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This image shows the phylogenetic tree for 31 HSV-1 strains and their 6 clades, based on geographic origin. Studies of human genomes have shown that human ancestors emerged from Africa roughly 150,000 to 200,000 years ago, and then spread eastward toward Asia, and westward toward Europe. Scientists have previously studied HSV-1 by looking at a single gene, or a small cluster of genes, but this approach can be misleading. Prof Brandt’s team broke the genomes into 26 pieces, made family trees for each piece and then combined each of the trees into one network tree of the whole genome. HSV-1 was an ideal virus for the study because it is easy to collect, usually not lethal, and able to form lifelong latent infections.
Organic St Johns Wort tincture is useful in nervous problems with moderate depression, anxiety, tension & insomnia. History: St Johns wort has been documented by Hippocrates, Pliny, Dioscorides, Galen, Paracelsus, Gerard and Culpepper.
Science: In 1996 the BMJ published a meta-analyis of 23 randomised trials which demonstrated effectiveness of st Johns wort in depression. In 15 clinical trials volunteers given placebo exhibited more side effects than those who got the st. We found that all of the African isolates cluster together, all the virus from the Far East, Korea, Japan, China clustered together, all the viruses in Europe and America, with one exception, clustered together,” explained Prof Curtis Brandt from the University of Wisconsin-Madison, who is the senior author of the paper published in the open-access journal PLoS ONE.

The new study used high-capacity genetic sequencing and advanced bioinformatics to analyze the massive amount of data from the 31 HSV-1 genomes. Every HSV-1 sample from the United States except one matched the European strains, but one strain that was isolated in Texas looked Asian. Either the sample had come from someone who had traveled from the Far East, or it came from a native American whose ancestors had crossed the land bridge across the Bering Strait roughly 15,000 years ago,” said lead author Dr Aaron Kolb from the University of Wisconsin-Madison.
The dates match, so we postulate that this was an Amerindian virus,” Prof Brandt added. Our results clearly support the anthropological data, and other genetic data, that explain how humans came from Africa into the Middle East and started to spread from there,” Prof Brandt concluded. Can be used as a nerve restorative & can be helpful in reducing attacks of herpes zooster. The Centre for Complementary Health Studies in Exeter made a critical assessment of 18 clinical trials n St Johns Wort. Furthermore, HSV-1 is much simpler than the human genome, which cuts the cost of sequencing, yet its genome is much larger than another virus that also has been used for this type of study. They concluded that 11 studies met the rigorous acceptable critieria and that St Johns Wort was superior to placebo and equally as effective as the standard medication in mild to moderate depression. Genetics often comes down to a numbers game; larger numbers produce stronger evidence, so a larger genome produces much more detail.

Johns Wort as a wound healing herb that was also useful against stings and bites of animals and insects.
Subsequent trials have all confirmed the effects.The anti-viral properties of this herb are the subject of intense ongoing research. John’s wort is known to inhibit the effectiveness of some drugs so if this is a concern to you, advice should be sought of a medical practitioner. Since the 16th century this herb has been extensively used for wounds, bites and bruises and particularly nerve injuries. Avoid all sexual contact while you are taking Famvir. Side effects Famvir (famciclovir) can cause side effects. The most common include gastrointestinal complaints such as nausea, diarrhea, stomach ache and vomiting. See package leaflet for a complete list of side effects. Pregnancy and breastfeeding Do not use Famvir (famciclovir) if you are pregnant or breastfeeding. Inform your doctor of any other medicines you are taking to avoid potential interaction between Famvir and other medication.

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