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Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections. Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients.
At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding. The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity.
The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen.
The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M. Mice were infected by the vaginal route with the MS strain of herpes simplex virus type 2 (HSV-2). ReferencesBaringer JR (1975) Herpes simplex virus infection of nervous tissues in animal and man. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. The herpes simplex virus strains, herpes simplex virus 1 (HSV1) and herpes simplex virus 2 (HSV 2), are responsible for the outbreak of vaginal herpes in sexually active women. This infectious disease is transmitted to sexually active, healthy women from partners who are afflicted with genital herpes. Noodles are a favorite among many but it is associated with a lot of oil and fat content too! Tangerine essential oil is derived from citrus fruits and gets extracted through cold compression method. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003.
David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction.
12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver.
The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected.
In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection.
Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. Prog Med Virol 30:1–26Cook ML, Stevens JG (1973) Pathogenesis of herpetic neuritis and ganglionitis in mice.


Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases.
Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners.
The symptoms of vaginal herpes appear within two weeks of contracting this venereal disease.  The initial symptoms of vaginal herpes may be very mild. Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2.
Semithin Epon-sections were stained for viral antigen using a rabbit anti-HSV-2 antiserum and the Avidin-Biotin (ABC) method. Thin sections from antigen-positive blocks were examined by electron microscopy, and the number and types of infected cells detected by these two methods were compared.
J Infect Dis, 127:365–372Dillard SH, Cheatham WJ, Moses HL (1972) Electron microscopy of zosteriform herpes simplex infection in the mouse. However, there are small groups of women who exhibit no outwardly symptoms despite being exposed to the herpes simplex virus. Lab Invest 26:391–402Erlandsen SL, Parsons JA, Rodning CB (1979) Technical parameters of immunostaining of osmicated tissue in epoxy sections. Infected cells included neurons of dorsal root ganglia and spinal cord, satellite cells of dorsal root ganglia, non-myelinating Schwann cells, astrocytes, oligodendrocytes and arachnoidal cells.
Symptoms associated with the future or recurrent outbreaks of this sexually contracted disease are not as bad as the first attack. J Gen Virol 21:123–133Hill TJ, Field HJ, Roome APC (1972) Intra-axonal location of herpes simplex virus particles. Some  Common Symptoms Of Vaginal Herpes Blistering One of the first symptoms of vaginal herpes is the appearance of blisters or pimples in the region surrounding the vagina and even inside the vagina (the cervix).
The temporal and spatial distribution of infected cells was consistent with neural spread to and within the CNS. The blisters or sores appear in waves with one set of blisters drying off before the next set appears. Once the fluid filled blisters break, blood and pus begin to ooze from the sore. The pathological lesions showed a good correlation with the distribution and number of infected cells and are probably due to a direct virus effect.
Virus pathways to the nervous system of suckling mice demonstrated by fluorescent antibody staining.
Approximately three days after the blister bursts, a yellowish crust forms around the affected area. This crust flakes off once the vaginal herpes outbreak subsides.
The similar sensitivity of the Epon-ABC method to electron microscopy in detecting infected cells indicates that this method may have useful applications in both experimental and diagnostic work.
J Exp Med 119:343–356Kristensson K, Lycke E, Sjostrand J (1971) Spread of herpes simplex virus in peripheral nerves.
Acta Neuropathol (Berl) 17:44–53Kristensson K, Vahlne A, Persson LA, Lycke E (1978) Neural spread of herpes simplex virus types 1 and 2 in mice after corneal or subcutaneous (footpad) inoculation. J Neurol Sci 35:331–340Kristensson K, Svennerholm B, Persson L, Vahlne A, Lycke E (1979) Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system.
Flu Like Symptoms Another common symptom associated with vagina herpes is the sudden onset of flu.


J Neurol Sci 43:253–264Lascano EF, Berria MI (1980) Histological study of the progression of herpes simplex virus in mice. During an outbreak of vaginal herpes, women complain of body pain, headache, general malaise, severe fatigue. The glands also become swollen and painful. Arch Virol 64:67–79Lukas B, Wiesendanger W, Schmidt-Ruppin KH (1975) Herpes genitalis in Guinea pigs. The flu like symptoms generally disappears within a week of the initial onset of vaginal herpes.  In some women, the flu like symptoms is accompanied by skin lesions as well.
Arch Virol 49:1–11Martin JR (1984) Intra-axonal virus in demyelinative lesions of experimental herpes simples type 2 infection. J Neurol Sci 63:63–74Martin JR, Stoner GL, (1984) The nervous system in genital herpes simplex virus type 2 infections in mice.
Lab Invest 51:556–566Martin JR, Stoner GL, Webster H de F (1982) Lethal encephalitis and non-lethal multifocal central nervous system demyelination in herpes simplex virus type 2 infections in mice. Vaginal Itching During a vaginal herpes outbreak women may experience severe vaginal itching or a burning sensation around the vagina.
J Immunol 119:2030–2036Overall JC Jr, Kern ER, Schlitzer RL, Friedman SB, Glasgow LA (1975) Genital herpes-virus hominis infection in mice. When the vaginal herpes outbreak subsides, the itching and burning sensation in the vagina also abates. Malodorous Vaginal Discharge Thick, malodorous vaginal discharge is yet another sign of vaginal herpes. Infect Immun 11:476–480Renis HE, Eidson EE, Mathews J, Gray JF (1976) Pathogenesis of herpes simplex virus type 1 and 2 in mice after various routes of inoculation.
If you observe thick, malodorous vaginal discharge for a couple of days, consult your gynecologist to determine whether you are suffering from vaginal herpes or some other gynaec problem.
Infect Immun 14:571–578Severin MJ, White RJ (1968) The neural transmission of herpes simplex virus in mice.
Am J Pathol 53:1009–1020Stanberry LR, Kern ER, Richards JT, Abbott TM, Overall JC Jr (1982) Genital herpes in guinea pigs. John Wiley and Sons, New YorkTownsend JJ (1981a) The relationship of astrocytes and macrophages to CNS demyelination after experimental herpes simplex infection. J Neuropathol Exp Neurol 40:369–379Townsend JJ (1981b) The demyelinating effect of corneal HSV infections in normal and nude (athymic) mice. J Neurol Sci 50:435–441Townsend JJ, Baringer JR (1976) Comparative vulnerability of peripheral and central nervous tissue to herpes simplex virus. J Neuropathol Exp Neurol 35:100 [abstr]Townsend JJ, Baringer JR (1978) Central nervous susceptibility to herpes simplex infection. J Neuropathol Exp Neurol 37:255–262Yamamoto T, Otani S, Shiraki H (1965) A study of the evolution of viral infection in experimental herpes simplex encephalitis and rabies by means of fluorescent antibody.
Acta Neuropathol (Berl) 5:288–306Yamamoto T, Otani S, Shiraki H (1973) Ultrastructure of herpes simplex virus infection of the nervous system of mice. Acta Neuropathol (Berl) 26:285–299Wildy P (1967) The progression of herpes simplex virus to the central nervous system of the mouse.



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