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OverviewHerpes simplex, a common viral disease, is caused by two strains of the herpes simplex virus (HSV).
The initial infection (primary stage) of oral herpes is generally asymptomatic and is acquired through person to person contact such as kissing. The stages of genital herpes are very similar to oral herpes with an initial stage that manifests with few symptoms and is less contagious. For both genital and oral herpes, the dormancy period involves the virus "resting" within the nervous tissue around the initially infected area.
Herpes is commonly diagnosed based upon the symptoms described above paired with frequent recurrence in the same area. Once diagnosed with herpes, managing the disease includes caring for sores during outbreaks as well as preventing their recurrence. Since genital and oral herpes are extremely common in the United States, with an estimate of 45 million people or one out of every five infected, there are many places to turn for support. Viral infections or exacerbations are still the most difficult problem in medicine to date. This practice surpasses my expectations in every way, from the staff, dress code, advances in technology and overall care of the patient. By age 40, nearly 90% of adults have been exposed to the herpes simplex virus-1 (HSV-1), which causes cold sores.
Until now, research has generally concentrated on keeping HSV1 inactive — and preventing cold sores from ever showing up. Understanding how to override the microRNA could allow scientists to activate the virus and then kill it using acyclovir. The theory is that by activating the virus, then preventing it from returning to hibernation, which is when researchers think it gains strength, it can be completely eradicated.
Cullen and his colleagues, as well as several biotech firms, are already investigating such treatments and how best to deliver them. Sexually transmitted diseases are those diseases that are passed on from one infected partner to another during vaginal, anal or oral sexual intercourse. While oral STDs can sometimes pass off unnoticed, there are some oral STDs that have characteristic symptoms. A redness in the throat which is very similar to a strep throat. The infected person may experience pain and difficulty when swallowing.
It is much easier to contract syphilis through vaginal and anal intercourse than through oral intercourse.


The first symptom of oral syphilis is the presence of an open sore known as a ‘chancre’ that appears about three weeks after contact with an infected person. Long-term prophylaxis of cold sores is indicated when you get cold sores frequently, at a rate of about 6 or more times per year.
The doctor herself is a pro, I was very impressed and will definitely recommend her to others, especially of my race. The doctor was very thorough.Also, now I know what do do the next time my problem reappears and know that it can be taken care of. The decor and overall appearance has the feel of your living room but also reminds you that you are in a clinical environment as well.
But the Duke researchers took the opposite tack: figuring out precisely how to switch the virus from latency to its active stage. Cullen believes that a drug could be developed to block the microRNA that suppress HSV-1 into latency; once it's active, acyclovir can be used to destroy the virus permanently. In the case of an oral STD, the infection is usually transferred when it comes in contact with the mucus lining of the oral cavity. The symptoms are not limited to the oral cavity alone and may erupt on other parts of the bodies in the form of a rash or fever.
While the symptoms are often noticed around the lips, they can also travel deep into the oral cavity. This is usually seen on the lips; however, it is not uncommon for it to appear on the tongue. Organ damage, blindness and even death is possible if the disease is allowed to progress to this stage.
When it does occur, it is usually asymptomatic; however, when the disease presents with symptoms, the symptoms include a sore throat and flu-like symptoms such as fever, body pain and nausea. The potential side effects of daily oral medication must be considered with infrequent cold sores. Its very hard to find a good dermatologist and I believe she is wonderful and really knows what she's doing. For those who do, however, cold sores are a painful and permanent nuisance, always erupting in the same location, at the original site of infection on the lips or mouth. In its latent stage, HSV-1 produces a single molecular product, called latency-associated transcript RNA, or LAT RNA.
Cullen suggests that this new research may also eventually be applied to other latent viruses, such as herpes simplex virus-2 (HSV-2), which causes genital herpes, or the chicken pox virus, which causes shingles in adults.


But when one looks at the larger picture, oral sex, like any other type of sexual intercourse, carries the risk of sexually transmitted diseases. When the infection spreads inside the mouth these sores can be seen on the gums and even on the tongue. After the first phase, both the sores and the fever disappear but may appear again at a later stage. If left untreated, the chancre disappears on its own and the disease progresses to the next stage. Worse yet, once you're infected with the virus that causes them, you're stuck with it for good.
Once HSV-1 enters the body it hunkers down for life, most of the time hiding dormant in the cranial nerves near the spine.
Unlike most messenger RNA, LAT RNA doesn't produce proteins, so scientists have never been able to determine LAT RNA's exact function.
Cullen warns that some patients, especially those suffering genital herpes, may have to take acyclovir on a regular basis (HSV-2 is a hardier virus), but for people with HSV-1, the virus could be eradicated with just one dose. But landmark research reported today by microbiologists at Duke University may offer the potential for a cure.
The virus can be triggered by outside stress, such as exposure to sunlight, a fever or emotional distress.
But by inserting the LAT RNA into mice, Cullen found that it breaks down into even smaller strands called microRNA.
In some instances, samples of representative lesions are taken and tested for the presence of the HSV1 or HSV2 virus.
After it's active and a cold sore appears, it's treatable with the drug acyclovir, marketed under the name Zovirax, which kills replicating HSV-1.
Researchers then discovered that it was the microRNA that blocked production of the protein that activates HSV-1.
But the mystery has been how to eliminate the virus while it's hiding, before it produces unsightly symptoms.



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