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admin 22.04.2016

Now that you know a little about herpes in general, let's start with learning about these two most well-known types. Aplasia cutis congenita is a rare skin condition characterized by the absence of localized or widespread areas of skin at birth.
Aplasia cutis congenita (ACC) is a condition characterized by the absence of skin at birth. A new born baby boy was seen in the neonatal Intensive Care Unit (ICU) just after birth, who had almost complete absence of the skin except for some area around the nose (Figure-1) and on the buttocks (Figure-2) where skin had formed. Pemphigus Vulgaris during pregnancy is very rare.1 Our case was further complicated by the birth of a neonate with extensive skin aplasia. Our case is more likely associated with Type 8 ACC, which is the type associated with teratogens.
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Warning all mums across the world, Doncaster-based Claire Henderson recalled how her little baby, Brooke, was hospitalized for five days with horrific blisters that could have caused liver and brain damage. I know this sounds like I am scaremongering but if my friend had not told me about this my baby girl could have been very seriously ill. The moral of the story is DO NOT let anyone kiss your newborns mouth, even if they don’t look like they have a cold sore – 85% of the population carry the virus.
One of Claire’s followers commented: ‘Well said Claire people do need to be aware of this as I didn’t know this could happen to babies. BABY HERPES PICTURESResources, pictures, herpies picturesdoctors give trusted, helpful answers look nasty, and others. It's a DNA virus, which means that its genetic material is made of DNA and it replicates through RNA in the nucleus of a cell. When the virus is active, an infected person experiences symptoms and associated illnesses.


We are reporting a variant aplasia cutis congenita, which involved over 90% of the body surface area, which occurred in a baby born to a mother with pemphigus vulgaris who was on oral prednisolone and azathioprine. The entire body was covered in a membrane which had numerous vessels visible on its surface.
I noticed the signs early and got her to A&E, we have now been in hospital on a drip for 3 days and have another 2 to go.
If you haven't gotten cold sores, you're still not home free -- if you've had chicken pox, you're carrying a different type of herpes. A case of extensive aplasia cutis congenita was seen and oral intake of azathioprine by the mother during pregnancy was suspected as an etiologic factor. What makes the case interesting is that this neonate was exposed to two drugs in utero, prednisolone before and throughout pregnancy and azathioprine 6 weeks before and for the first 20 weeks of pregnancy.Corticosteroids, prednisone and prednisolone cross the placental barrier, but are metabolized by a placental 11- hydroxygenase and thus the foetus is exposed to only 10% of the maternal dose. Type 1 although not associated with multiple abnormalities and has only localized lesions on the scalp; but as the investigations were not done, the abnormalities cannot be ruled out. Everyone who I have spoken to had not heard this before so I felt it was important to share Brooke’s story and raise awareness to stop anyone else going through what we have this week,” the concerned mum posted on Facebook.The post has so far garnered over 35,000 shares. Often, though, that's the extent of the average person's knowledge when it comes to herpes.
During the shedding stage of the cycle, the virus replicates itself, which can occur even when the virus is inactive.
The parents of the patient did not consent for biopsy or autopsy so the histopathological picture was not available and hence involvement of other systems could not be ascertained.
The effects of immunosuppressive drugs and anti-inflammatory medications on fertility, pregnancy, and lactation. Due, to financial constraints some of the investigations which might have helped in assigning the patient to a particular category of aplasia cutis such as karyotyping and CT scan brain could not be carried out.
Azathioprine and mercaptopurine both cross the placenta and mercaptopurine can be measured in foetal blood.


Many people have no idea that they have a herpes virus because they've never had any symptoms. Our patient suffered from isolated extensive ACC and was exposed in utero to both, azathioprine, and prednisolone. He was nursed in an incubator but died on the 4th day of birth of neonatal sepsis in spite of supportive management, including antibiotic therapy.He was born to non consanguineous parents by lower segment caesarian section at 38 weeks of gestation because the baby showed signs of intrauterine growthretardation.
Azathioprine has been held responsible for an increase in congenital malformations although not specifically ACC and prednisolone is regarded safe in pregnancy. Unfortunately our patient could not be investigated extensively due to financial constraints.Our patient had extensive ACC and it appeared to be an isolated finding. So we conclude that our patient is most likely type 8 ACC — as there was no evidence of limb reduction defects, epidermolysis bullosa, intrauterine infection or twin pregnancy, on the other hand, exposure to azathioprine at the time of conception and for the following 20 weeks could be responsible for this occurrence.
The mother who was 26 years of age had a history of pemphigus vulgaris for the past 1 year, confirmed on histopathology and direct immunoflourescence. We believe it is important to document this extensive skin aplasia and although a chance occurrence cannot be ruled out, the extensive and severe nature of the defect makes us wary and wonder if azathioprine really is an innocent bystander? Her disease had been particularly difficult to control and she had been on tablet prednisolone 60 mg daily for the first 2 months of pregnancy. The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. After delivery of the baby the dose of prednisolone was reduced gradually and her disease was controlled on 15 mg of prednisolone on alternate days.



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