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admin 03.10.2013

Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections.
Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept.
Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients.
At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding.
The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity. The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen.
The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M.
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Herpes Simplex Virus Type 1(HSV-1), which causes cold sores, is transmitted by direct contact with body fluids, such as saliva (through kissing). Herpes Simplex Virus Type 2(HSV-2), or genital herpes, is transmitted by sexual intercourse or direct contact with a herpes sore. A periocular herpes outbreak occurred around the eye of a 7-year-old child with a history of recurrent herpes labialis. This patient has a characteristic vesiculopapular herpes simplex lesions on his anterior thigh.


A micrograph picture of the herpes simplex virus, within tissue taken from a penile lesion of a patient with genital herpes.
For the science geek in everyone, Live Science offers a fascinating window into the natural and technological world, delivering comprehensive and compelling news and analysis on everything from dinosaur discoveries, archaeological finds and amazing animals to health, innovation and wearable technology. Genital herpes is a sexually transmitted disease (STD) that is caused by the herpes simplex virus type 1 (HSV1) or type 2 (HSV2).
There is no cure for genital herpes but there is treatment available to suppress the signs and symptoms. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003. David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. 12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver.
The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected. In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus.
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I have the discharge, I got a bladder infection after having sex with a new partner, then when I check I found out I have chlamydia, now am worried about herpes.


Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases. Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. Genital herpes, with symptoms including lesions on or around the genitals and rectum and even thighs and buttocks, is caused by Herpes Simplex Virus Type 2 (HSV-2) and is sexually transmitted. Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. These pictures are among the least graphic and are published here in the interest of providing information to those who may wonder if they or a loved one has contracted herpes. Doctors refer to the cold sores as recurrent herpes labialis; they are also known as fever blisters. When signs and symptoms do occur they will visually be sores or blisters on or around your genitals. However, none of these images nor the information on this page should be construed as medical advice nor an attempt to make diagnoses. Anyone who thinks they may be infected with the herpes virus should seek medical attention.
There is no cure, but antiviral drugs can cut down on the frequency and severity of outbreaks. There is no cure, but antiviral medication can reduce the frequency and severity of outbreaks.



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