared to 9 percent of days for those who took a placebo. Genital herpes is caused by the herpes simplex virus, specifically the strain called HSV-2.
In many cases the virus causes mild to no symptoms, so those infected but show none of the symptoms, are not even aware that they need treatment.

The ultimate hope is to develop drugs that eliminate dormant (latent) HSV from the nerve cells.
Researchers report that “an experimental drug could eventually offer a new treatment option for genital herpes (HSV-2), a common and incurable sexually transmitted infection (1).” The drug is designed to work differently than current drugs on the market.
While there are no drugs yet that target the latent (dormant) HSV, there is already a natural remedy called Novirin that was designed to target the latent or “dormant” (as Dr. Reach out to the author: contact and available social following information is listed in the top-right of all news releases.
Salim Abdool Karim of the Centre for the AIDS Program of Research in South Africa told Reuters Health.
The virus is the most common cause of genital ulcers, and in South Africa, the estimated infection rate is 50 percent to 60 percent. The test of its ability to protect against genital herpes was grafted onto an existing study, which ultimately demonstrated that the gel reduced the odds of getting HIV by 39 percent. They were told to insert the gel within 12 hours before they expected to have sex and as soon as possible within 12 hours after sex. Connie Celum, director of the International Clinical Research Center at the University of Washington in Seattle, by email. When drug levels in the vagina were high, the annual rate of herpes-2 infection was less than 6 percent compared to almost 16 percent when there was no detectable tenofovir in the vaginal fluid.
Richard Whitley, a professor of pediatric infectious diseases at the University of Alabama at Birmingham. Because the virus hides in nerve cells and reactivates periodically, there is no cure for genital herpes. Lawrence Stanberry said “The ultimate hope is to develop drugs that eliminate dormant (latent) HSV from the nerve cells (1).” Dr. Scientists scanned thousands of scientific and medical papers published in various medical and scientific journals around the world to identify the highest quality, safest, most effective natural ingredients that target latent viruses. All orders of Novirin are completely confidential, and no information is shared or sold to any third party. Polansky published the highly acclaimed scientific discovery, called Microcompetition with Foreign DNA. Throughout Sub-Saharan Africa the rate is thought to be as high as 80 percent in women and 50 percent in men. Centers for Disease Control and Prevention (CDC), about 16 percent of Americans aged 14-49 are infected with HSV-2. However, medication can be taken to treat its symptoms and suppress the outbreak of new symptoms.

Richard Whitley said that “There is still a lot of research to be done,” and that the study on pritelivir was only a “proof of concept” at this time. Followers of the current paradigm believe in only treating individuals with the active virus, and not in treating individuals infected with the dormant (latent) virus. The discovery explains how foreign DNA fragments, and specifically, DNA of latent viruses, cause most major diseases. Interestingly, those who received the drug in 400 mg dosage on a weekly basis, showed shedding on 5.3 percent of the days.
Since pritelivir and other next generation drugs are still in early research phases, polyDNA recommends that individuals who want to help their immune system target the latent herpes virus talk to their doctors about Novirin. For instance, a meta-analysis of five placebo-controlled and two dose comparison studies evaluated the effect of aciclovir, famciclovir or valaciclovir on symptoms.
The FDA even states on its website: “Some viruses, however, can enter a state known as latency in which the virus is not being replicated.
The difference between the two is that Novirin has higher quality, more expensive ingredients. One group was given placebo pills, while the other four were given different doses of pritelivir. This is significant because if once a week dosage is effective, treatment among patients would be more acceptable and convenient. This effective, natural treatment option was shown to reduce symptoms of a herpes infection in a post-marketing clinical study that followed FDA guidelines.
In the latent state, the virus does not cause disease.” (See the FDA, from October 24, 2001) (4).
Anna Wald, lead researcher on the pritelivir study said that “Even with that daily treatment (with approved drugs), there is still viral shedding and the drugs cut HSV transmission by only about half.
These ingredients were selected to fight the latent herpes virus even more effectively than Gene-Eden-VIR.
Even while taking these drugs, infected individuals can still transmit the virus to their partners.

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